NZ188163A - Crystalline sodium salt of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-methoxymino-acetamido)-ceph-3-em-4-carboxylic acid syn isomer - Google Patents

Crystalline sodium salt of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-methoxymino-acetamido)-ceph-3-em-4-carboxylic acid syn isomer

Info

Publication number
NZ188163A
NZ188163A NZ188163A NZ18816378A NZ188163A NZ 188163 A NZ188163 A NZ 188163A NZ 188163 A NZ188163 A NZ 188163A NZ 18816378 A NZ18816378 A NZ 18816378A NZ 188163 A NZ188163 A NZ 188163A
Authority
NZ
New Zealand
Prior art keywords
methoxymino
ceph
acetoxymethyl
acetamido
thiazolyl
Prior art date
Application number
NZ188163A
Other languages
English (en)
Inventor
G Amiard
J Jolly
D Bormann
W Duerckheimer
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ188163(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of NZ188163A publication Critical patent/NZ188163A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ188163A 1977-08-17 1978-08-16 Crystalline sodium salt of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-methoxymino-acetamido)-ceph-3-em-4-carboxylic acid syn isomer NZ188163A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7725142A FR2400519A1 (fr) 1977-08-17 1977-08-17 Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament

Publications (1)

Publication Number Publication Date
NZ188163A true NZ188163A (en) 1981-10-19

Family

ID=9194564

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ188163A NZ188163A (en) 1977-08-17 1978-08-16 Crystalline sodium salt of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-methoxymino-acetamido)-ceph-3-em-4-carboxylic acid syn isomer

Country Status (34)

Country Link
US (1) US4224371A (cg-RX-API-DMAC7.html)
EP (1) EP0001024B1 (cg-RX-API-DMAC7.html)
JP (1) JPS5441890A (cg-RX-API-DMAC7.html)
AT (2) AT366049B (cg-RX-API-DMAC7.html)
AU (1) AU520898B2 (cg-RX-API-DMAC7.html)
BG (2) BG33888A3 (cg-RX-API-DMAC7.html)
CA (1) CA1121343A (cg-RX-API-DMAC7.html)
CS (2) CS207646B2 (cg-RX-API-DMAC7.html)
DD (1) DD137588A5 (cg-RX-API-DMAC7.html)
DE (1) DE2860358D1 (cg-RX-API-DMAC7.html)
DK (2) DK152213C (cg-RX-API-DMAC7.html)
EG (1) EG13520A (cg-RX-API-DMAC7.html)
ES (1) ES472381A1 (cg-RX-API-DMAC7.html)
FI (1) FI65433C (cg-RX-API-DMAC7.html)
FR (1) FR2400519A1 (cg-RX-API-DMAC7.html)
GE (2) GEP19960476B (cg-RX-API-DMAC7.html)
GR (1) GR73661B (cg-RX-API-DMAC7.html)
HR (1) HRP931395B1 (cg-RX-API-DMAC7.html)
HU (1) HU181497B (cg-RX-API-DMAC7.html)
IE (1) IE47230B1 (cg-RX-API-DMAC7.html)
IL (1) IL55186A (cg-RX-API-DMAC7.html)
IT (1) IT1107961B (cg-RX-API-DMAC7.html)
MD (2) MD247C2 (cg-RX-API-DMAC7.html)
MX (2) MX155976A (cg-RX-API-DMAC7.html)
NO (1) NO156168C (cg-RX-API-DMAC7.html)
NZ (1) NZ188163A (cg-RX-API-DMAC7.html)
OA (1) OA06016A (cg-RX-API-DMAC7.html)
PL (1) PL126619B1 (cg-RX-API-DMAC7.html)
PT (1) PT68431A (cg-RX-API-DMAC7.html)
RO (1) RO79999A (cg-RX-API-DMAC7.html)
SI (1) SI7811917A8 (cg-RX-API-DMAC7.html)
SU (2) SU799666A3 (cg-RX-API-DMAC7.html)
YU (1) YU42166B (cg-RX-API-DMAC7.html)
ZA (1) ZA784187B (cg-RX-API-DMAC7.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4866055A (en) * 1986-11-25 1989-09-12 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives and their crystalline derivatives
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4888332A (en) * 1983-12-29 1989-12-19 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5064953A (en) * 1983-12-29 1991-11-12 Mochida Pharmaceutical Co., Ltd. Intermediates cephalosporin derivatives

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
DE3650526T2 (de) * 1985-08-12 1996-10-31 Upjohn Co Umwandlung des cephalosporin-hydrohalid-salzes zu einem alkalimetallsalz
RU2021274C1 (ru) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
WO2001092254A1 (en) * 2000-05-30 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. Method for replacing organic solvents contained in clathrate crystals
WO2004063203A1 (en) * 2003-01-10 2004-07-29 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cefotaxime sodium
CN100361995C (zh) * 2004-10-27 2008-01-16 山东瑞阳制药有限公司 注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888332A (en) * 1983-12-29 1989-12-19 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5064953A (en) * 1983-12-29 1991-11-12 Mochida Pharmaceutical Co., Ltd. Intermediates cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4956474A (en) * 1985-04-01 1990-09-11 Mochida Pharmaceutical Co., Ltd. Intermediates of cephalosporin compounds
US4866055A (en) * 1986-11-25 1989-09-12 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives and their crystalline derivatives
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives

Also Published As

Publication number Publication date
MD247B1 (ro) 1995-07-31
HRP931395B1 (en) 1996-04-30
MD225C2 (ro) 1995-12-31
DD137588A5 (de) 1979-09-12
DK152213C (da) 1988-07-11
NO156168C (no) 1987-08-19
PL126619B1 (en) 1983-08-31
IT7850648A0 (it) 1978-08-08
OA06016A (fr) 1981-06-30
BG33887A3 (bg) 1983-05-16
MD247C2 (ro) 1995-12-31
DK361078A (da) 1979-02-18
GR73661B (cg-RX-API-DMAC7.html) 1984-03-28
YU191778A (en) 1983-02-28
ES472381A1 (es) 1979-03-16
SU852175A3 (ru) 1981-07-30
MX5448E (es) 1983-08-09
YU42166B (en) 1988-06-30
IE47230B1 (en) 1984-01-25
JPS6145626B2 (cg-RX-API-DMAC7.html) 1986-10-08
EP0001024B1 (fr) 1981-01-21
AT366049B (de) 1982-03-10
AU3896578A (en) 1980-02-21
NO156168B (no) 1987-04-27
FI65433C (fi) 1984-05-10
GEP19960476B (en) 1996-07-22
DK159786D0 (da) 1986-04-09
RO79999A (ro) 1982-10-11
DE2860358D1 (en) 1981-03-12
IE781669L (en) 1979-02-17
ZA784187B (en) 1979-09-26
AU520898B2 (en) 1982-03-04
PL209080A1 (pl) 1979-06-04
AT366050B (de) 1982-03-10
FR2400519A1 (fr) 1979-03-16
GEP19960475B (en) 1996-07-22
JPS5441890A (en) 1979-04-03
IT1107961B (it) 1985-12-02
DK159786A (da) 1986-04-09
US4224371A (en) 1980-09-23
IL55186A (en) 1981-07-31
FR2400519B1 (cg-RX-API-DMAC7.html) 1980-05-16
HU181497B (en) 1983-07-28
MD225B1 (ro) 1995-06-30
ATA563578A (de) 1981-07-15
CS207646B2 (en) 1981-08-31
ATA52280A (de) 1981-07-15
DK163514C (da) 1992-07-27
CA1121343A (fr) 1982-04-06
SU799666A3 (ru) 1981-01-23
DK163514B (da) 1992-03-09
FI65433B (fi) 1984-01-31
FI782494A7 (fi) 1979-02-18
PT68431A (fr) 1978-09-01
SI7811917A8 (en) 1997-12-31
MX155976A (es) 1988-06-06
DK152213B (da) 1988-02-08
NO782782L (no) 1979-02-20
IL55186A0 (en) 1978-09-29
BG33888A3 (bg) 1983-05-16
CS207647B2 (en) 1981-08-31
EP0001024A1 (fr) 1979-03-07
EG13520A (en) 1982-03-31

Similar Documents

Publication Publication Date Title
AU520898B2 (en) Crystalline sodium salt ofthe oxime derivative of 7-amino thiazolyl acetamido celphalosporanic acid
DE2862468D1 (en) Process for the preparation of a (d-alpha-amino-(p-hydroxyphenyl)-acetamido) group containing cephalosporanic acid derivatives
KR880009961A (ko) 5-클로로-3--2-옥신돌-1-카복스아미드의 무수 결정성 나트륨 염
JPS53102898A (en) Method of making substantially crystalline alunimun sodium silicate
FR2549836B1 (fr) Procede de preparation du sel de sodium de cefuroxime
IL51956A (en) Crystalline form of l-lysine salt of cefuroxime
IT1109398B (it) Procedimento per preparare composti di cefalosporina
JPS5681569A (en) Salt of dihaloo22quinoxalinecarboxylic acid
SU671732A3 (ru) Способ получени кристаллической безводной натриевой соли 7-( -2окси-2-фенилацетамидо)-3-(1-метил1н-тетразол-5-илтиометил)-3-цефем-4-карбоновой кислоты
JPS5340771A (en) Novel polymorph of heterocyclic compound
JPS5424894A (en) Novel preparation of heterocyclic benzamide compound
SG93185G (en) A crystalline salt of a cephalosporin derivative
PT65932A (en) Process for the preparation of a crystalline modification of a sodium salt
GB1540783A (en) Crystalline potassium salt of beta-nicotinamide-adenine-dinucleotide-phosphoric acid
JPS536415A (en) Ppeparation of solid amoxycilline sodium salt
NZ190548A (en) Preparation of the crystalline methanolate form of sodium cefamandole
YU108180A (en) Process for obtaining the d-sesqui sodium salt of oxa-beta-lactam diacid
AU512026B2 (en) Alkyl derivatives of prostanoic acid
KR780000599B1 (en) Method for crystallization of sodium salt of 5'-inosinic acid
GB2048103B (en) Stabilisation of hygroscopic salts
YU274577A (en) Process for obtaining salts of indanedione derivatives
GR65247B (en) Method for the preparation compounds of n-(phosphonoacetylo)-l-asparticun acid
JPS53145964A (en) Production of salt for tempra
AU3338678A (en) Manufacture of sodium carbonate monohydrate crystals
CS187013B1 (en) Method of producing crystalline sodium salt of 6-/alpha-phenoxycarbonyl phenylacetamido/-penicillanic acid