DK0712862T3 - Selektiv acylering af epsilon-aminogrupper i insulin - Google Patents

Selektiv acylering af epsilon-aminogrupper i insulin

Info

Publication number
DK0712862T3
DK0712862T3 DK95308167T DK95308167T DK0712862T3 DK 0712862 T3 DK0712862 T3 DK 0712862T3 DK 95308167 T DK95308167 T DK 95308167T DK 95308167 T DK95308167 T DK 95308167T DK 0712862 T3 DK0712862 T3 DK 0712862T3
Authority
DK
Denmark
Prior art keywords
insulin
amino groups
epsilon amino
selective acylation
acylation
Prior art date
Application number
DK95308167T
Other languages
Danish (da)
English (en)
Inventor
Jeffrey Clayton Baker
Brian Allen Moser
Jose Michael Hanquier
Robert Theodore Shuman
Victor John Chen
Aidas Vladas Kriauciunas
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0712862T3 publication Critical patent/DK0712862T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95308167T 1994-11-17 1995-11-14 Selektiv acylering af epsilon-aminogrupper i insulin DK0712862T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
DK0712862T3 true DK0712862T3 (da) 2006-09-25

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95308167T DK0712862T3 (da) 1994-11-17 1995-11-14 Selektiv acylering af epsilon-aminogrupper i insulin

Country Status (27)

Country Link
US (2) US5646242A (enExample)
EP (2) EP0712862B1 (enExample)
JP (1) JP4312828B2 (enExample)
CN (1) CN1171742A (enExample)
AR (1) AR003915A1 (enExample)
AT (1) ATE328902T1 (enExample)
AU (2) AU691066B2 (enExample)
BR (1) BR9509652A (enExample)
CA (1) CA2205061A1 (enExample)
CO (1) CO4520285A1 (enExample)
CZ (1) CZ287731B6 (enExample)
DE (1) DE69535031T2 (enExample)
DK (1) DK0712862T3 (enExample)
ES (1) ES2264124T3 (enExample)
HU (2) HU217585B (enExample)
IL (1) IL115972A (enExample)
IN (1) IN179820B (enExample)
NO (1) NO972185D0 (enExample)
NZ (1) NZ297256A (enExample)
PL (1) PL320556A1 (enExample)
PT (1) PT712862E (enExample)
RU (1) RU2155773C2 (enExample)
SI (1) SI0712862T1 (enExample)
TR (1) TR199501421A2 (enExample)
WO (1) WO1996015803A1 (enExample)
YU (1) YU71495A (enExample)
ZA (1) ZA959680B (enExample)

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US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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WO2003010186A2 (en) * 2001-07-24 2003-02-06 Novo Nordisk A/S Method for making acylated polypeptides
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
PT1430082E (pt) 2001-09-07 2010-01-15 Biocon Ltd Métodos de síntese de conjugados de polipéptido de insulina-oligómero, e conjugados de polipéptido de pró-insulina-oligómero e método de síntese dos mesmos
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
DE60328112D1 (de) * 2002-09-25 2009-08-06 Novo Nordisk As Verfahren zur herstellung acylierter peptide
KR101159559B1 (ko) * 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
MX2007000883A (es) 2004-07-19 2007-04-02 Biocon Ltd Conjugados de insulina-oligomero, formulaciones y usos de los mismos.
CN101243190B (zh) 2005-08-16 2015-05-13 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
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JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
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CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
ZA959680B (en) 1997-05-14
DE69535031D1 (de) 2006-07-20
PT712862E (pt) 2006-08-31
AU691066B2 (en) 1998-05-07
HU217585B (hu) 2000-02-28
WO1996015803A1 (en) 1996-05-30
NO972185L (no) 1997-05-13
AU7885498A (en) 1998-11-05
PL320556A1 (en) 1997-10-13
HUT77737A (hu) 1998-07-28
HK1014007A1 (en) 1999-09-17
CA2205061A1 (en) 1996-05-30
AU720820B2 (en) 2000-06-15
NO972185D0 (no) 1997-05-13
EP0712862B1 (en) 2006-06-07
TR199501421A2 (tr) 1996-06-21
CO4520285A1 (es) 1997-10-15
JPH10509176A (ja) 1998-09-08
CZ287731B6 (en) 2001-01-17
SI0712862T1 (sl) 2006-10-31
CN1171742A (zh) 1998-01-28
AU4237296A (en) 1996-06-17
USRE37971E1 (en) 2003-01-28
DE69535031T2 (de) 2006-12-28
BR9509652A (pt) 1997-09-16
RU2155773C2 (ru) 2000-09-10
EP0712862A3 (en) 1998-03-04
EP0712862A2 (en) 1996-05-22
YU71495A (sh) 1998-09-18
NZ297256A (en) 2000-01-28
IL115972A0 (en) 1996-01-31
CZ145697A3 (en) 1997-12-17
IL115972A (en) 2000-09-28
ATE328902T1 (de) 2006-06-15
AR003915A1 (es) 1998-09-30
JP4312828B2 (ja) 2009-08-12
EP1227107A1 (en) 2002-07-31
HU9903007D0 (en) 1999-11-29
MX9703506A (es) 1997-07-31
IN179820B (enExample) 1997-12-13
ES2264124T3 (es) 2006-12-16
US5646242A (en) 1997-07-08

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