NO975496L - Isotiazoloner - Google Patents

Isotiazoloner

Info

Publication number
NO975496L
NO975496L NO975496A NO975496A NO975496L NO 975496 L NO975496 L NO 975496L NO 975496 A NO975496 A NO 975496A NO 975496 A NO975496 A NO 975496A NO 975496 L NO975496 L NO 975496L
Authority
NO
Norway
Prior art keywords
isothiazolones
Prior art date
Application number
NO975496A
Other languages
English (en)
Norwegian (no)
Other versions
NO975496D0 (no
Inventor
Gary Louis Bolton
John Michael Domagala
Edward Faith Elslager
Rocco Dean Gogliotti
Terri Stoeber Purchase
Joseph Peter Sanchez
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO975496D0 publication Critical patent/NO975496D0/no
Publication of NO975496L publication Critical patent/NO975496L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO975496A 1995-05-31 1997-11-28 Isotiazoloner NO975496L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/456,149 US5620997A (en) 1995-05-31 1995-05-31 Isothiazolones
PCT/US1996/005821 WO1996038144A1 (en) 1995-05-31 1996-04-26 Isothiazolones

Publications (2)

Publication Number Publication Date
NO975496D0 NO975496D0 (no) 1997-11-28
NO975496L true NO975496L (no) 1998-01-22

Family

ID=23811632

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975496A NO975496L (no) 1995-05-31 1997-11-28 Isotiazoloner

Country Status (37)

Country Link
US (4) US5620997A (de)
EP (1) EP0828488B1 (de)
JP (1) JP2002502353A (de)
KR (2) KR19990022132A (de)
CN (1) CN1114402C (de)
AR (1) AR002740A1 (de)
AT (1) ATE232385T1 (de)
AU (1) AU723233B2 (de)
BG (1) BG62792B1 (de)
CA (1) CA2218253A1 (de)
CO (1) CO4700292A1 (de)
CZ (1) CZ373997A3 (de)
DE (1) DE69626203T2 (de)
DK (1) DK0828488T3 (de)
EA (1) EA000898B1 (de)
EE (1) EE9700287A (de)
ES (1) ES2192224T3 (de)
GE (1) GEP20012375B (de)
GT (1) GT199600026A (de)
HN (1) HN1996000017A (de)
HR (1) HRP960216B1 (de)
HU (1) HUP9900917A3 (de)
IL (1) IL117859A (de)
MX (1) MX9707948A (de)
MY (1) MY118452A (de)
NO (1) NO975496L (de)
NZ (1) NZ307023A (de)
OA (1) OA10745A (de)
PE (1) PE55097A1 (de)
PL (1) PL323683A1 (de)
PT (1) PT828488E (de)
SK (1) SK162297A3 (de)
SV (2) SV1996000026A (de)
TW (1) TW418206B (de)
UY (1) UY24244A1 (de)
WO (1) WO1996038144A1 (de)
ZA (1) ZA964441B (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
ATE336483T1 (de) * 1998-06-19 2006-09-15 Us Health Thiolester und ihre anwendungen
US6706729B1 (en) 1998-06-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services Thiolesters and uses thereof
CA2344300A1 (en) 1998-09-17 2000-03-23 Jeffrey A. Robl Method for treating atherosclerosis employing an ap2 inhibitor and combination
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
TW591031B (en) * 2000-02-29 2004-06-11 Takeda Chemical Industries Ltd Thienopyridine derivatives, their production and use
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US6432433B1 (en) 2000-06-05 2002-08-13 Isp Investments Inc. Liquid biocidal composition of a formaldehyde adduct and an isothiazolone and method of use
NZ523749A (en) 2000-07-26 2005-03-24 Smithkline Beecham P Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
ES2258141T3 (es) 2001-04-11 2006-08-16 Bristol-Myers Squibb Company Complejos de aminoacidos de glucosidos c-arilo para el tratamiento de la diabetes y procedimiento.
US7238671B2 (en) 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
KR20040054729A (ko) 2001-10-18 2004-06-25 브리스톨-마이어스 스큅 컴퍼니 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도
WO2003043624A1 (en) 2001-11-16 2003-05-30 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
AU2002367173A1 (en) * 2001-12-21 2003-07-15 Achillion Pharmaceuticals, Inc. Antifungal compositions
US7101676B2 (en) * 2002-01-11 2006-09-05 Douglas Buechter Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
US7312212B2 (en) 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
BR0307522A (pt) * 2002-02-08 2004-12-07 Hoffmann La Roche Utilização de um inibidor de lipoxigenase-15 para a manufatura de um medicamento, métodos para tratamento e prevenção e kit para o diagnóstico de predisposição à perda óssea
GB0208223D0 (en) * 2002-04-10 2002-05-22 Celltech R&D Ltd Chemical compounds
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
ATE469645T1 (de) 2002-10-23 2010-06-15 Bristol Myers Squibb Co Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
EP1689757B1 (de) 2003-11-12 2014-08-27 Phenomix Corporation Heterocyclische boronsäureverbindungen
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CN1922149A (zh) * 2003-12-29 2007-02-28 塞普拉科公司 吡咯和吡唑daao抑制剂
ZA200605384B (en) * 2003-12-29 2007-10-31 Sepracor Inc Benzo[D]isoxazol-3-OL DAAO inhibitors
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US7145040B2 (en) 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
CA2573848A1 (en) 2004-07-12 2006-02-16 Phenomix Corporation Constrained cyano compounds
AR051446A1 (es) 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
US7589088B2 (en) 2004-12-29 2009-09-15 Bristol-Myers Squibb Company Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7635699B2 (en) 2004-12-29 2009-12-22 Bristol-Myers Squibb Company Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7317024B2 (en) 2005-01-13 2008-01-08 Bristol-Myers Squibb Co. Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2527337A1 (de) 2005-04-14 2012-11-28 Bristol-Myers Squibb Company Hemmer des 11-Beta-Hydroxysteroid-Dehydrogenase-1-Enzyms
CN101189230A (zh) * 2005-05-04 2008-05-28 弗·哈夫曼-拉罗切有限公司 抗病毒的杂环化合物
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP2487154B1 (de) 2005-10-31 2013-10-16 Bristol-Myers Squibb Company Pyrrolidinyl-beta-amino-amid-basierte Inhibitoren von Dipeptidylpeptidase IV und Verfahren
US7464565B2 (en) * 2005-11-29 2008-12-16 Maytag Corporation Rapid temperature change device for a refrigerator
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
EP1976513B1 (de) 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamine als monoamin-wiederaufnahmehemmer
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7803778B2 (en) 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
WO2007139589A1 (en) 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP2089355A2 (de) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kappa-b-aktivität und deren verwendung
CN101573340A (zh) 2006-11-01 2009-11-04 百时美施贵宝公司 糖皮质激素受体AP-1和/或NF-κB活性的调节剂及其用途
JP2010516697A (ja) * 2007-01-18 2010-05-20 セプラコール インク. D−アミノ酸オキシダーゼ阻害剤
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
AR065809A1 (es) 2007-03-22 2009-07-01 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
WO2008130951A1 (en) 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
PE20090696A1 (es) 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
CN101668759A (zh) 2007-05-04 2010-03-10 百时美施贵宝公司 [6,5]-双环gpr119g蛋白-偶合受体激动剂
ES2388967T3 (es) 2007-05-04 2012-10-22 Bristol-Myers Squibb Company Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G
NZ581309A (en) * 2007-05-25 2012-02-24 Vertex Pharma Ion channel modulators and methods of use
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
TW200904440A (en) 2007-07-17 2009-02-01 Bristol Myers Squibb Co Method for modulating GPR119 G protein-coupled receptor and selected compounds
CN101808995A (zh) 2007-07-27 2010-08-18 百时美施贵宝公司 新颖的葡糖激酶激活剂及其使用方法
WO2009026537A1 (en) 2007-08-23 2009-02-26 Theracos, Inc. Benzylbenzene derivatives and methods of use
CN101910171A (zh) 2007-11-01 2010-12-08 百时美施贵宝公司 可用作糖皮质激素受体AP-1和/或者NF-κB活性调节剂的非甾类化合物及其用途
EP2574610A1 (de) * 2007-11-15 2013-04-03 Gilead Sciences, Inc. Hemmer der Replikation des menschlichen Immundefizienz-Virus
CA2705338A1 (en) * 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
WO2010009243A1 (en) 2008-07-15 2010-01-21 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
TW201006821A (en) 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
ES2689107T3 (es) 2009-11-13 2018-11-08 Astrazeneca Ab Formulaciones de tabletas bicapa
MX2012005425A (es) 2009-11-13 2012-06-14 Astrazeneca Uk Ltd Formulaciones de metformina de masa reducida.
CN104825417A (zh) 2009-11-13 2015-08-12 阿斯利康(瑞典)有限公司 立即释放片剂
TWI562775B (en) 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2011116355A2 (en) * 2010-03-19 2011-09-22 Sanford-Burnham Medical Research Institute Benzoisothiazolones as inhibitors of phosphomannose isomerase
EA201270755A1 (ru) 2010-04-08 2013-03-29 Бристол-Майерс Сквибб Компани Аналоги пиримидинилпиперидинилоксипиридинона в качестве модуляторов рецептора gpr119
WO2011130459A1 (en) 2010-04-14 2011-10-20 Bristol-Myers Squibb Company Novel glucokinase activators and methods of using same
WO2011140160A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Bicyclic heteroaryl compounds as gpr119 modulators
WO2011140161A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
EP2600716A4 (de) 2010-08-03 2014-02-19 Beth Israel Hospital Verfahren und zusammensetzungen zur behandlung von stoffwechselerkrankungen
US9662328B2 (en) 2010-11-29 2017-05-30 National Yang-Ming University Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
TWI445696B (zh) * 2010-11-29 2014-07-21 Univ Nat Yang Ming 標靶人類胸線核苷酸激酶誘導惡性腫瘤中的dna修復毒性
IL295438B2 (en) 2011-01-05 2026-05-01 Lexicon Pharmaceuticals Inc Compositions containing and methods for using inhibitors of sodium-glucose cotransporters 1 and 2
WO2013173198A1 (en) 2012-05-16 2013-11-21 Bristol-Myers Squibb Company Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
EP2925735B1 (de) 2012-11-20 2019-03-13 Lexicon Pharmaceuticals, Inc. Inhibitoren der natriumglucose-cotransporter 1
CN103232842B (zh) * 2013-04-15 2015-11-18 山东大学 一种基于聚集诱导荧光增强材料的亚硫酸氢根离子的荧光探针及快速检验试纸
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2015061272A1 (en) 2013-10-22 2015-04-30 Bristol-Myers Squibb Company Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
US20160046651A1 (en) * 2014-07-22 2016-02-18 Washington University Treatment of malaria using inhibitors of the ispd enzyme in the non-mevalonate pathway
CN104230839A (zh) * 2014-09-25 2014-12-24 上海化学试剂研究所有限公司 一种n-取代苯并异噻唑啉酮衍生物的合成方法
US9925190B2 (en) * 2015-02-16 2018-03-27 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting HIV-1 Nef
EP3288584A2 (de) 2015-04-30 2018-03-07 President and Fellows of Harvard College Anti-ap2-antikörper und antigenbindemittel zur behandlung von stoffwechselerkrankungen
MA45714A (fr) 2016-07-22 2019-05-29 Bristol Myers Squibb Co Activateurs de glucokinase et leurs procédés d'utilisation
CN111518770B (zh) 2017-12-19 2023-01-06 北京吉源生物科技有限公司 一种表达glp1和fgf21的干细胞及其用途
US20200385406A1 (en) * 2017-12-22 2020-12-10 Southern Research Institute Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors
WO2020038464A1 (zh) 2018-08-23 2020-02-27 北京厚燊药德科技有限责任公司 苯氧酸类化合物及其医药用途
AU2019346497A1 (en) 2018-09-26 2021-04-08 Lexicon Pharmaceuticals, Inc. Crystalline forms of n-(1 -((2-(dimethylamino)ethyl)amino)-2-m ethyl-1 -oopropan-2-yl)-4-(4-(2-methyl-5- (2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl) phenl)butanamide and methods of their synthesis
CN111253335B (zh) * 2020-03-12 2023-06-06 浙江扬帆新材料股份有限公司 一种n-取代苯并异噻唑啉-3-酮衍生物的新合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE724034C (de) * 1938-11-04 1942-08-17 Algemeene Kunstvezel Mij N V Verfahren zum Erzeugen farbiger Glasfasern
US3012039A (en) * 1958-03-14 1961-12-05 Ici Ltd 2-p-chlorobenzyl-1, 2-benzisothiazolone
US3517022A (en) * 1967-10-03 1970-06-23 Rohm & Haas Certain 2-carbamoyl-1,2-benzisothiazolones
US3661974A (en) * 1970-04-27 1972-05-09 Sherwin Williams Co 2-carbalkoxy-phenyl sulfenamides
GB1306493A (en) * 1970-04-27 1973-02-14 Sherwin Williams Co Aromatic sulphenamides the preparation thereof and cyclization thereof
US3761489A (en) * 1971-12-20 1973-09-25 Sherwin Williams Co Substituted n-alkyl benzisothiazolinones
US4049817A (en) * 1972-08-14 1977-09-20 Sandoz Ltd. Synergistic compositions
US3965107A (en) * 1974-07-08 1976-06-22 Rohm And Haas Company Isothiazolopyridinones
IT1039699B (it) * 1975-07-03 1979-12-10 Prephar Composizione spermicida a base di derivati benzisotiazolici
DE2602643C2 (de) * 1976-01-24 1984-12-20 Bayer Ag, 5090 Leverkusen 1,2-Benzisothiazolinone-3, Verfahren zu ihrer Herstellung sowie Arzneimittel
GB1560726A (en) * 1976-04-28 1980-02-06 Beecham Group Ltd Isothiazolo-pyridines
FR2492376A1 (fr) * 1980-10-17 1982-04-23 Cird Polymethylene-4,5 isothiazoline-4 ones-3, leur procede de preparation et leurs utilisation comme agents bactericides et fongicides
DE3041036A1 (de) * 1980-10-31 1982-06-09 A. Nattermann & Cie GmbH, 5000 Köln Verwendung von benzisothiazolen
US4458942A (en) * 1981-12-07 1984-07-10 American Seating Company Three-quarter fold retracting chair
LU84091A1 (fr) * 1982-04-16 1984-03-02 Oreal Derives n-carbamoyl d'isothiazolo-(5,4b)pyridine one-3,leur procede de preparation et leurs utilisations comme agents bactericides et fongicides
FR2555450B1 (fr) * 1983-11-24 1988-04-01 Oreal Composition anti-acneique contenant en tant que compose actif un derive d'isothiazolo-(5,4b) pyridine one-3
FR2631028B1 (fr) * 1988-05-09 1990-07-13 Cird Adamantyl-2 isothiazoline-4 ones-3, leur procede de preparation et leur utilisation comme agents bactericides et fongicides
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds
JPH0477476A (ja) * 1990-07-19 1992-03-11 Sankyo Co Ltd 抗潰瘍剤
US5219875A (en) * 1990-11-27 1993-06-15 Rohm And Haas Company Antimicrobial compositions comprising iodopropargyl butylcarbamate and 1,2-benzisothiazolin-3-one and methods of controlling microbes
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
FR2695378B1 (fr) * 1992-09-10 1994-12-02 Aerospatiale Dispositif à sangle pour le maintien temporaire d'objets ensemble.
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли

Also Published As

Publication number Publication date
SV1996000026A (es) 1997-03-05
ATE232385T1 (de) 2003-02-15
HRP960216A2 (en) 1997-08-31
AU5577196A (en) 1996-12-18
US5733921A (en) 1998-03-31
NZ307023A (en) 2001-03-30
EP0828488B1 (de) 2003-02-12
CN1114402C (zh) 2003-07-16
HUP9900917A2 (hu) 1999-09-28
DE69626203D1 (en) 2003-03-20
AR002740A1 (es) 1998-04-29
US6133270A (en) 2000-10-17
HN1996000017A (es) 2000-03-24
ZA964441B (en) 1996-12-10
BG62792B1 (bg) 2000-08-31
US5668162A (en) 1997-09-16
EA000898B1 (ru) 2000-06-26
MX9707948A (es) 1997-12-31
IL117859A (en) 2000-07-16
WO1996038144A1 (en) 1996-12-05
PL323683A1 (en) 1998-04-14
CZ373997A3 (cs) 1998-11-11
KR19990022132A (ko) 1999-03-25
EA199700444A1 (ru) 1998-06-25
EE9700287A (et) 1998-06-15
PT828488E (pt) 2003-06-30
OA10745A (en) 2002-12-10
TW418206B (en) 2001-01-11
US5620997A (en) 1997-04-15
JP2002502353A (ja) 2002-01-22
SK162297A3 (en) 2000-04-10
HUP9900917A3 (en) 2003-04-28
DK0828488T3 (da) 2003-05-19
NO975496D0 (no) 1997-11-28
UY24244A1 (es) 2001-10-25
CO4700292A1 (es) 1998-12-29
DE69626203T2 (de) 2003-11-20
CN1185737A (zh) 1998-06-24
AU723233B2 (en) 2000-08-24
GEP20012375B (en) 2001-03-25
HRP960216B1 (en) 2001-12-31
BG102077A (en) 1998-11-30
IL117859A0 (en) 1996-08-04
GT199600026A (es) 1997-11-15
PE55097A1 (es) 1998-01-16
ES2192224T3 (es) 2003-10-01
EP0828488A1 (de) 1998-03-18
KR20040004547A (ko) 2004-01-13
SV1996000033A (es) 1998-01-29
MY118452A (en) 2004-11-30
CA2218253A1 (en) 1996-12-05

Similar Documents

Publication Publication Date Title
DK0828488T3 (da) Isothiazoloner
DE69608259D1 (de) Verbunddamenbinde
DE69623578D1 (de) Kappsägeschlitten
NO973955D0 (no) Personsökesystem
FIU950469U0 (fi) Plaostruktur
ATE198470T1 (de) Alkenyl-benzoylguanidine
BR9609863A (pt) Fecho
SE9501817D0 (sv) När/långsyntssimdykningsglasögon
KR960030307U (ko) 다시
IT236709Y1 (it) Bitasca
FI2191U1 (fi) Bandformigt foerpackningsmaterial
FI1967U1 (fi) Kulboessa
BR7500192U (pt) Parasitofiltro
BR7500040U (pt) Raquet mastit
BR7500437U (pt) Girolight
FI954901A0 (fi) Dubbdaeckfoerfarande
BR9501962A (pt) Lotofone
BR7501836U (pt) Protecheque
BR7502714U (pt) Impresscard
BR7500991U (pt) Caríndio
BR7501399U (pt) Ciclonavegador
BR7501828U (pt) Multicopo
BR7502098U (pt) T-compacto
BR7501298U (pt) Torre-audio-visual
BR9500075A (pt) Carrapetilha

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application