HUP0201394A2 - Pirrolszármazékok alkalmazása gyógyszerkészítmények előállítására - Google Patents

Pirrolszármazékok alkalmazása gyógyszerkészítmények előállítására

Info

Publication number
HUP0201394A2
HUP0201394A2 HU0201394A HUP0201394A HUP0201394A2 HU P0201394 A2 HUP0201394 A2 HU P0201394A2 HU 0201394 A HU0201394 A HU 0201394A HU P0201394 A HUP0201394 A HU P0201394A HU P0201394 A2 HUP0201394 A2 HU P0201394A2
Authority
HU
Hungary
Prior art keywords
disorder
general formula
compound
treatment
prodrug
Prior art date
Application number
HU0201394A
Other languages
English (en)
Inventor
Cathryn Montgomery Clary
Sean David Donevan
Perry Steven Eisman
Richard James Kavousssi
Lyou-Fu Ma
Atul Chandra Pande
Jeroen Bernard Van Beek
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HU0201394D0 publication Critical patent/HU0201394D0/hu
Publication of HUP0201394A2 publication Critical patent/HUP0201394A2/hu
Publication of HUP0201394A3 publication Critical patent/HUP0201394A3/hu
Publication of HU228826B1 publication Critical patent/HU228826B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya a (I) általános képletű vegyületnek vagygyógyászatilag elfogadható sójának, optikai izomerének vagy gyógyszerelőalakjának alkalmazása rögeszmés-kényszeres betegség, hevenystresszbetegség, sérülés utáni stresszbetegség, szociális szorongásosbetegség, testi, szervi tünetekben jelentkező betegség, speciálisszociális fóbia, a menstruációt megelőző rossz közérzet, orvosikezelésre szoruló állapottal kapcsolatos szorongás, alkalmazkodásirendellenesség szorongó kedélyállapottal, kóros lehangoltság,specifikus fóbia vagy fibromialgia kezelésére szolgálógyógyszerkészítmény előállítására. A találmány tárgyát képezik továbbákészítmények, amelyek a (I) általános képletű vegyületet vagygyógyászatilag elfogadható sóját, optikai izomerét vagy gyógyszerelőalakját és a fent említett kóros állapotok kezelésére használhatótovábbi vegyületet tartalmazzák. Az (I) általános képletben Hetjelentése adott esetben helyettesített naftridilcsoport, Y jelentése CO-, C=N-OH vagy CHOH-csoport; és R jelentése 3-10szénatomos alkanil-, 4-10 szénatomos alkilcsoport, amely adott esetbenhelyettesített. Ó
HU0201394A 2001-04-30 2002-04-29 Use of pyrrole derivatives for making pharmaceutical compositions HU228826B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28754501P 2001-04-30 2001-04-30

Publications (4)

Publication Number Publication Date
HU0201394D0 HU0201394D0 (hu) 2002-06-29
HUP0201394A2 true HUP0201394A2 (hu) 2002-12-28
HUP0201394A3 HUP0201394A3 (en) 2003-12-29
HU228826B1 HU228826B1 (en) 2013-05-28

Family

ID=23103396

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201394A HU228826B1 (en) 2001-04-30 2002-04-29 Use of pyrrole derivatives for making pharmaceutical compositions

Country Status (21)

Country Link
US (2) US7026332B2 (hu)
EP (2) EP1254660B1 (hu)
JP (1) JP2002326934A (hu)
KR (1) KR20020084413A (hu)
CN (1) CN1384104A (hu)
AT (2) ATE424820T1 (hu)
AU (1) AU783516B2 (hu)
CA (1) CA2383599C (hu)
CY (1) CY1109129T1 (hu)
DE (2) DE60231568D1 (hu)
DK (1) DK1642576T3 (hu)
ES (2) ES2267943T3 (hu)
HK (1) HK1094307A1 (hu)
HU (1) HU228826B1 (hu)
IL (2) IL149280A0 (hu)
MY (1) MY129575A (hu)
NZ (1) NZ518615A (hu)
PL (2) PL207725B1 (hu)
PT (1) PT1642576E (hu)
TW (1) TWI302455B (hu)
ZA (1) ZA200203347B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05012391A (es) * 2003-05-16 2006-02-02 Pfizer Prod Inc Tratamiento de trastornos psicoticos y depresivos.
CA2525868A1 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Anxiety treatments with ziprasidone
CA2537402C (en) * 2003-09-12 2009-05-05 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
EP1675582A1 (en) * 2003-09-12 2006-07-05 Warner-Lambert Company LLC Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders
US20050232983A1 (en) * 2004-04-14 2005-10-20 Indevus Pharmaceuticals, Inc. Transdermal patch
WO2005107719A2 (en) * 2004-05-06 2005-11-17 Sandoz Ag Pharmaceutical composition comprising hydrophobic drug having improved solubility
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2012116288A1 (en) * 2011-02-25 2012-08-30 Concert Pharmaceuticals Inc. 2-amino-naphthyridine derivatives
US20220152037A1 (en) * 2019-03-18 2022-05-19 Neurocycle Therapeutic, Inc. Use of gabaa receptor modulators for treatment of pain

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607503B1 (fr) 1986-12-02 1989-02-24 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
DE3814022A1 (de) * 1988-04-26 1989-11-09 Davy Mckee Ag Verfahren zur herstellung linearer polyester, insbesondere fuer filme und folien
EP0521622B1 (en) 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
FR2678934B1 (fr) 1991-07-12 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone.
FR2678932B1 (fr) 1991-07-12 1993-09-24 Rhone Poulenc Rorer Sa Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine.
FR2681068B1 (fr) 1991-09-09 1993-11-19 Rhone Poulenc Rorer Sa Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone.
FR2684673B1 (fr) 1991-12-04 1994-01-21 Rhone Poulenc Rorer Sa Procede de preparation d'un derive de l'amino-2 naphtyridine racemique.
FR2687154B1 (fr) * 1992-02-07 1995-05-12 Rhone Poulenc Rorer Sa Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
FR2695389B1 (fr) 1992-09-08 1994-11-04 Rhone Poulenc Rorer Sa Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent.
US5498716A (en) 1994-01-12 1996-03-12 Rhone-Poulenc Rorer S.A. 2-amino naphthyridine derivative, its preparation and its use
GB2305859A (en) * 1996-03-29 1997-04-23 Lilly Co Eli Treatment of obsessive-compulsive disorder
US6362371B1 (en) * 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
WO2001008670A2 (en) * 1999-07-29 2001-02-08 Interneuron Pharmaceuticals, Inc. Methods and compositions for alleviating stuttering
DE19939980A1 (de) 1999-08-24 2001-03-01 Merck Patent Gmbh Inhibitoren des Integrins alphavbeta¶3¶
AU2756602A (en) * 2001-04-25 2002-10-31 Pfizer Products Inc. Methods and kits for treating depression or preventing deterioration of cognitive function

Also Published As

Publication number Publication date
EP1254660B1 (en) 2006-06-28
AU783516B2 (en) 2005-11-03
PL207738B1 (pl) 2011-01-31
PL390683A1 (pl) 2010-05-24
ATE331513T1 (de) 2006-07-15
PT1642576E (pt) 2009-05-21
HK1094307A1 (en) 2007-03-30
JP2002326934A (ja) 2002-11-15
US7553847B2 (en) 2009-06-30
EP1254660A3 (en) 2003-03-26
PL353681A1 (en) 2002-11-04
PL207725B1 (pl) 2011-01-31
EP1254660A2 (en) 2002-11-06
IL149280A0 (en) 2002-11-10
ATE424820T1 (de) 2009-03-15
US20030022915A1 (en) 2003-01-30
EP1642576A2 (en) 2006-04-05
CA2383599C (en) 2006-10-31
AU2760902A (en) 2002-10-31
KR20020084413A (ko) 2002-11-07
TWI302455B (en) 2008-11-01
CY1109129T1 (el) 2014-07-02
CA2383599A1 (en) 2002-10-30
MY129575A (en) 2007-04-30
ZA200203347B (en) 2003-11-26
US20060128746A1 (en) 2006-06-15
HUP0201394A3 (en) 2003-12-29
DK1642576T3 (da) 2009-04-14
IL204665A (en) 2011-05-31
HU0201394D0 (hu) 2002-06-29
US7026332B2 (en) 2006-04-11
NZ518615A (en) 2004-03-26
ES2267943T3 (es) 2007-03-16
EP1642576A3 (en) 2007-01-10
DE60231568D1 (de) 2009-04-23
DE60212757T2 (de) 2007-06-28
CN1384104A (zh) 2002-12-11
EP1642576B1 (en) 2009-03-11
DE60212757D1 (de) 2006-08-10
ES2323646T3 (es) 2009-07-22
HU228826B1 (en) 2013-05-28

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