NZ509985A - Improved stability for injection solutions - Google Patents
Improved stability for injection solutionsInfo
- Publication number
- NZ509985A NZ509985A NZ50998599A NZ50998599A NZ509985A NZ 509985 A NZ509985 A NZ 509985A NZ 50998599 A NZ50998599 A NZ 50998599A NZ 50998599 A NZ50998599 A NZ 50998599A NZ 509985 A NZ509985 A NZ 509985A
- Authority
- NZ
- New Zealand
- Prior art keywords
- improved stability
- injection solutions
- inogatran
- melagatran
- cyclodextrin
- Prior art date
Links
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 239000000243 solution Substances 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229920001971 elastomer Polymers 0.000 abstract 2
- -1 hydroxy-propyl- Chemical group 0.000 abstract 2
- CDPROXZBMHOBTQ-SJORKVTESA-N 2-[[(2r)-3-cyclohexyl-1-[(2s)-2-[3-(diaminomethylideneamino)propylcarbamoyl]piperidin-1-yl]-1-oxopropan-2-yl]amino]acetic acid Chemical compound NC(N)=NCCCNC(=O)[C@@H]1CCCCN1C(=O)[C@H](NCC(O)=O)CC1CCCCC1 CDPROXZBMHOBTQ-SJORKVTESA-N 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229920005557 bromobutyl Polymers 0.000 abstract 1
- 229950003291 inogatran Drugs 0.000 abstract 1
- 229960002137 melagatran Drugs 0.000 abstract 1
- DKWNMCUOEDMMIN-PKOBYXMFSA-N melagatran Chemical compound C1=CC(C(=N)N)=CC=C1CNC(=O)[C@H]1N(C(=O)[C@H](NCC(O)=O)C2CCCCC2)CC1 DKWNMCUOEDMMIN-PKOBYXMFSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 229940071643 prefilled syringe Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/062—Carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9802938A SE9802938D0 (sv) | 1998-09-01 | 1998-09-01 | Improved stability for injection solutions |
| PCT/SE1999/001440 WO2000012043A1 (en) | 1998-09-01 | 1999-08-24 | Improved stability for injection solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ509985A true NZ509985A (en) | 2002-12-20 |
Family
ID=20412436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ50998599A NZ509985A (en) | 1998-09-01 | 1999-08-24 | Improved stability for injection solutions |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US6576245B1 (https=) |
| EP (1) | EP1109526B1 (https=) |
| JP (1) | JP2002523184A (https=) |
| KR (1) | KR100614162B1 (https=) |
| CN (1) | CN1230141C (https=) |
| AR (1) | AR033788A1 (https=) |
| AT (1) | ATE262882T1 (https=) |
| AU (1) | AU754447C (https=) |
| BR (1) | BR9913261A (https=) |
| CA (1) | CA2340238C (https=) |
| CZ (1) | CZ2001743A3 (https=) |
| DE (1) | DE69916082T2 (https=) |
| DK (1) | DK1109526T3 (https=) |
| EE (1) | EE04768B1 (https=) |
| ES (1) | ES2217808T3 (https=) |
| HU (1) | HUP0104161A3 (https=) |
| ID (1) | ID28015A (https=) |
| IL (2) | IL141333A0 (https=) |
| IS (1) | IS2230B (https=) |
| MY (1) | MY120822A (https=) |
| NO (1) | NO322292B1 (https=) |
| NZ (1) | NZ509985A (https=) |
| PL (1) | PL195244B1 (https=) |
| PT (1) | PT1109526E (https=) |
| RU (1) | RU2224499C2 (https=) |
| SA (1) | SA99200573B1 (https=) |
| SE (1) | SE9802938D0 (https=) |
| SK (1) | SK285474B6 (https=) |
| TR (1) | TR200100679T2 (https=) |
| TW (1) | TWI228987B (https=) |
| UA (1) | UA73282C2 (https=) |
| WO (1) | WO2000012043A1 (https=) |
| ZA (1) | ZA200101590B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9802938D0 (sv) * | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
| US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| US6802828B2 (en) * | 2001-11-23 | 2004-10-12 | Duoject Medical Systems, Inc. | System for filling and assembling pharmaceutical delivery devices |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| SE0201659D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| KR20050100617A (ko) * | 2003-01-14 | 2005-10-19 | 테바 파마슈티컬 인더스트리즈 리미티드 | 전신 홍반 루푸스 치료용 펩티드의 비 경구 제형 |
| KR100505557B1 (ko) * | 2003-02-10 | 2005-08-03 | 조을룡 | 약병마개 제조용 고무 조성물 |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| US8476010B2 (en) | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
| US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
| US20070166187A1 (en) * | 2006-01-18 | 2007-07-19 | Song Jing F | Stabilization of paricalcitol using chlorobutyl or chlorinated butyl stoppers |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| EP2760509B1 (en) * | 2011-09-27 | 2023-04-05 | Becton Dickinson France | Use of plasma treated silicone oil as a coating in a medical injection device |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4381779A (en) | 1981-07-16 | 1983-05-03 | Sterling Drug Inc. | Deformable slidable piston to provide self-aspiration in hypodermic cartridge ampoules |
| DE69000716T2 (de) | 1989-03-28 | 1993-07-22 | Duphar Int Res | Vorgefuellte injektionsvorrichtung mit einem fass, das mit einer fluessigen diazepam-formulierung gefuellt ist. |
| US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| SE9402332D0 (sv) * | 1994-07-01 | 1994-07-01 | Pharmacia Ab | Igf-1 |
| SE9501472D0 (sv) * | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| SE9601556D0 (sv) | 1996-04-24 | 1996-04-24 | Astra Ab | New pharmaceutical formulation of a thrombin inhibitor for parenteral use |
| SE9802938D0 (sv) * | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
-
1998
- 1998-09-01 SE SE9802938A patent/SE9802938D0/xx unknown
-
1999
- 1999-08-18 AR ARP990104129 patent/AR033788A1/es active IP Right Grant
- 1999-08-20 TW TW088114257A patent/TWI228987B/zh not_active IP Right Cessation
- 1999-08-24 ID ID20010430A patent/ID28015A/id unknown
- 1999-08-24 DE DE1999616082 patent/DE69916082T2/de not_active Expired - Lifetime
- 1999-08-24 JP JP2000567167A patent/JP2002523184A/ja active Pending
- 1999-08-24 ES ES99946504T patent/ES2217808T3/es not_active Expired - Lifetime
- 1999-08-24 EE EEP200100131A patent/EE04768B1/xx not_active IP Right Cessation
- 1999-08-24 RU RU2001104425A patent/RU2224499C2/ru not_active IP Right Cessation
- 1999-08-24 SK SK282-2001A patent/SK285474B6/sk not_active IP Right Cessation
- 1999-08-24 IL IL14133399A patent/IL141333A0/xx active IP Right Grant
- 1999-08-24 US US09/423,185 patent/US6576245B1/en not_active Expired - Fee Related
- 1999-08-24 DK DK99946504T patent/DK1109526T3/da active
- 1999-08-24 CN CNB998101931A patent/CN1230141C/zh not_active Expired - Fee Related
- 1999-08-24 EP EP99946504A patent/EP1109526B1/en not_active Expired - Lifetime
- 1999-08-24 CZ CZ2001743A patent/CZ2001743A3/cs unknown
- 1999-08-24 PT PT99946504T patent/PT1109526E/pt unknown
- 1999-08-24 PL PL99346471A patent/PL195244B1/pl not_active IP Right Cessation
- 1999-08-24 KR KR1020017002618A patent/KR100614162B1/ko not_active Expired - Fee Related
- 1999-08-24 HU HU0104161A patent/HUP0104161A3/hu unknown
- 1999-08-24 AU AU58903/99A patent/AU754447C/en not_active Ceased
- 1999-08-24 NZ NZ50998599A patent/NZ509985A/xx not_active IP Right Cessation
- 1999-08-24 CA CA 2340238 patent/CA2340238C/en not_active Expired - Fee Related
- 1999-08-24 BR BR9913261A patent/BR9913261A/pt not_active IP Right Cessation
- 1999-08-24 TR TR200100679T patent/TR200100679T2/xx unknown
- 1999-08-24 WO PCT/SE1999/001440 patent/WO2000012043A1/en not_active Ceased
- 1999-08-24 AT AT99946504T patent/ATE262882T1/de not_active IP Right Cessation
- 1999-08-24 UA UA2001021045A patent/UA73282C2/uk unknown
- 1999-08-30 MY MYPI9903750 patent/MY120822A/en unknown
- 1999-09-14 SA SA99200573A patent/SA99200573B1/ar unknown
-
2001
- 2001-02-08 IL IL141333A patent/IL141333A/en not_active IP Right Cessation
- 2001-02-15 IS IS5845A patent/IS2230B/is unknown
- 2001-02-26 ZA ZA200101590A patent/ZA200101590B/xx unknown
- 2001-02-28 NO NO20011032A patent/NO322292B1/no not_active IP Right Cessation
-
2003
- 2003-01-17 US US10/347,046 patent/US6660279B2/en not_active Expired - Fee Related
- 2003-10-15 US US10/687,540 patent/US6998136B2/en not_active Expired - Fee Related
-
2005
- 2005-11-08 US US11/270,309 patent/US20060233778A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |