ES2070322T3 - Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta. - Google Patents

Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta.

Info

Publication number
ES2070322T3
ES2070322T3 ES90908073T ES90908073T ES2070322T3 ES 2070322 T3 ES2070322 T3 ES 2070322T3 ES 90908073 T ES90908073 T ES 90908073T ES 90908073 T ES90908073 T ES 90908073T ES 2070322 T3 ES2070322 T3 ES 2070322T3
Authority
ES
Spain
Prior art keywords
leu
arg
polypeptide
tgf
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908073T
Other languages
English (en)
Inventor
John A Burnier
George J Cianciolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2070322T3 publication Critical patent/ES2070322T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTA UN POLIPEPTICO QUE EXCLUYE (A) UNA MOLECULA DEL TGF-(BETA) MADURA DE LONGITUD TOTAL O UNA MOLECULA DEL TGF-(BETA) PRECURSORA O VARIANTES DE SUPRESION DE MOLECULAS DEL TGF-(BETA) PRECURSORAS O MADURAS EN QUE SE HAN SUPRIMIDO DE 1 A 10 RESIDUOS AMINOACIDOS APROXIMADAMENTE, (B) UN POLIPEPTIDO DE LA SECUENCIA: CYS-VAL-ARG-GLN-LEU-TYR-ILE-ASP-PHE-ARG-LYS -ASP-LEU-GLY-TRP-LYS Y (C) UN POLIPEPTIDO DE LA SECUENCIA: ARG-ASN-LEU-GLU -GLU-ASN-CYS-CYS-VAL-ARG-PRO-LEU-TYR-ILE-ASP-PHE-ARG-GLN-ASP-LEU, CONTENIENDO DICHO POLIPEPTIDO UNA SECUENCIA AMINOACIDA BASADA EN SECUENCIAS CONSERVADAS EN LA FAMILIA DE MOLECULAS DE TGF-(BETA). DICHOS POLIPEPTIDOS SON PARTICULARMENTE UTILES TERAPEUTICAMENTE COMO AGENTES INMUNOSUPRESORES CUANDO SE ENCUENTRAN ACOPLADOS A PROTEINAS PORTADORAS O ENLAZADAS EN CRUZ PARA FORMAR POLIMEROS.
ES90908073T 1989-05-25 1990-04-04 Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta. Expired - Lifetime ES2070322T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/356,964 US5061786A (en) 1989-05-25 1989-05-25 Biologically active polypeptides based on transforming growth factor-β

Publications (1)

Publication Number Publication Date
ES2070322T3 true ES2070322T3 (es) 1995-06-01

Family

ID=23403710

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908073T Expired - Lifetime ES2070322T3 (es) 1989-05-25 1990-04-04 Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta.

Country Status (7)

Country Link
US (1) US5061786A (es)
EP (1) EP0473649B1 (es)
AT (1) ATE118015T1 (es)
CA (1) CA2057896C (es)
DE (1) DE69016655T2 (es)
ES (1) ES2070322T3 (es)
WO (1) WO1990014359A1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04502328A (ja) * 1988-12-05 1992-04-23 ザ・トラステイーズ・オブ・コロンビア・ユニヴアーシテイ・イン・ザ・シテイ・オブ・ニユー・ヨーク シクロスポリンａの新規誘導体、それに対する抗体及びその使用
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5824647A (en) * 1990-12-12 1998-10-20 Postlethwaite; Arnold E. Chemotactic wound healing peptides
US5436228A (en) * 1990-12-12 1995-07-25 Postlethwaite; Arnold E. Chemotactic wound healing peptides
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US7067637B1 (en) * 1992-02-12 2006-06-27 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Antibody or antibody fragments specific for a protein of the TGF-β family
US6558661B1 (en) 1992-12-29 2003-05-06 Genentech, Inc. Treatment of inflammatory bowel disease with IFN-γ inhibitors
EP1439190A1 (en) * 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
AU697916B2 (en) * 1993-01-26 1998-10-22 Celtrix Pharmaceuticals, Inc. Biologically active TGF-beta1 and TGF-beta2 peptides
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
EP0670733A1 (en) * 1993-09-29 1995-09-13 Alcon Laboratories, Inc. Compositions containing growth factors and antiplastic agents
US5411940A (en) * 1993-09-29 1995-05-02 Alcon Laboratories, Inc. Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma
JPH08503968A (ja) * 1993-09-29 1996-04-30 アルコン ラボラトリーズ，インコーポレイテッド 増殖因子と代謝拮抗物質を含有する組成物
TW440566B (en) * 1994-07-25 2001-06-16 Novartis Ag Novel process for the production of biologically active dimeric protein
TW517059B (en) * 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
US5616561A (en) * 1995-03-31 1997-04-01 Regents Of The University Of California TGF-β antagonists as mitigators of radiation-induced tissue damage
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
EP0876401B1 (en) 1996-01-22 2007-06-13 Curis, Inc. Methods for producing op-1 morphogen analogs
EP0877031A1 (en) * 1997-05-06 1998-11-11 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) TGF-Beta1 derived peptides mimicking the activity of transforming growth factor-Beta1
EP1088084B1 (en) 1998-06-15 2006-09-13 GTC Biotherapeutics, Inc. Erythropoietin analog-human serum albumin fusion protein
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US6703480B1 (en) * 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
WO2001049220A1 (en) 1999-12-30 2001-07-12 Osteotech, Inc. Intervertebral implants
WO2001072331A1 (en) * 2000-03-31 2001-10-04 Vaccine Chip Technology Aps Immunostimulating properties of a fragment of tgf-beta
US20030190322A1 (en) * 2000-03-31 2003-10-09 Peter Kaastrup Immunostimulating properties of a fragment of tgf-beta
US6638310B2 (en) 2000-07-26 2003-10-28 Osteotech, Inc. Intervertebral spacer and implant insertion instrumentation
US20030120274A1 (en) 2000-10-20 2003-06-26 Morris John W. Implant retaining device
US6908899B2 (en) * 2001-08-17 2005-06-21 U.S. Dept. Of Veterans Affairs Pro-inflammatory fibrinopeptide
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
US8333985B2 (en) 2004-01-27 2012-12-18 Warsaw Orthopedic, Inc. Non-glycerol stabilized bone graft
WO2005097832A2 (en) 2004-03-31 2005-10-20 Genentech, Inc. Humanized anti-tgf-beta antibodies
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP1838736B1 (en) 2005-01-05 2013-03-06 Biogen Idec MA Inc. Cripto binding molecules
USD580551S1 (en) * 2007-02-01 2008-11-11 Zimmer Spine, Inc. Spinal implant
US8372157B2 (en) 2007-02-12 2013-02-12 Warsaw Orthopedic, Inc. Joint revision implant
NZ605400A (en) 2010-07-09 2015-05-29 Biogen Idec Hemophilia Inc Chimeric clotting factors
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
CA2860579A1 (en) 2012-01-10 2013-07-18 Biogen Idec Ma Inc. Enhancement of transport of therapeutic molecules across the blood brain barrier
US11761951B2 (en) 2015-02-04 2023-09-19 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
US4843063A (en) * 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
EP0169016B2 (en) * 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Polypeptide cartilage-inducing factors found in bone
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
US4816442A (en) * 1986-11-07 1989-03-28 Collagen Corporation Method of inhibiting tumor growth sensitive to CIF-βtreatment
EP0300031A4 (en) * 1987-01-28 1990-05-14 Ortho Pharma Corp IMMUNE SUPPRESSIVE PEPTIDES AND METHOD FOR THEIR USE.
US4931548A (en) * 1987-01-30 1990-06-05 Techne Corporation Heterodimer form of transforming growth factor-beta
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity

Also Published As

Publication number Publication date
EP0473649B1 (en) 1995-02-01
CA2057896A1 (en) 1990-11-26
WO1990014359A1 (en) 1990-11-29
ATE118015T1 (de) 1995-02-15
DE69016655D1 (de) 1995-03-16
DE69016655T2 (de) 1995-08-17
US5061786A (en) 1991-10-29
CA2057896C (en) 2000-06-06
EP0473649A1 (en) 1992-03-11

Similar Documents

Publication Publication Date Title
ES2070322T3 (es) Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta.
Thomas et al. Fibroblast growth factors: broad spectrum mitogens with potent angiogenic activity
DE69129865D1 (de) Osteogene peptide
ATE128715T1 (de) Polypeptide induzierende faktoren in knochen und knorpel.
ES2124685T3 (es) Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.
KR880010130A (ko) 폴리 펩티드, dna 및 그의 용도
DK0458959T3 (da) Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf
ES2196088T3 (es) Analogos del factor de crecimiento de los queratinocitos.
MX9203879A (es) Muteina de il-6 con cisteina parcialmente suprimida.
DE69029377D1 (de) Substituierungsanaloge von magaininpeptiden
CA2005154A1 (en) Method for purifying fibroblast growth factor protein
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
ES2112847T3 (es) Somatotropina con alteraciones en la region de la alfa-helice 1 y combinaciones con otras mutaciones.
ATE135407T1 (de) Peptide, welche hiv-retroviren-hemmende antikörper induzieren, sowie gegen diese peptide gerichtete antikörper
KR930004326A (ko) 콘드로모듈린-ii 단백질
WO1989001490A3 (en) Biologically active molecules
DE69032574D1 (de) Antibakterielle- und antimalariapeptide
NO178151C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive peptider
Yajima et al. Synthesis of a 53-residue peptide with EGF activity
ATE432985T1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
DK56995A (da) Rekombinante lymphotoxin-varianter

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 473649

Country of ref document: ES