NZ190076A - 3-oxoandrost-4-ene-17 beta-thiocarboxylate derivatives and pharmaceutical compositions - Google Patents
3-oxoandrost-4-ene-17 beta-thiocarboxylate derivatives and pharmaceutical compositionsInfo
- Publication number
- NZ190076A NZ190076A NZ190076A NZ19007679A NZ190076A NZ 190076 A NZ190076 A NZ 190076A NZ 190076 A NZ190076 A NZ 190076A NZ 19007679 A NZ19007679 A NZ 19007679A NZ 190076 A NZ190076 A NZ 190076A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- diene
- compound
- fluoro
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/893,388 US4188385A (en) | 1978-04-05 | 1978-04-05 | Thioetianic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ190076A true NZ190076A (en) | 1984-07-31 |
Family
ID=25401484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ190076A NZ190076A (en) | 1978-04-05 | 1979-04-02 | 3-oxoandrost-4-ene-17 beta-thiocarboxylate derivatives and pharmaceutical compositions |
Country Status (28)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263289A (en) * | 1978-04-05 | 1981-04-21 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
| US4261984A (en) * | 1978-04-05 | 1981-04-14 | Syntex (U.S.A.) Inc. | 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes |
| US4310466A (en) * | 1979-08-31 | 1982-01-12 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
| US4335121A (en) * | 1980-02-15 | 1982-06-15 | Glaxo Group Limited | Androstane carbothioates |
| NL191792C (nl) * | 1980-02-15 | 1996-08-02 | Glaxo Group Ltd | Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten. |
| GB2137206B (en) * | 1980-02-15 | 1985-04-03 | Glaxo Group Ltd | Androstane 17-carbothioc acid derivatives |
| US4578221A (en) * | 1980-04-23 | 1986-03-25 | Glaxo Group Limited | Androstane carbothioic acids |
| SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
| IL78144A0 (en) * | 1985-04-04 | 1986-07-31 | Draco Ab | Novel androstane-17beta-carboxylic acid esters |
| GB9225923D0 (en) * | 1992-12-11 | 1993-02-03 | Rhone Poulenc Rorer Ltd | New compositions of matter |
| NZ259401A (en) * | 1992-12-24 | 1996-10-28 | Rhone Poulenc Rorer Ltd | (20s)-16<alpha>,17<alpha>-methylenedioxy-11<beta>-hydroxy-17<beta>-( sulphur substituted)androst- -an-3-one or -en-3-one derivatives |
| EP0876392B1 (en) * | 1995-12-29 | 2000-07-05 | Glaxo Group Limited | Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives |
| US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
| US20020133032A1 (en) * | 2000-02-25 | 2002-09-19 | Jufang Barkalow | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods |
| GB0017988D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Novel process |
| US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| CZ2003353A3 (cs) * | 2000-08-05 | 2003-05-14 | Glaxo Group Limited | Estery steroidních thiokyselin |
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| GB0019172D0 (en) * | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| US6750210B2 (en) * | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| US6777400B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6858593B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6787532B2 (en) * | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| UA77656C2 (en) * | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| ES2314052T3 (es) * | 2001-04-30 | 2009-03-16 | Glaxo Group Limited | Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa. |
| WO2002100879A1 (en) * | 2001-06-12 | 2002-12-19 | Glaxo Group Limited | Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives |
| US20050175545A1 (en) * | 2002-02-04 | 2005-08-11 | Keith Biggadike | Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist |
| GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
| GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| IL150654A (en) | 2002-07-09 | 2006-12-10 | Ori Lerman | Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate |
| US20070270584A1 (en) * | 2003-04-04 | 2007-11-22 | Trond Loevli | Process for the Preparation of Steroidal Carbothioic Acid Derivatives and Intermediates |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| AR059216A1 (es) * | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
| GB0615108D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
| CL2008003803A1 (es) * | 2007-12-21 | 2010-02-19 | Schering Corp | Compuestos derivados de esteroides c20-21 sustituidos, agonistas del receptor de glucocorticoide; composicion farmaceutica que comprende a dicho compuesto; y uso para tratar o prevenir una enfermedad o afeccion inmune, autoinmune o inflamatoria, tales como colitis inflamatoria y artritis reumatoide. |
| WO2010147947A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2509171A (en) * | 1946-02-06 | 1950-05-23 | Ciba Ltd | Primary alcohols from thiocarboxylic acids and esters |
| US3636010A (en) * | 1968-12-23 | 1972-01-18 | Ciba Geigy Corp | Esters of steroid-17-carboxylic acids |
| US3989686A (en) * | 1972-06-15 | 1976-11-02 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstane series and process for preparing same |
| GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| CH628355A5 (de) * | 1976-02-24 | 1982-02-26 | Ciba Geigy Ag | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
-
1978
- 1978-04-05 US US05/893,388 patent/US4188385A/en not_active Expired - Lifetime
-
1979
- 1979-03-28 IT IT67652/79A patent/IT1120954B/it active
- 1979-03-28 FR FR7907823A patent/FR2421912A1/fr active Granted
- 1979-03-28 DE DE19792912331 patent/DE2912331A1/de not_active Ceased
- 1979-03-28 GB GB7910862A patent/GB2018256B/en not_active Expired
- 1979-03-28 EP EP79300500A patent/EP0004741B1/en not_active Expired
- 1979-03-28 DE DE7979300500T patent/DE2960096D1/de not_active Expired
- 1979-03-29 AU AU45583/79A patent/AU526025B2/en not_active Ceased
- 1979-03-29 IL IL56972A patent/IL56972A0/xx not_active IP Right Cessation
- 1979-03-29 CS CS792107A patent/CS203956B2/cs unknown
- 1979-03-30 CA CA000324557A patent/CA1134345A/en not_active Expired
- 1979-03-30 PT PT69409A patent/PT69409A/pt unknown
- 1979-03-30 AR AR276014A patent/AR226035A1/es active
- 1979-03-31 GR GR58748A patent/GR67275B/el unknown
- 1979-04-02 FI FI791081A patent/FI66393C/fi not_active IP Right Cessation
- 1979-04-02 NZ NZ190076A patent/NZ190076A/en unknown
- 1979-04-03 HU HU79SI1682A patent/HU179314B/hu not_active IP Right Cessation
- 1979-04-03 DK DK136579A patent/DK147735C/da not_active IP Right Cessation
- 1979-04-04 AT AT0251979A patent/AT368168B/de not_active IP Right Cessation
- 1979-04-04 PL PL1979214676A patent/PL121469B1/pl unknown
- 1979-04-04 ES ES479271A patent/ES479271A1/es not_active Expired
- 1979-04-04 NO NO791140A patent/NO152935C/no unknown
- 1979-04-04 SU SU792787402A patent/SU1052161A3/ru active
- 1979-04-04 YU YU803/79A patent/YU40929B/xx unknown
- 1979-04-05 ZA ZA791635A patent/ZA791635B/xx unknown
- 1979-04-05 JP JP4041479A patent/JPS54141758A/ja active Granted
-
1984
- 1984-05-10 HK HK412/80A patent/HK41284A/xx unknown
- 1984-07-27 JP JP59155726A patent/JPS6069019A/ja active Granted
-
1985
- 1985-12-30 MY MY575/85A patent/MY8500575A/xx unknown
-
1986
- 1986-01-22 SG SG67/86A patent/SG6786G/en unknown
Also Published As
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