GT199900008A - Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1 - Google Patents

Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1

Info

Publication number
GT199900008A
GT199900008A GT199900008A GT199900008A GT199900008A GT 199900008 A GT199900008 A GT 199900008A GT 199900008 A GT199900008 A GT 199900008A GT 199900008 A GT199900008 A GT 199900008A GT 199900008 A GT199900008 A GT 199900008A
Authority
GT
Guatemala
Prior art keywords
compounds
piperidine
receptor agonists
benzylimidazolinyl
ceto
Prior art date
Application number
GT199900008A
Other languages
English (en)
Inventor
Fumitaka Ito
Hirochi Kondo
Hirohide Kondo
Yoriko Ohashi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199900008A publication Critical patent/GT199900008A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVOS COMPUESTOS 4(2CETO1BENZIMIDAZOLINIL)PIPERIDINA O SUS SALES FARMACEUTICAMENTE ACEPTABLES, A LAS COMPOSICIONES QUE LOS CONTIENEN Y A SUS USOS MÈDICOS. LOS COMPUESTOS DE ÈSTA INVENCIÒN TIENEN ACTIVIDAD COMO AGONISTAS DEL RECEPTOR ORL1 Y COMO TALES, SON ÙTILES
GT199900008A 1998-01-19 1999-01-19 Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1 GT199900008A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19

Publications (1)

Publication Number Publication Date
GT199900008A true GT199900008A (es) 2000-07-12

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900008A GT199900008A (es) 1998-01-19 1999-01-19 Compuestos 4-(2-ceto-1-benzilimidazolinil) piperidina como agonistas del receptor orl1

Country Status (30)

Country Link
US (1) US6423725B1 (es)
EP (1) EP1049689B1 (es)
JP (1) JP3342478B2 (es)
CN (1) CN1288464A (es)
AP (1) AP9901442A0 (es)
AR (1) AR014421A1 (es)
AT (1) ATE219772T1 (es)
AU (1) AU1679099A (es)
BG (1) BG104670A (es)
BR (1) BR9907104A (es)
CA (1) CA2317462C (es)
CO (1) CO4990962A1 (es)
DE (1) DE69901934T2 (es)
DK (1) DK1049689T3 (es)
EA (1) EA200000683A1 (es)
ES (1) ES2175925T3 (es)
GT (1) GT199900008A (es)
IL (1) IL137149A0 (es)
IS (1) IS5539A (es)
MA (1) MA26598A1 (es)
NO (1) NO20003671L (es)
OA (1) OA11445A (es)
PA (1) PA8467101A1 (es)
PE (1) PE20000166A1 (es)
PL (1) PL342046A1 (es)
PT (1) PT1049689E (es)
TN (1) TNSN99006A1 (es)
TR (1) TR200002090T2 (es)
WO (1) WO1999036421A1 (es)
ZA (1) ZA99314B (es)

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ES2237047T3 (es) * 1998-10-23 2005-07-16 Pfizer Inc. Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ATE275141T1 (de) 1999-10-13 2004-09-15 Banyu Pharma Co Ltd Substituierte imidazolin-derivate
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
EP1244437A4 (en) 1999-12-06 2005-02-09 Euro Celtique Sa TERTIARY AMINO COMPOUNDS HAVING AFFINITY FOR OPIOID RECEPTOR
DE60022226D1 (de) * 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
US6969712B2 (en) 2000-11-15 2005-11-29 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
BR0209128A (pt) 2001-04-18 2005-11-01 Euro Celtique Sa Compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
CA2443938C (en) 2001-04-18 2010-06-22 R. Richard Goehring Spiroindene and spiroindane compounds as opioid ligands useful for treating pain
SI1385518T1 (sl) 2001-04-18 2009-02-28 Euro Celtique Sa Benzimidazolonske spojine
EP1598339B1 (en) * 2001-04-18 2009-06-24 Euro-Celtique S.A. 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain
RU2299883C2 (ru) 2001-04-18 2007-05-27 Эро-Селтик, С.А. Соединения спиропиразола, содержащая их фармацевтическая композиция, способ модуляции опиоидного рецептора и способ лечения с применением таких соединений
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
DK1491212T3 (da) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
WO2004043902A1 (de) * 2002-11-12 2004-05-27 Grünenthal GmbH 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
EP1954137A4 (en) * 2005-11-18 2008-12-17 Janssen Pharmaceutica Nv 2-KETO-OXAZOLE AS MODULATORS OF FATTY ACID AMIDHYDROLASE
WO2007085357A1 (en) 2006-01-30 2007-08-02 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
CN101600433B (zh) * 2006-10-16 2012-09-26 田边三菱制药株式会社 用于预防或治疗酒精依赖或药物依赖的药剂
EP2280008B1 (en) * 2007-01-16 2013-05-29 Purdue Pharma L.P. Heterocyclic-substituted piperidines as orl-1 ligands
CN101622241B (zh) 2007-03-01 2013-05-22 田边三菱制药株式会社 苯并咪唑化合物及其医药用途
RU2488585C2 (ru) 2007-08-31 2013-07-27 Пэдью Фарма Л.П. Замещенные пиперидиновые соединения хиноксалинового типа и их применение
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
CN102947275A (zh) * 2010-06-17 2013-02-27 诺瓦提斯公司 哌啶基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
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Also Published As

Publication number Publication date
MA26598A1 (fr) 2004-12-20
DE69901934D1 (de) 2002-08-01
JP3342478B2 (ja) 2002-11-11
IS5539A (is) 2000-06-16
PL342046A1 (en) 2001-05-21
PA8467101A1 (es) 2000-09-29
AR014421A1 (es) 2001-02-28
CN1288464A (zh) 2001-03-21
IL137149A0 (en) 2001-07-24
AU1679099A (en) 1999-08-02
ATE219772T1 (de) 2002-07-15
US6423725B1 (en) 2002-07-23
TR200002090T2 (tr) 2000-11-21
JP2002509148A (ja) 2002-03-26
EA200000683A1 (ru) 2000-12-25
DE69901934T2 (de) 2002-11-07
EP1049689A1 (en) 2000-11-08
CA2317462A1 (en) 1999-07-22
BG104670A (en) 2001-05-31
WO1999036421A1 (en) 1999-07-22
NO20003671L (no) 2000-09-18
PT1049689E (pt) 2002-09-30
CA2317462C (en) 2005-09-13
CO4990962A1 (es) 2000-12-26
OA11445A (en) 2004-04-30
TNSN99006A1 (fr) 2005-11-10
BR9907104A (pt) 2000-10-24
NO20003671D0 (no) 2000-07-18
ZA99314B (en) 2000-07-18
ES2175925T3 (es) 2002-11-16
EP1049689B1 (en) 2002-06-26
AP9901442A0 (en) 1999-03-31
PE20000166A1 (es) 2000-03-07
DK1049689T3 (da) 2002-07-22

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