TR200002090T2 - Orl1-alıcı agonistleri olan 4-(2-keto-1-benzimidazolinil)piperidin bileşikleri - Google Patents

Orl1-alıcı agonistleri olan 4-(2-keto-1-benzimidazolinil)piperidin bileşikleri

Info

Publication number
TR200002090T2
TR200002090T2 TR2000/02090T TR200002090T TR200002090T2 TR 200002090 T2 TR200002090 T2 TR 200002090T2 TR 2000/02090 T TR2000/02090 T TR 2000/02090T TR 200002090 T TR200002090 T TR 200002090T TR 200002090 T2 TR200002090 T2 TR 200002090T2
Authority
TR
Turkey
Prior art keywords
orl1
receptor agonists
benzimidazolinyl
keto
piperidine compounds
Prior art date
Application number
TR2000/02090T
Other languages
English (en)
Inventor
Ito Fumitaka
Kondo Hiroshi
Noguchi Hirohide
Ohashi Yoriko
Yamagishi Tatsuya
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of TR200002090T2 publication Critical patent/TR200002090T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

R1, R2, R3, R4,ve R5' in yukarida tanimladigi formül (I)'e ait bir bilesik veya bunun farmasötik açidan kabul gören tuzlari, ORL1-alici agonistleri olarak ve analjezikler olarak veya memeli subjelerde oldugu gibi faydalidir. Sekil var
TR2000/02090T 1998-01-19 1999-01-08 Orl1-alıcı agonistleri olan 4-(2-keto-1-benzimidazolinil)piperidin bileşikleri TR200002090T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19

Publications (1)

Publication Number Publication Date
TR200002090T2 true TR200002090T2 (tr) 2000-11-21

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02090T TR200002090T2 (tr) 1998-01-19 1999-01-08 Orl1-alıcı agonistleri olan 4-(2-keto-1-benzimidazolinil)piperidin bileşikleri

Country Status (30)

Country Link
US (1) US6423725B1 (tr)
EP (1) EP1049689B1 (tr)
JP (1) JP3342478B2 (tr)
CN (1) CN1288464A (tr)
AP (1) AP9901442A0 (tr)
AR (1) AR014421A1 (tr)
AT (1) ATE219772T1 (tr)
AU (1) AU1679099A (tr)
BG (1) BG104670A (tr)
BR (1) BR9907104A (tr)
CA (1) CA2317462C (tr)
CO (1) CO4990962A1 (tr)
DE (1) DE69901934T2 (tr)
DK (1) DK1049689T3 (tr)
EA (1) EA200000683A1 (tr)
ES (1) ES2175925T3 (tr)
GT (1) GT199900008A (tr)
IL (1) IL137149A0 (tr)
IS (1) IS5539A (tr)
MA (1) MA26598A1 (tr)
NO (1) NO20003671L (tr)
OA (1) OA11445A (tr)
PA (1) PA8467101A1 (tr)
PE (1) PE20000166A1 (tr)
PL (1) PL342046A1 (tr)
PT (1) PT1049689E (tr)
TN (1) TNSN99006A1 (tr)
TR (1) TR200002090T2 (tr)
WO (1) WO1999036421A1 (tr)
ZA (1) ZA99314B (tr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
DE69923744T2 (de) * 1998-10-23 2006-02-23 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ATE275141T1 (de) 1999-10-13 2004-09-15 Banyu Pharma Co Ltd Substituierte imidazolin-derivate
DE60022226D1 (de) 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
WO2001039767A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Tertiary amino compounds having opioid receptor affinity
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
CA2428787A1 (en) 2000-11-15 2002-05-23 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
US6867222B2 (en) * 2001-04-18 2005-03-15 Euro-Celtique, S.A. Nociceptin analogs
ES2312616T3 (es) * 2001-04-18 2009-03-01 Euro-Celtique S.A. Compuestos de bencimidazolona.
WO2002085354A1 (en) 2001-04-18 2002-10-31 Euro-Celtique S.A. Spiroindene and spiroindane compounds
ATE403429T1 (de) 2001-04-18 2008-08-15 Euro Celtique Sa Spiropyrazol-verbindungen
KR100855204B1 (ko) 2001-04-18 2008-09-01 유로-셀티크 소시에떼 아노뉨 노시셉틴 유사체
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
EP1560807B1 (de) * 2002-11-12 2010-02-10 Grünenthal GmbH 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative
AR045939A1 (es) * 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
WO2007061862A2 (en) * 2005-11-18 2007-05-31 Janssen Pharmaceutica N.V. 2-keto-oxazoles as modulators of fatty acid amide hydrolase
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
WO2008050698A2 (en) 2006-10-16 2008-05-02 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
RS51474B (en) * 2007-01-16 2011-04-30 Purdue Pharma L.P. HETEROCYCLICALLY SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS
JP5313865B2 (ja) * 2007-03-01 2013-10-09 田辺三菱製薬株式会社 ベンゾイミダゾール化合物およびその医薬用途
BRPI0815327A2 (pt) * 2007-08-31 2015-12-15 Purdue Pharma Lp "compostos de piperidina do tipo quinoxalina substituída e os usos destes"
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
EP2582681A1 (en) * 2010-06-17 2013-04-24 Novartis AG Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
KR20190092464A (ko) * 2016-11-28 2019-08-07 미쓰비시 타나베 파마 코퍼레이션 코카인 의존증의 치료 또는 재발 예방약
WO2019141803A1 (en) * 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CN116496270A (zh) * 2022-01-27 2023-07-28 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
AT388731B (de) 1987-12-15 1989-08-25 Gerot Pharmazeutika Neue derivate von benzimidazol, ihre herstellung und verwendung
WO1997016186A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine agonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
EP0898568B1 (en) * 1996-04-19 2006-10-04 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
KR20010020172A (ko) 1997-05-30 2001-03-15 나가사까 겐지로 2-옥소이미다졸 유도체

Also Published As

Publication number Publication date
BR9907104A (pt) 2000-10-24
PL342046A1 (en) 2001-05-21
PT1049689E (pt) 2002-09-30
CO4990962A1 (es) 2000-12-26
IS5539A (is) 2000-06-16
EP1049689B1 (en) 2002-06-26
EP1049689A1 (en) 2000-11-08
BG104670A (en) 2001-05-31
CA2317462A1 (en) 1999-07-22
DE69901934T2 (de) 2002-11-07
EA200000683A1 (ru) 2000-12-25
NO20003671D0 (no) 2000-07-18
DK1049689T3 (da) 2002-07-22
JP3342478B2 (ja) 2002-11-11
JP2002509148A (ja) 2002-03-26
AP9901442A0 (en) 1999-03-31
MA26598A1 (fr) 2004-12-20
TNSN99006A1 (fr) 2005-11-10
PE20000166A1 (es) 2000-03-07
AR014421A1 (es) 2001-02-28
PA8467101A1 (es) 2000-09-29
OA11445A (en) 2004-04-30
ES2175925T3 (es) 2002-11-16
CN1288464A (zh) 2001-03-21
DE69901934D1 (de) 2002-08-01
CA2317462C (en) 2005-09-13
GT199900008A (es) 2000-07-12
US6423725B1 (en) 2002-07-23
AU1679099A (en) 1999-08-02
ATE219772T1 (de) 2002-07-15
ZA99314B (en) 2000-07-18
IL137149A0 (en) 2001-07-24
WO1999036421A1 (en) 1999-07-22
NO20003671L (no) 2000-09-18

Similar Documents

Publication Publication Date Title
TR200002090T2 (tr) Orl1-alıcı agonistleri olan 4-(2-keto-1-benzimidazolinil)piperidin bileşikleri
BG105271A (en) 1h-imidazopyridine derivatives
TW342310B (en) Non-systemic external dermal control of parasites
TR199700844T1 (tr) Pirazolil-Benzoil Türevleri.
TR200100075T2 (tr) 2-Kuinolon ihtiva eden farmasötik bileşimler
NO983493L (no) Nye benzimidazol-, benzoksazol- og benzotiazolforbindelser, fremgangsmÕte ved fremstilling derav og farmas°ytiske sammensetninger inneholdende slike
TR199700206A2 (tr) Floralkil- ve floralkoksi ikame edilmis heterosiklik bradikinin-antagonistleri, bunlarin imal edilmesine mahsus usul ve bunlarin kullanilmalari.
TR200003652T2 (tr) Glisin antagonistleri olarak tetrahidrokuinolin türevleri.
TR200100660T2 (tr) Piperidin türevleri.
ATE95816T1 (de) 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
ATE204567T1 (de) 1,4-dihydropyridine als bradykinin antagonisten
TR200100133T2 (tr) FKBP İnhibitörleri
DE60025171D1 (de) 1-acyl-7-nitroindolin derivate, deren herstellung und deren verwendung als photospaltbare vorstufen
TR199901583T2 (tr) CNS-Düzensizliklerinin iyilestirilmesi için ikame edilmis 4-(6-fluoro-(1H)- indol-3-il)-1,2,3,6-Tetrahidropirindin.
TR200000057T2 (tr) 6-pirolidin-2-ilpirindinler, hazırlanmaları ve terapötik uygulamaları.
DE69402703T2 (de) 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
DE69300162D1 (de) 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidin-4-carbonsäureamidderivate, ihre Herstellung und ihre Anwendung in der Therapeutica.
TR199801683A2 (tr) Yeni üre türevleri.
FI865057A (fi) Nya fluorhaltiga 1,4-dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
TR200300359T4 (tr) İkameli yeni (dihidro)benzoksazin ve (dihidro)benzotiyazin türevleri bunların hazırlanma yöntemleri ve bunları içeren farmasötik bileşimler
DE59814233D1 (de) Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten
NO20001228L (no) Fremgangsmate for fremstilling av N-(5-(difenylfosfinoylmetyl)-4-(4-fluorfenyl)-6-isopropylpyrimidin-2-yl)-N-metylmetansulfonamid
DE69108225T2 (de) Thioformamidderivate.
BR9406765A (pt) N-((1-(4-(4-fluorofenoxi)Butil)-4-Piperidinil)-N-Metilamino)-2-Benzotiazolois como agentes antiarritmicos classe III
MY120751A (en) Pharmaceutical formulation comprising a 2-aminoacetamide derivative and an ion exchange resin