KR100614162B1 - 안정성이 개선된 주사액 - Google Patents

안정성이 개선된 주사액 Download PDF

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Publication number
KR100614162B1
KR100614162B1 KR1020017002618A KR20017002618A KR100614162B1 KR 100614162 B1 KR100614162 B1 KR 100614162B1 KR 1020017002618 A KR1020017002618 A KR 1020017002618A KR 20017002618 A KR20017002618 A KR 20017002618A KR 100614162 B1 KR100614162 B1 KR 100614162B1
Authority
KR
South Korea
Prior art keywords
primary container
solution
melagatran
thrombin inhibitor
rubber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017002618A
Other languages
English (en)
Korean (ko)
Other versions
KR20010073070A (ko
Inventor
안나 룬드그렌
매츠 순드그렌
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20010073070A publication Critical patent/KR20010073070A/ko
Application granted granted Critical
Publication of KR100614162B1 publication Critical patent/KR100614162B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020017002618A 1998-09-01 1999-08-24 안정성이 개선된 주사액 Expired - Fee Related KR100614162B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802938A SE9802938D0 (sv) 1998-09-01 1998-09-01 Improved stability for injection solutions
SE9802938-2 1998-09-01

Publications (2)

Publication Number Publication Date
KR20010073070A KR20010073070A (ko) 2001-07-31
KR100614162B1 true KR100614162B1 (ko) 2006-08-25

Family

ID=20412436

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017002618A Expired - Fee Related KR100614162B1 (ko) 1998-09-01 1999-08-24 안정성이 개선된 주사액

Country Status (33)

Country Link
US (4) US6576245B1 (https=)
EP (1) EP1109526B1 (https=)
JP (1) JP2002523184A (https=)
KR (1) KR100614162B1 (https=)
CN (1) CN1230141C (https=)
AR (1) AR033788A1 (https=)
AT (1) ATE262882T1 (https=)
AU (1) AU754447C (https=)
BR (1) BR9913261A (https=)
CA (1) CA2340238C (https=)
CZ (1) CZ2001743A3 (https=)
DE (1) DE69916082T2 (https=)
DK (1) DK1109526T3 (https=)
EE (1) EE04768B1 (https=)
ES (1) ES2217808T3 (https=)
HU (1) HUP0104161A3 (https=)
ID (1) ID28015A (https=)
IL (2) IL141333A0 (https=)
IS (1) IS2230B (https=)
MY (1) MY120822A (https=)
NO (1) NO322292B1 (https=)
NZ (1) NZ509985A (https=)
PL (1) PL195244B1 (https=)
PT (1) PT1109526E (https=)
RU (1) RU2224499C2 (https=)
SA (1) SA99200573B1 (https=)
SE (1) SE9802938D0 (https=)
SK (1) SK285474B6 (https=)
TR (1) TR200100679T2 (https=)
TW (1) TWI228987B (https=)
UA (1) UA73282C2 (https=)
WO (1) WO2000012043A1 (https=)
ZA (1) ZA200101590B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
US6802828B2 (en) * 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
EP1594434B1 (en) * 2003-01-14 2016-09-07 Yeda Research and Development Co. Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
KR100505557B1 (ko) * 2003-02-10 2005-08-03 조을룡 약병마개 제조용 고무 조성물
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
US20070166187A1 (en) * 2006-01-18 2007-07-19 Song Jing F Stabilization of paricalcitol using chlorobutyl or chlorinated butyl stoppers
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
CN103957966B (zh) * 2011-09-27 2017-09-29 贝克顿迪金森法国公司 等离子体处理过的硅油作为医用注射装置中的涂层的用途
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381779A (en) 1981-07-16 1983-05-03 Sterling Drug Inc. Deformable slidable piston to provide self-aspiration in hypodermic cartridge ampoules
DE69000716T2 (de) 1989-03-28 1993-07-22 Duphar Int Res Vorgefuellte injektionsvorrichtung mit einem fass, das mit einer fluessigen diazepam-formulierung gefuellt ist.
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SE9402332D0 (sv) * 1994-07-01 1994-07-01 Pharmacia Ab Igf-1
SE9501472D0 (sv) 1995-04-21 1995-04-21 Pharmacia Ab Truncated IGF-I
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9601556D0 (sv) * 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions

Also Published As

Publication number Publication date
IS2230B (is) 2007-04-15
AR033788A1 (es) 2004-01-07
SK285474B6 (sk) 2007-02-01
NO20011032L (no) 2001-04-30
ATE262882T1 (de) 2004-04-15
IL141333A (en) 2006-07-05
SA99200573A (ar) 2005-12-03
PL195244B1 (pl) 2007-08-31
TWI228987B (en) 2005-03-11
PL346471A1 (en) 2002-02-11
NZ509985A (en) 2002-12-20
CA2340238C (en) 2009-01-06
DE69916082D1 (de) 2004-05-06
JP2002523184A (ja) 2002-07-30
EP1109526B1 (en) 2004-03-31
PT1109526E (pt) 2004-07-30
SK2822001A3 (en) 2001-08-06
SE9802938D0 (sv) 1998-09-01
US6998136B2 (en) 2006-02-14
CA2340238A1 (en) 2000-03-09
HUP0104161A2 (hu) 2002-04-29
NO20011032D0 (no) 2001-02-28
EE200100131A (et) 2002-06-17
RU2224499C2 (ru) 2004-02-27
ZA200101590B (en) 2002-05-27
UA73282C2 (en) 2005-07-15
MY120822A (en) 2005-11-30
CN1314804A (zh) 2001-09-26
WO2000012043A1 (en) 2000-03-09
AU754447B2 (en) 2002-11-14
NO322292B1 (no) 2006-09-11
BR9913261A (pt) 2001-05-22
IS5845A (is) 2001-02-15
SA99200573B1 (ar) 2006-09-20
AU5890399A (en) 2000-03-21
ES2217808T3 (es) 2004-11-01
DE69916082T2 (de) 2004-10-21
DK1109526T3 (da) 2004-07-05
TR200100679T2 (tr) 2001-07-23
CN1230141C (zh) 2005-12-07
EE04768B1 (et) 2007-02-15
HK1035482A1 (en) 2001-11-30
US20030190310A1 (en) 2003-10-09
AU754447C (en) 2006-10-19
EP1109526A1 (en) 2001-06-27
US20040235731A1 (en) 2004-11-25
CZ2001743A3 (cs) 2002-01-16
US6660279B2 (en) 2003-12-09
ID28015A (id) 2001-05-03
IL141333A0 (en) 2002-03-10
KR20010073070A (ko) 2001-07-31
US20060233778A1 (en) 2006-10-19
US6576245B1 (en) 2003-06-10
HUP0104161A3 (en) 2002-08-28

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