PE109998A1 - Compuestos de pirrolidinil y pirrolinil etilamina como agonistas kappa - Google Patents
Compuestos de pirrolidinil y pirrolinil etilamina como agonistas kappaInfo
- Publication number
- PE109998A1 PE109998A1 PE1997000834A PE00083497A PE109998A1 PE 109998 A1 PE109998 A1 PE 109998A1 PE 1997000834 A PE1997000834 A PE 1997000834A PE 00083497 A PE00083497 A PE 00083497A PE 109998 A1 PE109998 A1 PE 109998A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- alkyl
- formula
- pirrolinil
- pirrolidinil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES H, OH, HALOGENO, OY, ENTRE OTROS; O SI LA LINEA DE TRAZOS ES UN DOBLE ENLACE, ENTONCES "A" ESTA AUSENTE; "Y" ES UN GRUPO PROTECTOR HIDROXI; Ar1 ES FENILO OPCIONALMENTE SUSTITUIDO; Ar2 ES ARILO O HETEROARILO SELECCIONADO DE FENILO, PIRIDILO O TIENILO, ENTRE OTROS, LOS CUALES SE ENCUENTRAN OPCIONALMENTE SUSTITUIDOS; R1 ES H, OH, ALQUILO C1-C4, ENTRE OTROS; R2 Y R3 SON H, ALQUILO C1-C7 (OPCIONALMENTE SUSTITUIDO CON UNO O MAS SUSTITUYENTES OH o HALOGENO), ENTRE OTROS o CUANDO Ar1 ES FENILO, ENTONCES -Ar2-CO-NR2- ES UN GRUPO FTALIMIDA Y R3 ES ALQUILO C1-C7 o R2 Y R3 JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UNA PIRROLIDINA, PIPERIDINA o MORFOLINA. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I) Y A LOS COMPUESTOS INTERMEDIOS PARA SU OBTENCION. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO AGONISTAS FRENTE AL RECEPTOR KAPPA DE LOS RECEPTORES OPIACEOS, POR LO QUE PUEDEN SER UTILES COMO AGENTES ANALGESICO-ANESTESICO, ANTIINFLAMATORIO O NEUROPROTECTOR, UTILES EN EL TRATAMIENTO DE LA ARTRITIS, ACCIDENTES CEREBROVASCULARES O ENFERMEDADES FUNCIONALES DEL INTESTINO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB96/00957 | 1996-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE109998A1 true PE109998A1 (es) | 1999-01-13 |
Family
ID=11004480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000834A PE109998A1 (es) | 1996-09-18 | 1997-09-18 | Compuestos de pirrolidinil y pirrolinil etilamina como agonistas kappa |
Country Status (38)
Country | Link |
---|---|
US (7) | US6201007B1 (es) |
EP (1) | EP0934264B1 (es) |
JP (2) | JP3195368B2 (es) |
KR (1) | KR100339666B1 (es) |
CN (1) | CN1237962A (es) |
AP (1) | AP1016A (es) |
AR (1) | AR008168A1 (es) |
AT (1) | ATE249433T1 (es) |
AU (1) | AU719895B2 (es) |
BG (1) | BG64194B1 (es) |
BR (1) | BR9711506A (es) |
CA (1) | CA2266006C (es) |
CO (1) | CO4920224A1 (es) |
DE (1) | DE69724805T2 (es) |
DK (1) | DK0934264T3 (es) |
DZ (1) | DZ2309A1 (es) |
EA (1) | EA001341B1 (es) |
ES (1) | ES2205248T3 (es) |
HR (1) | HRP970509A2 (es) |
ID (1) | ID19611A (es) |
IL (3) | IL147368A0 (es) |
IS (1) | IS4992A (es) |
MA (1) | MA26441A1 (es) |
NO (1) | NO313550B1 (es) |
NZ (1) | NZ334439A (es) |
OA (1) | OA10996A (es) |
PA (1) | PA8437201A1 (es) |
PE (1) | PE109998A1 (es) |
PL (1) | PL332546A1 (es) |
PT (1) | PT934264E (es) |
SK (1) | SK32799A3 (es) |
TN (2) | TNSN97092A1 (es) |
TR (1) | TR199900590T2 (es) |
TW (1) | TW432047B (es) |
UA (1) | UA60310C2 (es) |
WO (1) | WO1998012177A1 (es) |
YU (1) | YU13899A (es) |
ZA (1) | ZA978358B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420391B1 (en) | 1998-04-01 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Fused thiophone derivatives and drugs containing the same as the active ingredient |
EP0982297A3 (en) * | 1998-08-24 | 2001-08-01 | Pfizer Products Inc. | Process for the preparation of hydroxy-pyrrolidinyl hydroxamic acid derivatives being opioid kappa receptor agonists |
CA2445874A1 (en) * | 2001-04-30 | 2002-11-07 | Fumitaka Ito | Process for preparing hydroxypyrrolidinyl ethylamine compounds useful as kappa agonists |
WO2003072544A1 (en) * | 2002-02-28 | 2003-09-04 | Pfizer Products Inc. | Crystalline anhydrous and monohydrate benzoate salts of (2's,3s)-3-hydroxy-n-{2{n-methyl-n-4-(n-propylamino-carbonyl)phenyl]amino-2-phenyl}-ethylpyrrolidine |
AU2003269399A1 (en) * | 2002-11-01 | 2004-05-25 | Pfizer Products Inc. | Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination |
JP2007531753A (ja) * | 2004-03-31 | 2007-11-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 非イミダゾール系複素環式化合物 |
US7746514B2 (en) * | 2004-04-14 | 2010-06-29 | Hung-Yi Hsu | Scanner and exposure control method thereof |
WO2007081978A2 (en) * | 2006-01-11 | 2007-07-19 | Angion Biomedica Corporation | Modulators of hepatocyte growth factor / c-met activity |
JP5285603B2 (ja) | 2006-05-30 | 2013-09-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンh3受容体のモジュレーターとしての置換ピリジルアミド化合物 |
JP2009542706A (ja) * | 2006-06-29 | 2009-12-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンh3受容体の置換ベンズアミドモジュレーター |
JP5498390B2 (ja) | 2007-11-20 | 2014-05-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンh3受容体のモジュレーターとしてのシクロアルキルオキシ−及びヘテロシクロアルキルオキシピリジン化合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8801304D0 (en) | 1988-01-21 | 1988-02-17 | Ici Plc | Diamine compounds |
DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
DE3935371A1 (de) | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | Stickstoffhaltige ringverbindungen |
WO1994018165A1 (en) * | 1993-02-12 | 1994-08-18 | Pfizer Inc. | Sulfonamide compounds as opioid k-receptor agonists |
IL117440A0 (en) | 1995-03-31 | 1996-07-23 | Pfizer | Pyrrolidinyl hydroxamic acid compounds and their production process |
-
1997
- 1997-05-27 TN TNTNSN97092A patent/TNSN97092A1/fr unknown
- 1997-08-20 TW TW086111948A patent/TW432047B/zh active
- 1997-08-21 EA EA199900209A patent/EA001341B1/ru not_active IP Right Cessation
- 1997-08-21 US US09/254,805 patent/US6201007B1/en not_active Expired - Fee Related
- 1997-08-21 AU AU37812/97A patent/AU719895B2/en not_active Ceased
- 1997-08-21 WO PCT/IB1997/001021 patent/WO1998012177A1/en not_active Application Discontinuation
- 1997-08-21 ES ES97934676T patent/ES2205248T3/es not_active Expired - Lifetime
- 1997-08-21 YU YU13899A patent/YU13899A/sh unknown
- 1997-08-21 IL IL14736897A patent/IL147368A0/xx unknown
- 1997-08-21 DK DK97934676T patent/DK0934264T3/da active
- 1997-08-21 AT AT97934676T patent/ATE249433T1/de not_active IP Right Cessation
- 1997-08-21 IL IL14736797A patent/IL147367A0/xx unknown
- 1997-08-21 CN CN97199817A patent/CN1237962A/zh active Pending
- 1997-08-21 EP EP97934676A patent/EP0934264B1/en not_active Expired - Lifetime
- 1997-08-21 IL IL12895997A patent/IL128959A0/xx unknown
- 1997-08-21 PT PT97934676T patent/PT934264E/pt unknown
- 1997-08-21 CA CA002266006A patent/CA2266006C/en not_active Expired - Fee Related
- 1997-08-21 JP JP51443398A patent/JP3195368B2/ja not_active Expired - Fee Related
- 1997-08-21 NZ NZ334439A patent/NZ334439A/xx unknown
- 1997-08-21 SK SK327-99A patent/SK32799A3/sk unknown
- 1997-08-21 BR BR9711506A patent/BR9711506A/pt not_active Application Discontinuation
- 1997-08-21 PL PL97332546A patent/PL332546A1/xx unknown
- 1997-08-21 DE DE69724805T patent/DE69724805T2/de not_active Expired - Fee Related
- 1997-08-21 KR KR1019997002287A patent/KR100339666B1/ko not_active IP Right Cessation
- 1997-08-21 TR TR1999/00590T patent/TR199900590T2/xx unknown
- 1997-08-21 UA UA99031459A patent/UA60310C2/uk unknown
- 1997-08-29 PA PA19978437201A patent/PA8437201A1/es unknown
- 1997-09-04 AR ARP970104054A patent/AR008168A1/es not_active Application Discontinuation
- 1997-09-11 AP APAP/P/1997/001082A patent/AP1016A/en active
- 1997-09-15 MA MA24796A patent/MA26441A1/fr unknown
- 1997-09-16 ID IDP973203A patent/ID19611A/id unknown
- 1997-09-16 TN TNTNSN97156A patent/TNSN97156A1/fr unknown
- 1997-09-17 DZ DZ970159A patent/DZ2309A1/xx active
- 1997-09-17 CO CO97054286A patent/CO4920224A1/es unknown
- 1997-09-17 ZA ZA978358A patent/ZA978358B/xx unknown
- 1997-09-18 HR HRPCT/IB96/00957A patent/HRP970509A2/hr not_active Application Discontinuation
- 1997-09-18 PE PE1997000834A patent/PE109998A1/es not_active Application Discontinuation
-
1999
- 1999-03-05 IS IS4992A patent/IS4992A/is unknown
- 1999-03-11 BG BG103239A patent/BG64194B1/bg unknown
- 1999-03-12 OA OA9900057A patent/OA10996A/en unknown
- 1999-03-17 NO NO19991294A patent/NO313550B1/no unknown
-
2001
- 2001-01-26 US US09/771,030 patent/US6294557B1/en not_active Expired - Fee Related
- 2001-01-26 US US09/770,514 patent/US6294569B2/en not_active Expired - Fee Related
- 2001-01-26 US US09/770,515 patent/US6310061B2/en not_active Expired - Fee Related
- 2001-01-26 US US09/770,512 patent/US6303602B1/en not_active Expired - Fee Related
- 2001-01-26 US US09/771,029 patent/US6307061B2/en not_active Expired - Fee Related
- 2001-01-26 US US09/770,513 patent/US6313302B2/en not_active Expired - Fee Related
- 2001-03-28 JP JP2001092342A patent/JP2001316344A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2161231T3 (es) | Compuestos heterociclicos como antagonistas de bradiquinina. | |
PE109998A1 (es) | Compuestos de pirrolidinil y pirrolinil etilamina como agonistas kappa | |
PA8546601A1 (es) | Nuevos derivados de indol con afinidad por el receptor 5-ht6 | |
ES2157366T3 (es) | Derivados de pirimidindiona, pirimidintriona, triacindiona como antagonistas de receptores alfa-1-adrenergicos. | |
ES2151652T3 (es) | Derivados de indol como antagonistas del receptor 5ht. | |
GT199900189A (es) | Agonistas de receptores 5-ht1 y metoclopramida para el tratamiento de la migraña. | |
PE65098A1 (es) | Derivados indolicos utiles para terapia | |
ES2134755T3 (es) | Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion. | |
ES2194937T3 (es) | Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina. | |
AR023727A1 (es) | Compuestos empleados en el tratamiento de padecimientos inflamatorios | |
PE20030471A1 (es) | Compuesto de imidazopiridin como moduladores del receptor 5-ht4 | |
ES2150918T3 (es) | 1h-imidazo(4,5-c)quinolin-4-aminas 1-sustituidas; compuestos intermedios y composiciones farmaceuticas. | |
GT199900008A (es) | Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1 | |
PA8593101A1 (es) | Composiciones para el tratamiento de crecimiento celular anormal | |
EA200101177A1 (ru) | Производные индола в качестве антагонистов прогестерона | |
PE10499A1 (es) | Antagonistas del receptor de vitronectina | |
ES2180625T3 (es) | Derivados de camptotecina solubles en agua, proceso para su preparacion y su uso como agentes antitumorales. | |
DOP2003000624A (es) | Derivados de tropano como moduladores de ccr5 | |
PE20021019A1 (es) | Grupos azabiciclicos sustituidos | |
AR037065A1 (es) | Una composicion farmaceutica en base a bloqueadores de receptores 5ht3 y 5ht4, inhibidores de la bomba de protones y antagonistas de receptores de h2, util para tratar los desordenes gastrointestinales | |
PE29798A1 (es) | Acetidinas | |
AR016433A1 (es) | Procedimiento para el tratamiento de la impotencia y composiciones. | |
ES2180041T3 (es) | Derivados de 5-oxido de piridazino(4,5-b)quinoleina, su preparacion y su uso como antagonistas de glicina. | |
ATE225349T1 (de) | Crf rezeptor-antagonisten und darauf bezogene methoden | |
PA8561501A1 (es) | Lactamas como antagonistas de taquiquininas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |