NZ562003A - Macrocyclic biphenyl-peptide compounds - Google Patents

Macrocyclic biphenyl-peptide compounds

Info

Publication number
NZ562003A
NZ562003A NZ562003A NZ56200306A NZ562003A NZ 562003 A NZ562003 A NZ 562003A NZ 562003 A NZ562003 A NZ 562003A NZ 56200306 A NZ56200306 A NZ 56200306A NZ 562003 A NZ562003 A NZ 562003A
Authority
NZ
New Zealand
Prior art keywords
amino
represents hydrogen
independently
boc
methyl
Prior art date
Application number
NZ562003A
Other languages
English (en)
Inventor
Rainer Endermann
Kerstin Ehlert
Siegfried Raddatz
Martin Michels
Yolanda Cancho-Grande
Stefan Weigand
Karin Fischer
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of NZ562003A publication Critical patent/NZ562003A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ562003A 2005-03-30 2006-03-22 Macrocyclic biphenyl-peptide compounds NZ562003A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005014245A DE102005014245A1 (de) 2005-03-30 2005-03-30 Antibakterielle Amid-Makrozyklen V
PCT/EP2006/002617 WO2006103015A1 (de) 2005-03-30 2006-03-22 Antibakterielle amid-makrozyklen v

Publications (1)

Publication Number Publication Date
NZ562003A true NZ562003A (en) 2010-11-26

Family

ID=36572224

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ562003A NZ562003A (en) 2005-03-30 2006-03-22 Macrocyclic biphenyl-peptide compounds

Country Status (17)

Country Link
US (1) US20080275018A1 (enExample)
EP (1) EP1869068A1 (enExample)
JP (1) JP2008534540A (enExample)
KR (1) KR20070116169A (enExample)
CN (1) CN101228182A (enExample)
AU (1) AU2006228751A1 (enExample)
BR (1) BRPI0612219A2 (enExample)
CA (1) CA2602755A1 (enExample)
DE (1) DE102005014245A1 (enExample)
IL (1) IL185899A0 (enExample)
MX (1) MX2007012146A (enExample)
NO (1) NO20075270L (enExample)
NZ (1) NZ562003A (enExample)
RU (1) RU2409588C2 (enExample)
UA (1) UA91541C2 (enExample)
WO (1) WO2006103015A1 (enExample)
ZA (1) ZA200709336B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CA2892027A1 (en) 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
KR20170027721A (ko) 2014-05-20 2017-03-10 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
IL288294B (en) 2019-05-28 2022-09-01 Hoffmann La Roche A broad-spectrum macrocyclic antibiotic
WO2024262518A1 (ja) * 2023-06-20 2024-12-26 国立大学法人北海道大学 スキャニング用アミノ酸化合物、スキャニング用改変ペプチド、スキャニング用キット及びペプチドの活性部位のスキャニング方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
CA2540646A1 (en) * 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibacterial amide macrocycles
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
IL185899A0 (en) 2008-12-29
RU2007139760A (ru) 2009-05-10
MX2007012146A (es) 2007-12-10
KR20070116169A (ko) 2007-12-06
US20080275018A1 (en) 2008-11-06
CA2602755A1 (en) 2006-10-05
ZA200709336B (en) 2009-09-30
EP1869068A1 (de) 2007-12-26
BRPI0612219A2 (pt) 2009-01-13
NO20075270L (no) 2007-12-18
RU2409588C2 (ru) 2011-01-20
CN101228182A (zh) 2008-07-23
JP2008534540A (ja) 2008-08-28
WO2006103015A1 (de) 2006-10-05
UA91541C2 (ru) 2010-08-10
DE102005014245A1 (de) 2006-10-05
AU2006228751A1 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
US20080275018A1 (en) Antibacterial amide-macrocycles v
AU2015228898B2 (en) Polymyxin derivatives and their use in combination therapy together with different antibiotics
JP4990456B2 (ja) 抗菌剤としてのダプトマイシンアナログ
US7262268B2 (en) Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
US7446102B2 (en) Antibacterial amide macrocycles IV
US20070129288A1 (en) Antibacterial amide macrocycles
US20020035239A1 (en) Peptide antibiotics
CA2540646A1 (en) Antibacterial amide macrocycles
US20060258571A1 (en) Antibacterial ester macrocycles
US20080300231A1 (en) Antibacterial amide macrocycles VI
US8076285B2 (en) Lysobactin amides
JP4843615B2 (ja) 環状ノナペプチドアミド
ES2359572T3 (es) Macrociclos iv de amida antibacterianos.
US20080306040A1 (en) Antibacterial amide macrocycles VII
HK1083511B (en) Antibacterial amide macrocycles
TW200526688A (en) Antibacterial amide macrocycles

Legal Events

Date Code Title Description
PSEA Patent sealed