NZ525664A - Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates - Google Patents
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulatesInfo
- Publication number
- NZ525664A NZ525664A NZ525664A NZ52566401A NZ525664A NZ 525664 A NZ525664 A NZ 525664A NZ 525664 A NZ525664 A NZ 525664A NZ 52566401 A NZ52566401 A NZ 52566401A NZ 525664 A NZ525664 A NZ 525664A
- Authority
- NZ
- New Zealand
- Prior art keywords
- ungulate
- nucleic acid
- cell
- human
- gene
- Prior art date
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- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
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| US71418500A | 2000-11-17 | 2000-11-17 | |
| US25645800P | 2000-12-20 | 2000-12-20 | |
| US31162501P | 2001-08-09 | 2001-08-09 | |
| PCT/US2001/043128 WO2002070648A2 (en) | 2000-11-17 | 2001-11-16 | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
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| NZ525664A true NZ525664A (en) | 2008-08-29 |
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| NZ525664A NZ525664A (en) | 2000-11-17 | 2001-11-16 | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
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| JP (2) | JP3797974B2 (enExample) |
| KR (2) | KR100882030B1 (enExample) |
| CN (1) | CN1486365B (enExample) |
| AT (2) | ATE503012T1 (enExample) |
| AU (2) | AU2001297523B2 (enExample) |
| CA (1) | CA2428053C (enExample) |
| DE (2) | DE60138832D1 (enExample) |
| MX (1) | MXPA03004313A (enExample) |
| NZ (1) | NZ525664A (enExample) |
| WO (1) | WO2002070648A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7414170B2 (en) | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| US7074983B2 (en) | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| IL165088A0 (en) * | 2002-05-17 | 2005-12-18 | Kirin Brewery | Transgenic ungulates capable of human antibody production |
| US20060185025A1 (en) * | 2002-10-04 | 2006-08-17 | Kirin Beer Kabushiki Kaisha | Human artificial chromosome (hac) vector |
| JP2006505291A (ja) * | 2002-11-08 | 2006-02-16 | ヘマテック，エルエルシー | プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途 |
| JP2007528721A (ja) | 2003-08-14 | 2007-10-18 | ダイアックス コーポレイション | エンドセリアーゼ−２リガンド |
| AR047720A1 (es) * | 2003-09-30 | 2006-02-15 | Bio Sidus S A | Un proceso para la obtencion de mamiferos transgenicos que produzcan proteinas exogenas en leche y los mamiferos producidos por dicho proceso |
| CA2563064A1 (en) | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Transgenic animals and uses thereof |
| US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
| NZ554824A (en) * | 2004-10-22 | 2010-10-29 | Revivicor Inc | Porcines that lack endogenous antibody chains and express exogenous immunoglobulins |
| WO2006117910A1 (ja) | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
| DK2348827T3 (en) | 2008-10-27 | 2015-07-20 | Revivicor Inc | IMMUNICIPLY COMPROMATED PETS |
| CA2747534C (en) * | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| EP2502992A4 (en) | 2009-11-17 | 2013-06-12 | CHROMOSOME ARTIFICIAL HUMAN VECTOR | |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| BR112014006405A2 (pt) | 2011-09-21 | 2017-04-04 | Fujirebio Kk | anticorpo, conjunto, e, método para medir um complexo de afinidade |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| HRP20200744T1 (hr) * | 2011-12-22 | 2020-07-24 | F. Hoffmann - La Roche Ag | Organizacija ekspresijskog vektora, novi postupci generiranja proizvodnje stanica i njihova uporaba za rekombinantnu proizvodnju polipeptida |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| KR102159163B1 (ko) | 2012-08-03 | 2020-09-23 | 에스에이비, 엘엘씨 | 유전자삽입 동물에서 인간 항체의 제조를 위한 복합 염색체 조작 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| EP3229586B1 (en) | 2014-12-10 | 2025-07-30 | Regents of the University of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| US20190335726A1 (en) * | 2016-06-14 | 2019-11-07 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| CN109906272A (zh) | 2016-10-31 | 2019-06-18 | 国立大学法人鸟取大学 | 产生人抗体的非人动物和使用该非人动物的人抗体制作方法 |
| EP4103603A4 (en) * | 2020-02-12 | 2024-03-27 | Sab, Llc | ANTI-THYMOCYTE GLOBULIN |
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| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5789650A (en) * | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2301158T3 (es) * | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| EP0689597A4 (en) | 1993-03-16 | 1998-10-21 | Austin Research Inst | USE OF PIG GAL-g (a) (1,3) GALACTOSYL TRANSFERASE FOR XENOGENE THERAPIES |
| WO1995016670A1 (en) | 1993-12-16 | 1995-06-22 | The Procter & Gamble Company | Process for making sulfonated fatty acid alkyl ester surfactant |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| US5683993A (en) | 1995-06-22 | 1997-11-04 | Ciba Vision Corporation | Compositions and methods for stabilizing polymers |
| CA2230759C (en) | 1995-08-29 | 2012-02-21 | Kirin Beer Kabushiki Kaisha | Chimeric animal and method for producing the same |
| JP3030092B2 (ja) | 1995-08-29 | 2000-04-10 | 麒麟麦酒株式会社 | キメラ動物およびその作製法 |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| TWI255853B (en) | 1998-08-21 | 2006-06-01 | Kirin Brewery | Method for modifying chromosomes |
| AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US6721750B1 (en) | 2001-07-03 | 2004-04-13 | Bellsouth Intellectual Property Corporation | System and method for broadband capacity tracking |
-
2001
- 2001-11-16 MX MXPA03004313A patent/MXPA03004313A/es not_active Application Discontinuation
- 2001-11-16 EP EP01273248A patent/EP1343880B1/en not_active Expired - Lifetime
- 2001-11-16 CN CN018220762A patent/CN1486365B/zh not_active Expired - Lifetime
- 2001-11-16 DE DE60138832T patent/DE60138832D1/de not_active Expired - Lifetime
- 2001-11-16 AT AT08016978T patent/ATE503012T1/de not_active IP Right Cessation
- 2001-11-16 DE DE60144305T patent/DE60144305D1/de not_active Expired - Lifetime
- 2001-11-16 AT AT01273248T patent/ATE432343T1/de not_active IP Right Cessation
- 2001-11-16 KR KR1020077030804A patent/KR100882030B1/ko not_active Expired - Fee Related
- 2001-11-16 EP EP08016978A patent/EP2042594B1/en not_active Expired - Lifetime
- 2001-11-16 WO PCT/US2001/043128 patent/WO2002070648A2/en not_active Ceased
- 2001-11-16 JP JP2002570676A patent/JP3797974B2/ja not_active Expired - Fee Related
- 2001-11-16 KR KR1020037006659A patent/KR100882029B1/ko not_active Expired - Fee Related
- 2001-11-16 CA CA2428053A patent/CA2428053C/en not_active Expired - Lifetime
- 2001-11-16 AU AU2001297523A patent/AU2001297523B2/en not_active Expired
- 2001-11-16 NZ NZ525664A patent/NZ525664A/en not_active IP Right Cessation
-
2005
- 2005-05-09 JP JP2005136675A patent/JP2005224250A/ja active Pending
-
2007
- 2007-04-17 AU AU2007201700A patent/AU2007201700A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002070648A3 (en) | 2003-02-13 |
| CN1486365A (zh) | 2004-03-31 |
| KR20080005616A (ko) | 2008-01-14 |
| DE60138832D1 (de) | 2009-07-09 |
| EP1343880A2 (en) | 2003-09-17 |
| KR100882030B1 (ko) | 2009-02-09 |
| KR100882029B1 (ko) | 2009-02-09 |
| AU2001297523B2 (en) | 2007-01-18 |
| CA2428053A1 (en) | 2002-09-12 |
| EP1343880B1 (en) | 2009-05-27 |
| EP2042594A1 (en) | 2009-04-01 |
| MXPA03004313A (es) | 2007-02-27 |
| JP2005224250A (ja) | 2005-08-25 |
| EP2042594B1 (en) | 2011-03-23 |
| KR20030059260A (ko) | 2003-07-07 |
| CN1486365B (zh) | 2010-05-12 |
| JP2005504507A (ja) | 2005-02-17 |
| EP1343880A4 (en) | 2005-03-16 |
| JP3797974B2 (ja) | 2006-07-19 |
| DE60144305D1 (de) | 2011-05-05 |
| ATE432343T1 (de) | 2009-06-15 |
| CA2428053C (en) | 2012-08-21 |
| ATE503012T1 (de) | 2011-04-15 |
| WO2002070648A2 (en) | 2002-09-12 |
| AU2007201700A1 (en) | 2007-05-10 |
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