OA12229A - Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. - Google Patents

Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. Download PDF

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Publication number
OA12229A
OA12229A OA1200200285A OA1200200285A OA12229A OA 12229 A OA12229 A OA 12229A OA 1200200285 A OA1200200285 A OA 1200200285A OA 1200200285 A OA1200200285 A OA 1200200285A OA 12229 A OA12229 A OA 12229A
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OA
OAPI
Prior art keywords
hydrochloride
methyl
compound
dione
amino
Prior art date
Application number
OA1200200285A
Other languages
English (en)
Inventor
Andrew Simon Craig
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of OA12229A publication Critical patent/OA12229A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA1200200285A 2000-03-14 2001-03-14 Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. OA12229A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0006133.3A GB0006133D0 (en) 2000-03-14 2000-03-14 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
OA12229A true OA12229A (en) 2003-11-07

Family

ID=9887600

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200285A OA12229A (en) 2000-03-14 2001-03-14 Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione.

Country Status (31)

Country Link
US (2) US7074811B2 (xx)
EP (1) EP1265893B1 (xx)
JP (1) JP2003527393A (xx)
KR (1) KR100746813B1 (xx)
CN (1) CN100516062C (xx)
AP (1) AP1545A (xx)
AT (1) ATE302202T1 (xx)
AU (1) AU777987B2 (xx)
BG (1) BG65924B1 (xx)
BR (1) BR0108870A (xx)
CA (1) CA2403109A1 (xx)
CZ (1) CZ20023074A3 (xx)
DE (1) DE60112729T2 (xx)
DK (1) DK1265893T3 (xx)
DZ (1) DZ3316A1 (xx)
EA (1) EA005115B1 (xx)
ES (1) ES2243458T3 (xx)
GB (1) GB0006133D0 (xx)
HK (1) HK1052502A1 (xx)
HU (1) HUP0300158A3 (xx)
IL (2) IL151425A0 (xx)
MA (1) MA25658A1 (xx)
MX (1) MXPA02008972A (xx)
NO (1) NO323448B1 (xx)
NZ (1) NZ520910A (xx)
OA (1) OA12229A (xx)
PL (1) PL357283A1 (xx)
SK (1) SK286399B6 (xx)
UA (1) UA73974C2 (xx)
WO (1) WO2001068646A1 (xx)
ZA (1) ZA200207292B (xx)

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EP1448559B1 (en) * 2001-11-21 2006-12-27 Smithkline Beecham Plc 5-(4-(2-(n-methyl-n-(2-pyridyl)amino)ethoxy)benzyl)thiazolidine-2,4-dione benzenesulfonate; process for its preparation; polymorphs i, ii and iii thereof; and its use as pharmaceutical active ingredient
WO2003050112A1 (en) * 2001-12-13 2003-06-19 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
NO347644B1 (no) 2006-05-04 2024-02-12 Boehringer Ingelheim Int Polymorfer
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US20090076093A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched rosiglitazone
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
US8513264B2 (en) 2008-09-10 2013-08-20 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US20100158821A1 (en) * 2008-12-22 2010-06-24 Eastman Chemical Company Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
MX2011006713A (es) 2008-12-23 2011-07-13 Boehringer Ingelheim Int Formas salinas de compuesto organico.
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
US8106111B2 (en) * 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
BR112012032579B1 (pt) 2010-06-24 2021-05-11 Boehringer Ingelheim International Gmbh uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
KR101985384B1 (ko) 2011-07-15 2019-06-03 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合

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US5708012A (en) * 1995-04-28 1998-01-13 Sankyo Company, Limited Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus
CZ298469B6 (cs) 1997-06-18 2007-10-10 Smithkline Beecham Plc Farmaceutický prostredek obsahující 5-[4-/2-(N-methyl-N-(2-pyridyl)amino)ethoxy/benzyl]thiazolidin-2,4-dion a metformin, a lécivo pro lécení diabetesmellitus
US20020137940A1 (en) * 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en) * 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9909041D0 (en) 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
GB9909075D0 (en) 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
CO5170421A1 (es) 1999-04-23 2002-06-27 Smithkline Beecham Plc Nuevo compuesto farmaceutico maleico
AP1607A (en) 1999-04-23 2006-05-03 Smithkline Beecham Plc Thiazolidinedione derivative and its use as antidiabetic.
DE60004658T2 (de) 1999-04-23 2004-06-24 Smithkline Beecham Plc, Brentford Thiazolidindionderivat und seine verwendung als antidiabetikum
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GB0021865D0 (en) 2000-09-06 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
AU4084301A (en) 2001-09-24
SK286399B6 (sk) 2008-09-05
DK1265893T3 (da) 2005-11-14
WO2001068646A1 (en) 2001-09-20
NO323448B1 (no) 2007-05-07
NO20024307L (no) 2002-09-09
UA73974C2 (en) 2005-10-17
KR100746813B1 (ko) 2007-08-06
HK1052502A1 (en) 2003-09-19
IL151425A (en) 2009-08-03
DE60112729T2 (de) 2006-06-08
ZA200207292B (en) 2003-05-06
US20040152901A1 (en) 2004-08-05
JP2003527393A (ja) 2003-09-16
CA2403109A1 (en) 2001-09-20
US7074811B2 (en) 2006-07-11
AU777987B2 (en) 2004-11-11
CN100516062C (zh) 2009-07-22
MA25658A1 (fr) 2002-12-31
BG107012A (bg) 2003-04-30
BG65924B1 (bg) 2010-05-31
KR20020079998A (ko) 2002-10-21
PL357283A1 (en) 2004-07-26
US20050267162A1 (en) 2005-12-01
DE60112729D1 (de) 2005-09-22
SK13302002A3 (sk) 2003-02-04
IL151425A0 (en) 2003-04-10
CN1358184A (zh) 2002-07-10
EP1265893A1 (en) 2002-12-18
MXPA02008972A (es) 2003-02-10
EP1265893B1 (en) 2005-08-17
HUP0300158A3 (en) 2005-04-28
EA200200975A1 (ru) 2003-02-27
EA005115B1 (ru) 2004-10-28
BR0108870A (pt) 2002-12-17
HUP0300158A2 (en) 2003-05-28
GB0006133D0 (en) 2000-05-03
AP2002002600A0 (en) 2002-09-30
DZ3316A1 (fr) 2001-09-20
AP1545A (en) 2006-01-12
CZ20023074A3 (cs) 2003-02-12
ATE302202T1 (de) 2005-09-15
NO20024307D0 (no) 2002-09-09
ES2243458T3 (es) 2005-12-01
NZ520910A (en) 2004-06-25

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