DE69901934D1 - 4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste - Google Patents

4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste

Info

Publication number
DE69901934D1
DE69901934D1 DE69901934T DE69901934T DE69901934D1 DE 69901934 D1 DE69901934 D1 DE 69901934D1 DE 69901934 T DE69901934 T DE 69901934T DE 69901934 T DE69901934 T DE 69901934T DE 69901934 D1 DE69901934 D1 DE 69901934D1
Authority
DE
Germany
Prior art keywords
agoniste
benzimidazolinyl
keto
piperidine derivatives
orl1 receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69901934T
Other languages
English (en)
Other versions
DE69901934T2 (de
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Yoriko Ohashi
Tatsuya Yamagishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69901934D1 publication Critical patent/DE69901934D1/de
Publication of DE69901934T2 publication Critical patent/DE69901934T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69901934T 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste Expired - Fee Related DE69901934T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19
PCT/IB1999/000012 WO1999036421A1 (en) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists

Publications (2)

Publication Number Publication Date
DE69901934D1 true DE69901934D1 (de) 2002-08-01
DE69901934T2 DE69901934T2 (de) 2002-11-07

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901934T Expired - Fee Related DE69901934T2 (de) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste

Country Status (30)

Country Link
US (1) US6423725B1 (de)
EP (1) EP1049689B1 (de)
JP (1) JP3342478B2 (de)
CN (1) CN1288464A (de)
AP (1) AP9901442A0 (de)
AR (1) AR014421A1 (de)
AT (1) ATE219772T1 (de)
AU (1) AU1679099A (de)
BG (1) BG104670A (de)
BR (1) BR9907104A (de)
CA (1) CA2317462C (de)
CO (1) CO4990962A1 (de)
DE (1) DE69901934T2 (de)
DK (1) DK1049689T3 (de)
EA (1) EA200000683A1 (de)
ES (1) ES2175925T3 (de)
GT (1) GT199900008A (de)
IL (1) IL137149A0 (de)
IS (1) IS5539A (de)
MA (1) MA26598A1 (de)
NO (1) NO20003671L (de)
OA (1) OA11445A (de)
PA (1) PA8467101A1 (de)
PE (1) PE20000166A1 (de)
PL (1) PL342046A1 (de)
PT (1) PT1049689E (de)
TN (1) TNSN99006A1 (de)
TR (1) TR200002090T2 (de)
WO (1) WO1999036421A1 (de)
ZA (1) ZA99314B (de)

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US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
DE69923744T2 (de) * 1998-10-23 2006-02-23 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ATE275141T1 (de) 1999-10-13 2004-09-15 Banyu Pharma Co Ltd Substituierte imidazolin-derivate
DE60022226D1 (de) 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
WO2001039767A1 (en) 1999-12-06 2001-06-07 Euro-Celtique, S.A. Tertiary amino compounds having opioid receptor affinity
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
CA2428787A1 (en) 2000-11-15 2002-05-23 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
US6867222B2 (en) * 2001-04-18 2005-03-15 Euro-Celtique, S.A. Nociceptin analogs
ES2312616T3 (es) * 2001-04-18 2009-03-01 Euro-Celtique S.A. Compuestos de bencimidazolona.
WO2002085354A1 (en) 2001-04-18 2002-10-31 Euro-Celtique S.A. Spiroindene and spiroindane compounds
ATE403429T1 (de) 2001-04-18 2008-08-15 Euro Celtique Sa Spiropyrazol-verbindungen
KR100855204B1 (ko) 2001-04-18 2008-09-01 유로-셀티크 소시에떼 아노뉨 노시셉틴 유사체
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
EP1560807B1 (de) * 2002-11-12 2010-02-10 Grünenthal GmbH 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative
AR045939A1 (es) * 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
WO2007061862A2 (en) * 2005-11-18 2007-05-31 Janssen Pharmaceutica N.V. 2-keto-oxazoles as modulators of fatty acid amide hydrolase
US8354434B2 (en) 2006-01-30 2013-01-15 Purdue Pharma L.P. Cyclourea compounds as calcium channel blockers
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
WO2008050698A2 (en) 2006-10-16 2008-05-02 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
RS51474B (en) * 2007-01-16 2011-04-30 Purdue Pharma L.P. HETEROCYCLICALLY SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS
JP5313865B2 (ja) * 2007-03-01 2013-10-09 田辺三菱製薬株式会社 ベンゾイミダゾール化合物およびその医薬用途
BRPI0815327A2 (pt) * 2007-08-31 2015-12-15 Purdue Pharma Lp "compostos de piperidina do tipo quinoxalina substituída e os usos destes"
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
EP2582681A1 (de) * 2010-06-17 2013-04-24 Novartis AG Piperidinylsubstituierte 1,3-dihydro-benzoimidazol-2-ylidenaminderivate
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
KR20190092464A (ko) * 2016-11-28 2019-08-07 미쓰비시 타나베 파마 코퍼레이션 코카인 의존증의 치료 또는 재발 예방약
WO2019141803A1 (en) * 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CN116496270A (zh) * 2022-01-27 2023-07-28 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途

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US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
AT388731B (de) 1987-12-15 1989-08-25 Gerot Pharmazeutika Neue derivate von benzimidazol, ihre herstellung und verwendung
WO1997016186A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine agonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
EP0898568B1 (de) * 1996-04-19 2006-10-04 Neurosearch A/S 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität
KR20010020172A (ko) 1997-05-30 2001-03-15 나가사까 겐지로 2-옥소이미다졸 유도체

Also Published As

Publication number Publication date
BR9907104A (pt) 2000-10-24
PL342046A1 (en) 2001-05-21
PT1049689E (pt) 2002-09-30
CO4990962A1 (es) 2000-12-26
IS5539A (is) 2000-06-16
EP1049689B1 (de) 2002-06-26
EP1049689A1 (de) 2000-11-08
BG104670A (en) 2001-05-31
CA2317462A1 (en) 1999-07-22
DE69901934T2 (de) 2002-11-07
TR200002090T2 (tr) 2000-11-21
EA200000683A1 (ru) 2000-12-25
NO20003671D0 (no) 2000-07-18
DK1049689T3 (da) 2002-07-22
JP3342478B2 (ja) 2002-11-11
JP2002509148A (ja) 2002-03-26
AP9901442A0 (en) 1999-03-31
MA26598A1 (fr) 2004-12-20
TNSN99006A1 (fr) 2005-11-10
PE20000166A1 (es) 2000-03-07
AR014421A1 (es) 2001-02-28
PA8467101A1 (es) 2000-09-29
OA11445A (en) 2004-04-30
ES2175925T3 (es) 2002-11-16
CN1288464A (zh) 2001-03-21
CA2317462C (en) 2005-09-13
GT199900008A (es) 2000-07-12
US6423725B1 (en) 2002-07-23
AU1679099A (en) 1999-08-02
ATE219772T1 (de) 2002-07-15
ZA99314B (en) 2000-07-18
IL137149A0 (en) 2001-07-24
WO1999036421A1 (en) 1999-07-22
NO20003671L (no) 2000-09-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee