OA12246A - Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. - Google Patents
Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. Download PDFInfo
- Publication number
- OA12246A OA12246A OA1200200313A OA1200200313A OA12246A OA 12246 A OA12246 A OA 12246A OA 1200200313 A OA1200200313 A OA 1200200313A OA 1200200313 A OA1200200313 A OA 1200200313A OA 12246 A OA12246 A OA 12246A
- Authority
- OA
- OAPI
- Prior art keywords
- formula
- compound
- synthesis
- process according
- perindopril
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0004610A FR2807430B1 (fr) | 2000-04-11 | 2000-04-11 | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
Publications (1)
Publication Number | Publication Date |
---|---|
OA12246A true OA12246A (en) | 2003-12-08 |
Family
ID=8849107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200200313A OA12246A (en) | 2000-04-11 | 2001-04-10 | Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. |
Country Status (36)
Country | Link |
---|---|
US (1) | US6774259B2 (el) |
EP (1) | EP1272454B1 (el) |
JP (1) | JP3872344B2 (el) |
KR (1) | KR100520700B1 (el) |
CN (1) | CN1176903C (el) |
AP (1) | AP1417A (el) |
AR (1) | AR027782A1 (el) |
AT (1) | ATE362913T1 (el) |
AU (2) | AU5046701A (el) |
BG (1) | BG65833B1 (el) |
BR (1) | BR0109963A (el) |
CA (1) | CA2405466C (el) |
CY (1) | CY1106720T1 (el) |
CZ (1) | CZ302603B6 (el) |
DE (1) | DE60128554T2 (el) |
DK (1) | DK1272454T3 (el) |
EA (1) | EA004265B1 (el) |
EE (1) | EE05030B1 (el) |
ES (1) | ES2287114T3 (el) |
FR (1) | FR2807430B1 (el) |
GE (1) | GEP20063798B (el) |
HK (1) | HK1053300A1 (el) |
HR (1) | HRP20020887B1 (el) |
HU (1) | HU229189B1 (el) |
ME (1) | ME00442B (el) |
MX (1) | MXPA02009888A (el) |
NO (1) | NO327970B1 (el) |
NZ (1) | NZ521846A (el) |
OA (1) | OA12246A (el) |
PL (1) | PL346553A1 (el) |
PT (1) | PT1272454E (el) |
RS (1) | RS50240B (el) |
SK (1) | SK287067B6 (el) |
UA (1) | UA72040C2 (el) |
WO (1) | WO2001056972A1 (el) |
ZA (1) | ZA200207689B (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2807037B1 (fr) * | 2000-03-31 | 2002-05-10 | Adir | NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL |
FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
DK1603558T3 (da) | 2003-02-28 | 2008-09-01 | Servier S A Lab | Fremgangsmåde til fremstilling af perindopril og salte deraf |
EP1362845B1 (fr) * | 2003-09-01 | 2009-10-14 | Les Laboratoires Servier | Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril |
SI1400531T1 (sl) * | 2003-09-30 | 2006-04-30 | Servier Lab | Postopek za sintezo n-((s)-1-karbetoksibutil)-(s)-alanina in uporaba pri sintezi perindoprila |
ES2240926T3 (es) * | 2003-09-30 | 2005-10-16 | Les Laboratoires Servier | Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril. |
WO2005094793A1 (en) * | 2004-03-29 | 2005-10-13 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing a solid pharmaceutical composition |
SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
EP1792896A1 (en) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
FI126564B (fi) | 2011-02-28 | 2017-02-15 | Andritz Oy | Menetelmä ja laitteisto meesan polttamiseksi |
CN107098949B (zh) * | 2017-04-20 | 2021-03-16 | 上药东英(江苏)药业有限公司 | 一种制备培哚普利叔丁胺盐的绿色合成新工艺 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4296110A (en) * | 1980-10-28 | 1981-10-20 | E. I. Du Pont De Nemours And Company | Antihypertensive I-substituted cyclic lactam-2-carboxylic acids |
US4503043A (en) * | 1981-12-07 | 1985-03-05 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
-
2000
- 2000-04-11 FR FR0004610A patent/FR2807430B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-20 PL PL01346553A patent/PL346553A1/xx not_active Application Discontinuation
- 2001-03-30 HU HU0101337A patent/HU229189B1/hu not_active IP Right Cessation
- 2001-04-09 AR ARP010101670A patent/AR027782A1/es not_active Application Discontinuation
- 2001-04-10 CN CNB018079210A patent/CN1176903C/zh not_active Expired - Fee Related
- 2001-04-10 NZ NZ521846A patent/NZ521846A/en not_active IP Right Cessation
- 2001-04-10 EE EEP200200586A patent/EE05030B1/xx not_active IP Right Cessation
- 2001-04-10 ES ES01923776T patent/ES2287114T3/es not_active Expired - Lifetime
- 2001-04-10 OA OA1200200313A patent/OA12246A/en unknown
- 2001-04-10 MX MXPA02009888A patent/MXPA02009888A/es active IP Right Grant
- 2001-04-10 US US10/257,239 patent/US6774259B2/en not_active Expired - Lifetime
- 2001-04-10 DE DE60128554T patent/DE60128554T2/de not_active Expired - Lifetime
- 2001-04-10 AU AU5046701A patent/AU5046701A/xx active Pending
- 2001-04-10 CA CA002405466A patent/CA2405466C/fr not_active Expired - Fee Related
- 2001-04-10 GE GEAP20016688A patent/GEP20063798B/en unknown
- 2001-04-10 KR KR10-2002-7013604A patent/KR100520700B1/ko not_active IP Right Cessation
- 2001-04-10 PT PT01923776T patent/PT1272454E/pt unknown
- 2001-04-10 SK SK1457-2002A patent/SK287067B6/sk not_active IP Right Cessation
- 2001-04-10 RS YU76702A patent/RS50240B/sr unknown
- 2001-04-10 EA EA200201049A patent/EA004265B1/ru not_active IP Right Cessation
- 2001-04-10 AU AU2001250467A patent/AU2001250467B2/en not_active Ceased
- 2001-04-10 JP JP2001556822A patent/JP3872344B2/ja not_active Expired - Fee Related
- 2001-04-10 ME MEP-2008-671A patent/ME00442B/me unknown
- 2001-04-10 AP APAP/P/2002/002639A patent/AP1417A/en active
- 2001-04-10 EP EP01923776A patent/EP1272454B1/fr not_active Expired - Lifetime
- 2001-04-10 BR BR0109963-9A patent/BR0109963A/pt not_active Application Discontinuation
- 2001-04-10 WO PCT/FR2001/001088 patent/WO2001056972A1/fr active IP Right Grant
- 2001-04-10 CZ CZ20023323A patent/CZ302603B6/cs not_active IP Right Cessation
- 2001-04-10 AT AT01923776T patent/ATE362913T1/de active
- 2001-04-10 DK DK01923776T patent/DK1272454T3/da active
- 2001-10-04 UA UA2002118916A patent/UA72040C2/uk unknown
-
2002
- 2002-09-25 ZA ZA200207689A patent/ZA200207689B/xx unknown
- 2002-10-04 NO NO20024811A patent/NO327970B1/no not_active IP Right Cessation
- 2002-11-04 BG BG107250A patent/BG65833B1/bg unknown
- 2002-11-11 HR HR20020887A patent/HRP20020887B1/xx not_active IP Right Cessation
-
2003
- 2003-08-01 HK HK03105540A patent/HK1053300A1/xx not_active IP Right Cessation
-
2007
- 2007-07-12 CY CY20071100924T patent/CY1106720T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
OA12242A (en) | Method for synthesis of perindopril and its pharmaceutically acceptable salts. | |
AU2002334027B8 (en) | Novel method for synthesis of (2S, 3AS, 7AS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid derivatives and use for synthesis of perindopril | |
OA12246A (en) | Method for synthesis of N-Ä(S)-1-carboxybutylÜ-(S)-alanine esters and use in synthesis of perindopril. | |
US6818788B2 (en) | Method for synthesis of n-[(s)-1-carboxybutyl]-(s)-alanine esters and use in synthesis of perindopril | |
JP4279871B2 (ja) | (2s,3as,7as)−1−[(s)−アラニル]−オクタヒドロ−1h−インドール−2−カルボン酸誘導体類を合成する新規な方法およびペリンドプリル合成におけるその使用 | |
US7361757B2 (en) | Method for synthesizing esters of N-[(S)-1-carboxybutyl]-(S)-alanine and use thereof for synthesizing perindopril | |
WO2006006183A2 (en) | An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine |