JP2002507543A - 二環系化合物、その製造方法およびそれらを含有する薬学的組成物 - Google Patents

二環系化合物、その製造方法およびそれらを含有する薬学的組成物

Info

Publication number
JP2002507543A
JP2002507543A JP2000516956A JP2000516956A JP2002507543A JP 2002507543 A JP2002507543 A JP 2002507543A JP 2000516956 A JP2000516956 A JP 2000516956A JP 2000516956 A JP2000516956 A JP 2000516956A JP 2002507543 A JP2002507543 A JP 2002507543A
Authority
JP
Japan
Prior art keywords
ethoxy
dihydro
phenyl
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000516956A
Other languages
English (en)
Japanese (ja)
Inventor
ローライ、ブライ・ブーシャン
ローライ、ビディヤ・ブーシャン
バジー、アショク・チャナビーラッパ
カルチャー、シバラマッヤ
ラマヌジャム、ラジャゴパラン
チャクラバーティ、ランジャン
Original Assignee
ドクター・レディーズ・リサーチ・ファウンデーション
レディー − ケミナー・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/085,292 external-priority patent/US6265401B1/en
Application filed by ドクター・レディーズ・リサーチ・ファウンデーション, レディー − ケミナー・インコーポレーテッド filed Critical ドクター・レディーズ・リサーチ・ファウンデーション
Publication of JP2002507543A publication Critical patent/JP2002507543A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2000516956A 1998-05-27 1998-10-26 二環系化合物、その製造方法およびそれらを含有する薬学的組成物 Withdrawn JP2002507543A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/085,292 1998-05-27
US09/085,292 US6265401B1 (en) 1997-10-27 1998-05-27 Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
PCT/US1998/022570 WO1999020614A1 (fr) 1998-05-27 1998-10-26 Composes bicycliques, procede de preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
JP2002507543A true JP2002507543A (ja) 2002-03-12

Family

ID=22190649

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000516956A Withdrawn JP2002507543A (ja) 1998-05-27 1998-10-26 二環系化合物、その製造方法およびそれらを含有する薬学的組成物

Country Status (6)

Country Link
EP (1) EP1082313A1 (fr)
JP (1) JP2002507543A (fr)
CN (1) CN100357281C (fr)
NZ (1) NZ504106A (fr)
PL (1) PL341795A1 (fr)
WO (1) WO1999020614A1 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532416A (ja) * 1998-12-17 2002-10-02 マインドセット・バイオファーマシューティカルズ・（ユーエスエイ）・インコーポレイテッド 脳のグルコース利用の増進
AU3957800A (en) * 1999-04-16 2000-11-02 Dr. Reddy's Research Foundation Crystalline r- guanidines, arginine or (l) -arginine (2(s)) -2- ethoxy -3-(4- (2-(10(h) -phenoxazin -10-yl)ethoxy}phenyl)propanoate
US6528507B1 (en) 1999-04-16 2003-03-04 Dr. Reddy's Laboratories Limited Polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them
RU2001130883A (ru) * 1999-04-16 2004-03-20 Др. Редди`З Лабораториз Лимитед (In) Новые полиморфные формы антидиабетического средства, способ их получения и содержащие их фармацевтические композиции
JP2002542237A (ja) * 1999-04-20 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 新規な化合物、それらの製造及び使用
US6369055B1 (en) 1999-04-20 2002-04-09 Novo Nordisk A/S Compounds, their preparation and use
AU3958100A (en) 1999-04-20 2000-11-02 Novo Nordisk A/S New compounds, their preparation and use
IL145789A0 (en) * 1999-04-20 2002-07-25 Novo Nordisk As Derivatives of propionic acid, their preparation and pharmaceutical compositions containing them
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
WO2000066572A1 (fr) * 1999-04-28 2000-11-09 Dr. Reddy's Research Foundation Heterocycles bicycliques substitues, procede pour leur preparation et leur utilisation comme agents contre l'obesite et comme agents hypocholesterolemiques
KR100649304B1 (ko) * 2000-01-19 2006-11-24 카딜라 헬스케어 리미티드 저지방혈증, 저콜레스테롤혈증 활성을 가지는 신규화합물, 그 제조방법 및 이를 포함하는 제약학적 조성물
WO2001055085A1 (fr) * 2000-01-28 2001-08-02 Novo Nordisk A/S Derives de l'acide propionique et leur utilisation dans le traitement du diabete et de l'obesite
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
AU2001263083A1 (en) * 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4h-benzo(1,4)oxazin-3-ones
WO2001087860A2 (fr) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Nouveaux benzoxazinones utilises comme modulateurs du recepteur gamma active de la proliferation des peroxysomes, et methode de traitement associee
AU2001261503A1 (en) * 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
US6908908B2 (en) 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
AU2001284335A1 (en) * 2000-09-04 2002-03-22 Dr. Reddy's Research Foundation Process for the preparation of 2-(3,4-dihydro-1,4-benzothiazin-4-yl)ethylmethane sulphonate
WO2002030914A1 (fr) * 2000-10-12 2002-04-18 Dr. Reddy's Research Foundation Sels de derives de benzothiazine et de benzoxazine et compositions pharmaceutiques a base de ces sels
WO2002100397A1 (fr) * 2001-06-07 2002-12-19 Wyeth Combinaison d'un inhibiteur de proteine-tyrosine phosphatase et d'un agent hypolipemiant
WO2003006022A1 (fr) * 2001-07-09 2003-01-23 Dr. Reddy's Laboratories Ltd. Derives de tetrahydroquinoline et leur utilisation en medecine, procede de preparation associe et compositions pharmaceutiques contenant lesdits composes
US6987123B2 (en) * 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
WO2003033456A1 (fr) * 2001-10-16 2003-04-24 Dr. Reddy's Laboratories Ltd. Derives d'acide propionique beta-phenyl-alpha-oxysubstitues, procedes d'elaboration, et utilisation dans la preparation de composes pharmaceutiques importants
AU2002351752A1 (en) 2001-12-29 2003-07-30 Novo Nordisk A/S Combined use of a glp-1 compound and another drug for treating dyslipidemia
WO2003099800A1 (fr) * 2002-05-23 2003-12-04 Dr. Reddy's Laboratories Limited Procede ameliore pour la preparation d'agents antidiabetiques bicycliques
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2730603C (fr) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
CN102264228A (zh) 2008-10-22 2011-11-30 默沙东公司 用于抗糖尿病药的新的环状苯并咪唑衍生物
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2011106273A1 (fr) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2825456C (fr) 2011-01-31 2016-01-05 Cadila Healthcare Limited Traitement de la lipodystrophie
CA2826649C (fr) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Nouveaux derives d'azabenzimidazole cyclique utiles en tant qu'agents antidiabetiques
US20150004144A1 (en) 2011-12-02 2015-01-01 The General Hospital Corporation Differentiation into brown adipocytes
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
BR112015019836A2 (pt) 2013-02-22 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
CN105377246B (zh) 2013-04-22 2018-03-20 卡迪拉保健有限公司 针对非酒精性脂肪性肝病(nafld)的新组合物
EP3004053B1 (fr) 2013-05-30 2021-03-24 Cadila Healthcare Limited Procédé de préparation de pyrroles présentant des activités hypocholestérolémiques hypolipidémiques
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
TW201636015A (zh) 2013-07-05 2016-10-16 卡地拉保健有限公司 協同性組成物
IN2013MU02470A (fr) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
WO2015033357A2 (fr) 2013-09-06 2015-03-12 Cadila Healthcare Limited Procédé amélioré de préparation de dérivés de pyrrole
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
BR112019011740A2 (pt) 2016-12-09 2019-10-29 Cadila Healthcare Ltd composição farmacêutica e método para o tratamento de colangite biliar primária
EP3558298A4 (fr) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. Composés de spirochromane antidiabétiques
CN110092774B (zh) * 2018-01-29 2022-04-08 中国科学院上海药物研究所 芳香丙酸类衍生物、及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
CA2035147A1 (fr) * 1990-02-08 1991-08-09 Kousuke Yasuda Derives de la thiazine (ou de l'oxazine) et leur preparation
US5496815A (en) * 1990-02-08 1996-03-05 Tanabe Seiyaku Co., Ltd. Thiazine (or oxazine) derivatives and preparation thereof
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
JPH05194236A (ja) * 1991-07-25 1993-08-03 Tanabe Seiyaku Co Ltd 中枢性カルシウム拮抗剤
BR9508468A (pt) * 1994-07-29 1997-11-25 Smithkline Beecham Plc Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário
JPH0912575A (ja) * 1995-06-28 1997-01-14 Sankyo Co Ltd ベンゾオキサジンおよびベンゾチアジン誘導体

Also Published As

Publication number Publication date
EP1082313A1 (fr) 2001-03-14
WO1999020614A1 (fr) 1999-04-29
PL341795A1 (en) 2001-05-07
CN1281443A (zh) 2001-01-24
CN100357281C (zh) 2007-12-26
NZ504106A (en) 2003-02-28

Similar Documents

Publication Publication Date Title
JP2002507543A (ja) 二環系化合物、その製造方法およびそれらを含有する薬学的組成物
US6130214A (en) Benzothiazin and benzoxazin derivatives; their preparation and uses
RU2235094C2 (ru) Бета-арил-альфа-оксизамещенные алкилкарбоновые кислоты, способы их получения, промежуточные соединения, способы их получения, фармацевтическая композиция, способы лечения или предупреждения заболеваний на основе новых соединений
US6608194B1 (en) Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
EP1051403A1 (fr) Nouveaux acides alcanoiques et leur utilisation en medecine, leur procede de preparation et compositions pharmaceutiques les contenant
RU2278114C2 (ru) Замещенные бициклические гетероциклические соединения, способ их получения (варианты) и применение в качестве средств против ожирения и гиперхолестеринемии
JP2004534733A (ja) 血中コレステロール低下剤剤としてのアリール置換アルキルカルボン酸
US7157581B2 (en) Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6265401B1 (en) Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
RU2247722C2 (ru) Производные арилкарбоновых кислот, способы их получения, фармацевтическая композиция на их основе, способы лечения и предупреждения различных заболеваний, промежуточные соединения и способы их получения
JP4091251B2 (ja) 新規三環系化合物と医薬におけるそれらの使用；それらの調製方法、及びそれらを含有する薬学的組成物
CZ20001540A3 (cs) Bicyklické sloučeniny, způsob jejich přípravy a farmaceutické kompozice s jejich obsahem
MXPA00004032A (en) Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
AU2006225184A1 (en) Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL135839A (en) Bicyclic compounds, processes or the preparation thereof and pharmaceutical compositions containing the same
WO2003006022A1 (fr) Derives de tetrahydroquinoline et leur utilisation en medecine, procede de preparation associe et compositions pharmaceutiques contenant lesdits composes

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050921

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090209