OA11736A - Novel streptococcus antigens. - Google Patents
Novel streptococcus antigens. Download PDFInfo
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- OA11736A OA11736A OA1200100165A OA1200100165A OA11736A OA 11736 A OA11736 A OA 11736A OA 1200100165 A OA1200100165 A OA 1200100165A OA 1200100165 A OA1200100165 A OA 1200100165A OA 11736 A OA11736 A OA 11736A
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- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11380098P | 1998-12-23 | 1998-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11736A true OA11736A (en) | 2005-06-12 |
Family
ID=22351610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200100165A OA11736A (en) | 1998-12-23 | 1999-12-20 | Novel streptococcus antigens. |
Country Status (30)
| Country | Link |
|---|---|
| EP (2) | EP2261358B1 (fr) |
| JP (2) | JP4761623B2 (fr) |
| KR (4) | KR100802198B1 (fr) |
| CN (3) | CN1191362C (fr) |
| AP (1) | AP2001002199A0 (fr) |
| AR (1) | AR029322A1 (fr) |
| AT (1) | ATE394489T1 (fr) |
| AU (1) | AU1764900A (fr) |
| BR (1) | BR9916477A (fr) |
| CA (1) | CA2356836C (fr) |
| CL (1) | CL2009002037A1 (fr) |
| CY (3) | CY1108223T1 (fr) |
| CZ (2) | CZ303675B6 (fr) |
| DE (1) | DE69938670D1 (fr) |
| DK (3) | DK2261358T3 (fr) |
| EA (1) | EA007409B1 (fr) |
| ES (3) | ES2306528T3 (fr) |
| HK (1) | HK1118575A1 (fr) |
| HU (1) | HU229664B1 (fr) |
| IL (3) | IL143905A0 (fr) |
| MX (1) | MXPA01006427A (fr) |
| NO (1) | NO330800B1 (fr) |
| NZ (1) | NZ512574A (fr) |
| OA (1) | OA11736A (fr) |
| PL (3) | PL204073B1 (fr) |
| PT (3) | PT1950302E (fr) |
| TR (2) | TR200102497T2 (fr) |
| UY (1) | UY25877A1 (fr) |
| WO (1) | WO2000039299A2 (fr) |
| ZA (1) | ZA200105114B (fr) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2000001886A0 (en) | 1998-02-20 | 2000-09-30 | Iaf Biochem Int | Group B streptococcus antigens. |
| US20030134407A1 (en) | 1998-07-27 | 2003-07-17 | Le Page Richard William Falla | Nucleic acids and proteins from Streptococcus pneumoniae |
| EP1801218A3 (fr) * | 1998-07-27 | 2007-10-10 | Sanofi Pasteur Limited | Acides nucléiques et protéines de la pneumonie à streptocoques |
| JP4689044B2 (ja) | 1998-12-21 | 2011-05-25 | メディミューン，インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
| KR100802198B1 (ko) * | 1998-12-23 | 2008-02-11 | 샤이어 바이오켐 인코포레이티드 | 신규한 스트렙토코커스 항원 |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| EP1294771B1 (fr) | 2000-06-12 | 2008-10-29 | University Of Saskatchewan | Protéine chimérique GapC de Streptococcus et son utilisation pour la vaccination et la diagnostique |
| US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| WO2001098334A2 (fr) * | 2000-06-20 | 2001-12-27 | Shire Biochem Inc. | Antigenes de streptocoque |
| AU2002242549A1 (en) * | 2001-03-30 | 2002-10-15 | Shire Biochem Inc. | Streptococcus pyogenes antigens and corresponding dna fragments |
| ATE452191T1 (de) * | 2001-07-06 | 2010-01-15 | Id Biomedical Corp | Gruppe-b streptococcus antigene und entsprechende dna-fragmente |
| GB0130228D0 (en) * | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| AU2002351623A1 (en) | 2001-12-20 | 2003-07-09 | Shire Biochem Inc. | Streptococcus antigens |
| CN1756843B (zh) | 2003-03-04 | 2012-03-21 | 英特塞尔股份公司 | 化脓链球菌抗原 |
| EP2311988A1 (fr) | 2003-04-15 | 2011-04-20 | Intercell AG | Antigènes de S. pneumoniae |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2808919C (fr) | 2005-12-22 | 2016-04-19 | Glaxosmithkline Biologicals S.A. | Vaccin comportant des conjugues polysaccharides capsulaires streptococcus pneumoniae |
| EP2687228B1 (fr) | 2007-06-26 | 2017-07-19 | GlaxoSmithKline Biologicals S.A. | Vaccin contenant des conjugues de polysaccharide capsulaire de streptococcus pneumoniae |
| AU2008280799B2 (en) * | 2007-07-23 | 2013-07-11 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| KR20110009157A (ko) * | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| WO2010036938A2 (fr) | 2008-09-26 | 2010-04-01 | Nanobio Corporation | Compositions thérapeutiques de nanoémulsion et procédés d'utilisation de celles-ci |
| WO2010125480A1 (fr) | 2009-04-30 | 2010-11-04 | Coley Pharmaceutical Group, Inc. | Vaccin anti-pneumococcique et ses utilisations |
| WO2010132833A1 (fr) | 2009-05-14 | 2010-11-18 | The Regents Of The University Of Michigan | Compositions vaccinales contre streptococcus et méthodes d'utilisation associées |
| ES2670576T3 (es) | 2009-09-03 | 2018-05-31 | Pfizer Vaccines Llc | Vacuna de PCSK9 |
| GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| WO2012075428A1 (fr) | 2010-12-03 | 2012-06-07 | Sanofi Pasteur Limited | Composition pour l'immunisation contre streptococcus pneumoniae |
| MY163871A (en) | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| WO2012131504A1 (fr) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Vaccin à base de pcsk9 |
| US20140072622A1 (en) | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| US10161940B2 (en) * | 2012-01-05 | 2018-12-25 | Deutsches Krebsforschungszentrum | Means and methods for treating or diagnosing IDH1 R132H mutant-positive cancers |
| WO2014089706A1 (fr) * | 2012-12-14 | 2014-06-19 | Sanofi Pasteur, Ltd. | Méthodes pour évaluer l'immunogénicité |
| PL3096785T3 (pl) | 2014-01-21 | 2021-03-08 | Pfizer Inc. | Kompozycje immunogenne zawierające skoniugowane antygeny sacharydów otoczkowych i ich zastosowania |
| RU2710393C2 (ru) | 2014-01-21 | 2019-12-26 | Пфайзер Инк. | Способ получения иммуногенного конъюгата капсульный полисахарид Streptococcus pneumoniae-белок-носитель |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PL3583947T3 (pl) | 2014-01-21 | 2024-04-02 | Pfizer Inc. | Polisacharydy otoczkowe streptococcus pneumoniae i ich koniugaty |
| EP3443983B1 (fr) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Conjugués immunogènes de glycoprotéine |
| EP3244917B1 (fr) | 2015-01-15 | 2023-04-19 | Pfizer Inc. | Compositions immunogènes destinées à être utilisées dans des vaccins antipneumococciques |
| MY192183A (en) | 2015-07-21 | 2022-08-05 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| JP6884145B2 (ja) | 2015-11-20 | 2021-06-09 | ファイザー・インク | 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物 |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| CN110198735A (zh) | 2017-01-20 | 2019-09-03 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| JP2022512345A (ja) | 2018-12-12 | 2022-02-03 | ファイザー・インク | 免疫原性多重ヘテロ抗原多糖－タンパク質コンジュゲートおよびその使用 |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CA3136278A1 (fr) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Compositions immunogenes comprenant des antigenes saccharidiques capsulaires conjugues, kits les comprenant et leurs utilisations |
| KR20220042378A (ko) | 2019-07-31 | 2022-04-05 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 및 그 사용 방법 |
| KR20220092572A (ko) | 2019-11-01 | 2022-07-01 | 화이자 인코포레이티드 | 에스케리키아 콜라이 조성물 및 그 방법 |
| CA3171864A1 (fr) | 2020-02-21 | 2021-08-26 | Pfizer Inc. | Purification de saccharides |
| CN115605498A (zh) | 2020-02-23 | 2023-01-13 | 辉瑞公司（Us） | 大肠杆菌组合物及其方法 |
| EP4232593A1 (fr) | 2020-10-22 | 2023-08-30 | Pfizer Inc. | Procédés de purification de polysaccharides bactériens |
| MX2023004912A (es) | 2020-10-27 | 2023-05-16 | Pfizer | Composiciones de escherichia coli y metodos de las mismas. |
| KR20230097160A (ko) | 2020-11-04 | 2023-06-30 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| US20220202923A1 (en) | 2020-12-23 | 2022-06-30 | Pfizer Inc. | E. coli fimh mutants and uses thereof |
| CA3218544A1 (fr) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination contre des infections bacteriennes et a betacoronavirus |
| WO2022234416A1 (fr) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination contre des infections à pneumocoque et à covid-19 |
| BR112023023671A2 (pt) | 2021-05-28 | 2024-02-06 | Pfizer | Composições imunogênicas compreendendo antígenos de sacarídeo capsular conjugados e usos dos mesmos |
| TW202306969A (zh) | 2021-05-28 | 2023-02-16 | 美商輝瑞大藥廠 | 包含結合之莢膜醣抗原的免疫原組合物及其用途 |
| WO2023135515A1 (fr) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Compositions immunogènes à base d'antigènes saccharidiques capsulaires conjugués et leurs utilisations |
| WO2023161817A1 (fr) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Procédés d'incorporation de groupes azido dans des polysaccharides capsulaires bactériens |
| WO2023218322A1 (fr) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Procédé de production de formulations de vaccin avec des conservateurs |
| WO2024084397A1 (fr) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination contre infections à pneumocoques et à covid-19 |
| WO2024110827A1 (fr) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Procédés de préparation d'antigènes saccharidiques capsulaires conjugués et leurs utilisations |
| WO2024110839A2 (fr) | 2022-11-22 | 2024-05-30 | Pfizer Inc. | Compositions immunogènes comprenant des antigènes saccharidiques capsulaires conjugués et leurs utilisations |
| WO2024116096A1 (fr) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Formulations de vaccin pneumococcique conjugué |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| CA2158658A1 (fr) * | 1993-03-19 | 1994-09-29 | Margaretha Stalhammar-Carlemalm | Proteine appelee rib, proteine cellulaire de surface qui confere l'immunite a un grand nombre de souches du groupe du streptocoque b; methode pour purifier la proteine; trousse dereactif et composition pharmaceutique |
| JPH11507214A (ja) * | 1995-06-07 | 1999-06-29 | バイオケム ヴァシーンズ インク． | Ｈｓｐ７０ファミリーに属する連鎖球菌の熱ショック蛋白質メンバー |
| US5882896A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| US5928895A (en) * | 1996-09-24 | 1999-07-27 | Smithkline Beecham Corporation | IgA Fc binding protein |
| EP0941335A2 (fr) * | 1996-10-31 | 1999-09-15 | Human Genome Sciences | Polynucleotides et sequences de streptococcus pneumoniae |
| EP1017828A1 (fr) * | 1997-09-24 | 2000-07-12 | Regents Of The University Of Minnesota | PROTEINASE DE DEGRADATION DE LA PROTEINE DE COMPLEMENT HUMAIN C3, TIREE DU $i(STREPTOCOCCUS PNEUMONIAE) |
| AU770378B2 (en) * | 1998-04-23 | 2004-02-19 | Uab Research Foundation | Pneumococcal surface protein C(PspC), epitopic regions and strain selection thereof, and uses therefor |
| JP2002521058A (ja) * | 1998-07-27 | 2002-07-16 | マイクロビアル テクニクス リミティッド | 肺炎連鎖球菌由来の核酸及びタンパク質 |
| EP2053126A1 (fr) * | 1998-07-27 | 2009-04-29 | Sanofi Pasteur Limited | Protéines de pneumonie à streptocoques et molécules d'acide nucléique |
| IL142017A0 (en) * | 1998-09-24 | 2002-03-10 | Univ Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
| JP4689044B2 (ja) * | 1998-12-21 | 2011-05-25 | メディミューン，インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
| KR100802198B1 (ko) * | 1998-12-23 | 2008-02-11 | 샤이어 바이오켐 인코포레이티드 | 신규한 스트렙토코커스 항원 |
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1999
- 1999-12-20 KR KR1020017007963A patent/KR100802198B1/ko not_active IP Right Cessation
- 1999-12-20 AU AU17649/00A patent/AU1764900A/en not_active Abandoned
- 1999-12-20 AT AT99960748T patent/ATE394489T1/de active
- 1999-12-20 DK DK10180372.4T patent/DK2261358T3/da active
- 1999-12-20 OA OA1200100165A patent/OA11736A/en unknown
- 1999-12-20 KR KR1020107009285A patent/KR101078919B1/ko not_active IP Right Cessation
- 1999-12-20 ES ES99960748T patent/ES2306528T3/es not_active Expired - Lifetime
- 1999-12-20 EA EA200100565A patent/EA007409B1/ru not_active IP Right Cessation
- 1999-12-20 TR TR2001/02497T patent/TR200102497T2/xx unknown
- 1999-12-20 DK DK99960748T patent/DK1141306T3/da active
- 1999-12-20 KR KR1020087008264A patent/KR101170203B1/ko not_active IP Right Cessation
- 1999-12-20 CZ CZ20012161A patent/CZ303675B6/cs not_active IP Right Cessation
- 1999-12-20 BR BR9916477-9A patent/BR9916477A/pt active Search and Examination
- 1999-12-20 DE DE69938670T patent/DE69938670D1/de not_active Expired - Lifetime
- 1999-12-20 PT PT81553174T patent/PT1950302E/pt unknown
- 1999-12-20 EP EP10180372.4A patent/EP2261358B1/fr not_active Expired - Lifetime
- 1999-12-20 PL PL382438A patent/PL204073B1/pl not_active IP Right Cessation
- 1999-12-20 PT PT99960748T patent/PT1141306E/pt unknown
- 1999-12-20 PT PT101803724T patent/PT2261358E/pt unknown
- 1999-12-20 AP APAP/P/2001/002199A patent/AP2001002199A0/en unknown
- 1999-12-20 IL IL14390599A patent/IL143905A0/xx unknown
- 1999-12-20 DK DK08155317.4T patent/DK1950302T3/da active
- 1999-12-20 WO PCT/CA1999/001218 patent/WO2000039299A2/fr active Application Filing
- 1999-12-20 CN CNB998149047A patent/CN1191362C/zh not_active Expired - Fee Related
- 1999-12-20 CA CA2356836A patent/CA2356836C/fr not_active Expired - Fee Related
- 1999-12-20 KR KR1020067025282A patent/KR100891398B1/ko not_active IP Right Cessation
- 1999-12-20 PL PL349777A patent/PL206576B1/pl unknown
- 1999-12-20 CN CNB2005100037492A patent/CN100398653C/zh not_active Expired - Fee Related
- 1999-12-20 NZ NZ512574A patent/NZ512574A/xx not_active IP Right Cessation
- 1999-12-20 PL PL382437A patent/PL205041B1/pl unknown
- 1999-12-20 JP JP2000591190A patent/JP4761623B2/ja not_active Expired - Fee Related
- 1999-12-20 HU HU0104774A patent/HU229664B1/hu not_active IP Right Cessation
- 1999-12-20 CN CNA2007101481600A patent/CN101134775A/zh active Pending
- 1999-12-20 ES ES08155317T patent/ES2400280T3/es not_active Expired - Lifetime
- 1999-12-20 TR TR2002/00633T patent/TR200200633T2/xx unknown
- 1999-12-20 EP EP99960748A patent/EP1141306B1/fr not_active Expired - Lifetime
- 1999-12-20 MX MXPA01006427A patent/MXPA01006427A/es not_active IP Right Cessation
- 1999-12-20 ES ES10180372.4T patent/ES2480417T3/es not_active Expired - Lifetime
- 1999-12-20 CZ CZ20100674A patent/CZ302790B6/cs not_active IP Right Cessation
- 1999-12-23 AR ARP990106746A patent/AR029322A1/es not_active Application Discontinuation
- 1999-12-23 UY UY25877A patent/UY25877A1/es unknown
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2001
- 2001-06-19 NO NO20013045A patent/NO330800B1/no not_active IP Right Cessation
- 2001-06-21 IL IL143905A patent/IL143905A/en not_active IP Right Cessation
- 2001-06-21 ZA ZA200105114A patent/ZA200105114B/en unknown
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2008
- 2008-07-29 CY CY20081100787T patent/CY1108223T1/el unknown
- 2008-09-10 HK HK08110047.4A patent/HK1118575A1/xx not_active IP Right Cessation
- 2008-09-21 IL IL194230A patent/IL194230A/en not_active IP Right Cessation
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2009
- 2009-11-05 CL CL2009002037A patent/CL2009002037A1/es unknown
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2010
- 2010-02-09 JP JP2010026521A patent/JP5039802B2/ja not_active Expired - Fee Related
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2012
- 2012-12-27 CY CY20121101268T patent/CY1114722T1/el unknown
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2014
- 2014-07-16 CY CY20141100536T patent/CY1115340T1/el unknown
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