PT1642576E - Utilização de derivados de pirrole para combate da ansiedade - Google Patents
Utilização de derivados de pirrole para combate da ansiedade Download PDFInfo
- Publication number
- PT1642576E PT1642576E PT05028364T PT05028364T PT1642576E PT 1642576 E PT1642576 E PT 1642576E PT 05028364 T PT05028364 T PT 05028364T PT 05028364 T PT05028364 T PT 05028364T PT 1642576 E PT1642576 E PT 1642576E
- Authority
- PT
- Portugal
- Prior art keywords
- compound
- pyrrole derivatives
- isoindolinone
- prodrug
- chloro
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
- 150000003233 pyrroles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000003287 optical effect Effects 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ADHYPRBHQVZOTP-UHFFFAOYSA-N 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-hydroxy-5-methyl-2-oxohexyl)-3h-isoindol-1-one Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)(O)C)=CC=C21 ADHYPRBHQVZOTP-UHFFFAOYSA-N 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- HIUPRQPBWVEQJJ-UHFFFAOYSA-N pagoclone Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)C)=CC=C21 HIUPRQPBWVEQJJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28754501P | 2001-04-30 | 2001-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1642576E true PT1642576E (pt) | 2009-05-21 |
Family
ID=23103396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05028364T PT1642576E (pt) | 2001-04-30 | 2002-04-16 | Utilização de derivados de pirrole para combate da ansiedade |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7026332B2 (enExample) |
| EP (2) | EP1642576B1 (enExample) |
| JP (1) | JP2002326934A (enExample) |
| KR (1) | KR20020084413A (enExample) |
| CN (1) | CN1384104A (enExample) |
| AT (2) | ATE331513T1 (enExample) |
| AU (1) | AU783516B2 (enExample) |
| CA (1) | CA2383599C (enExample) |
| CY (1) | CY1109129T1 (enExample) |
| DE (2) | DE60231568D1 (enExample) |
| DK (1) | DK1642576T3 (enExample) |
| ES (2) | ES2323646T3 (enExample) |
| HU (1) | HU228826B1 (enExample) |
| IL (2) | IL149280A0 (enExample) |
| MY (1) | MY129575A (enExample) |
| NZ (1) | NZ518615A (enExample) |
| PL (2) | PL207725B1 (enExample) |
| PT (1) | PT1642576E (enExample) |
| TW (1) | TWI302455B (enExample) |
| ZA (1) | ZA200203347B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0410419A (pt) * | 2003-05-16 | 2006-05-30 | Pfizer Prod Inc | tratamento para a ansiedade com ziprasidona |
| JP2007502856A (ja) * | 2003-05-16 | 2007-02-15 | ファイザー・プロダクツ・インク | 精神病性障害および抑うつ性障害の治療 |
| ATE449633T1 (de) * | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
| WO2005025563A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders |
| WO2005105061A2 (en) * | 2004-04-14 | 2005-11-10 | Indevus Pharmaceuticals, Inc. | Transdermal patch |
| EP1744750A2 (en) * | 2004-05-06 | 2007-01-24 | Sandoz AG | Pharmaceutical composition comprising hydrophobic drug having improved solubility |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| EP2678337A1 (en) * | 2011-02-25 | 2014-01-01 | Concert Pharmaceuticals Inc. | 2-amino-naphthyridine derivatives |
| WO2020191047A1 (en) * | 2019-03-18 | 2020-09-24 | Neurocycle Therapeutics, Inc. | Use of gabaa receptor modulators for treatment of pain |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607503B1 (fr) | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE3814022A1 (de) * | 1988-04-26 | 1989-11-09 | Davy Mckee Ag | Verfahren zur herstellung linearer polyester, insbesondere fuer filme und folien |
| EP0521622B1 (en) | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| FR2678932B1 (fr) | 1991-07-12 | 1993-09-24 | Rhone Poulenc Rorer Sa | Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine. |
| FR2678934B1 (fr) | 1991-07-12 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone. |
| FR2681068B1 (fr) | 1991-09-09 | 1993-11-19 | Rhone Poulenc Rorer Sa | Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone. |
| FR2684673B1 (fr) | 1991-12-04 | 1994-01-21 | Rhone Poulenc Rorer Sa | Procede de preparation d'un derive de l'amino-2 naphtyridine racemique. |
| FR2687154B1 (fr) * | 1992-02-07 | 1995-05-12 | Rhone Poulenc Rorer Sa | Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent. |
| FR2695389B1 (fr) | 1992-09-08 | 1994-11-04 | Rhone Poulenc Rorer Sa | Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent. |
| US5498716A (en) | 1994-01-12 | 1996-03-12 | Rhone-Poulenc Rorer S.A. | 2-amino naphthyridine derivative, its preparation and its use |
| GB2305859A (en) * | 1996-03-29 | 1997-04-23 | Lilly Co Eli | Treatment of obsessive-compulsive disorder |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| WO2001008670A2 (en) * | 1999-07-29 | 2001-02-08 | Interneuron Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
| DE19939980A1 (de) | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
| AU2756602A (en) * | 2001-04-25 | 2002-10-31 | Pfizer Products Inc. | Methods and kits for treating depression or preventing deterioration of cognitive function |
-
2002
- 2002-03-22 AU AU27609/02A patent/AU783516B2/en not_active Ceased
- 2002-03-28 MY MYPI20021125A patent/MY129575A/en unknown
- 2002-04-16 DK DK05028364T patent/DK1642576T3/da active
- 2002-04-16 DE DE60231568T patent/DE60231568D1/de not_active Expired - Lifetime
- 2002-04-16 EP EP05028364A patent/EP1642576B1/en not_active Expired - Lifetime
- 2002-04-16 ES ES05028364T patent/ES2323646T3/es not_active Expired - Lifetime
- 2002-04-16 ES ES02252684T patent/ES2267943T3/es not_active Expired - Lifetime
- 2002-04-16 AT AT02252684T patent/ATE331513T1/de not_active IP Right Cessation
- 2002-04-16 PT PT05028364T patent/PT1642576E/pt unknown
- 2002-04-16 DE DE60212757T patent/DE60212757T2/de not_active Expired - Lifetime
- 2002-04-16 AT AT05028364T patent/ATE424820T1/de active
- 2002-04-16 EP EP02252684A patent/EP1254660B1/en not_active Expired - Lifetime
- 2002-04-18 CN CN02116105A patent/CN1384104A/zh active Pending
- 2002-04-22 IL IL14928002A patent/IL149280A0/xx not_active IP Right Cessation
- 2002-04-22 IL IL204665A patent/IL204665A/en not_active IP Right Cessation
- 2002-04-25 US US10/133,471 patent/US7026332B2/en not_active Expired - Fee Related
- 2002-04-25 JP JP2002123928A patent/JP2002326934A/ja active Pending
- 2002-04-26 ZA ZA2002/03347A patent/ZA200203347B/en unknown
- 2002-04-26 CA CA002383599A patent/CA2383599C/en not_active Expired - Fee Related
- 2002-04-29 PL PL390683A patent/PL207725B1/pl unknown
- 2002-04-29 PL PL353681A patent/PL207738B1/pl unknown
- 2002-04-29 TW TW091108876A patent/TWI302455B/zh not_active IP Right Cessation
- 2002-04-29 HU HU0201394A patent/HU228826B1/hu not_active IP Right Cessation
- 2002-04-29 NZ NZ518615A patent/NZ518615A/en not_active IP Right Cessation
- 2002-04-29 KR KR1020020023430A patent/KR20020084413A/ko not_active Ceased
-
2006
- 2006-02-13 US US11/352,286 patent/US7553847B2/en not_active Expired - Fee Related
-
2009
- 2009-06-01 CY CY20091100582T patent/CY1109129T1/el unknown
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