NO972185D0 - Selektiv acylering av <epsilon>-aminogrupper - Google Patents

Selektiv acylering av <epsilon>-aminogrupper

Info

Publication number
NO972185D0
NO972185D0 NO972185A NO972185A NO972185D0 NO 972185 D0 NO972185 D0 NO 972185D0 NO 972185 A NO972185 A NO 972185A NO 972185 A NO972185 A NO 972185A NO 972185 D0 NO972185 D0 NO 972185D0
Authority
NO
Norway
Prior art keywords
epsilon
amino groups
selective acylation
acylation
selective
Prior art date
Application number
NO972185A
Other languages
English (en)
Norwegian (no)
Other versions
NO972185L (no
Inventor
Jeffrey Clayton Baker
Victor John Chen
Jose Michel Hanquier
Aidas Vladas Kriauciunas
Brian Allen Moser
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO972185L publication Critical patent/NO972185L/no
Publication of NO972185D0 publication Critical patent/NO972185D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO972185A 1994-11-17 1997-05-13 Selektiv acylering av <epsilon>-aminogrupper NO972185D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
PCT/US1995/014872 WO1996015803A1 (en) 1994-11-17 1995-11-14 SELECTIVE ACYLATION OF ε-AMINO GROUPS

Publications (2)

Publication Number Publication Date
NO972185L NO972185L (no) 1997-05-13
NO972185D0 true NO972185D0 (no) 1997-05-13

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972185A NO972185D0 (no) 1994-11-17 1997-05-13 Selektiv acylering av <epsilon>-aminogrupper

Country Status (27)

Country Link
US (2) US5646242A (enExample)
EP (2) EP1227107A1 (enExample)
JP (1) JP4312828B2 (enExample)
CN (1) CN1171742A (enExample)
AR (1) AR003915A1 (enExample)
AT (1) ATE328902T1 (enExample)
AU (2) AU691066B2 (enExample)
BR (1) BR9509652A (enExample)
CA (1) CA2205061A1 (enExample)
CO (1) CO4520285A1 (enExample)
CZ (1) CZ287731B6 (enExample)
DE (1) DE69535031T2 (enExample)
DK (1) DK0712862T3 (enExample)
ES (1) ES2264124T3 (enExample)
HU (2) HU217585B (enExample)
IL (1) IL115972A (enExample)
IN (1) IN179820B (enExample)
NO (1) NO972185D0 (enExample)
NZ (1) NZ297256A (enExample)
PL (1) PL320556A1 (enExample)
PT (1) PT712862E (enExample)
RU (1) RU2155773C2 (enExample)
SI (1) SI0712862T1 (enExample)
TR (1) TR199501421A2 (enExample)
WO (1) WO1996015803A1 (enExample)
YU (1) YU71495A (enExample)
ZA (1) ZA959680B (enExample)

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US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
BR0211346A (pt) * 2001-07-24 2004-09-21 Novo Nordisk As Método para produzir um polipeptìdeo, e, precursor de polipeptìdeo para um polipeptìdeo desejado
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US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) * 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
ATE446971T1 (de) 2001-09-07 2009-11-15 Biocon Ltd Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren synthese
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
WO2004029077A2 (en) * 2002-09-25 2004-04-08 Novo Nordisk A/S Method for producing acylated peptides
JP4463814B2 (ja) * 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
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ES2464282T3 (es) 2006-09-27 2014-06-02 Novo Nordisk A/S Método para preparar polipéptidos de insulina madura
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
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CN101939023B (zh) 2007-10-16 2016-08-03 百康有限公司 可经口给药的固体药物组合物及其方法
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CN102149411A (zh) 2008-09-12 2011-08-10 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
JP4959005B2 (ja) * 2008-10-30 2012-06-20 ノボ・ノルデイスク・エー／エス 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
US20120040886A1 (en) * 2009-02-20 2012-02-16 Zheng Xin Dong Analogues of Neuropeptide Y Having Proline Substitution At Position 34
WO2011064316A2 (en) 2009-11-25 2011-06-03 Paolo Botti Mucosal delivery of peptides
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
EP1227107A1 (en) 2002-07-31
RU2155773C2 (ru) 2000-09-10
CZ287731B6 (en) 2001-01-17
DE69535031D1 (de) 2006-07-20
BR9509652A (pt) 1997-09-16
HU217585B (hu) 2000-02-28
JPH10509176A (ja) 1998-09-08
US5646242A (en) 1997-07-08
CA2205061A1 (en) 1996-05-30
WO1996015803A1 (en) 1996-05-30
PT712862E (pt) 2006-08-31
AU7885498A (en) 1998-11-05
NO972185L (no) 1997-05-13
ES2264124T3 (es) 2006-12-16
AU720820B2 (en) 2000-06-15
YU71495A (sh) 1998-09-18
AU4237296A (en) 1996-06-17
TR199501421A2 (tr) 1996-06-21
CZ145697A3 (en) 1997-12-17
IN179820B (enExample) 1997-12-13
SI0712862T1 (sl) 2006-10-31
DE69535031T2 (de) 2006-12-28
AR003915A1 (es) 1998-09-30
IL115972A0 (en) 1996-01-31
CN1171742A (zh) 1998-01-28
MX9703506A (es) 1997-07-31
EP0712862A3 (en) 1998-03-04
EP0712862B1 (en) 2006-06-07
HU9903007D0 (en) 1999-11-29
ZA959680B (en) 1997-05-14
JP4312828B2 (ja) 2009-08-12
NZ297256A (en) 2000-01-28
USRE37971E1 (en) 2003-01-28
PL320556A1 (en) 1997-10-13
HUT77737A (hu) 1998-07-28
ATE328902T1 (de) 2006-06-15
CO4520285A1 (es) 1997-10-15
IL115972A (en) 2000-09-28
AU691066B2 (en) 1998-05-07
HK1014007A1 (en) 1999-09-17
DK0712862T3 (da) 2006-09-25
EP0712862A2 (en) 1996-05-22

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