DE60133288D1 - Verfahren zur herstellung von fexofenadinen - Google Patents

Verfahren zur herstellung von fexofenadinen

Info

Publication number
DE60133288D1
DE60133288D1 DE60133288T DE60133288T DE60133288D1 DE 60133288 D1 DE60133288 D1 DE 60133288D1 DE 60133288 T DE60133288 T DE 60133288T DE 60133288 T DE60133288 T DE 60133288T DE 60133288 D1 DE60133288 D1 DE 60133288D1
Authority
DE
Germany
Prior art keywords
sub
compound
formula
alkyl
hereinbefore defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60133288T
Other languages
English (en)
Other versions
DE60133288T2 (de
Inventor
Federico Junquera Milla
William Paul Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texcontor
Original Assignee
Texcontor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texcontor filed Critical Texcontor
Publication of DE60133288D1 publication Critical patent/DE60133288D1/de
Application granted granted Critical
Publication of DE60133288T2 publication Critical patent/DE60133288T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
DE60133288T 2000-07-28 2001-07-19 Verfahren zur Herstellung von Fexofenadin und Derivaten hiervon Expired - Fee Related DE60133288T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0018691.6A GB0018691D0 (en) 2000-07-28 2000-07-28 Process
GB0018691 2000-07-28
PCT/IB2001/001294 WO2002010115A1 (en) 2000-07-28 2001-07-19 New processes for the production of fexofenadine

Publications (2)

Publication Number Publication Date
DE60133288D1 true DE60133288D1 (de) 2008-04-30
DE60133288T2 DE60133288T2 (de) 2009-04-16

Family

ID=9896639

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133288T Expired - Fee Related DE60133288T2 (de) 2000-07-28 2001-07-19 Verfahren zur Herstellung von Fexofenadin und Derivaten hiervon

Country Status (9)

Country Link
US (1) US7176318B2 (de)
EP (1) EP1307423B1 (de)
AT (1) ATE389631T1 (de)
AU (1) AU2001269388A1 (de)
DE (1) DE60133288T2 (de)
ES (1) ES2302737T3 (de)
GB (1) GB0018691D0 (de)
PT (1) PT1307423E (de)
WO (1) WO2002010115A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2450858C (en) * 2001-06-18 2009-04-07 Dr. Reddy's Laboratories Limited Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.alpha.-dimethylbenzene acetic acid and its hydrochloride
US7700779B2 (en) 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
EP1616861A3 (de) * 2004-06-15 2006-02-08 Dipharma S.p.A. Verfahren zur Herstellung von Keto-Verbindungen
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
WO2009102155A2 (en) * 2008-02-12 2009-08-20 Yuhan Corporation Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
CN102070512B (zh) * 2009-11-21 2014-11-19 浙江华海药业股份有限公司 一种高纯度非索非那定及其中间体的合成路线与制备方法
CN102070490B (zh) * 2009-11-21 2014-07-30 浙江华海药业股份有限公司 一种非索非那定中间体2-(4-(4-羟基丁酰基)苯基)-2-甲基丙氰的制备方法
ITMI20120589A1 (it) * 2012-04-12 2013-10-13 Chemelectiva S R L Intermedi utili per la sintesi di fexofenadina, processo per la loro preparazione e per la preparazione di fexofenadina
US20130237709A1 (en) * 2012-03-02 2013-09-12 Chemelectiva S.R.L. Intermediates useful for the synthesis of fexofenadine, processes for their preparation and for the preparation of fexofenadine
CA2974449C (en) 2015-01-22 2023-08-29 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
WO2017068129A1 (en) 2015-10-22 2017-04-27 Sanofi-Aventis Deutschland Gmbh Process for the preparation of fexofenadine and of intermediates used therein
CN107782804B (zh) * 2016-08-25 2020-11-13 人福普克药业（武汉）有限公司 检测盐酸非索非那定样品中有关物质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5499135A (en) * 1990-12-24 1996-03-12 Alcatel N.V. Optical amplifier
DE69415319T2 (de) * 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
ATE230395T1 (de) * 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
IT1271417B (it) 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
JPH08237203A (ja) * 1995-02-23 1996-09-13 Fujitsu Ltd 光フィルタアレイ、光送信機及び光送信システム
US6101200A (en) * 1997-12-24 2000-08-08 Nortel Networks Corporation Laser module allowing simultaneous wavelength and power control
US6134253A (en) * 1998-02-19 2000-10-17 Jds Uniphase Corporation Method and apparatus for monitoring and control of laser emission wavelength
FR2776302B1 (fr) 1998-03-19 2002-04-12 Hoechst Marion Roussel Inc Nouveau procede de preparation de la fexofenadine
JP3197869B2 (ja) * 1998-03-31 2001-08-13 アンリツ株式会社 波長可変レーザ光源装置
US6018536A (en) * 1998-11-20 2000-01-25 Sarnoff Corporation Multiple-wavelength mode-locked laser

Also Published As

Publication number Publication date
ATE389631T1 (de) 2008-04-15
ES2302737T3 (es) 2008-08-01
GB0018691D0 (en) 2000-09-20
EP1307423A1 (de) 2003-05-07
PT1307423E (pt) 2008-06-09
AU2001269388A1 (en) 2002-02-13
US20030166682A1 (en) 2003-09-04
EP1307423B1 (de) 2008-03-19
US7176318B2 (en) 2007-02-13
WO2002010115A1 (en) 2002-02-07
DE60133288T2 (de) 2009-04-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee