BG106107A - Заместени амиди на фенилциклохексанкарбонова киселина с действие, инхибиращо усвояването на аденозин - Google Patents

Заместени амиди на фенилциклохексанкарбонова киселина с действие, инхибиращо усвояването на аденозин Download PDF

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Publication number
BG106107A
BG106107A BG106107A BG10610701A BG106107A BG 106107 A BG106107 A BG 106107A BG 106107 A BG106107 A BG 106107A BG 10610701 A BG10610701 A BG 10610701A BG 106107 A BG106107 A BG 106107A
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BG
Bulgaria
Prior art keywords
alkyl
compounds
general formula
radical
optionally
Prior art date
Application number
BG106107A
Other languages
Bulgarian (bg)
English (en)
Inventor
Wolf - Dietrich FREUND
Stephen Lensky
Stephan Mueller
Holger Paulsen
Joerg Keldenich
Ervin Horvath
Joachim Schuhmacher
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG106107A publication Critical patent/BG106107A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG106107A 1999-05-29 2001-11-13 Заместени амиди на фенилциклохексанкарбонова киселина с действие, инхибиращо усвояването на аденозин BG106107A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19924818A DE19924818A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäureamide
PCT/EP2000/004417 WO2000073275A1 (de) 1999-05-29 2000-05-16 Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung

Publications (1)

Publication Number Publication Date
BG106107A true BG106107A (bg) 2002-05-31

Family

ID=7909712

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106107A BG106107A (bg) 1999-05-29 2001-11-13 Заместени амиди на фенилциклохексанкарбонова киселина с действие, инхибиращо усвояването на аденозин

Country Status (36)

Country Link
US (2) US6716849B1 (xx)
EP (1) EP1185516B1 (xx)
JP (1) JP2003500475A (xx)
KR (1) KR20020003397A (xx)
CN (1) CN1200932C (xx)
AR (1) AR024100A1 (xx)
AT (1) ATE238997T1 (xx)
AU (1) AU765752B2 (xx)
BG (1) BG106107A (xx)
BR (1) BR0011061A (xx)
CA (1) CA2375186A1 (xx)
CZ (1) CZ20014288A3 (xx)
DE (2) DE19924818A1 (xx)
DK (1) DK1185516T3 (xx)
EE (1) EE200100634A (xx)
ES (1) ES2197870T3 (xx)
GT (1) GT200000083A (xx)
HK (1) HK1048810A1 (xx)
HN (1) HN2000000072A (xx)
HR (1) HRP20010955A2 (xx)
HU (1) HUP0201350A3 (xx)
IL (1) IL146392A0 (xx)
MA (1) MA25414A1 (xx)
MX (1) MXPA01012241A (xx)
MY (1) MY122576A (xx)
NO (1) NO20015810L (xx)
PE (1) PE20010167A1 (xx)
PL (1) PL352101A1 (xx)
PT (1) PT1185516E (xx)
RU (1) RU2246490C9 (xx)
SI (1) SI1185516T1 (xx)
SK (1) SK17052001A3 (xx)
SV (1) SV2004000087A (xx)
UA (1) UA73126C2 (xx)
WO (1) WO2000073275A1 (xx)
ZA (1) ZA200109263B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
KR101677915B1 (ko) * 2008-06-16 2016-11-21 베링거 인겔하임 인터내셔날 게엠베하 다비가트란 에텍실레이트의 중간체 생성물의 제조 방법
BR112014030940B1 (pt) 2012-06-11 2022-09-06 UCB Biopharma SRL Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos
CN113939525A (zh) * 2018-11-25 2022-01-14 蓝谷制药有限责任公司 吉西他滨的口服活性前药

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685918B1 (fr) 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4221009A1 (de) 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
EP0582164B1 (en) * 1992-07-31 1998-12-23 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
DE4304455A1 (de) 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4401893A1 (de) 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
DE19503160A1 (de) 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
HRP960015B1 (en) 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives

Also Published As

Publication number Publication date
EE200100634A (et) 2003-02-17
UA73126C2 (en) 2005-06-15
PE20010167A1 (es) 2001-04-25
DE50001982D1 (de) 2003-06-05
AR024100A1 (es) 2002-09-04
SI1185516T1 (en) 2003-10-31
CA2375186A1 (en) 2000-12-07
CN1200932C (zh) 2005-05-11
GT200000083A (es) 2001-11-17
SV2004000087A (es) 2004-05-07
PT1185516E (pt) 2003-09-30
CZ20014288A3 (cs) 2002-03-13
NO20015810L (no) 2002-01-25
ZA200109263B (en) 2003-01-29
ES2197870T3 (es) 2004-01-16
HUP0201350A2 (en) 2002-08-28
RU2246490C2 (ru) 2005-02-20
HK1048810A1 (zh) 2003-04-17
EP1185516A1 (de) 2002-03-13
HUP0201350A3 (en) 2003-05-28
HRP20010955A2 (en) 2003-08-31
IL146392A0 (en) 2002-07-25
AU765752B2 (en) 2003-09-25
PL352101A1 (en) 2003-07-28
CN1365356A (zh) 2002-08-21
MA25414A1 (fr) 2002-04-01
WO2000073275A1 (de) 2000-12-07
NO20015810D0 (no) 2001-11-28
KR20020003397A (ko) 2002-01-12
US20040186106A1 (en) 2004-09-23
SK17052001A3 (sk) 2002-06-04
MY122576A (en) 2006-04-29
MXPA01012241A (es) 2002-08-12
AU4405500A (en) 2000-12-18
BR0011061A (pt) 2002-03-05
US6716849B1 (en) 2004-04-06
DE19924818A1 (de) 2000-11-30
EP1185516B1 (de) 2003-05-02
JP2003500475A (ja) 2003-01-07
ATE238997T1 (de) 2003-05-15
DK1185516T3 (da) 2003-08-11
RU2246490C9 (ru) 2005-09-20
HN2000000072A (es) 2001-02-02

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