NZ504106A - Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them - Google Patents
Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- NZ504106A NZ504106A NZ504106A NZ50410698A NZ504106A NZ 504106 A NZ504106 A NZ 504106A NZ 504106 A NZ504106 A NZ 504106A NZ 50410698 A NZ50410698 A NZ 50410698A NZ 504106 A NZ504106 A NZ 504106A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pharmaceutically acceptable
- compositions containing
- compounds
- pipyridine
- thiazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/085,292 US6265401B1 (en) | 1997-10-27 | 1998-05-27 | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
PCT/US1998/022570 WO1999020614A1 (fr) | 1998-05-27 | 1998-10-26 | Composes bicycliques, procede de preparation et compositions pharmaceutiques les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ504106A true NZ504106A (en) | 2003-02-28 |
Family
ID=22190649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ504106A NZ504106A (en) | 1998-05-27 | 1998-10-26 | Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1082313A1 (fr) |
JP (1) | JP2002507543A (fr) |
CN (1) | CN100357281C (fr) |
NZ (1) | NZ504106A (fr) |
PL (1) | PL341795A1 (fr) |
WO (1) | WO1999020614A1 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035437A2 (fr) * | 1998-12-17 | 2000-06-22 | Mindset Biopharmaceuticals (Usa), Inc. | Utilisation accrue de glucose par le cerveau |
US6528507B1 (en) | 1999-04-16 | 2003-03-04 | Dr. Reddy's Laboratories Limited | Polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
AU3957800A (en) * | 1999-04-16 | 2000-11-02 | Dr. Reddy's Research Foundation | Crystalline r- guanidines, arginine or (l) -arginine (2(s)) -2- ethoxy -3-(4- (2-(10(h) -phenoxazin -10-yl)ethoxy}phenyl)propanoate |
TR200103851T2 (tr) * | 1999-04-16 | 2002-04-22 | Dr. Reddy' S Research Foundation | Bir antidiyabetik maddenin yeni polimorfik formları, bunların hazırlanması için işlem ve bunları farmasötik bileşimler |
JP2002542237A (ja) * | 1999-04-20 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 新規な化合物、それらの製造及び使用 |
CZ20013558A3 (cs) * | 1999-04-20 | 2002-05-15 | Novo Nordisk A/S | Sloučenina, farmaceutický prostředek, způsob léčby, jejich příprava a vyuľití |
US6369055B1 (en) | 1999-04-20 | 2002-04-09 | Novo Nordisk A/S | Compounds, their preparation and use |
EP1171438A1 (fr) | 1999-04-20 | 2002-01-16 | Novo Nordisk A/S | Composes, preparation et utilisation associees |
US6972294B1 (en) | 1999-04-20 | 2005-12-06 | Novo Nordisk, A/S | Compounds, their preparation and use |
MXPA01010916A (es) * | 1999-04-28 | 2002-06-21 | Reddy Research Foundation | Heterociclos biciclicos sustituidos, procedimiento para su preparacion y su uso como agentes contra la obesidad y como agentes hipocolesterolemicos. |
AP1522A (en) * | 2000-01-19 | 2005-12-22 | Cadila Healthcare Ltd | Compounds having hypolipedemic and hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them. |
US6555577B1 (en) | 2000-01-28 | 2003-04-29 | Novo Nordisk A/S | Compounds, their preparation and use |
US6569901B2 (en) | 2000-01-28 | 2003-05-27 | Novo Nordisk A/S | Alkynyl-substituted propionic acid derivatives, their preparation and use |
PL357010A1 (en) * | 2000-01-28 | 2004-07-12 | Novo Nordisk A/S | Propionic acid derivatives and their use in the treatment of diabetes and obesity |
US6908908B2 (en) | 2000-05-12 | 2005-06-21 | Ortho-Mcneil Pharmaceutical, Inc. | Biologically active 4H-benzo [1,4] oxazin-3-ones |
EP1280784B1 (fr) * | 2000-05-12 | 2007-06-27 | Ortho-McNeil Pharmaceutical, Inc. | 4h-benzo 1,4|oxazine-3-ones biologiquement actives |
AU2001261503A1 (en) * | 2000-05-12 | 2001-11-26 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators |
US6599899B2 (en) | 2000-05-12 | 2003-07-29 | Ortho-Mcneil Pharmaceutical, Inc. | Benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment |
AU2001284335A1 (en) * | 2000-09-04 | 2002-03-22 | Dr. Reddy's Research Foundation | Process for the preparation of 2-(3,4-dihydro-1,4-benzothiazin-4-yl)ethylmethane sulphonate |
AU2002212672A1 (en) * | 2000-10-12 | 2002-04-22 | Dr. Reddy's Research Foundation | Salts of benzothiazine and benzoxazine derivatives and pharmaceutical compositions containing them |
US20020198202A1 (en) * | 2001-06-07 | 2002-12-26 | Wyeth | Combination of a PTPase inhibitor and an antilipemic agent |
WO2003006022A1 (fr) * | 2001-07-09 | 2003-01-23 | Dr. Reddy's Laboratories Ltd. | Derives de tetrahydroquinoline et leur utilisation en medecine, procede de preparation associe et compositions pharmaceutiques contenant lesdits composes |
US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
PL369732A1 (en) | 2001-10-16 | 2005-05-02 | Dr.Reddy's Laboratories Ltd. | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them |
JP2005518408A (ja) | 2001-12-29 | 2005-06-23 | ノボ ノルディスク アクティーゼルスカブ | 異常脂肪血症を治療するための、glp−1化合物と他の薬物との組み合わせ使用 |
WO2003099800A1 (fr) * | 2002-05-23 | 2003-12-04 | Dr. Reddy's Laboratories Limited | Procede ameliore pour la preparation d'agents antidiabetiques bicycliques |
EP1734963A4 (fr) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques |
US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
EP3241839B1 (fr) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
AU2009307884B2 (en) | 2008-10-22 | 2014-07-31 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
SG191772A1 (en) | 2011-01-31 | 2013-08-30 | Cadila Healthcare Ltd | Treatment for lipodystrophy |
CN105001219A (zh) | 2011-02-25 | 2015-10-28 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
US20150004144A1 (en) | 2011-12-02 | 2015-01-01 | The General Hospital Corporation | Differentiation into brown adipocytes |
KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
EP2970119B1 (fr) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques |
WO2014151206A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
MA38385A1 (fr) | 2013-04-22 | 2017-09-29 | Cadila Healthcare Ltd | Nouvelle composition pour la stéatose hépatique non alcoolique (nafld) |
WO2014195967A2 (fr) | 2013-05-30 | 2014-12-11 | Cadila Healthcare Limited | Procédé de préparation de pyrroles présentant des activités hypocholestérolémiques hypolipidémiques |
EA201592263A1 (ru) | 2013-06-05 | 2016-05-31 | Синерджи Фармасьютикалз, Инк. | Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования |
TW201636015A (zh) | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
IN2013MU02470A (fr) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
WO2015033357A2 (fr) | 2013-09-06 | 2015-03-12 | Cadila Healthcare Limited | Procédé amélioré de préparation de dérivés de pyrrole |
WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
WO2018104916A1 (fr) | 2016-12-09 | 2018-06-14 | Cadila Healthcare Limited | Traitement de la cholangite biliaire primitive |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
CN110092774B (zh) * | 2018-01-29 | 2022-04-08 | 中国科学院上海药物研究所 | 芳香丙酸类衍生物、及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
US5496815A (en) * | 1990-02-08 | 1996-03-05 | Tanabe Seiyaku Co., Ltd. | Thiazine (or oxazine) derivatives and preparation thereof |
CA2035147A1 (fr) * | 1990-02-08 | 1991-08-09 | Kousuke Yasuda | Derives de la thiazine (ou de l'oxazine) et leur preparation |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
JPH05194236A (ja) * | 1991-07-25 | 1993-08-03 | Tanabe Seiyaku Co Ltd | 中枢性カルシウム拮抗剤 |
WO1996004261A1 (fr) * | 1994-07-29 | 1996-02-15 | Smithkline Beecham Plc | Benzoxoazoles et derives de pryridine destines a etre utilises pour le traitement du diabete tardif |
JPH0912575A (ja) * | 1995-06-28 | 1997-01-14 | Sankyo Co Ltd | ベンゾオキサジンおよびベンゾチアジン誘導体 |
-
1998
- 1998-10-26 WO PCT/US1998/022570 patent/WO1999020614A1/fr not_active Application Discontinuation
- 1998-10-26 JP JP2000516956A patent/JP2002507543A/ja not_active Withdrawn
- 1998-10-26 EP EP98953970A patent/EP1082313A1/fr not_active Ceased
- 1998-10-26 PL PL98341795A patent/PL341795A1/xx unknown
- 1998-10-26 NZ NZ504106A patent/NZ504106A/xx unknown
- 1998-10-26 CN CNB988116618A patent/CN100357281C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN100357281C (zh) | 2007-12-26 |
JP2002507543A (ja) | 2002-03-12 |
EP1082313A1 (fr) | 2001-03-14 |
WO1999020614A1 (fr) | 1999-04-29 |
PL341795A1 (en) | 2001-05-07 |
CN1281443A (zh) | 2001-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ASS | Change of ownership |
Owner name: DR. REDDY S LABORATORIES LIMITED, IN Free format text: OLD OWNER(S): REDDY-CHEMINOR, INC.; DR. REDDY S RESEARCH FOUNDATION |
|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) | ||
RENW | Renewal (renewal fees accepted) |