DK1185516T3 - Substituerede phenylcyclohexancarboxylsyreamider med adenosinoptagelseshæmmende virkning - Google Patents
Substituerede phenylcyclohexancarboxylsyreamider med adenosinoptagelseshæmmende virkningInfo
- Publication number
- DK1185516T3 DK1185516T3 DK00925288T DK00925288T DK1185516T3 DK 1185516 T3 DK1185516 T3 DK 1185516T3 DK 00925288 T DK00925288 T DK 00925288T DK 00925288 T DK00925288 T DK 00925288T DK 1185516 T3 DK1185516 T3 DK 1185516T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid amides
- inhibitory effect
- adenosine uptake
- uptake inhibitory
- phenylcyclohexanecarboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924818A DE19924818A1 (de) | 1999-05-29 | 1999-05-29 | Substituierte Phenylcyclohexancarbonsäureamide |
PCT/EP2000/004417 WO2000073275A1 (de) | 1999-05-29 | 2000-05-16 | Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1185516T3 true DK1185516T3 (da) | 2003-08-11 |
Family
ID=7909712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00925288T DK1185516T3 (da) | 1999-05-29 | 2000-05-16 | Substituerede phenylcyclohexancarboxylsyreamider med adenosinoptagelseshæmmende virkning |
Country Status (36)
Country | Link |
---|---|
US (2) | US6716849B1 (zh) |
EP (1) | EP1185516B1 (zh) |
JP (1) | JP2003500475A (zh) |
KR (1) | KR20020003397A (zh) |
CN (1) | CN1200932C (zh) |
AR (1) | AR024100A1 (zh) |
AT (1) | ATE238997T1 (zh) |
AU (1) | AU765752B2 (zh) |
BG (1) | BG106107A (zh) |
BR (1) | BR0011061A (zh) |
CA (1) | CA2375186A1 (zh) |
CZ (1) | CZ20014288A3 (zh) |
DE (2) | DE19924818A1 (zh) |
DK (1) | DK1185516T3 (zh) |
EE (1) | EE200100634A (zh) |
ES (1) | ES2197870T3 (zh) |
GT (1) | GT200000083A (zh) |
HK (1) | HK1048810A1 (zh) |
HN (1) | HN2000000072A (zh) |
HR (1) | HRP20010955A2 (zh) |
HU (1) | HUP0201350A3 (zh) |
IL (1) | IL146392A0 (zh) |
MA (1) | MA25414A1 (zh) |
MX (1) | MXPA01012241A (zh) |
MY (1) | MY122576A (zh) |
NO (1) | NO20015810L (zh) |
PE (1) | PE20010167A1 (zh) |
PL (1) | PL352101A1 (zh) |
PT (1) | PT1185516E (zh) |
RU (1) | RU2246490C9 (zh) |
SI (1) | SI1185516T1 (zh) |
SK (1) | SK17052001A3 (zh) |
SV (1) | SV2004000087A (zh) |
UA (1) | UA73126C2 (zh) |
WO (1) | WO2000073275A1 (zh) |
ZA (1) | ZA200109263B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1834090B (zh) * | 2005-03-18 | 2011-06-29 | 中国科学院上海药物研究所 | 苯并咪唑类化合物、其制备方法以及用途 |
BRPI0914788B1 (pt) * | 2008-06-16 | 2020-04-07 | Boehringer Ingelheim Int | processo para produção de um produto intermediário de etexilato de dabigatran |
BR112014030940B1 (pt) | 2012-06-11 | 2022-09-06 | UCB Biopharma SRL | Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos |
SG11202105512PA (en) * | 2018-11-25 | 2021-06-29 | Tnt Medical Corp | Orally active prodrug of gemcitabine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2685918B1 (fr) * | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
DE4221009A1 (de) * | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Cyclohexanderivate |
ES2125285T3 (es) | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
DE4304455A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
HRP960015B1 (en) | 1995-02-01 | 2000-12-31 | Bayer Ag | Substituted indole derivatives |
DE19503160A1 (de) * | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
-
1999
- 1999-05-29 DE DE19924818A patent/DE19924818A1/de not_active Withdrawn
-
2000
- 2000-05-10 HN HN2000000072A patent/HN2000000072A/es unknown
- 2000-05-16 KR KR1020017015263A patent/KR20020003397A/ko active IP Right Grant
- 2000-05-16 UA UA2001129201A patent/UA73126C2/uk unknown
- 2000-05-16 RU RU2001135715/04A patent/RU2246490C9/ru not_active IP Right Cessation
- 2000-05-16 ES ES00925288T patent/ES2197870T3/es not_active Expired - Lifetime
- 2000-05-16 CN CNB008110492A patent/CN1200932C/zh not_active Expired - Fee Related
- 2000-05-16 HU HU0201350A patent/HUP0201350A3/hu unknown
- 2000-05-16 DK DK00925288T patent/DK1185516T3/da active
- 2000-05-16 AU AU44055/00A patent/AU765752B2/en not_active Ceased
- 2000-05-16 EE EEP200100634A patent/EE200100634A/xx unknown
- 2000-05-16 US US09/980,243 patent/US6716849B1/en not_active Expired - Fee Related
- 2000-05-16 JP JP2000621341A patent/JP2003500475A/ja active Pending
- 2000-05-16 WO PCT/EP2000/004417 patent/WO2000073275A1/de not_active Application Discontinuation
- 2000-05-16 SK SK1705-2001A patent/SK17052001A3/sk unknown
- 2000-05-16 SI SI200030147T patent/SI1185516T1/xx unknown
- 2000-05-16 DE DE50001982T patent/DE50001982D1/de not_active Expired - Fee Related
- 2000-05-16 MX MXPA01012241A patent/MXPA01012241A/es active IP Right Grant
- 2000-05-16 CA CA002375186A patent/CA2375186A1/en not_active Abandoned
- 2000-05-16 BR BR0011061-2A patent/BR0011061A/pt not_active IP Right Cessation
- 2000-05-16 EP EP00925288A patent/EP1185516B1/de not_active Expired - Lifetime
- 2000-05-16 AT AT00925288T patent/ATE238997T1/de not_active IP Right Cessation
- 2000-05-16 PL PL00352101A patent/PL352101A1/xx not_active Application Discontinuation
- 2000-05-16 CZ CZ20014288A patent/CZ20014288A3/cs unknown
- 2000-05-16 IL IL14639200A patent/IL146392A0/xx unknown
- 2000-05-16 PT PT00925288T patent/PT1185516E/pt unknown
- 2000-05-24 AR ARP000102549A patent/AR024100A1/es not_active Application Discontinuation
- 2000-05-26 MY MYPI20002352A patent/MY122576A/en unknown
- 2000-05-26 GT GT200000083A patent/GT200000083A/es unknown
- 2000-05-26 SV SV2000000087A patent/SV2004000087A/es unknown
- 2000-05-26 PE PE2000000506A patent/PE20010167A1/es not_active Application Discontinuation
-
2001
- 2001-11-09 ZA ZA200109263A patent/ZA200109263B/xx unknown
- 2001-11-13 BG BG106107A patent/BG106107A/bg unknown
- 2001-11-26 MA MA26427A patent/MA25414A1/fr unknown
- 2001-11-28 NO NO20015810A patent/NO20015810L/no not_active Application Discontinuation
- 2001-12-24 HR HR20010955A patent/HRP20010955A2/hr not_active Application Discontinuation
-
2003
- 2003-02-07 HK HK03100922.0A patent/HK1048810A1/zh unknown
-
2004
- 2004-03-18 US US10/805,548 patent/US20040186106A1/en not_active Abandoned
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