OA12229A - Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. - Google Patents
Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. Download PDFInfo
- Publication number
- OA12229A OA12229A OA1200200285A OA1200200285A OA12229A OA 12229 A OA12229 A OA 12229A OA 1200200285 A OA1200200285 A OA 1200200285A OA 1200200285 A OA1200200285 A OA 1200200285A OA 12229 A OA12229 A OA 12229A
- Authority
- OA
- OAPI
- Prior art keywords
- hydrochloride
- methyl
- compound
- dione
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0006133.3A GB0006133D0 (en) | 2000-03-14 | 2000-03-14 | Novel pharmaceutical |
Publications (1)
Publication Number | Publication Date |
---|---|
OA12229A true OA12229A (en) | 2003-11-07 |
Family
ID=9887600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200200285A OA12229A (en) | 2000-03-14 | 2001-03-14 | Hydrochloride salts of 5-Ä4-Ä2-(N-methyl-N-(2-pyridy))amino)ethoxyÜbenzylÜthiazolidine-2.4-dione. |
Country Status (31)
Country | Link |
---|---|
US (2) | US7074811B2 (fr) |
EP (1) | EP1265893B1 (fr) |
JP (1) | JP2003527393A (fr) |
KR (1) | KR100746813B1 (fr) |
CN (1) | CN100516062C (fr) |
AP (1) | AP1545A (fr) |
AT (1) | ATE302202T1 (fr) |
AU (1) | AU777987B2 (fr) |
BG (1) | BG65924B1 (fr) |
BR (1) | BR0108870A (fr) |
CA (1) | CA2403109A1 (fr) |
CZ (1) | CZ20023074A3 (fr) |
DE (1) | DE60112729T2 (fr) |
DK (1) | DK1265893T3 (fr) |
DZ (1) | DZ3316A1 (fr) |
EA (1) | EA005115B1 (fr) |
ES (1) | ES2243458T3 (fr) |
GB (1) | GB0006133D0 (fr) |
HK (1) | HK1052502A1 (fr) |
HU (1) | HUP0300158A3 (fr) |
IL (2) | IL151425A0 (fr) |
MA (1) | MA25658A1 (fr) |
MX (1) | MXPA02008972A (fr) |
NO (1) | NO323448B1 (fr) |
NZ (1) | NZ520910A (fr) |
OA (1) | OA12229A (fr) |
PL (1) | PL357283A1 (fr) |
SK (1) | SK286399B6 (fr) |
UA (1) | UA73974C2 (fr) |
WO (1) | WO2001068646A1 (fr) |
ZA (1) | ZA200207292B (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0021865D0 (en) * | 2000-09-06 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
GB0023971D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
EP1448559B1 (fr) * | 2001-11-21 | 2006-12-27 | Smithkline Beecham Plc | 5-(4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione benzenesulfonate, procede de preparation, polymorphes i, ii et iii de celui-ci et son utilisation comme ingredient actif |
WO2003050112A1 (fr) * | 2001-12-13 | 2003-06-19 | Smithkline Beecham Plc | Hydrates de toluenesulfonate d'un derive de thiazolidinedione |
GB0129876D0 (en) * | 2001-12-13 | 2002-02-06 | Smithkline Beecham Plc | Novel pharmaceutical |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
WO2006018853A2 (fr) | 2004-08-19 | 2006-02-23 | Hetero Drugs Limited | Nouveaux polymorphes d'efavirenz |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
NO347644B1 (no) | 2006-05-04 | 2024-02-12 | Boehringer Ingelheim Int | Polymorfer |
EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
US20090076093A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched rosiglitazone |
AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
US8513264B2 (en) | 2008-09-10 | 2013-08-20 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
US20100158821A1 (en) * | 2008-12-22 | 2010-06-24 | Eastman Chemical Company | Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products |
MX2011006713A (es) | 2008-12-23 | 2011-07-13 | Boehringer Ingelheim Int | Formas salinas de compuesto organico. |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
US8106111B2 (en) * | 2009-05-15 | 2012-01-31 | Eastman Chemical Company | Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions |
EA034869B1 (ru) | 2009-11-27 | 2020-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин |
MX341025B (es) | 2010-05-05 | 2016-08-04 | Boehringer Ingelheim Int Gmbh * | Terapia de combinacion. |
BR112012032579B1 (pt) | 2010-06-24 | 2021-05-11 | Boehringer Ingelheim International Gmbh | uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
KR101985384B1 (ko) | 2011-07-15 | 2019-06-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도 |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013171167A1 (fr) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | Dérivé de xanthine en tant qu'inhibiteur de dpp-4 pour l'utilisation dans le traitement de troubles associés aux podocytes et/ou un syndrome néphrotique |
WO2013174767A1 (fr) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US137940A (en) * | 1873-04-15 | Improvement in elevators | ||
US120078A (en) * | 1871-10-17 | Improvement in revolving flower-stands | ||
US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
EP0842925A1 (fr) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Thiazolidinédiones substituées |
GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
CZ298469B6 (cs) | 1997-06-18 | 2007-10-10 | Smithkline Beecham Plc | Farmaceutický prostredek obsahující 5-[4-/2-(N-methyl-N-(2-pyridyl)amino)ethoxy/benzyl]thiazolidin-2,4-dion a metformin, a lécivo pro lécení diabetesmellitus |
US20020137940A1 (en) * | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
US6664278B2 (en) * | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
GB9909041D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
GB9909075D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
CO5170421A1 (es) | 1999-04-23 | 2002-06-27 | Smithkline Beecham Plc | Nuevo compuesto farmaceutico maleico |
AP1607A (en) | 1999-04-23 | 2006-05-03 | Smithkline Beecham Plc | Thiazolidinedione derivative and its use as antidiabetic. |
DE60004658T2 (de) | 1999-04-23 | 2004-06-24 | Smithkline Beecham Plc, Brentford | Thiazolidindionderivat und seine verwendung als antidiabetikum |
HU225919B1 (en) | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
CN1277965A (zh) | 2000-06-14 | 2000-12-27 | 中国医药研究开发中心 | 盐酸罗格列酮及其应用 |
GB0021865D0 (en) | 2000-09-06 | 2000-10-18 | Smithkline Beecham Plc | Novel pharmaceutical |
-
2000
- 2000-03-14 GB GBGB0006133.3A patent/GB0006133D0/en not_active Ceased
-
2001
- 2001-03-14 CA CA002403109A patent/CA2403109A1/fr not_active Abandoned
- 2001-03-14 IL IL15142501A patent/IL151425A0/xx unknown
- 2001-03-14 EA EA200200975A patent/EA005115B1/ru not_active IP Right Cessation
- 2001-03-14 WO PCT/GB2001/001131 patent/WO2001068646A1/fr active IP Right Grant
- 2001-03-14 CZ CZ20023074A patent/CZ20023074A3/cs unknown
- 2001-03-14 CN CNB018000010A patent/CN100516062C/zh not_active Expired - Fee Related
- 2001-03-14 BR BR0108870-0A patent/BR0108870A/pt not_active IP Right Cessation
- 2001-03-14 NZ NZ520910A patent/NZ520910A/en not_active IP Right Cessation
- 2001-03-14 PL PL01357283A patent/PL357283A1/xx not_active Application Discontinuation
- 2001-03-14 HU HU0300158A patent/HUP0300158A3/hu unknown
- 2001-03-14 JP JP2001567737A patent/JP2003527393A/ja active Pending
- 2001-03-14 AT AT01911921T patent/ATE302202T1/de active
- 2001-03-14 DE DE60112729T patent/DE60112729T2/de not_active Expired - Lifetime
- 2001-03-14 DZ DZ013316A patent/DZ3316A1/fr active
- 2001-03-14 MX MXPA02008972A patent/MXPA02008972A/es active IP Right Grant
- 2001-03-14 UA UA2002097390A patent/UA73974C2/uk unknown
- 2001-03-14 EP EP01911921A patent/EP1265893B1/fr not_active Expired - Lifetime
- 2001-03-14 DK DK01911921T patent/DK1265893T3/da active
- 2001-03-14 AP APAP/P/2002/002600A patent/AP1545A/en active
- 2001-03-14 SK SK1330-2002A patent/SK286399B6/sk not_active IP Right Cessation
- 2001-03-14 OA OA1200200285A patent/OA12229A/en unknown
- 2001-03-14 KR KR1020027011997A patent/KR100746813B1/ko not_active IP Right Cessation
- 2001-03-14 AU AU40843/01A patent/AU777987B2/en not_active Ceased
- 2001-03-14 US US10/221,686 patent/US7074811B2/en not_active Expired - Fee Related
- 2001-03-14 ES ES01911921T patent/ES2243458T3/es not_active Expired - Lifetime
-
2002
- 2002-08-20 BG BG107012A patent/BG65924B1/bg unknown
- 2002-08-22 IL IL151425A patent/IL151425A/en not_active IP Right Cessation
- 2002-09-09 NO NO20024307A patent/NO323448B1/no not_active IP Right Cessation
- 2002-09-11 ZA ZA200207292A patent/ZA200207292B/en unknown
- 2002-09-12 MA MA26814A patent/MA25658A1/fr unknown
-
2003
- 2003-05-13 HK HK03103374A patent/HK1052502A1/xx not_active IP Right Cessation
-
2005
- 2005-07-18 US US11/183,353 patent/US20050267162A1/en not_active Abandoned
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