NZ598927A - Antiviral nucleoside analogs - Google Patents
Antiviral nucleoside analogsInfo
- Publication number
- NZ598927A NZ598927A NZ598927A NZ59892708A NZ598927A NZ 598927 A NZ598927 A NZ 598927A NZ 598927 A NZ598927 A NZ 598927A NZ 59892708 A NZ59892708 A NZ 59892708A NZ 598927 A NZ598927 A NZ 598927A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compounds
- methyltetrahydrofuran
- triazin
- hydroxymethyl
- diol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88027807P | 2007-01-12 | 2007-01-12 | |
| PCT/US2008/050929 WO2008089105A2 (en) | 2007-01-12 | 2008-01-11 | Antiviral nucleoside analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ598927A true NZ598927A (en) | 2013-09-27 |
Family
ID=39471795
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ578556A NZ578556A (en) | 2007-01-12 | 2008-01-11 | Antiviral nucleoside analogs |
| NZ598927A NZ598927A (en) | 2007-01-12 | 2008-01-11 | Antiviral nucleoside analogs |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ578556A NZ578556A (en) | 2007-01-12 | 2008-01-11 | Antiviral nucleoside analogs |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8440813B2 (show.php) |
| EP (2) | EP2535345A1 (show.php) |
| JP (1) | JP2010515760A (show.php) |
| CN (1) | CN101611046A (show.php) |
| AU (1) | AU2008206406A1 (show.php) |
| CA (1) | CA2674589A1 (show.php) |
| CY (1) | CY1113282T1 (show.php) |
| DK (1) | DK2114980T3 (show.php) |
| ES (1) | ES2390188T3 (show.php) |
| HR (1) | HRP20120758T1 (show.php) |
| IL (1) | IL199664A0 (show.php) |
| MX (1) | MX2009007333A (show.php) |
| NZ (2) | NZ578556A (show.php) |
| PH (1) | PH12012502284A1 (show.php) |
| PL (1) | PL2114980T3 (show.php) |
| PT (1) | PT2114980E (show.php) |
| SG (1) | SG177974A1 (show.php) |
| SI (1) | SI2114980T1 (show.php) |
| WO (1) | WO2008089105A2 (show.php) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124759B2 (en) * | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
| US8242085B2 (en) | 2007-05-10 | 2012-08-14 | Biocryst Pharmaceuticals, Inc. | Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer |
| TW200942243A (en) * | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| US20090247750A1 (en) * | 2008-03-28 | 2009-10-01 | Biocryst Pharmaceuticals, Inc. | Process for preparing nucleoside analogs |
| HUE038946T2 (hu) | 2008-04-23 | 2018-12-28 | Gilead Sciences Inc | 1'-szubsztituált carba-nukleozid analógok antivirális kezelésre |
| WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| KR101834707B1 (ko) | 2009-02-10 | 2018-03-05 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카르바-뉴클레오시드 유사체 |
| JP5767643B2 (ja) | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
| BR112012006261B1 (pt) | 2009-09-21 | 2021-12-21 | Gilead Sciences, Inc | Compostos análogos de 2'-flúor substituído carbanucleosídeo, composto útil para a preparação do mesmo, composição farmacêutica e uso dos compostos análogos de 2'-flúor substituído carbanucleosídeo |
| US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| WO2011123493A1 (en) | 2010-03-31 | 2011-10-06 | Bristol-Myers Squibb Company | Substituted pyrrolotriazines as protein kinase inhibitors |
| TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| KR101995598B1 (ko) | 2010-07-19 | 2019-07-02 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
| PE20130400A1 (es) | 2010-07-22 | 2013-04-10 | Gilead Sciences Inc | Metodos y compuestos para tratar infecciones virales por paramyxoviridae |
| TW201305185A (zh) * | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| SG188223A1 (en) | 2010-09-20 | 2013-04-30 | Gilead Sciences Inc | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
| CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| US8877733B2 (en) | 2011-04-13 | 2014-11-04 | Gilead Sciences, Inc. | 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment |
| PE20140570A1 (es) | 2011-07-01 | 2014-04-28 | Bayer Ip Gmbh | Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| CA2752008A1 (en) | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
| EP2794627B1 (en) | 2011-12-22 | 2018-09-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EA201791916A1 (ru) | 2012-03-13 | 2018-07-31 | Джилид Сайэнс, Инк. | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| AR090699A1 (es) | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
| SI2861595T1 (sl) | 2012-06-13 | 2017-04-26 | Incyte Holdings Corporation | Substituirane triciklične spojine kot inhibitorji fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| HK1212235A1 (en) * | 2012-11-16 | 2016-06-10 | Biocryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| TWI678369B (zh) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| ES2749679T3 (es) | 2014-10-22 | 2020-03-23 | Bristol Myers Squibb Co | Compuestos de pirrolotriazina amina sustituidos como inhibidores de PI3k |
| US10214537B2 (en) | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
| TWI698444B (zh) * | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| SG10201913036RA (en) | 2015-02-20 | 2020-02-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| HK1247829A1 (zh) | 2015-03-06 | 2018-10-05 | Atea Pharmaceuticals, Inc. | 用於治疗HCV的β-D-2'-脱氧-2'Α-氟-2'-β-C-取代-2-改性N6-取代的嘌呤核苷酸 |
| CN104876935B (zh) * | 2015-05-18 | 2017-04-19 | 南方医科大学 | 2‑氨基吡咯并[1,2‑f][1,2,4]三嗪类化合物、合成方法及应用 |
| PT3349758T (pt) | 2015-09-16 | 2022-07-13 | Gilead Sciences Inc | Métodos para o tratamento de infeções pelo vírus arenaviridae |
| US10953029B2 (en) | 2015-09-23 | 2021-03-23 | Merck Sharp & Dohme Corp. | 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
| CN109071467B (zh) | 2016-03-09 | 2023-04-04 | 艾丽奥斯生物制药有限公司 | 无环抗病毒药 |
| WO2017155949A1 (en) | 2016-03-09 | 2017-09-14 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Methods and kits for use in preventing and treating vulvovaginal candidiasis |
| JP7034084B2 (ja) | 2016-03-28 | 2022-03-11 | インサイト・コーポレイション | Ｔａｍ阻害剤としてのピロロトリアジン化合物 |
| LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3512863B1 (en) | 2016-09-07 | 2021-12-08 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| CA3040540A1 (en) | 2016-11-10 | 2018-05-17 | Oyagen, Inc. | Methods of treating and inhibiting ebola virus infection |
| EP4450129A3 (en) | 2017-02-01 | 2025-03-19 | ATEA Pharmaceuticals, Inc. | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| CN107056775A (zh) * | 2017-05-24 | 2017-08-18 | 佛山科学技术学院 | 丙型肝炎病毒ns5b聚合酶抑制剂 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| US10675296B2 (en) | 2017-07-11 | 2020-06-09 | Gilead Sciences, Inc. | Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections |
| US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
| TW202012001A (zh) | 2018-04-10 | 2020-04-01 | 美商亞堤製藥公司 | C型肝炎病毒(hcv)感染硬化之患者的治療 |
| PL3788047T3 (pl) | 2018-05-04 | 2025-04-14 | Incyte Corporation | Stałe postacie inhibitora fgfr i sposoby ich otrzymywania |
| KR20210018264A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
| EP3894395A2 (en) | 2018-12-12 | 2021-10-20 | Janssen BioPharma, Inc. | Cyclopentyl nucleoside analogs as anti-virals |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| AU2020395185A1 (en) | 2019-12-04 | 2022-06-02 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| WO2021158248A1 (en) | 2020-02-04 | 2021-08-12 | Oyagen, Inc. | Method for treating coronavirus infections |
| CN113214262B (zh) * | 2020-02-05 | 2023-07-07 | 华创合成制药股份有限公司 | 一种含有胍基的化合物及其制备方法和用途 |
| CA3171648A1 (en) | 2020-02-18 | 2021-08-26 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI791193B (zh) | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CA3169340A1 (en) | 2020-03-12 | 2021-09-16 | Pavel R. Badalov | Methods of preparing 1'-cyano nucleosides |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| PL4157272T3 (pl) | 2020-05-29 | 2025-10-20 | Gilead Sciences, Inc. | Remdesiwir do leczenia zakażeń wirusowych |
| JP2023531524A (ja) | 2020-06-24 | 2023-07-24 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシド類似体及びその使用 |
| JP2023542455A (ja) * | 2020-07-14 | 2023-10-10 | スーチュワン ユニバーシティ | ３－デオキシ－２－ケトアルドン酸窒素含有誘導体、その製造方法及びその使用 |
| LT4204421T (lt) | 2020-08-27 | 2024-06-25 | Gilead Sciences, Inc. | Virusinių infekcijų gydymui skirti junginiai ir būdai |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| PL4323362T3 (pl) | 2021-04-16 | 2025-08-18 | Gilead Sciences, Inc. | Sposoby wytwarzania karbanukleozydów z zastosowaniem amidów |
| EP4352060A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| CN117500494A (zh) | 2021-06-17 | 2024-02-02 | 阿堤亚制药公司 | 有利的抗hcv联合疗法 |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| CN118119624A (zh) * | 2021-08-20 | 2024-05-31 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的核苷衍生物及其前药 |
| US20230295172A1 (en) | 2022-03-02 | 2023-09-21 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL350042A1 (en) | 1999-01-13 | 2002-10-21 | Genentech Inc | Serine protease inhibitors |
| CZ301182B6 (cs) * | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| US20070032448A1 (en) * | 2002-01-17 | 2007-02-08 | Zhi Hong | Sugar modified nucleosides as viral replication inhibitors |
| EP1628685B1 (en) | 2003-04-25 | 2010-12-08 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| AU2005302448B2 (en) | 2004-10-29 | 2012-07-19 | Biocryst Pharmaceuticals, Inc. | Therapeutic furopyrimidines and thienopyrimidines |
| TW200942243A (en) * | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| WO2010002877A2 (en) | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
-
2008
- 2008-01-11 NZ NZ578556A patent/NZ578556A/en not_active IP Right Cessation
- 2008-01-11 SG SG2012002614A patent/SG177974A1/en unknown
- 2008-01-11 PL PL08727625T patent/PL2114980T3/pl unknown
- 2008-01-11 WO PCT/US2008/050929 patent/WO2008089105A2/en not_active Ceased
- 2008-01-11 PT PT08727625T patent/PT2114980E/pt unknown
- 2008-01-11 ES ES08727625T patent/ES2390188T3/es active Active
- 2008-01-11 NZ NZ598927A patent/NZ598927A/xx not_active IP Right Cessation
- 2008-01-11 HR HRP20120758AT patent/HRP20120758T1/hr unknown
- 2008-01-11 SI SI200830771T patent/SI2114980T1/sl unknown
- 2008-01-11 EP EP12168831A patent/EP2535345A1/en not_active Withdrawn
- 2008-01-11 JP JP2009545720A patent/JP2010515760A/ja active Pending
- 2008-01-11 US US12/522,892 patent/US8440813B2/en active Active
- 2008-01-11 MX MX2009007333A patent/MX2009007333A/es active IP Right Grant
- 2008-01-11 EP EP08727625A patent/EP2114980B1/en not_active Not-in-force
- 2008-01-11 CN CNA2008800038586A patent/CN101611046A/zh active Pending
- 2008-01-11 AU AU2008206406A patent/AU2008206406A1/en not_active Abandoned
- 2008-01-11 CA CA002674589A patent/CA2674589A1/en not_active Abandoned
- 2008-01-11 DK DK08727625.9T patent/DK2114980T3/da active
-
2009
- 2009-07-02 IL IL199664A patent/IL199664A0/en unknown
-
2012
- 2012-09-25 CY CY20121100876T patent/CY1113282T1/el unknown
- 2012-11-20 PH PH12012502284A patent/PH12012502284A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2114980B1 (en) | 2012-06-27 |
| WO2008089105A3 (en) | 2008-09-12 |
| EP2535345A1 (en) | 2012-12-19 |
| PL2114980T3 (pl) | 2012-11-30 |
| MX2009007333A (es) | 2009-08-31 |
| PT2114980E (pt) | 2012-09-25 |
| CY1113282T1 (el) | 2016-04-13 |
| CN101611046A (zh) | 2009-12-23 |
| CA2674589A1 (en) | 2008-07-24 |
| US20100015094A1 (en) | 2010-01-21 |
| WO2008089105A2 (en) | 2008-07-24 |
| AU2008206406A1 (en) | 2008-07-24 |
| DK2114980T3 (da) | 2012-09-24 |
| HRP20120758T1 (hr) | 2012-10-31 |
| IL199664A0 (en) | 2010-04-15 |
| SG177974A1 (en) | 2012-02-28 |
| NZ578556A (en) | 2012-04-27 |
| JP2010515760A (ja) | 2010-05-13 |
| EP2114980A2 (en) | 2009-11-11 |
| US8440813B2 (en) | 2013-05-14 |
| PH12012502284A1 (en) | 2015-10-12 |
| SI2114980T1 (sl) | 2012-11-30 |
| ES2390188T3 (es) | 2012-11-07 |
| HK1138286A1 (en) | 2010-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ598927A (en) | Antiviral nucleoside analogs | |
| HUE035947T2 (hu) | A (2S,3R,4R,5S,6R)-2-(4-klór-3-benzilfenil)-6-(hidroximetil)tetrahidro-2H-pirán-3,4,5-triol származékainak felhasználása a diabétesz kezelésében | |
| NL300701I2 (show.php) | ||
| IL225672B (en) | Pharmaceutical composition comprising (2s,3s,4r,5r)-2-(4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol for inhibiting rna viral polymerase | |
| NZ601486A (en) | 2',4'-substituted nucleosides as antiviral agents | |
| NZ700583A (en) | Novel 7-deazapurine nucleosides for therapeutic uses | |
| RU2651892C3 (ru) | Нуклеозидфосфорамидаты в качестве противовирусных агентов | |
| MY150059A (en) | Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors | |
| GEP20125658B (en) | Imidazotriazines and imidazo pyrimidines as kinase inhibitors | |
| GEP20135780B (en) | Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents | |
| EP1749830A4 (en) | CURCUMOL DERIVATIVES, COMPOSITION COMPRISING THE SAME, AND THEIR USE FOR THE PRODUCTION OF MEDICAMENTS | |
| BRPI0910455B8 (pt) | análogos de carba-nucleosídeo 1-substituído para tratamento antiviral e composição farmacêutica que os compreende | |
| NZ606156A (en) | Methods and compounds for treating paramyxoviridae virus infections | |
| MX2010003668A (es) | Derivados de purina sustituidas con primidina. | |
| TW200637562A (en) | Anti-cancer agent containing α-α-α-trifluorothymidine and thymidine phosphorylase inhibitor in combination | |
| MXPA05010293A (es) | 4-amino[1,2,4]triazolo[4,3-a]quinoxalinas sustituidas. | |
| WO2008070313A3 (en) | 3-(dihydro-1h-pyrazolo [4,3-d] pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use | |
| EA200800992A1 (ru) | 2-амино-7,8-дигидро-6н-пиридо[4,3-d]пиримидин-5-оны, способ их получения, способ терапии с их помощью, компонент композиции и композиция на их основе, 2,4-диоксопиперидиновые соединения для их получения | |
| WO2006124861A3 (en) | Benzofuran compounds | |
| WO2014152566A3 (en) | Methods of synthesizing substituted purine compounds | |
| WO2006116733A3 (en) | Protein kinase inhibitors | |
| WO2006058628A3 (en) | Substituted benzoquinolizines as dpp-iv inhibitors for the treatment of diabetes | |
| WO2009034547A3 (en) | New 4-substituted derivatives of pyrazolo[3,4-d pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof | |
| WO2006083949A3 (en) | Sepsis prevention through adenosine receptor modulation | |
| WO2010091185A3 (en) | Inhibitors of fructose 1,6-bisphosphatase and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ERR | Error or correction |
Free format text: THE MISSING INVENTOR HAS BEEN ADDED (1276945, KOTIAN, PRAVIN L; 1348301, CHAND, POORAN; 1348303, WU, MINWAN; 1348304, KUMAR, V. SATISH; 3043104, BABU, YARLAGADDA, S.) Effective date: 20131008 |
|
| PSEA | Patent sealed | ||
| LAPS | Patent lapsed |