NZ546931A - Method for synthesis of perindopril and the pharmaceutically acceptable salts thereof - Google Patents

Method for synthesis of perindopril and the pharmaceutically acceptable salts thereof

Info

Publication number
NZ546931A
NZ546931A NZ546931A NZ54693104A NZ546931A NZ 546931 A NZ546931 A NZ 546931A NZ 546931 A NZ546931 A NZ 546931A NZ 54693104 A NZ54693104 A NZ 54693104A NZ 546931 A NZ546931 A NZ 546931A
Authority
NZ
New Zealand
Prior art keywords
compound
process according
formula
dba
synthesis process
Prior art date
Application number
NZ546931A
Other languages
English (en)
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NZ546931A publication Critical patent/NZ546931A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ546931A 2003-11-19 2004-11-18 Method for synthesis of perindopril and the pharmaceutically acceptable salts thereof NZ546931A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03292864A EP1420028B1 (fr) 2003-11-19 2003-11-19 Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/002936 WO2005054276A1 (fr) 2003-11-19 2004-11-18 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
NZ546931A true NZ546931A (en) 2010-01-29

Family

ID=32116380

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ546931A NZ546931A (en) 2003-11-19 2004-11-18 Method for synthesis of perindopril and the pharmaceutically acceptable salts thereof

Country Status (29)

Country Link
US (1) US7208607B1 (ko)
EP (1) EP1420028B1 (ko)
JP (1) JP4377412B2 (ko)
KR (1) KR100863394B1 (ko)
CN (1) CN100447152C (ko)
AR (1) AR047312A1 (ko)
AT (1) ATE354586T1 (ko)
AU (1) AU2004295132B2 (ko)
BR (1) BRPI0416746B1 (ko)
CA (1) CA2546506C (ko)
CY (1) CY1106544T1 (ko)
DE (1) DE60311942T2 (ko)
DK (1) DK1420028T3 (ko)
EA (1) EA010102B1 (ko)
EG (1) EG26629A (ko)
ES (1) ES2282586T3 (ko)
GE (1) GEP20084547B (ko)
HK (1) HK1096689A1 (ko)
MA (1) MA28144A1 (ko)
MX (1) MXPA06005607A (ko)
MY (1) MY138550A (ko)
NO (1) NO336349B1 (ko)
NZ (1) NZ546931A (ko)
PL (1) PL210769B1 (ko)
PT (1) PT1420028E (ko)
SI (1) SI1420028T1 (ko)
UA (1) UA83269C2 (ko)
WO (1) WO2005054276A1 (ko)
ZA (1) ZA200603675B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1380591T1 (sl) * 2003-08-29 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
JP2009500425A (ja) 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN112047869B (zh) * 2020-08-20 2021-12-21 华南理工大学 一种氮杂5,6-并环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
MY138550A (en) 2009-06-30
AR047312A1 (es) 2006-01-18
ZA200603675B (en) 2007-09-26
ES2282586T3 (es) 2007-10-16
JP4377412B2 (ja) 2009-12-02
GEP20084547B (en) 2008-11-25
KR20060121202A (ko) 2006-11-28
CY1106544T1 (el) 2012-01-25
EA200600898A1 (ru) 2006-10-27
MA28144A1 (fr) 2006-09-01
PL380409A1 (pl) 2007-01-22
WO2005054276A1 (fr) 2005-06-16
HK1096689A1 (en) 2007-06-08
DK1420028T3 (da) 2007-06-18
PL210769B1 (pl) 2012-02-29
CA2546506A1 (fr) 2005-06-16
ATE354586T1 (de) 2007-03-15
US20070083052A1 (en) 2007-04-12
SI1420028T1 (sl) 2007-06-30
UA83269C2 (uk) 2008-06-25
CN100447152C (zh) 2008-12-31
NO20062599L (no) 2006-06-06
EA010102B1 (ru) 2008-06-30
EP1420028B1 (fr) 2007-02-21
PT1420028E (pt) 2007-05-31
AU2004295132B2 (en) 2010-07-15
DE60311942T2 (de) 2007-12-06
BRPI0416746B1 (pt) 2018-02-14
DE60311942D1 (de) 2007-04-05
JP2008502587A (ja) 2008-01-31
CA2546506C (fr) 2010-04-06
KR100863394B1 (ko) 2008-10-14
MXPA06005607A (es) 2006-08-17
NO336349B1 (no) 2015-08-03
BRPI0416746A (pt) 2007-01-16
US7208607B1 (en) 2007-04-24
EP1420028A3 (fr) 2004-05-26
AU2004295132A1 (en) 2005-06-16
EG26629A (en) 2014-04-13
CN1882607A (zh) 2006-12-20
EP1420028A2 (fr) 2004-05-19

Similar Documents

Publication Publication Date Title
NO336349B1 (no) Mellomproduktet og fremgangsmåte for syntese av perindopril og farmasøytisk akseptable salter derav
US7223872B2 (en) Process for the synthesis of perindopril and its pharmaceutically acceptable salts
NZ521324A (en) A process for the synthesis of N-[(S)-1-carboxybutyl]- (S)-alanine esters and use in synthesis of perindopril and its salts
US7183308B1 (en) Metod for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
US7534896B2 (en) Process for the synthesis of perindopril and its pharmaceutically acceptable salts
US7358372B2 (en) Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
US7368580B2 (en) Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
PT1422236E (pt) Processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 18 NOV 2017 BY AJ PARK

Effective date: 20140814

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 18 NOV 2018 BY AJ PARK

Effective date: 20171103

LAPS Patent lapsed