NZ706269A - Non-invasive determination of methylome of fetus or tumor from plasma - Google Patents

Non-invasive determination of methylome of fetus or tumor from plasma

Info

Publication number
NZ706269A
NZ706269A NZ706269A NZ70626913A NZ706269A NZ 706269 A NZ706269 A NZ 706269A NZ 706269 A NZ706269 A NZ 706269A NZ 70626913 A NZ70626913 A NZ 70626913A NZ 706269 A NZ706269 A NZ 706269A
Authority
NZ
New Zealand
Prior art keywords
methylation
fetus
tumor
dna
profile
Prior art date
Application number
NZ706269A
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ706269(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Priority to NZ717423A priority Critical patent/NZ717423A/en
Publication of NZ706269A publication Critical patent/NZ706269A/en

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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/125Bisulfite(s)
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    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122Massive parallel sequencing
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
NZ706269A 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma NZ706269A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ717423A NZ717423A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
NZ706269A true NZ706269A (en) 2016-08-26

Family

ID=50340462

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ706269A NZ706269A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma
NZ717423A NZ717423A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

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Application Number Title Priority Date Filing Date
NZ717423A NZ717423A (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

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JP (6) JP6317354B2 (cg-RX-API-DMAC7.html)
KR (5) KR102307424B1 (cg-RX-API-DMAC7.html)
CN (2) CN117757932A (cg-RX-API-DMAC7.html)
AU (5) AU2013317708C1 (cg-RX-API-DMAC7.html)
BR (3) BR112015006183B1 (cg-RX-API-DMAC7.html)
CA (2) CA3122779A1 (cg-RX-API-DMAC7.html)
CY (1) CY1124139T1 (cg-RX-API-DMAC7.html)
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LT (2) LT3354747T (cg-RX-API-DMAC7.html)
MX (1) MX360034B (cg-RX-API-DMAC7.html)
MY (2) MY187444A (cg-RX-API-DMAC7.html)
NZ (2) NZ706269A (cg-RX-API-DMAC7.html)
PH (2) PH12022552061A1 (cg-RX-API-DMAC7.html)
PL (4) PL3354747T3 (cg-RX-API-DMAC7.html)
PT (4) PT3536807T (cg-RX-API-DMAC7.html)
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WO (1) WO2014043763A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP2898100B9 (en) 2012-09-20 2023-08-02 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3029148B1 (en) * 2013-07-30 2018-06-27 BGI Genomics Co., Limited Method for determining nucleic acid composition of nucleic acid mixture
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
WO2015126840A1 (en) * 2014-02-18 2015-08-27 Bionano Genomics, Inc. Improved methods of determining nucleic acid structural information
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
JP6659575B2 (ja) * 2014-04-21 2020-03-04 ナテラ, インコーポレイテッド 変異の検出および染色体分節の倍数性
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
WO2015169947A1 (en) 2014-05-09 2015-11-12 Lifecodexx Ag Detection of dna that originates from a specific cell-type and related methods
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
HUE056267T2 (hu) 2014-07-18 2022-02-28 Univ Hong Kong Chinese DNS-keverékek szöveteinek metilációs mintázatelemzése
JP2017522908A (ja) 2014-07-25 2017-08-17 ユニヴァーシティ オブ ワシントン セルフリーdnaを生じる組織及び/又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法
EP3240911B1 (en) * 2014-12-31 2020-08-26 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
DK3256605T3 (da) 2015-02-10 2022-03-14 Univ Hong Kong Chinese Påvisning af mutationer til cancerscreening og føtal analyse
EP3739061B1 (en) 2015-07-20 2022-03-23 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
ES2960201T3 (es) * 2015-07-23 2024-03-01 Univ Hong Kong Chinese Análisis de los patrones de fragmentación del ADN acelular
MY188348A (en) 2015-08-12 2021-12-02 Univ Hong Kong Chinese Single-molecule sequencing of plasma dna
TWI858334B (zh) 2015-09-22 2024-10-11 香港中文大學 藉由母體血漿dna之淺深度測序以準確定量胎兒dna含量
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
CA3004527A1 (en) * 2015-11-09 2017-05-18 Progenity, Inc. Methods for determining the origin of dna molecules
HUE050491T2 (hu) 2015-11-10 2020-12-28 Eurofins Lifecodexx Gmbh Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
EP4648053A2 (en) * 2015-12-17 2025-11-12 Illumina, Inc. Distinguishing methylation levels in complex biological samples
SG11201806609TA (en) * 2016-02-02 2018-09-27 Guardant Health Inc Cancer evolution detection and diagnostic
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
EP4425178A3 (en) * 2016-05-03 2024-12-18 University Health Network Methods of capturing cell-free methylated dna and uses of same
WO2017201606A1 (en) * 2016-05-04 2017-11-30 Queen's University At Kingston Cell-free detection of methylated tumour dna
IL303115B2 (en) * 2016-05-30 2025-09-01 Univ Hong Kong Chinese Detection of hematological disorders using cell-free DNA in blood
EP3472358B1 (en) * 2016-06-16 2021-08-18 The Johns Hopkins University Methods and system for epigenetic analysis
CN107779485B (zh) 2016-08-24 2022-03-18 中国科学院分子细胞科学卓越创新中心 Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用
MY205940A (en) * 2016-10-19 2024-11-21 Univ Hong Kong Chinese Gestational age assessment by methylation and size profiling of maternal plasma dna
CA3041647A1 (en) 2016-10-24 2018-05-03 The Chinese University Of Hong Kong Methods and systems for tumor detection
JP2020503003A (ja) 2016-11-30 2020-01-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 尿および他のサンプルにおける無細胞dnaの分析
EP4450648A3 (en) * 2016-12-13 2025-01-15 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
US20200255896A1 (en) * 2017-01-11 2020-08-13 Quest Diagnostics Investments Llc Method for non-invasive prenatal screening for aneuploidy
HRP20240709T1 (hr) * 2017-01-24 2024-08-16 Bgi Genomics Co., Ltd. Postupak za određivanje udjela nukleinskih kiselina bez stanica iz unaprijed određenog izvora u biološkom uzorku
US10633713B2 (en) 2017-01-25 2020-04-28 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
JP7368235B2 (ja) * 2017-05-12 2023-10-24 プレジデント アンド フェローズ オブ ハーバード カレッジ ユニバーサル早期がん診断
CN118782138A (zh) * 2017-07-12 2024-10-15 安德股份有限公司 模式识别系统
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
WO2019010564A1 (en) * 2017-07-12 2019-01-17 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS
DK3658684T3 (da) 2017-07-26 2023-10-09 Univ Hong Kong Chinese Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP4269583B1 (en) 2017-09-28 2025-12-31 Grail, Inc. ENRICHEMENT OF SHORT NUCLEIC ACID FRAGMENTS IN SEQUENCING BANK PREPARATION
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
TW202434742A (zh) 2018-03-13 2024-09-01 美商格瑞爾有限責任公司 異常片段偵測及分類
CA3093971A1 (en) * 2018-03-15 2019-09-19 Grail, Inc. Tissue-specific methylation marker
GB2587939B (en) 2018-04-02 2023-06-14 Grail Llc Methylation markers and targeted methylation probe panels
EP3776381A4 (en) * 2018-04-13 2022-01-05 Freenome Holdings, Inc. IMPLEMENTATION OF MACHINE LEARNING FOR MULTI-ANALYTE TESTS OF BIOLOGICAL SAMPLES
EP3781709A4 (en) * 2018-04-16 2022-11-30 Grail, LLC Systems and methods for determining tumor fraction in cell-free nucleic acid
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
CN113286881A (zh) 2018-09-27 2021-08-20 格里尔公司 甲基化标记和标靶甲基化探针板
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
AU2019384154B2 (en) 2018-11-21 2025-11-20 Agilent Technologies, Inc. Methods for targeted nucleic acid library formation
KR20210113237A (ko) * 2018-12-19 2021-09-15 더 차이니즈 유니버시티 오브 홍콩 무 세포 dna 말단 특성
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
EP3921445B1 (en) 2019-02-05 2024-09-04 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
US12098429B2 (en) 2019-03-25 2024-09-24 The Chinese University Of Hong Kong Determining linear and circular forms of circulating nucleic acids
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
US20220243263A1 (en) * 2019-05-03 2022-08-04 Cornell University Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
CA3147613A1 (en) * 2019-08-19 2021-02-25 Chang-Seok Ki Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
CA3158101A1 (en) * 2019-11-27 2021-06-03 M. Cyrus MAHER Systems and methods for evaluating longitudinal biological feature data
EP4097231B1 (en) 2020-01-31 2025-03-19 Agilent Technologies, Inc. Systems and methods for targeted nucleic acid capture
EP4103740A1 (en) * 2020-02-10 2022-12-21 Palogen, Inc. Nanopore device and methods of detecting and classifying charged particles using same
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CN115443507A (zh) * 2020-02-28 2022-12-06 格里尔公司 鉴定可鉴别或指示癌症病状的甲基化模式
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚(北京)科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
CN116848262A (zh) * 2020-11-19 2023-10-03 纽克莱克斯有限公司 使用限制性酶和高通量测序检测dna样品中的甲基化改变
AU2021401813A1 (en) * 2020-12-17 2023-07-06 Dana-Farber Cancer Institute, Inc. Methods of cancer detection using extraembryonically methylated cpg islands
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技(北京)有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
EP4409468A4 (en) * 2021-09-28 2025-08-13 Act Genomics Ip Ltd APPARATUS AND METHODS FOR SELECTING METHYLATION BIOMARKERS
KR20230059423A (ko) 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
WO2023079047A1 (en) * 2021-11-04 2023-05-11 Universal Diagnostics S.A Systems and methods for preparing biological samples for genetic sequencing
JP2025506435A (ja) 2022-02-07 2025-03-11 センター フォー ノヴォスティクス メチル化及び疾患を測定するための断片化
EP4482985A2 (en) * 2022-02-22 2025-01-01 Flagship Pioneering Innovations VI, LLC Intra-individual analysis for presence of health conditions
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN118737268A (zh) * 2023-05-04 2024-10-01 杭州圣庭医疗科技有限公司 一种鉴定肿瘤组织来源的试剂盒的数据分析方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院(北京大学第三临床医学院) 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DE60207979T2 (de) 2002-03-05 2006-09-28 Epigenomics Ag Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
AU2003294315A1 (en) * 2002-11-19 2004-06-15 Amgen Inc. Amplified genes involved in cancer
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
US8440404B2 (en) * 2004-03-08 2013-05-14 Rubicon Genomics Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
WO2006128192A2 (en) 2005-05-27 2006-11-30 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) * 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
CN101153336B (zh) * 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
EP2173897A2 (en) 2007-06-19 2010-04-14 Oncomethylome Sciences SA Improved urine sample collecting and processing
KR102561664B1 (ko) 2007-07-23 2023-07-28 더 차이니즈 유니버시티 오브 홍콩 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법
JP4347372B2 (ja) 2007-08-10 2009-10-21 トヨタ自動車株式会社 静電塗装装置
US20110028333A1 (en) * 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
US20120208711A1 (en) 2009-10-02 2012-08-16 Centre For Addiction And Mental Health Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids
LT3783110T (lt) * 2009-11-05 2023-01-25 The Chinese University Of Hong Kong Vaisiaus genomo analizė iš motinos biologinio mėginio
US8620593B2 (en) 2009-11-06 2013-12-31 The Chinese University Of Hong Kong Size-based genomic analysis
CA2786564A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US9249462B2 (en) * 2010-01-26 2016-02-02 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
EP2564340B1 (en) 2010-04-29 2020-01-08 The Regents of The University of California Pathway recognition algorithm using data integration on genomic models (paradigm)
GB201007944D0 (en) * 2010-05-12 2010-06-30 Univ Aberystwyth Methods
ES2581594T3 (es) 2010-05-25 2016-09-06 The Johns Hopkins University Composiciones y métodos para detectar una neoplasia
MX382244B (es) * 2010-07-23 2025-03-13 Harvard College Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales
CN103069006A (zh) * 2010-07-23 2013-04-24 艾索特里克斯遗传实验室有限责任公司 区别表达的胚胎或母源基因组区的鉴定及其用途
WO2012031329A1 (en) * 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
EP2646579B1 (en) 2010-11-30 2017-06-14 The Chinese University Of Hong Kong Detection of genetic or molecular aberrations associated with cancer
EP2898100B9 (en) * 2012-09-20 2023-08-02 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma

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