NO982712L - FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin - Google Patents

FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin

Info

Publication number
NO982712L
NO982712L NO982712A NO982712A NO982712L NO 982712 L NO982712 L NO 982712L NO 982712 A NO982712 A NO 982712A NO 982712 A NO982712 A NO 982712A NO 982712 L NO982712 L NO 982712L
Authority
NO
Norway
Prior art keywords
alkyl
compound
formula
trifluoromethyl
alkoxy
Prior art date
Application number
NO982712A
Other languages
English (en)
Norwegian (no)
Other versions
NO982712D0 (no
Inventor
Keith M Devries
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO982712L publication Critical patent/NO982712L/no
Publication of NO982712D0 publication Critical patent/NO982712D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO982712A 1995-12-15 1998-06-12 FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin NO982712D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US875395P 1995-12-15 1995-12-15
PCT/IB1996/001076 WO1997022584A1 (en) 1995-12-15 1996-10-11 Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine

Publications (2)

Publication Number Publication Date
NO982712L true NO982712L (no) 1998-06-12
NO982712D0 NO982712D0 (no) 1998-06-12

Family

ID=21733469

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982712A NO982712D0 (no) 1995-12-15 1998-06-12 FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin

Country Status (33)

Country Link
EP (1) EP0883607A1 (hu)
JP (1) JP3066083B2 (hu)
KR (1) KR20000064387A (hu)
AP (1) AP708A (hu)
AR (1) AR004368A1 (hu)
AU (1) AU716462B2 (hu)
BG (1) BG102525A (hu)
BR (1) BR9612018A (hu)
CA (1) CA2237647A1 (hu)
CO (1) CO4750831A1 (hu)
CZ (1) CZ180898A3 (hu)
DZ (1) DZ2141A1 (hu)
GT (1) GT199600092A (hu)
HN (1) HN1996000065A (hu)
HR (1) HRP960592A2 (hu)
HU (1) HUP9904275A3 (hu)
IL (3) IL136420A0 (hu)
IS (1) IS4752A (hu)
MA (1) MA24032A1 (hu)
NO (1) NO982712D0 (hu)
NZ (1) NZ318843A (hu)
OA (1) OA10694A (hu)
PE (1) PE25698A1 (hu)
PL (1) PL197306B1 (hu)
RO (1) RO121382B1 (hu)
RU (1) RU2160731C2 (hu)
SK (1) SK75498A3 (hu)
TN (1) TNSN96153A1 (hu)
TW (1) TW414787B (hu)
UY (1) UY24401A1 (hu)
WO (1) WO1997022584A1 (hu)
YU (1) YU49486B (hu)
ZA (1) ZA9610533B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2237078T3 (es) 1998-01-16 2005-07-16 Eisai Co., Ltd. Procedimiento para producir derivados de donepezilo.
IL125809A (en) 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) * 2002-07-24 2006-12-12 Dr. Reddy's Laboratories Limited Process for preparation of donepezil
IL150982A (en) 2002-07-30 2007-02-11 Ori Lerman Process for making Donafzil
IL151253A0 (en) * 2002-08-14 2003-04-10 Finetech Lab Ltd Process for production of highly pure donepezil hydrochloride
US6649765B1 (en) 2003-02-12 2003-11-18 Usv Limited, Bsd Marg. Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en) 2003-02-12 2005-10-11 Usv, Limited Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
WO2004082685A1 (en) * 2003-03-21 2004-09-30 Ranbaxy Laboratories Limited Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
EP1654230A1 (en) 2003-07-01 2006-05-10 Hetero Drugs Limited Preparation of intermediates for acetyl cholinesterase inhibitors
CN1280273C (zh) 2003-11-05 2006-10-18 天津和美生物技术有限公司 合成多奈哌齐及其衍生物的方法
AU2005288521A1 (en) 2004-09-29 2006-04-06 Chemagis Ltd. Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) * 2005-07-29 2008-11-26 西南合成制药股份有限公司 盐酸多奈哌齐合成工艺
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
AR057910A1 (es) 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar donepezilo
AU2007203969B2 (en) 2006-01-04 2012-04-05 Cipla Limited Process and intermediate for preparation of donepezil
CA2672212A1 (en) * 2006-12-11 2008-06-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
WO2013078608A1 (en) 2011-11-29 2013-06-06 Ziqiang Gu Donepezil pamoate and methods of making and using the same
CA2921308A1 (en) 2013-08-16 2015-02-19 Universiteit Maastricht Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) * 1989-01-20 1991-04-12 Rhone Poulenc Sante Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) * 1994-11-08 1996-08-29 Bayer Ag Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

Also Published As

Publication number Publication date
HUP9904275A2 (hu) 2000-05-28
HN1996000065A (es) 1997-06-26
IL136420A0 (en) 2001-06-14
PL197306B1 (pl) 2008-03-31
BG102525A (en) 1999-05-31
AU716462B2 (en) 2000-02-24
CA2237647A1 (en) 1997-06-26
IL136421A0 (en) 2001-06-14
EP0883607A1 (en) 1998-12-16
BR9612018A (pt) 1999-02-17
TNSN96153A1 (fr) 2005-03-15
CZ180898A3 (cs) 1999-05-12
JP3066083B2 (ja) 2000-07-17
IS4752A (is) 1998-05-22
RU2160731C2 (ru) 2000-12-20
AR004368A1 (es) 1998-11-04
AP708A (en) 1998-12-04
RO121382B1 (ro) 2007-04-30
WO1997022584A1 (en) 1997-06-26
IL124452A0 (en) 1998-12-06
HUP9904275A3 (en) 2001-05-28
NO982712D0 (no) 1998-06-12
SK75498A3 (en) 1999-08-06
MA24032A1 (fr) 1997-07-01
UY24401A1 (es) 1997-06-09
JPH11500756A (ja) 1999-01-19
KR20000064387A (ko) 2000-11-06
YU66096A (en) 1999-11-22
NZ318843A (en) 2000-01-28
PL327512A1 (en) 1998-12-21
TW414787B (en) 2000-12-11
CO4750831A1 (es) 1999-03-31
DZ2141A1 (fr) 2002-07-23
AU7092596A (en) 1997-07-14
ZA9610533B (en) 1998-06-15
PE25698A1 (es) 1998-05-21
HRP960592A2 (en) 1998-06-30
GT199600092A (es) 1998-05-12
OA10694A (en) 2001-05-04
AP9600892A0 (en) 1997-01-31
YU49486B (sh) 2006-08-17
MX9804820A (es) 1998-10-31

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