BG60267B1 - Метод за получаване на производни на амидоксим - Google Patents

Метод за получаване на производни на амидоксим

Info

Publication number
BG60267B1
BG60267B1 BG092805A BG9280590A BG60267B1 BG 60267 B1 BG60267 B1 BG 60267B1 BG 092805 A BG092805 A BG 092805A BG 9280590 A BG9280590 A BG 9280590A BG 60267 B1 BG60267 B1 BG 60267B1
Authority
BG
Bulgaria
Prior art keywords
amidoxime
preparation
derivatives
piperidino
propyl
Prior art date
Application number
BG092805A
Other languages
English (en)
Other versions
BG60267B2 (bg
Inventor
Bela Bertok
Istvan Szekely
Angelika Thurner
Eva Somfai
Sandor Botar
Antal Gajary
Kalman Takacs
Lajos Nagy
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Publication of BG60267B1 publication Critical patent/BG60267B1/bg
Publication of BG60267B2 publication Critical patent/BG60267B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Networks Using Active Elements (AREA)

Abstract

Създаден е подобрен метод за получаване на производни на амидоксим с обща формула в която значенията на заместителите са уточнени в описанието, чрез взаимодействие на амидоксим с хидроокис или алкохолат на алкален метал и диметилформамид или 1,3-диметил-2-имидазолидинон, и следващо взаимодействие на получения амидоксимов комплекс, за предпочитане без изолиране със съответно заместен амин. Изобретението се отнася и до чист хидрохлорид и хидробромид на 0-/2-хидрокси-пиперидино-1-пропил/никотиновокисел амидоксим и 0-/2-хидрокси-3-пиперидино-1-пропил/никотиновокисел амидоксим, база. 10 претенции
BG92805A 1989-01-10 1990-09-07 Метод за получаване на производни на амидоксим BG60267B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU8970A HUT54347A (en) 1989-01-10 1989-01-10 Improved process for producing amidoximes
PCT/HU1990/000003 WO1990008131A1 (en) 1989-01-10 1990-01-10 Improved process for the preparation of amidoxime derivatives

Publications (2)

Publication Number Publication Date
BG60267B1 true BG60267B1 (bg) 1994-03-31
BG60267B2 BG60267B2 (bg) 1994-03-31

Family

ID=10947753

Family Applications (1)

Application Number Title Priority Date Filing Date
BG92805A BG60267B2 (bg) 1989-01-10 1990-09-07 Метод за получаване на производни на амидоксим

Country Status (14)

Country Link
US (2) US5239077A (bg)
EP (1) EP0406386B1 (bg)
JP (1) JPH03504016A (bg)
AT (1) ATE132485T1 (bg)
AU (1) AU639223B2 (bg)
BG (1) BG60267B2 (bg)
CA (1) CA2024808A1 (bg)
DE (1) DE69024546T2 (bg)
ES (1) ES2082847T3 (bg)
FI (1) FI904393A0 (bg)
HU (1) HUT54347A (bg)
NO (1) NO177821C (bg)
RU (1) RU2074854C1 (bg)
WO (1) WO1990008131A1 (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU222994B1 (hu) 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
US6458371B1 (en) * 1995-12-22 2002-10-01 Medgene, Limited Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin
HU220971B1 (hu) * 1997-04-03 2002-07-29 BIOREX Kutató és Fejlesztő Rt. Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
HU9701081D0 (en) 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
UA65635C2 (uk) 1998-09-03 2004-04-15 Н-Гене Кутато Кфт. НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ
ATE265998T1 (de) 2000-03-20 2004-05-15 N Gene Res Lab Inc Propancarbonsäure-amidoxim derivate, ein verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese entahlten
PL371251A1 (en) 2002-01-11 2005-06-13 Biorex Kutato Es Fejlesztö Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) * 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US20080227813A1 (en) * 2006-09-26 2008-09-18 Jack Raymond Barber Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
EP4247792A1 (en) 2020-11-19 2023-09-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7503311A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
HU177578B (en) * 1976-08-27 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
DE2927117A1 (de) * 1979-07-05 1981-01-08 Basf Ag Verfahren zur herstellung von o-substituierten ketoximen
EP0121701B1 (en) * 1983-04-04 1988-08-24 Allied Corporation Process for the production of o-substituted oximes
DE3620166A1 (de) * 1986-06-14 1987-12-17 Bayer Ag Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern

Also Published As

Publication number Publication date
CA2024808A1 (en) 1990-07-11
DE69024546D1 (de) 1996-02-15
ATE132485T1 (de) 1996-01-15
AU639223B2 (en) 1993-07-22
JPH03504016A (ja) 1991-09-05
NO903921D0 (no) 1990-09-07
US5239077A (en) 1993-08-24
ES2082847T3 (es) 1996-04-01
HUT54347A (en) 1991-02-28
EP0406386B1 (en) 1996-01-03
WO1990008131A1 (en) 1990-07-26
DE69024546T2 (de) 1996-08-29
FI904393A0 (fi) 1990-09-06
RU2074854C1 (ru) 1997-03-10
AU4823790A (en) 1990-08-13
NO177821B (no) 1995-08-21
US5278309A (en) 1994-01-11
EP0406386A1 (en) 1991-01-09
BG60267B2 (bg) 1994-03-31
NO177821C (no) 1995-11-29
NO903921L (no) 1990-09-07

Similar Documents

Publication Publication Date Title
CA2033392A1 (en) A-nor-steroid-3-carboxylic acid derivatives
BG60267B1 (bg) Метод за получаване на производни на амидоксим
NO20055226L (no) Fremgangsmate for fremstilling av N-substituerte 2-cyanopyrrolidoner
AR245933A1 (es) Procedimiento para preparar compuestos de 4-(3-hidroxifenil)metil-3-alquil-n-alquilpiperidina y sus sales.
KR840007011A (ko) 세펨 화합물의 제조방법
IL113011A0 (en) R-mandelic acid salt of phenylpiperidine derivative
GB861561A (en) N-substituted piperidines
CH614448A5 (en) Process for the preparation of novel tertiary amines and their acid addition salts, and compounds thus prepared
ES2033279T3 (es) Procedimiento para preparar un compuesto a base de quinolina.
GB1136933A (en) Process for the production of tetra--‡-substituted anthraquinone derivatives
RS49954B (sr) Postupak za sintezu inhibitora hiv proteaze
HUT43858A (en) Process for production of cefodisime
YU3099A (sh) Novi derivati eritromicina, postupak za njihovo dobijanje i njihova primena
GB1431078A (en) Mannich bases, a process for their preparation and their use in the preparation of polyurethanes
JPS5522699A (en) Novel 3-amino-1-benzylpyrrolidine derivative
GB765055A (en) New derivatives of the triamide of citric acid
KR940021531A (ko) 2-치환 5-클로로이미다졸-4-카르발데히드의 제조방법
KR930005953A (ko) 리그난, 이의 중간체 및 이러한 중간체의 제조방법
GB835802A (en) Process for the production of new anilides and salts thereof
JPS5695165A (en) Preparation of substituted benzoic acid amide
NO20010332L (no) Nye derivater av 6-deoksyerytromycin, deres fremstillingsprosess og deres anvendelse som medikamenter
KR840005089A (ko) N-치환된 이미노-에스테르의 제조방법
GB1374900A (en) Method of producing amides
NO995939L (no) Fremgangsmåte for fremstilling av chirale 3,4-dehydroproliner
ES471606A2 (es) Mejoras introducidas en el objeto de la patente principal, num. 450.300, presentada el 30 de julio de 1976, por: proce-dimiento de preparacion de derivados a-fenil-bencilidenicos de aminoacidos