NZ518615A - Methods, kits and compositions for using pyrrole derivatives - Google Patents
Methods, kits and compositions for using pyrrole derivativesInfo
- Publication number
- NZ518615A NZ518615A NZ518615A NZ51861502A NZ518615A NZ 518615 A NZ518615 A NZ 518615A NZ 518615 A NZ518615 A NZ 518615A NZ 51861502 A NZ51861502 A NZ 51861502A NZ 518615 A NZ518615 A NZ 518615A
- Authority
- NZ
- New Zealand
- Prior art keywords
- disorder
- compound
- medicament
- treating
- prodrug
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 29
- 239000000203 mixture Substances 0.000 title claims description 24
- 150000003233 pyrroles Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 137
- 239000003814 drug Substances 0.000 claims abstract description 20
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical group C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims description 67
- 229940002612 prodrug Drugs 0.000 claims description 59
- 239000000651 prodrug Substances 0.000 claims description 59
- 208000019901 Anxiety disease Diseases 0.000 claims description 53
- 206010041250 Social phobia Diseases 0.000 claims description 45
- 230000003287 optical effect Effects 0.000 claims description 38
- 230000036506 anxiety Effects 0.000 claims description 32
- 125000004432 carbon atom Chemical group C* 0.000 claims description 25
- 208000001640 Fibromyalgia Diseases 0.000 claims description 24
- 208000027030 Premenstrual dysphoric disease Diseases 0.000 claims description 22
- 208000024732 dysthymic disease Diseases 0.000 claims description 22
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- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 20
- 201000001716 specific phobia Diseases 0.000 claims description 19
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 18
- 208000033039 Somatisation disease Diseases 0.000 claims description 18
- 208000027520 Somatoform disease Diseases 0.000 claims description 18
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- 208000026345 acute stress disease Diseases 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- HIUPRQPBWVEQJJ-UHFFFAOYSA-N pagoclone Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)C)=CC=C21 HIUPRQPBWVEQJJ-UHFFFAOYSA-N 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 9
- 229960002296 paroxetine Drugs 0.000 claims description 9
- ADHYPRBHQVZOTP-UHFFFAOYSA-N 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-hydroxy-5-methyl-2-oxohexyl)-3h-isoindol-1-one Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)(O)C)=CC=C21 ADHYPRBHQVZOTP-UHFFFAOYSA-N 0.000 claims description 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 229950002286 pagoclone Drugs 0.000 claims description 8
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims description 6
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 claims description 6
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
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- 125000000168 pyrrolyl group Chemical group 0.000 claims description 6
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 4
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- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 claims description 3
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- LFMYNZPAVPMEGP-PIDGMYBPSA-N Fluvoxamine maleate Chemical compound OC(=O)\C=C/C(O)=O.COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 LFMYNZPAVPMEGP-PIDGMYBPSA-N 0.000 claims description 2
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- QCHSEDTUUKDTIG-UHFFFAOYSA-L dipotassium clorazepate Chemical compound [OH-].[K+].[K+].C12=CC(Cl)=CC=C2NC(=O)C(C(=O)[O-])N=C1C1=CC=CC=C1 QCHSEDTUUKDTIG-UHFFFAOYSA-L 0.000 claims description 2
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- XDDJGVMJFWAHJX-UHFFFAOYSA-M clorazepic acid anion Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(C(=O)[O-])N=C1C1=CC=CC=C1 XDDJGVMJFWAHJX-UHFFFAOYSA-M 0.000 claims 1
- 229940095990 inderal Drugs 0.000 claims 1
- 230000000053 inderal effect Effects 0.000 claims 1
- 229960002853 midazolam hydrochloride Drugs 0.000 claims 1
- PLYSCVSCYOQVRP-UHFFFAOYSA-N midazolam hydrochloride Chemical compound Cl.C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F PLYSCVSCYOQVRP-UHFFFAOYSA-N 0.000 claims 1
- 229960004535 oxazepam Drugs 0.000 claims 1
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- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US28754501P | 2001-04-30 | 2001-04-30 |
Publications (1)
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| NZ518615A true NZ518615A (en) | 2004-03-26 |
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| NZ518615A NZ518615A (en) | 2001-04-30 | 2002-04-29 | Methods, kits and compositions for using pyrrole derivatives |
Country Status (20)
| Country | Link |
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| US (2) | US7026332B2 (enExample) |
| EP (2) | EP1642576B1 (enExample) |
| JP (1) | JP2002326934A (enExample) |
| KR (1) | KR20020084413A (enExample) |
| CN (1) | CN1384104A (enExample) |
| AT (2) | ATE331513T1 (enExample) |
| AU (1) | AU783516B2 (enExample) |
| CA (1) | CA2383599C (enExample) |
| CY (1) | CY1109129T1 (enExample) |
| DE (2) | DE60231568D1 (enExample) |
| DK (1) | DK1642576T3 (enExample) |
| ES (2) | ES2323646T3 (enExample) |
| HU (1) | HU228826B1 (enExample) |
| IL (2) | IL149280A0 (enExample) |
| MY (1) | MY129575A (enExample) |
| NZ (1) | NZ518615A (enExample) |
| PL (2) | PL207725B1 (enExample) |
| PT (1) | PT1642576E (enExample) |
| TW (1) | TWI302455B (enExample) |
| ZA (1) | ZA200203347B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0410419A (pt) * | 2003-05-16 | 2006-05-30 | Pfizer Prod Inc | tratamento para a ansiedade com ziprasidona |
| JP2007502856A (ja) * | 2003-05-16 | 2007-02-15 | ファイザー・プロダクツ・インク | 精神病性障害および抑うつ性障害の治療 |
| ATE449633T1 (de) * | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
| WO2005025563A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders |
| WO2005105061A2 (en) * | 2004-04-14 | 2005-11-10 | Indevus Pharmaceuticals, Inc. | Transdermal patch |
| EP1744750A2 (en) * | 2004-05-06 | 2007-01-24 | Sandoz AG | Pharmaceutical composition comprising hydrophobic drug having improved solubility |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| EP2678337A1 (en) * | 2011-02-25 | 2014-01-01 | Concert Pharmaceuticals Inc. | 2-amino-naphthyridine derivatives |
| WO2020191047A1 (en) * | 2019-03-18 | 2020-09-24 | Neurocycle Therapeutics, Inc. | Use of gabaa receptor modulators for treatment of pain |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607503B1 (fr) | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE3814022A1 (de) * | 1988-04-26 | 1989-11-09 | Davy Mckee Ag | Verfahren zur herstellung linearer polyester, insbesondere fuer filme und folien |
| EP0521622B1 (en) | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| FR2678932B1 (fr) | 1991-07-12 | 1993-09-24 | Rhone Poulenc Rorer Sa | Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine. |
| FR2678934B1 (fr) | 1991-07-12 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone. |
| FR2681068B1 (fr) | 1991-09-09 | 1993-11-19 | Rhone Poulenc Rorer Sa | Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone. |
| FR2684673B1 (fr) | 1991-12-04 | 1994-01-21 | Rhone Poulenc Rorer Sa | Procede de preparation d'un derive de l'amino-2 naphtyridine racemique. |
| FR2687154B1 (fr) * | 1992-02-07 | 1995-05-12 | Rhone Poulenc Rorer Sa | Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent. |
| FR2695389B1 (fr) | 1992-09-08 | 1994-11-04 | Rhone Poulenc Rorer Sa | Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent. |
| US5498716A (en) | 1994-01-12 | 1996-03-12 | Rhone-Poulenc Rorer S.A. | 2-amino naphthyridine derivative, its preparation and its use |
| GB2305859A (en) * | 1996-03-29 | 1997-04-23 | Lilly Co Eli | Treatment of obsessive-compulsive disorder |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| WO2001008670A2 (en) * | 1999-07-29 | 2001-02-08 | Interneuron Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
| DE19939980A1 (de) | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
| AU2756602A (en) * | 2001-04-25 | 2002-10-31 | Pfizer Products Inc. | Methods and kits for treating depression or preventing deterioration of cognitive function |
-
2002
- 2002-03-22 AU AU27609/02A patent/AU783516B2/en not_active Ceased
- 2002-03-28 MY MYPI20021125A patent/MY129575A/en unknown
- 2002-04-16 DK DK05028364T patent/DK1642576T3/da active
- 2002-04-16 DE DE60231568T patent/DE60231568D1/de not_active Expired - Lifetime
- 2002-04-16 EP EP05028364A patent/EP1642576B1/en not_active Expired - Lifetime
- 2002-04-16 ES ES05028364T patent/ES2323646T3/es not_active Expired - Lifetime
- 2002-04-16 ES ES02252684T patent/ES2267943T3/es not_active Expired - Lifetime
- 2002-04-16 AT AT02252684T patent/ATE331513T1/de not_active IP Right Cessation
- 2002-04-16 PT PT05028364T patent/PT1642576E/pt unknown
- 2002-04-16 DE DE60212757T patent/DE60212757T2/de not_active Expired - Lifetime
- 2002-04-16 AT AT05028364T patent/ATE424820T1/de active
- 2002-04-16 EP EP02252684A patent/EP1254660B1/en not_active Expired - Lifetime
- 2002-04-18 CN CN02116105A patent/CN1384104A/zh active Pending
- 2002-04-22 IL IL14928002A patent/IL149280A0/xx not_active IP Right Cessation
- 2002-04-22 IL IL204665A patent/IL204665A/en not_active IP Right Cessation
- 2002-04-25 US US10/133,471 patent/US7026332B2/en not_active Expired - Fee Related
- 2002-04-25 JP JP2002123928A patent/JP2002326934A/ja active Pending
- 2002-04-26 ZA ZA2002/03347A patent/ZA200203347B/en unknown
- 2002-04-26 CA CA002383599A patent/CA2383599C/en not_active Expired - Fee Related
- 2002-04-29 PL PL390683A patent/PL207725B1/pl unknown
- 2002-04-29 PL PL353681A patent/PL207738B1/pl unknown
- 2002-04-29 TW TW091108876A patent/TWI302455B/zh not_active IP Right Cessation
- 2002-04-29 HU HU0201394A patent/HU228826B1/hu not_active IP Right Cessation
- 2002-04-29 NZ NZ518615A patent/NZ518615A/en not_active IP Right Cessation
- 2002-04-29 KR KR1020020023430A patent/KR20020084413A/ko not_active Ceased
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2006
- 2006-02-13 US US11/352,286 patent/US7553847B2/en not_active Expired - Fee Related
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- 2009-06-01 CY CY20091100582T patent/CY1109129T1/el unknown
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