NZ556654A - Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith - Google Patents
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewithInfo
- Publication number
- NZ556654A NZ556654A NZ556654A NZ55665406A NZ556654A NZ 556654 A NZ556654 A NZ 556654A NZ 556654 A NZ556654 A NZ 556654A NZ 55665406 A NZ55665406 A NZ 55665406A NZ 556654 A NZ556654 A NZ 556654A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- substituted
- disease
- unsubstituted
- kinase
- Prior art date
Links
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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PCT/US2006/001275 WO2006076595A1 (fr) | 2005-01-13 | 2006-01-13 | Aminopurines a substitution haloaryle, compositions les contenant, et methodes de traitement associees haloaryl |
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EP (3) | EP2289893B1 (fr) |
JP (3) | JP5475949B2 (fr) |
KR (1) | KR101294830B1 (fr) |
CN (1) | CN103087066A (fr) |
AT (1) | ATE435227T1 (fr) |
AU (1) | AU2006204792B2 (fr) |
BR (1) | BRPI0606702A2 (fr) |
CA (1) | CA2595182C (fr) |
CY (1) | CY1109306T1 (fr) |
DE (1) | DE602006007541D1 (fr) |
DK (1) | DK1838710T3 (fr) |
ES (3) | ES2497540T3 (fr) |
HK (1) | HK1136558A1 (fr) |
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IL (2) | IL184550A (fr) |
MX (1) | MX2007008485A (fr) |
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PL (1) | PL1838710T3 (fr) |
PT (1) | PT1838710E (fr) |
RS (1) | RS51176B (fr) |
SI (1) | SI1838710T1 (fr) |
WO (1) | WO2006076595A1 (fr) |
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US7256196B1 (en) * | 2003-12-09 | 2007-08-14 | The Procter & Gamble Company | Purine cytokine inhibitors |
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US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
GB0526042D0 (en) * | 2005-12-21 | 2006-02-01 | Syngenta Participations Ag | Chemical compounds |
EP1986633B1 (fr) | 2006-02-10 | 2014-07-30 | Summit Corporation Plc | Traitement de la dystrophie musculaire de duchenne |
JO3235B1 (ar) * | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
BRPI0717435A2 (pt) * | 2006-10-20 | 2014-03-18 | Organon Nv | Composto ou um sal do mesmo, composição farmacêutica, e, métodos de tratamento de uma doença mediada por célula-t, de câncer e de diabete. |
EP2076516B1 (fr) * | 2006-10-27 | 2013-12-11 | Signal Pharmaceuticals LLC | Formes solides comprenant un composé de 4-[9-(tétrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phénylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions contenant celles-ci et utilisation de celles-ci |
JP2010535708A (ja) | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
GB0715937D0 (en) * | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment og duchenne muscular dystrophy |
CL2009000904A1 (es) | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende. |
US8685980B2 (en) | 2008-08-22 | 2014-04-01 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
UY32138A (es) * | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
US20130034495A1 (en) * | 2009-12-09 | 2013-02-07 | Marie Georges Beauchamps | Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol |
EP2338888A1 (fr) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Dérivés d'imidazopyridine en tant qu'inhibiteurs JAK |
US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
CN102260263A (zh) * | 2010-05-26 | 2011-11-30 | 四川大学 | 一类二苯胺基嘌呤衍生物及制备方法和医药用途 |
US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
US8680076B2 (en) | 2010-10-25 | 2014-03-25 | Signal Pharmaceuticals, Llc | Methods of treatment, improvement and prevention using haloaryl substituted aminopurines |
US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
AR083868A1 (es) | 2010-12-03 | 2013-03-27 | Lilly Co Eli | Compuestos de oxazol[5,4-b]piridin-5-ilo |
US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
US9493464B2 (en) | 2012-02-29 | 2016-11-15 | The Scripps Research Institute | Wee1 degradation inhibitors |
CA2903901A1 (fr) | 2013-03-05 | 2014-09-12 | Merck Patent Gmbh | Derives de 9-(aryl ou heteroaryl)-2-(pyrazolyl, pyrrolidinyl ou cyclopentyl)aminopurine utilises en tant qu'agents anticancereux |
CN104098563A (zh) * | 2013-04-02 | 2014-10-15 | 山东亨利医药科技有限责任公司 | Jnk抑制剂化合物 |
ES2637721T3 (es) | 2013-05-06 | 2017-10-16 | Merck Patent Gmbh | Macrociclos como inhibidores de quinasa |
MX2017004600A (es) | 2014-10-06 | 2017-06-30 | Signal Pharm Llc | Compuestos de aminopurina sustituida, composiciones del mismo, y metodos de tratamiento con los mismos. |
PT3436019T (pt) | 2016-04-01 | 2021-11-04 | Signal Pharm Llc | (1s,4s)-4-(2-(((3s,4r)-3-fluorotetra-hidro-2h-piran-4- il)amino)-8-((2,4,6-triclorofenil)amino)-9h-purin-9-il)-1- metilciclo-hexano-1-carboxamida e métodos de utilização dos mesmos |
IL262007B2 (en) * | 2016-04-01 | 2023-04-01 | Signal Pharm Llc | Modified aminopurine compounds, their compositions and methods of treatment using them |
US10010555B2 (en) | 2016-06-02 | 2018-07-03 | Celgene Corporation | Animal and human anti-trypanosomonal and anti-leishmania agents |
ES2926149T3 (es) * | 2016-06-02 | 2022-10-24 | Celgene Corp | Agentes antipalúdicos animales y humanos |
WO2018029336A1 (fr) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes visant à déterminer si un patient a reçu un activateur de la voie de ppar bêta/delta |
EP4086257A1 (fr) * | 2016-09-30 | 2022-11-09 | SRI International | Inhibiteurs clk/cdk1 doubles pour le traitement du cancer |
CN106632339B (zh) * | 2016-12-16 | 2018-11-27 | 温州医科大学 | 一种6-取代-9h-嘌呤类衍生物及其制备方法和应用 |
SG11202002864PA (en) | 2017-10-04 | 2020-04-29 | Celgene Corp | Compositions and methods of use of cis-4-[2-{[(3s,4r)-3-fluorooxan-4-yl] amino}-8-(2,4,6-trichloroanilino)-9h-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
US10590136B2 (en) | 2017-10-04 | 2020-03-17 | Celgene Corporation | Processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
CN109694395B (zh) * | 2017-10-23 | 2020-08-28 | 武汉惠康达科技有限公司 | 一种用于缺血再灌注损伤的化合物及其制备方法 |
CN107892691B (zh) * | 2017-12-19 | 2020-04-28 | 西安交通大学 | 2,8,9-三取代-9h-嘌呤类化合物及其盐和应用 |
WO2020007698A1 (fr) * | 2018-07-06 | 2020-01-09 | Leo Pharma A/S | Nouveaux dérivés d'amino-imidazopyrimidine utilisés en tant qu'inhibiteurs de janus kinase et leur utilisation pharmaceutique |
AU2020221247A1 (en) | 2019-02-12 | 2021-08-05 | Sumitomo Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
CN112430632B (zh) * | 2020-11-18 | 2022-09-13 | 上海合全药物研发有限公司 | 2-((反式)-4-氨基环己烷基)异丙醇的制备方法 |
CN113582995B (zh) * | 2021-08-17 | 2022-08-16 | 西安交通大学 | 9-位含有丙烯酰氨基片段的-9h-嘌呤类化合物及其盐和应用 |
CN117430614B (zh) * | 2023-12-20 | 2024-03-08 | 首都医科大学 | 一种异喹啉类衍生物及其合成方法和应用 |
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US643796A (en) | 1899-08-03 | 1900-02-20 | William H Hunter | Washing-machine. |
US709980A (en) | 1901-02-04 | 1902-09-30 | Hubert Gilljam | Carding-machine. |
IL78643A0 (en) * | 1985-05-02 | 1986-08-31 | Wellcome Found | Purine derivatives,their preparation and pharmaceutical compositions containing them |
US5332744A (en) | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
JP2001516694A (ja) | 1997-08-07 | 2001-10-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プロテインキナーゼ、gプロテイン及びポリメラーゼのプリン阻害剤 |
CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
EP1232166A2 (fr) | 1999-11-12 | 2002-08-21 | Pharmasset Limited | Synthese de 2'-deoxy-l-nucleosides |
US20030187261A1 (en) | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
WO2002020495A2 (fr) | 2000-09-06 | 2002-03-14 | Chiron Corporation | Inhibiteurs de glycogene-synthase kinase 3 |
ES2302106T3 (es) | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
EP1381594A1 (fr) | 2001-04-13 | 2004-01-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Composes d'uree utilises en tant qu'agents anti-inflammatoires |
WO2003030909A1 (fr) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
US7256196B1 (en) | 2003-12-09 | 2007-08-14 | The Procter & Gamble Company | Purine cytokine inhibitors |
MX2007005159A (es) | 2004-10-29 | 2007-06-26 | Tibotec Pharm Ltd | Derivados de pirimidina biciclicos inhibidores del vih. |
US7759342B2 (en) * | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7723340B2 (en) | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
EP2076516B1 (fr) * | 2006-10-27 | 2013-12-11 | Signal Pharmaceuticals LLC | Formes solides comprenant un composé de 4-[9-(tétrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phénylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions contenant celles-ci et utilisation de celles-ci |
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2006
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