ATE174913T1 - Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosins - Google Patents
Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosinsInfo
- Publication number
- ATE174913T1 ATE174913T1 AT93111910T AT93111910T ATE174913T1 AT E174913 T1 ATE174913 T1 AT E174913T1 AT 93111910 T AT93111910 T AT 93111910T AT 93111910 T AT93111910 T AT 93111910T AT E174913 T1 ATE174913 T1 AT E174913T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- adenosine
- reuppost
- thiazole
- imidazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92339992A | 1992-07-31 | 1992-07-31 | |
US4833893A | 1993-04-15 | 1993-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE174913T1 true ATE174913T1 (de) | 1999-01-15 |
Family
ID=26726027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93111910T ATE174913T1 (de) | 1992-07-31 | 1993-07-26 | Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosins |
Country Status (20)
Country | Link |
---|---|
US (1) | US5382584A (de) |
EP (1) | EP0582164B1 (de) |
JP (1) | JP3478852B2 (de) |
KR (1) | KR940005614A (de) |
CN (1) | CN1085216A (de) |
AT (1) | ATE174913T1 (de) |
AU (1) | AU670953B2 (de) |
CA (1) | CA2101311A1 (de) |
DE (1) | DE69322707T2 (de) |
DK (1) | DK0582164T3 (de) |
ES (1) | ES2125285T3 (de) |
FI (1) | FI933398A (de) |
GR (1) | GR3029778T3 (de) |
HK (1) | HK1014714A1 (de) |
HU (1) | HUT67460A (de) |
IL (1) | IL106490A0 (de) |
MX (1) | MX9304547A (de) |
NO (1) | NO932694L (de) |
PL (1) | PL299888A1 (de) |
TW (1) | TW224096B (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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US5646281A (en) | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
WO1996016049A1 (en) * | 1994-11-23 | 1996-05-30 | Glaxo Wellcome Inc. | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS |
US5700826A (en) * | 1995-06-07 | 1997-12-23 | Ontogen Corporation | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance |
EP0775128A1 (de) * | 1995-06-07 | 1997-05-28 | Dade Chemistry Systems Inc. | Verfahren zur herstellung von immunogenen und anderen arzneimittelkonjugaten |
JP2001518067A (ja) * | 1996-04-03 | 2001-10-09 | メルク エンド カンパニー インコーポレーテッド | ファルネシルプロテイントランスフェラーゼの阻害剤 |
US5866574A (en) * | 1997-04-10 | 1999-02-02 | Kyowa Hakko Kogyo Co., Ltd. | Pancreatitis remedy |
US5840721A (en) * | 1997-07-09 | 1998-11-24 | Ontogen Corporation | Imidazole derivatives as MDR modulators |
AR014809A1 (es) | 1998-04-03 | 2001-03-28 | Advanced Medicine Inc | Compuestos multiligazon, composicion farmaceutica, metodo para prepara dichos compuestos y uso de dichos compuestos para preparar medicamentos |
US6462034B1 (en) | 1998-04-03 | 2002-10-08 | Theravance, Inc. | Local anesthetic compounds and uses |
US7582680B1 (en) * | 1998-11-12 | 2009-09-01 | Purdue Research Foundation | Methods and compositions for treating mammalian spinal cord injuries |
US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
DE19924819A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäurebenzylamid (Adenosinaufnahmeinhibitoren) |
DE19924818A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide |
WO2000075132A1 (en) * | 1999-06-03 | 2000-12-14 | Eli Lilly And Company | Process for preparing a 10,11-methanodibenzosuberane derivative |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
DE10044792A1 (de) | 2000-09-11 | 2002-04-04 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung |
PE20020420A1 (es) | 2000-10-02 | 2002-06-27 | Novartis Ag | Derivados de diazacicloalcanodiona como antagonistas del antigeno asociado a la funcion del linfocito-1 (lfa-1) |
WO2002076962A1 (fr) * | 2001-03-23 | 2002-10-03 | Nippon Soda Co.,Ltd. | Procede de production de 3-oxo-2-(2-thiazolyl)propanenitrile et intermediaire |
JP2004527573A (ja) * | 2001-04-24 | 2004-09-09 | パーデュー・リサーチ・ファウンデーション | 哺乳類の神経組織損傷の治療のための方法及び組成物 |
US6649761B2 (en) * | 2001-05-30 | 2003-11-18 | Merck & Co., Inc. | Process for preparing piperazinepentaneamide HIV protease inhibitors |
DE10150310A1 (de) * | 2001-10-11 | 2003-04-24 | Bayer Ag | Substituierte Piperazincyclohexancarbonsäureamide und ihre Verwendung |
AU2003255511B2 (en) * | 2002-06-24 | 2009-02-05 | Janssen Pharmaceutica N.V. | Process for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide |
KR100694181B1 (ko) * | 2005-11-25 | 2007-03-12 | 연세대학교 산학협력단 | 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법 |
TW201113280A (en) | 2009-07-03 | 2011-04-16 | Nensius Res As | Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the CNS |
KR101423176B1 (ko) | 2011-11-29 | 2014-07-25 | 제일모직 주식회사 | 포지티브형 감광성 수지 조성물, 이를 사용하여 제조된 감광성 수지막 및 상기 감광성 수지막을 포함하는 반도체 소자 |
KR101432603B1 (ko) | 2011-12-29 | 2014-08-21 | 제일모직주식회사 | 감광성 노볼락 수지, 이를 포함하는 포지티브형 감광성 수지 조성물, 이를 사용하여 제조된 감광성 수지막 및 이를 포함하는 반도체 소자 |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
WO2016073738A2 (en) | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
CN109456285A (zh) * | 2018-10-29 | 2019-03-12 | 安徽省庆云医药股份有限公司 | 一种雷诺嗪的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL137318C (de) * | 1964-06-09 | |||
IT1033040B (it) * | 1970-02-21 | 1979-07-10 | Serono Ist Farm | 4 5 difenilossazoli 2 amminometil e 2,2 amminoetil sostituiti |
US4020082A (en) * | 1970-02-21 | 1977-04-26 | Enzo Marchetti | 2-Aminomethyl- and 2-(2-aminoethyl)-substituted 4,5-diphenyloxazoles |
US4101660A (en) * | 1976-02-12 | 1978-07-18 | Mitsubishi Chemical Industries Limited | 2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable acid addition salts thereof |
FR2459242A1 (fr) * | 1979-06-21 | 1981-01-09 | Delalande Sa | Derives du benzimidazole portant en position 1 une chaine aralkyle substituee, leur procede de preparation et leur application en therapeutique |
US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
NZ223847A (en) * | 1987-04-01 | 1989-12-21 | Janssen Pharmaceutica Nv | Substituted piperazine derivatives and pharmaceutical compositions |
JP2852659B2 (ja) * | 1988-03-03 | 1999-02-03 | 富山化学工業株式会社 | ピペラジン誘導体およびその塩 |
JP3003148B2 (ja) * | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
CA2012716A1 (en) * | 1989-03-22 | 1990-09-22 | Akito Tanaka | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
AU643235B2 (en) * | 1989-09-15 | 1993-11-11 | Gensia Pharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
AU662588B2 (en) * | 1991-12-18 | 1995-09-07 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine H3 agonists/antagonists |
-
1993
- 1993-07-26 EP EP93111910A patent/EP0582164B1/de not_active Expired - Lifetime
- 1993-07-26 ES ES93111910T patent/ES2125285T3/es not_active Expired - Lifetime
- 1993-07-26 AT AT93111910T patent/ATE174913T1/de not_active IP Right Cessation
- 1993-07-26 DK DK93111910T patent/DK0582164T3/da active
- 1993-07-26 DE DE69322707T patent/DE69322707T2/de not_active Expired - Fee Related
- 1993-07-26 CA CA002101311A patent/CA2101311A1/en not_active Abandoned
- 1993-07-27 IL IL106490A patent/IL106490A0/xx unknown
- 1993-07-27 TW TW082106009A patent/TW224096B/zh active
- 1993-07-27 NO NO932694A patent/NO932694L/no unknown
- 1993-07-28 AU AU44232/93A patent/AU670953B2/en not_active Ceased
- 1993-07-28 HU HU9302198A patent/HUT67460A/hu unknown
- 1993-07-28 MX MX9304547A patent/MX9304547A/es unknown
- 1993-07-29 KR KR1019930014660A patent/KR940005614A/ko not_active Application Discontinuation
- 1993-07-29 FI FI933398A patent/FI933398A/fi unknown
- 1993-07-29 CN CN93109303A patent/CN1085216A/zh active Pending
- 1993-07-30 PL PL93299888A patent/PL299888A1/xx unknown
- 1993-07-30 JP JP18994793A patent/JP3478852B2/ja not_active Expired - Fee Related
-
1994
- 1994-03-04 US US08/206,572 patent/US5382584A/en not_active Expired - Lifetime
-
1998
- 1998-12-28 HK HK98116045A patent/HK1014714A1/xx not_active IP Right Cessation
-
1999
- 1999-03-23 GR GR990400866T patent/GR3029778T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL299888A1 (en) | 1994-04-18 |
ES2125285T3 (es) | 1999-03-01 |
GR3029778T3 (en) | 1999-06-30 |
EP0582164A1 (de) | 1994-02-09 |
DE69322707T2 (de) | 1999-08-19 |
IL106490A0 (en) | 1993-11-15 |
EP0582164B1 (de) | 1998-12-23 |
FI933398A0 (fi) | 1993-07-29 |
FI933398A (fi) | 1994-02-01 |
AU4423293A (en) | 1994-02-03 |
NO932694D0 (no) | 1993-07-27 |
DK0582164T3 (da) | 1999-08-23 |
US5382584A (en) | 1995-01-17 |
DE69322707D1 (de) | 1999-02-04 |
HUT67460A (en) | 1995-04-28 |
JP3478852B2 (ja) | 2003-12-15 |
MX9304547A (es) | 1994-02-28 |
TW224096B (de) | 1994-05-21 |
HK1014714A1 (en) | 1999-09-30 |
KR940005614A (ko) | 1994-03-21 |
CA2101311A1 (en) | 1994-02-01 |
JPH06157472A (ja) | 1994-06-03 |
AU670953B2 (en) | 1996-08-08 |
CN1085216A (zh) | 1994-04-13 |
NO932694L (no) | 1994-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |