JP2005504507A5 - - Google Patents

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Publication number
JP2005504507A5
JP2005504507A5 JP2002570676A JP2002570676A JP2005504507A5 JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5 JP 2002570676 A JP2002570676 A JP 2002570676A JP 2002570676 A JP2002570676 A JP 2002570676A JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5
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JP
Japan
Prior art keywords
human
cells
gene
ungulate
cell
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Application number
JP2002570676A
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English (en)
Japanese (ja)
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JP2005504507A (ja
JP3797974B2 (ja
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Priority claimed from PCT/US2001/043128 external-priority patent/WO2002070648A2/en
Publication of JP2005504507A publication Critical patent/JP2005504507A/ja
Publication of JP2005504507A5 publication Critical patent/JP2005504507A5/ja
Application granted granted Critical
Publication of JP3797974B2 publication Critical patent/JP3797974B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002570676A 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現 Expired - Fee Related JP3797974B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005136675A Division JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Publications (3)

Publication Number Publication Date
JP2005504507A JP2005504507A (ja) 2005-02-17
JP2005504507A5 true JP2005504507A5 (enExample) 2005-09-02
JP3797974B2 JP3797974B2 (ja) 2006-07-19

Family

ID=27400960

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002570676A Expired - Fee Related JP3797974B2 (ja) 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Country Status (11)

Country Link
EP (2) EP1343880B1 (enExample)
JP (2) JP3797974B2 (enExample)
KR (2) KR100882030B1 (enExample)
CN (1) CN1486365B (enExample)
AT (2) ATE503012T1 (enExample)
AU (2) AU2001297523B2 (enExample)
CA (1) CA2428053C (enExample)
DE (2) DE60138832D1 (enExample)
MX (1) MXPA03004313A (enExample)
NZ (1) NZ525664A (enExample)
WO (1) WO2002070648A2 (enExample)

Families Citing this family (34)

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US7414170B2 (en) 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
IL165088A0 (en) * 2002-05-17 2005-12-18 Kirin Brewery Transgenic ungulates capable of human antibody production
US20060185025A1 (en) * 2002-10-04 2006-08-17 Kirin Beer Kabushiki Kaisha Human artificial chromosome (hac) vector
JP2006505291A (ja) * 2002-11-08 2006-02-16 ヘマテック,エルエルシー プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途
JP2007528721A (ja) 2003-08-14 2007-10-18 ダイアックス コーポレイション エンドセリアーゼ−2リガンド
AR047720A1 (es) * 2003-09-30 2006-02-15 Bio Sidus S A Un proceso para la obtencion de mamiferos transgenicos que produzcan proteinas exogenas en leche y los mamiferos producidos por dicho proceso
CA2563064A1 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
NZ554824A (en) * 2004-10-22 2010-10-29 Revivicor Inc Porcines that lack endogenous antibody chains and express exogenous immunoglobulins
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
CA2747534C (en) * 2008-12-18 2020-08-18 Erasmus University Medical Center Rotterdam Non-human transgenic animals expressing humanised antibodies and use therof
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
CN102638971B (zh) 2009-07-08 2015-10-07 科马布有限公司 动物模型及治疗分子
EP2502992A4 (en) 2009-11-17 2013-06-12 CHROMOSOME ARTIFICIAL HUMAN VECTOR
AU2012311286B2 (en) 2011-09-19 2018-07-26 Kymab Limited Antibodies, variable domains and chains tailored for human use
BR112014006405A2 (pt) 2011-09-21 2017-04-04 Fujirebio Kk anticorpo, conjunto, e, método para medir um complexo de afinidade
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
HRP20200744T1 (hr) * 2011-12-22 2020-07-24 F. Hoffmann - La Roche Ag Organizacija ekspresijskog vektora, novi postupci generiranja proizvodnje stanica i njihova uporaba za rekombinantnu proizvodnju polipeptida
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
KR102159163B1 (ko) 2012-08-03 2020-09-23 에스에이비, 엘엘씨 유전자삽입 동물에서 인간 항체의 제조를 위한 복합 염색체 조작
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
CA2925723A1 (en) 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
EP3229586B1 (en) 2014-12-10 2025-07-30 Regents of the University of Minnesota Genetically modified cells, tissues, and organs for treating disease
US20190335726A1 (en) * 2016-06-14 2019-11-07 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
CN109906272A (zh) 2016-10-31 2019-06-18 国立大学法人鸟取大学 产生人抗体的非人动物和使用该非人动物的人抗体制作方法
EP4103603A4 (en) * 2020-02-12 2024-03-27 Sab, Llc ANTI-THYMOCYTE GLOBULIN

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AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
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