ATE132485T1 - Verfahren zur herstellung von amidoxim-derivaten - Google Patents

Verfahren zur herstellung von amidoxim-derivaten

Info

Publication number
ATE132485T1
ATE132485T1 AT90901653T AT90901653T ATE132485T1 AT E132485 T1 ATE132485 T1 AT E132485T1 AT 90901653 T AT90901653 T AT 90901653T AT 90901653 T AT90901653 T AT 90901653T AT E132485 T1 ATE132485 T1 AT E132485T1
Authority
AT
Austria
Prior art keywords
amidoxim
derivatives
producing
degrees
spectrum
Prior art date
Application number
AT90901653T
Other languages
English (en)
Inventor
Bela Bertok
Istvan Szekely
Angelika Thurner
Eva Somfai
Sandor Botar
Antal Gajary
Kalman Takacs
Lajos Nagy
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Application granted granted Critical
Publication of ATE132485T1 publication Critical patent/ATE132485T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Networks Using Active Elements (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
AT90901653T 1989-01-10 1990-01-10 Verfahren zur herstellung von amidoxim-derivaten ATE132485T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU8970A HUT54347A (en) 1989-01-10 1989-01-10 Improved process for producing amidoximes

Publications (1)

Publication Number Publication Date
ATE132485T1 true ATE132485T1 (de) 1996-01-15

Family

ID=10947753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90901653T ATE132485T1 (de) 1989-01-10 1990-01-10 Verfahren zur herstellung von amidoxim-derivaten

Country Status (14)

Country Link
US (2) US5239077A (de)
EP (1) EP0406386B1 (de)
JP (1) JPH03504016A (de)
AT (1) ATE132485T1 (de)
AU (1) AU639223B2 (de)
BG (1) BG60267B2 (de)
CA (1) CA2024808A1 (de)
DE (1) DE69024546T2 (de)
ES (1) ES2082847T3 (de)
FI (1) FI904393A0 (de)
HU (1) HUT54347A (de)
NO (1) NO177821C (de)
RU (1) RU2074854C1 (de)
WO (1) WO1990008131A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
US6458371B1 (en) * 1995-12-22 2002-10-01 Medgene, Limited Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin
HU220971B1 (hu) * 1997-04-03 2002-07-29 BIOREX Kutató és Fejlesztő Rt. Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
HU9701081D0 (en) * 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
UA65635C2 (uk) * 1998-09-03 2004-04-15 Н-Гене Кутато Кфт. НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ
SK287101B6 (sk) 2000-03-20 2009-12-07 N-Gene Research Laboratories Inc. Amidoxímové deriváty propénkarboxylovej kyseliny, spôsob ich prípravy a farmaceutické prípravky s ich obsahom
RS60604A (en) * 2002-01-11 2006-12-15 Biorex Kutato Es Feyleszto Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7503311A (nl) * 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
HU177578B (en) * 1976-08-27 1981-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4187220A (en) * 1977-08-30 1980-02-05 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
DE2927117A1 (de) * 1979-07-05 1981-01-08 Basf Ag Verfahren zur herstellung von o-substituierten ketoximen
EP0121701B1 (de) * 1983-04-04 1988-08-24 Allied Corporation Verfahren zur Herstellung von O-substituierten Oximen
DE3620166A1 (de) * 1986-06-14 1987-12-17 Bayer Ag Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern

Also Published As

Publication number Publication date
EP0406386B1 (de) 1996-01-03
BG60267B1 (bg) 1994-03-31
CA2024808A1 (en) 1990-07-11
AU639223B2 (en) 1993-07-22
HUT54347A (en) 1991-02-28
DE69024546T2 (de) 1996-08-29
NO903921D0 (no) 1990-09-07
US5278309A (en) 1994-01-11
NO177821B (no) 1995-08-21
US5239077A (en) 1993-08-24
EP0406386A1 (de) 1991-01-09
AU4823790A (en) 1990-08-13
NO903921L (no) 1990-09-07
JPH03504016A (ja) 1991-09-05
WO1990008131A1 (en) 1990-07-26
BG60267B2 (en) 1994-03-31
FI904393A0 (fi) 1990-09-06
DE69024546D1 (de) 1996-02-15
RU2074854C1 (ru) 1997-03-10
NO177821C (no) 1995-11-29
ES2082847T3 (es) 1996-04-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee