NO974513L - Pyrrolidinyl-hydroksamsyre-forbindelser og deres fremgangsmåte for fremstilling - Google Patents
Pyrrolidinyl-hydroksamsyre-forbindelser og deres fremgangsmåte for fremstillingInfo
- Publication number
- NO974513L NO974513L NO974513A NO974513A NO974513L NO 974513 L NO974513 L NO 974513L NO 974513 A NO974513 A NO 974513A NO 974513 A NO974513 A NO 974513A NO 974513 L NO974513 L NO 974513L
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- alkoxy
- formula
- hydroxamic acid
- acid compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Pyrrolidinyl-hydroksams}rc-forbindelscr og deres fremgangsmåte for fremstilling Forbindelse med formelen: Ar N. (D O N OR X og farmasøytisk godtagbare salter derav, hvor A er hydrogen, hydroksy eller OY, hvor Y er en hydroksy-beskyttelsesgruppe; Ar er fenyl eventuelt substituert med én eller flere substituenter valgt fra halogen, hydroksy, 0,-0^ alkyl, C,-C,alkoksy, GF3, C,-C4 alkoksy-C,-C, alkyloksy og karboksy-Ci-C^ alkyloksy; X er fenyl, naftyl, bifenyl, indanyl, benzofuranyl, benzotiofeny, 1-tetralon-6-yl, C,-C,, alkylendioksy, pyridyl, furyl og tienyl, idet disse grupper eventuelt er substituert med opptil tre substituenter valgt fra halogen, C,-C4 alkyl, 0,-0^ alkoksy, hydroksy, NO2, CF3 og SGjCHj; og R er hydrogen, 0,-0^ alkyl eller en hydroksy-beskyttelsesgruppe. Disse forbindelser og fanmasøytiske preparater inneholdende dem er nyttige som smertestillende, antiinflammatoriske, diuretiske, anestetiske eller nervebeskyttende midler eller som middel for behandling av slag eller funksjonelle tarm-sykdommer så som mavesmerte, for behandling av et pattedyr, spesielt et menneske. Foreliggende oppfinnelse tilveiebringer videre fremgangsmåter for fremstilling av hydroksamsyre-forbindelsene med formel (I) og mellomproduktene med formel (II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9500631 | 1995-03-31 | ||
| PCT/JP1996/000820 WO1996030339A1 (en) | 1995-03-31 | 1996-03-28 | Pyrrolidinyl hydroxamic acid compounds and their production process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO974513L true NO974513L (no) | 1997-09-29 |
| NO974513D0 NO974513D0 (no) | 1997-09-29 |
Family
ID=14125824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO974513A NO974513D0 (no) | 1995-03-31 | 1997-09-29 | Pyrrolidinyl-hydroksamsyre-forbindelser og deres fremgangsmåte for fremstilling |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US5952369A (no) |
| EP (1) | EP0817772B1 (no) |
| JP (1) | JP3035356B2 (no) |
| KR (1) | KR100258657B1 (no) |
| AP (1) | AP625A (no) |
| AR (1) | AR002729A1 (no) |
| AT (1) | ATE231840T1 (no) |
| AU (1) | AU693336B2 (no) |
| BG (1) | BG62611B1 (no) |
| BR (1) | BR9607750A (no) |
| CA (1) | CA2213815C (no) |
| CZ (1) | CZ306497A3 (no) |
| DE (1) | DE69626009T2 (no) |
| DK (1) | DK0817772T3 (no) |
| ES (1) | ES2188743T3 (no) |
| HR (1) | HRP960141A2 (no) |
| HU (1) | HUP9900767A3 (no) |
| IL (2) | IL117440A0 (no) |
| IS (1) | IS4547A (no) |
| LV (1) | LV11971B (no) |
| MA (1) | MA23832A1 (no) |
| NO (1) | NO974513D0 (no) |
| NZ (1) | NZ304113A (no) |
| OA (1) | OA10518A (no) |
| PE (1) | PE43397A1 (no) |
| PL (1) | PL322652A1 (no) |
| RU (1) | RU2144917C1 (no) |
| SI (1) | SI9620039A (no) |
| SK (1) | SK129897A3 (no) |
| TN (1) | TNSN96045A1 (no) |
| TR (1) | TR199701082T1 (no) |
| TW (1) | TW408111B (no) |
| WO (1) | WO1996030339A1 (no) |
| YU (1) | YU18696A (no) |
| ZA (1) | ZA962476B (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9701042A (es) * | 1996-02-07 | 1998-05-31 | Pfizer | Compuestos del acido hidroxamico. |
| TNSN97092A1 (ar) | 1996-09-18 | 1999-12-31 | Agouron Pharma | مثبطات انزيم بروتيني فلزي وتركيبات صيدلانية تحتوي على تلك المثبتطات واستخدامها الصيدلاني وطرق ومركبات وسيطة مفيدة لتحضير التركيبات المذكورة. |
| JP4167302B2 (ja) * | 1996-12-02 | 2008-10-15 | 杏林製薬株式会社 | 新規ｎ―置換ピロリジン誘導体及びその製造法 |
| JP2000507970A (ja) * | 1997-01-10 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | キラルメディエータの効率的な合成 |
| EP0982297A3 (en) * | 1998-08-24 | 2001-08-01 | Pfizer Products Inc. | Process for the preparation of hydroxy-pyrrolidinyl hydroxamic acid derivatives being opioid kappa receptor agonists |
| KR100295740B1 (ko) * | 1998-09-17 | 2001-11-05 | 박영구 | N-치환된-하이드록시고리화알킬아민유도체의제조방법 |
| US6444829B1 (en) * | 2000-07-19 | 2002-09-03 | Hoffmann-La Roche Inc. | Pyrrolidine compounds |
| AU2002247886A1 (en) | 2001-04-30 | 2002-11-11 | Pfizer Products Inc. | Process for preparing hydroxypyrrolidinyl ethylamine compounds useful as kappa agonists |
| US7091357B2 (en) * | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
| AU2003269399A1 (en) * | 2002-11-01 | 2004-05-25 | Pfizer Products Inc. | Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination |
| GB0821010D0 (en) * | 2008-11-17 | 2008-12-24 | Univ Warwick | Plant development control composition |
| WO2012155199A1 (en) | 2011-05-16 | 2012-11-22 | Bionomics Limited | Amine derivatives as potassium channel blockers |
| DK2822928T3 (en) * | 2012-03-05 | 2019-03-11 | Dr Reddys Laboratories Ltd | SUBSTITUTED HETEROCYCLIC ACETAMIDS AS CAPE-OPIOID RECEPTOR (CHOR) AGONISTS |
| GB201210395D0 (en) * | 2012-06-11 | 2012-07-25 | Syngenta Participations Ag | Crop enhancement compositions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3268539A (en) * | 1963-05-20 | 1966-08-23 | Universal Oil Prod Co | Tertiary-aminoalkyl derivatives of diaryl substituted acetohydroxamic acid esters |
-
1996
- 1996-03-11 IL IL11744096A patent/IL117440A0/xx unknown
- 1996-03-14 AP APAP/P/1996/000791A patent/AP625A/en active
- 1996-03-15 TW TW085103136A patent/TW408111B/zh active
- 1996-03-25 PE PE1996000208A patent/PE43397A1/es not_active Application Discontinuation
- 1996-03-25 MA MA24191A patent/MA23832A1/fr unknown
- 1996-03-26 HR HRPCT/JP95/631A patent/HRP960141A2/hr not_active Application Discontinuation
- 1996-03-27 YU YU18696A patent/YU18696A/sh unknown
- 1996-03-28 ES ES96907686T patent/ES2188743T3/es not_active Expired - Lifetime
- 1996-03-28 EP EP96907686A patent/EP0817772B1/en not_active Expired - Lifetime
- 1996-03-28 CZ CZ973064A patent/CZ306497A3/cs unknown
- 1996-03-28 AU AU51211/96A patent/AU693336B2/en not_active Ceased
- 1996-03-28 TR TR97/01082T patent/TR199701082T1/xx unknown
- 1996-03-28 JP JP08529174A patent/JP3035356B2/ja not_active Expired - Fee Related
- 1996-03-28 KR KR1019970706880A patent/KR100258657B1/ko not_active IP Right Cessation
- 1996-03-28 NZ NZ304113A patent/NZ304113A/xx unknown
- 1996-03-28 BR BR9607750A patent/BR9607750A/pt active Search and Examination
- 1996-03-28 SI SI9620039A patent/SI9620039A/sl not_active IP Right Cessation
- 1996-03-28 HU HU9900767A patent/HUP9900767A3/hu unknown
- 1996-03-28 PL PL96322652A patent/PL322652A1/xx unknown
- 1996-03-28 DE DE69626009T patent/DE69626009T2/de not_active Expired - Fee Related
- 1996-03-28 CA CA002213815A patent/CA2213815C/en not_active Expired - Fee Related
- 1996-03-28 US US08/913,823 patent/US5952369A/en not_active Expired - Fee Related
- 1996-03-28 WO PCT/JP1996/000820 patent/WO1996030339A1/en active IP Right Grant
- 1996-03-28 ZA ZA9602476A patent/ZA962476B/xx unknown
- 1996-03-28 SK SK1298-97A patent/SK129897A3/sk unknown
- 1996-03-28 RU RU97117590A patent/RU2144917C1/ru active
- 1996-03-28 AT AT96907686T patent/ATE231840T1/de not_active IP Right Cessation
- 1996-03-28 DK DK96907686T patent/DK0817772T3/da active
- 1996-03-29 AR ARP960101993A patent/AR002729A1/es unknown
- 1996-03-29 TN TNTNSN96045A patent/TNSN96045A1/fr unknown
-
1997
- 1997-08-19 IS IS4547A patent/IS4547A/is unknown
- 1997-09-17 BG BG101896A patent/BG62611B1/bg unknown
- 1997-09-29 NO NO974513A patent/NO974513D0/no not_active Application Discontinuation
- 1997-09-30 OA OA70091A patent/OA10518A/en unknown
- 1997-10-21 LV LVP-97-203A patent/LV11971B/en unknown
-
1999
- 1999-04-15 IL IL12947999A patent/IL129479A0/xx unknown
- 1999-04-29 US US09/302,097 patent/US6110947A/en not_active Expired - Fee Related
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