PE117399A1 - CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP - Google Patents

CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP

Info

Publication number
PE117399A1
PE117399A1 PE1998000838A PE00083898A PE117399A1 PE 117399 A1 PE117399 A1 PE 117399A1 PE 1998000838 A PE1998000838 A PE 1998000838A PE 00083898 A PE00083898 A PE 00083898A PE 117399 A1 PE117399 A1 PE 117399A1
Authority
PE
Peru
Prior art keywords
pthrp
positions
amino acid
helice
leu
Prior art date
Application number
PE1998000838A
Other languages
English (en)
Spanish (es)
Inventor
Brian Henry Vickery
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE117399A1 publication Critical patent/PE117399A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PE1998000838A 1997-09-09 1998-09-07 CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP PE117399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
PE117399A1 true PE117399A1 (es) 1999-11-20

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000838A PE117399A1 (es) 1997-09-09 1998-09-07 CICATRIZACION DE FRACTURAS UTILIZANDO ANALOGOS DE PTHrP

Country Status (31)

Country Link
US (1) US6583114B2 (https=)
EP (1) EP1005359B1 (https=)
JP (1) JP2002509854A (https=)
KR (1) KR100679778B1 (https=)
CN (1) CN1210059C (https=)
AR (1) AR015435A1 (https=)
AT (1) ATE297754T1 (https=)
AU (1) AU752925B2 (https=)
BR (1) BR9812068A (https=)
CA (1) CA2302255C (https=)
CO (1) CO4890856A1 (https=)
CZ (1) CZ298701B6 (https=)
DE (1) DE69830591T2 (https=)
ES (1) ES2244090T3 (https=)
HR (1) HRP20000109A2 (https=)
HU (1) HU226866B1 (https=)
IL (2) IL134719A0 (https=)
MA (1) MA26545A1 (https=)
MY (1) MY121291A (https=)
NO (1) NO323740B1 (https=)
NZ (1) NZ502970A (https=)
PE (1) PE117399A1 (https=)
PL (1) PL195703B1 (https=)
RS (1) RS49707B (https=)
RU (1) RU2224539C2 (https=)
SA (1) SA98190565B1 (https=)
TR (1) TR200000649T2 (https=)
TW (1) TW552139B (https=)
UY (1) UY25172A1 (https=)
WO (1) WO1999012561A2 (https=)
ZA (1) ZA988030B (https=)

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EP1769804B1 (en) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human
DZ2873A1 (fr) 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
EP1136076A1 (en) * 1998-08-19 2001-09-26 Eli Lilly And Company Method of increasing bone toughness and stiffness and reducing fractures
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
ATE281432T1 (de) 1999-03-05 2004-11-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6560487B1 (en) 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
EP1531855A4 (en) * 2002-01-10 2009-07-22 Osteotrophin Llc TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA
US7399826B1 (en) 2003-10-02 2008-07-15 Ali Sadat M Peptide for promoting healing of fractures
BRPI0516126A (pt) * 2004-10-08 2008-08-26 Forbes Medi Tech Res Inc produtos farmacêuticos de polipeptìdeos intestinais vasoativos
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US20090022684A1 (en) * 2006-05-09 2009-01-22 Paul Morley Methods for hematopoietic stimulation
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
BRPI0719821B8 (pt) 2006-10-03 2021-05-25 Ipsen Pharma Sas composição estável na armazenagem apropriada para administração a pacientes
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
BR112012013725A2 (pt) 2009-12-07 2017-01-10 Univ Michigan Tech paratormônio de urso preto e métodos de usar o paratormônio de uso preto.
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
US10568937B2 (en) 2016-04-18 2020-02-25 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
EP3924328A1 (en) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Processes and compounds
EP4027899A4 (en) 2019-09-12 2023-08-16 Radius Health, Inc. METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
GB9308033D0 (en) * 1993-04-19 1993-06-02 Sandoz Ltd Organic compounds
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1995011697A1 (en) * 1993-10-27 1995-05-04 Chugai Seiyaku Kabushiki Kaisha Cure accelerator in chondroplasty
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
CZ298701B6 (cs) 2007-12-27
YU12700A (sh) 2004-09-03
RS49707B (sr) 2007-12-31
TR200000649T2 (tr) 2000-09-21
PL195703B1 (pl) 2007-10-31
NZ502970A (en) 2002-03-01
JP2002509854A (ja) 2002-04-02
EP1005359A2 (en) 2000-06-07
MY121291A (en) 2006-01-28
CO4890856A1 (es) 2000-02-28
TW552139B (en) 2003-09-11
PL339449A1 (en) 2000-12-18
NO323740B1 (no) 2007-07-02
CN1210059C (zh) 2005-07-13
CZ2000862A3 (cs) 2000-09-13
HU226866B1 (en) 2009-12-28
IL134719A0 (en) 2001-04-30
CN1269726A (zh) 2000-10-11
RU2224539C2 (ru) 2004-02-27
ZA988030B (en) 1999-03-09
HUP0004560A3 (en) 2005-11-28
AR015435A1 (es) 2001-05-02
NO20001195L (no) 2000-03-08
NO20001195D0 (no) 2000-03-08
UY25172A1 (es) 2001-01-31
WO1999012561A9 (en) 2000-03-16
BR9812068A (pt) 2000-09-26
SA98190565B1 (ar) 2006-07-30
CA2302255C (en) 2011-11-08
KR100679778B1 (ko) 2007-02-07
DE69830591T2 (de) 2006-05-04
EP1005359B1 (en) 2005-06-15
HK1030753A1 (zh) 2001-05-18
US6583114B2 (en) 2003-06-24
HUP0004560A2 (hu) 2001-04-28
AU9740698A (en) 1999-03-29
WO1999012561A3 (en) 1999-05-14
AU752925B2 (en) 2002-10-03
US20020077281A1 (en) 2002-06-20
KR20010023795A (ko) 2001-03-26
ATE297754T1 (de) 2005-07-15
MA26545A1 (fr) 2004-12-20
ES2244090T3 (es) 2005-12-01
DE69830591D1 (de) 2005-07-21
IL134719A (en) 2010-04-29
WO1999012561A2 (en) 1999-03-18
CA2302255A1 (en) 1999-03-18
HRP20000109A2 (en) 2001-02-28

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