RU2409588C2 - Бактерицидные содержащие амидные группы макроциклы v - Google Patents
Бактерицидные содержащие амидные группы макроциклы v Download PDFInfo
- Publication number
- RU2409588C2 RU2409588C2 RU2007139760/04A RU2007139760A RU2409588C2 RU 2409588 C2 RU2409588 C2 RU 2409588C2 RU 2007139760/04 A RU2007139760/04 A RU 2007139760/04A RU 2007139760 A RU2007139760 A RU 2007139760A RU 2409588 C2 RU2409588 C2 RU 2409588C2
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- group
- binding
- indicates
- formula
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract 6
- 125000003368 amide group Chemical group 0.000 title abstract 2
- 150000002678 macrocyclic compounds Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 72
- 239000001257 hydrogen Substances 0.000 claims abstract 72
- 229910052799 carbon Inorganic materials 0.000 claims abstract 24
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 19
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 8
- 150000002431 hydrogen Chemical group 0.000 claims 53
- 229910052757 nitrogen Inorganic materials 0.000 claims 22
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 22
- 125000003277 amino group Chemical group 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 7
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 2
- 238000007039 two-step reaction Methods 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005014245.1 | 2005-03-30 | ||
| DE102005014245A DE102005014245A1 (de) | 2005-03-30 | 2005-03-30 | Antibakterielle Amid-Makrozyklen V |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007139760A RU2007139760A (ru) | 2009-05-10 |
| RU2409588C2 true RU2409588C2 (ru) | 2011-01-20 |
Family
ID=36572224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007139760/04A RU2409588C2 (ru) | 2005-03-30 | 2006-03-22 | Бактерицидные содержащие амидные группы макроциклы v |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080275018A1 (enExample) |
| EP (1) | EP1869068A1 (enExample) |
| JP (1) | JP2008534540A (enExample) |
| KR (1) | KR20070116169A (enExample) |
| CN (1) | CN101228182A (enExample) |
| AU (1) | AU2006228751A1 (enExample) |
| BR (1) | BRPI0612219A2 (enExample) |
| CA (1) | CA2602755A1 (enExample) |
| DE (1) | DE102005014245A1 (enExample) |
| IL (1) | IL185899A0 (enExample) |
| MX (1) | MX2007012146A (enExample) |
| NO (1) | NO20075270L (enExample) |
| NZ (1) | NZ562003A (enExample) |
| RU (1) | RU2409588C2 (enExample) |
| UA (1) | UA91541C2 (enExample) |
| WO (1) | WO2006103015A1 (enExample) |
| ZA (1) | ZA200709336B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10358824A1 (de) | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005032781A1 (de) * | 2005-07-14 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Markozyklen VII |
| MX2013003035A (es) | 2010-09-15 | 2013-12-16 | Scripps Research Inst | Analogos de arilomicina como antibióticos de amplio espectro. |
| WO2012166665A2 (en) * | 2011-05-27 | 2012-12-06 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| US10501493B2 (en) | 2011-05-27 | 2019-12-10 | Rqx Pharmaceuticals, Inc. | Broad spectrum antibiotics |
| CA2892027A1 (en) | 2012-11-21 | 2014-05-30 | Rqx Pharmaceuticals, Inc. | Macrocyclic broad spectrum antibiotics |
| KR20170027721A (ko) | 2014-05-20 | 2017-03-10 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| AU2016347456B2 (en) | 2015-10-27 | 2018-12-13 | F. Hoffmann-La Roche Ag | Peptide macrocycles against acinetobacter baumannii |
| KR20180109858A (ko) | 2015-11-20 | 2018-10-08 | 알큐엑스 파마슈티컬스, 인크. | 마크로시클릭 광범위 항생제 |
| EP3388444A1 (en) * | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Anti-bacterial peptide macrocycles and use thereof |
| MX2020002010A (es) | 2017-08-21 | 2020-07-13 | Celgene Corp | Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. |
| US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| IL288294B (en) | 2019-05-28 | 2022-09-01 | Hoffmann La Roche | A broad-spectrum macrocyclic antibiotic |
| WO2024262518A1 (ja) * | 2023-06-20 | 2024-12-26 | 国立大学法人北海道大学 | スキャニング用アミノ酸化合物、スキャニング用改変ペプチド、スキャニング用キット及びペプチドの活性部位のスキャニング方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840682A (en) * | 1994-05-20 | 1998-11-24 | Rhone-Poulenc Rorer S.A. | Peptide antagonists of neurotensin |
| RU2005100954A (ru) * | 2002-06-17 | 2005-07-10 | Байер ХельсКер АГ (DE) | Антибактериальные амидные макроциклы |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452136A (en) * | 1968-04-17 | 1969-06-24 | American Cyanamid Co | Antibiotic af283 and production thereof |
| DE10234422A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Antibakterielle Ester-Makrozyklen |
| CA2540646A1 (en) * | 2003-10-01 | 2005-04-14 | Bayer Healthcare Ag | Antibacterial amide macrocycles |
| DE10358824A1 (de) * | 2003-12-16 | 2005-07-21 | Bayer Healthcare Ag | Antibakterielle Makrozyklen mit substituiertem Biphenyl |
| DE102005014240A1 (de) * | 2004-09-24 | 2006-03-30 | Bayer Healthcare Ag | Antibakterielle Amid-Makrozyklen IV |
-
2005
- 2005-03-30 DE DE102005014245A patent/DE102005014245A1/de not_active Withdrawn
-
2006
- 2006-03-22 MX MX2007012146A patent/MX2007012146A/es not_active Application Discontinuation
- 2006-03-22 EP EP06723614A patent/EP1869068A1/de not_active Withdrawn
- 2006-03-22 NZ NZ562003A patent/NZ562003A/en unknown
- 2006-03-22 CN CNA2006800188391A patent/CN101228182A/zh active Pending
- 2006-03-22 ZA ZA200709336A patent/ZA200709336B/xx unknown
- 2006-03-22 WO PCT/EP2006/002617 patent/WO2006103015A1/de not_active Ceased
- 2006-03-22 JP JP2008503408A patent/JP2008534540A/ja not_active Withdrawn
- 2006-03-22 RU RU2007139760/04A patent/RU2409588C2/ru not_active IP Right Cessation
- 2006-03-22 CA CA002602755A patent/CA2602755A1/en not_active Abandoned
- 2006-03-22 KR KR1020077025008A patent/KR20070116169A/ko not_active Ceased
- 2006-03-22 BR BRPI0612219-1A patent/BRPI0612219A2/pt not_active IP Right Cessation
- 2006-03-22 UA UAA200711765A patent/UA91541C2/ru unknown
- 2006-03-22 AU AU2006228751A patent/AU2006228751A1/en not_active Abandoned
-
2007
- 2007-09-11 IL IL185899A patent/IL185899A0/en unknown
- 2007-09-28 US US11/906,088 patent/US20080275018A1/en not_active Abandoned
- 2007-10-15 NO NO20075270A patent/NO20075270L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840682A (en) * | 1994-05-20 | 1998-11-24 | Rhone-Poulenc Rorer S.A. | Peptide antagonists of neurotensin |
| RU2005100954A (ru) * | 2002-06-17 | 2005-07-10 | Байер ХельсКер АГ (DE) | Антибактериальные амидные макроциклы |
Also Published As
| Publication number | Publication date |
|---|---|
| IL185899A0 (en) | 2008-12-29 |
| RU2007139760A (ru) | 2009-05-10 |
| MX2007012146A (es) | 2007-12-10 |
| KR20070116169A (ko) | 2007-12-06 |
| NZ562003A (en) | 2010-11-26 |
| US20080275018A1 (en) | 2008-11-06 |
| CA2602755A1 (en) | 2006-10-05 |
| ZA200709336B (en) | 2009-09-30 |
| EP1869068A1 (de) | 2007-12-26 |
| BRPI0612219A2 (pt) | 2009-01-13 |
| NO20075270L (no) | 2007-12-18 |
| CN101228182A (zh) | 2008-07-23 |
| JP2008534540A (ja) | 2008-08-28 |
| WO2006103015A1 (de) | 2006-10-05 |
| UA91541C2 (ru) | 2010-08-10 |
| DE102005014245A1 (de) | 2006-10-05 |
| AU2006228751A1 (en) | 2006-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120323 |