NO924955L - Bis-benzo- eller benzopyridocykloheptapiperidin, piperidylidin og piperazinforbindelser og preparater - Google Patents
Bis-benzo- eller benzopyridocykloheptapiperidin, piperidylidin og piperazinforbindelser og preparaterInfo
- Publication number
- NO924955L NO924955L NO92924955A NO924955A NO924955L NO 924955 L NO924955 L NO 924955L NO 92924955 A NO92924955 A NO 92924955A NO 924955 A NO924955 A NO 924955A NO 924955 L NO924955 L NO 924955L
- Authority
- NO
- Norway
- Prior art keywords
- benzo
- bis
- pct
- piperidylidine
- benzopyridocycloheptapiperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54228090A | 1990-06-22 | 1990-06-22 | |
PCT/US1991/004162 WO1992000293A1 (en) | 1990-06-22 | 1991-06-21 | Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions |
Publications (3)
Publication Number | Publication Date |
---|---|
NO924955D0 NO924955D0 (no) | 1992-12-21 |
NO924955L true NO924955L (no) | 1993-02-22 |
NO303223B1 NO303223B1 (no) | 1998-06-15 |
Family
ID=24163110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO924955A NO303223B1 (no) | 1990-06-22 | 1992-12-21 | AnalogifremgangsmÕte for fremstilling av terapeutisk aktive bis-benzo- eller benzopyridocykloheptapiperiden-, piperidyliden- og piperazinforbindelser |
Country Status (26)
Country | Link |
---|---|
US (1) | US5422351A (no) |
EP (1) | EP0535152B1 (no) |
JP (1) | JPH0761998B2 (no) |
KR (1) | KR960012368B1 (no) |
AT (1) | ATE126226T1 (no) |
AU (1) | AU646878B2 (no) |
CA (1) | CA2085878C (no) |
CZ (1) | CZ284610B6 (no) |
DE (2) | DE122008000047I2 (no) |
DK (1) | DK0535152T3 (no) |
ES (1) | ES2096657T3 (no) |
FI (1) | FI925820A (no) |
GR (1) | GR3017924T3 (no) |
HK (1) | HK186496A (no) |
HU (1) | HU220622B1 (no) |
IE (1) | IE68935B1 (no) |
IL (1) | IL98572A (no) |
NL (1) | NL300378I2 (no) |
NO (1) | NO303223B1 (no) |
NZ (1) | NZ238629A (no) |
OA (1) | OA10032A (no) |
PL (1) | PL173224B1 (no) |
RU (1) | RU2086549C1 (no) |
SK (1) | SK280717B6 (no) |
WO (1) | WO1992000293A1 (no) |
ZA (1) | ZA914764B (no) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2093646A1 (en) * | 1990-10-10 | 1992-04-11 | Jesse K. Wong | Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use |
EP0586560A1 (en) * | 1991-05-23 | 1994-03-16 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
CA2114009A1 (en) * | 1991-07-23 | 1993-02-04 | Jesse K. Wong | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
KR100234627B1 (ko) * | 1992-03-23 | 1999-12-15 | 디르크 반테 | 항 자극제로서 사용하기 위한 제제 |
ES2042421B1 (es) * | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina. |
US5661152A (en) * | 1993-10-15 | 1997-08-26 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6075025A (en) | 1993-10-15 | 2000-06-13 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6365588B1 (en) | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
ES2087818B1 (es) * | 1993-11-24 | 1997-03-16 | Uriach & Cia Sa J | 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato. |
ES2087026B1 (es) * | 1994-07-28 | 1997-03-16 | Uriach & Cia Sa J | Nuevo derivado de la benzo(5,6)ciclohepta- (1.2-b) piridina. |
US5595997A (en) * | 1994-12-30 | 1997-01-21 | Sepracor Inc. | Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine |
US7211582B1 (en) | 1994-12-30 | 2007-05-01 | Sepracor Inc. | Methods for treating urticaria using descarboethoxyloratadine |
US7214683B1 (en) | 1994-12-30 | 2007-05-08 | Sepracor Inc. | Compositions of descarboethoxyloratadine |
US5684013A (en) * | 1995-03-24 | 1997-11-04 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5891872A (en) * | 1995-04-07 | 1999-04-06 | Schering Corporation | Tricyclic compounds |
US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
ATE345338T1 (de) * | 1996-09-13 | 2006-12-15 | Schering Corp | Tricyclische piperdinyl derivate verwendbar als farnesyl-protein transferase inhibitoren |
JP2001500506A (ja) * | 1996-09-13 | 2001-01-16 | シェーリング コーポレイション | ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な置換ベンゾシクロヘプタピリジン |
US5965570A (en) * | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
RU2188197C2 (ru) * | 1996-10-04 | 2002-08-27 | Ново Нордиск А/С | 1,4-дизамещенные пиперазины, способ их получения, фармацевтическая композиция и способ лечения нейрогенного воспаления |
US5900421A (en) * | 1997-02-11 | 1999-05-04 | Sepracor Inc. | Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine |
US5958940A (en) * | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
AU9683798A (en) * | 1997-10-10 | 1999-05-03 | Schering Corporation | Ethyl 4-(8-chloro-5, 6-dihydro-11h- benzo{5,6}cyclohepta {1,2-b}pyridin -11-ylidene)-1- piperidene carboxylate polymorph |
US6100274A (en) * | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
US6114346A (en) | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
SK287105B6 (sk) | 1999-12-20 | 2009-12-07 | Schering Corporation | Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním |
WO2001045668A2 (en) | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
WO2004106299A2 (en) * | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US7901190B2 (en) * | 2004-07-28 | 2011-03-08 | Ian Gray | Pump control system |
EP1896421B1 (en) | 2005-06-23 | 2011-09-14 | Merck Sharp & Dohme Corp. | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met |
WO2007054896A1 (en) * | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
WO2008020314A2 (en) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Statin stabilizing dosage formulations |
TW200813021A (en) | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
RU2009105089A (ru) * | 2006-07-14 | 2010-08-27 | Ранбакси Лабораториз Лимитед (In) | ПОЛИМОРФНЫЕ ФОРМЫ ГМГ-КоА-РЕДУКТАЗЫ И ИХ ПРИМЕНЕНИЕ |
JP5978296B2 (ja) * | 2011-06-28 | 2016-08-24 | フジアン・ミンドン・レジュヴネイション・ファーマスーティカル・カンパニー・リミテッド | 抗アレルギ性ベンゾシクロヘプタチオフェン誘導体 |
CN103113348B (zh) * | 2013-02-18 | 2015-03-25 | 扬子江药业集团江苏海慈生物药业有限公司 | 枸地氯雷他定的假多晶型及其制备方法 |
CN106588761B (zh) * | 2016-11-22 | 2018-12-14 | 宜昌东阳光药业股份有限公司 | 一种氯雷他定中间体的合成方法 |
CN109608438A (zh) * | 2018-12-05 | 2019-04-12 | 杭州澳医保灵药业有限公司 | 中间体化合物、其制备方法和应用、以及富马酸卢帕他定杂质j的制备方法 |
CN113004245B (zh) * | 2019-12-20 | 2022-04-15 | 南京亿华药业有限公司 | 一种地氯雷他定制备方法 |
CN113880801A (zh) * | 2020-07-03 | 2022-01-04 | 合肥医工医药股份有限公司 | 一类三环化合物、其制备方法及其医药用途 |
CN113880808A (zh) * | 2020-07-03 | 2022-01-04 | 合肥医工医药股份有限公司 | 一类三唑类化合物、制备方法及其医药用途 |
CN115433123B (zh) * | 2022-10-08 | 2024-06-28 | 上海壮铭生物医药有限公司 | 一种氯雷他定中间体的制备方法 |
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CA780443A (en) * | 1968-03-12 | Sandoz Patents Limited | 10 h-(1) benzothiopyrano (3,2-b) pyridine derivatives | |
US3267094A (en) * | 1962-09-12 | 1966-08-16 | Colgate Palmolive Co | Morphanthridine derivatives |
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US4086350A (en) * | 1974-11-06 | 1978-04-25 | Smithkline Corporation | Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms |
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US4021561A (en) * | 1975-12-22 | 1977-05-03 | Merck & Co., Inc. | Trifluoromethylthio- and trifluoromethylsulfonyl-thioxanthen-9-ylidenepiperidines |
DE2704934A1 (de) * | 1976-02-17 | 1977-08-18 | Sandoz Ag | Organische verbindungen, ihre herstellung und verwendung |
US4356184A (en) * | 1980-06-04 | 1982-10-26 | G. D. Searle & Co. | Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines |
US4355036A (en) * | 1980-06-19 | 1982-10-19 | Schering Corporation | Tricyclic-substituted piperidine antihistamines |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
EP0047226B1 (en) * | 1980-09-02 | 1985-05-15 | Sandoz Ag | Piperidylidene derivatives, their production and pharmaceutical compositions containing them |
WO1985003707A1 (en) * | 1984-02-15 | 1985-08-29 | Schering Corporation | 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
US4616023A (en) * | 1984-04-05 | 1986-10-07 | Merck & Co., Inc. | Pharmaceutical compositions of 4-(dibenzo-[a,d]cycloalkenyl)piperazine compounds and methods |
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-
1991
- 1991-06-20 IL IL9857291A patent/IL98572A/en not_active IP Right Cessation
- 1991-06-20 ZA ZA914764A patent/ZA914764B/xx unknown
- 1991-06-20 IE IE212491A patent/IE68935B1/en not_active IP Right Cessation
- 1991-06-20 NZ NZ238629A patent/NZ238629A/xx not_active IP Right Cessation
- 1991-06-21 PL PL91297300A patent/PL173224B1/pl unknown
- 1991-06-21 AU AU82252/91A patent/AU646878B2/en not_active Expired
- 1991-06-21 RU RU9192016540A patent/RU2086549C1/ru active
- 1991-06-21 EP EP91913317A patent/EP0535152B1/en not_active Expired - Lifetime
- 1991-06-21 JP JP3512417A patent/JPH0761998B2/ja not_active Expired - Lifetime
- 1991-06-21 KR KR1019920703292A patent/KR960012368B1/ko not_active IP Right Cessation
- 1991-06-21 ES ES91913317T patent/ES2096657T3/es not_active Expired - Lifetime
- 1991-06-21 US US07/949,810 patent/US5422351A/en not_active Expired - Lifetime
- 1991-06-21 CZ CS923748A patent/CZ284610B6/cs not_active IP Right Cessation
- 1991-06-21 DE DE122008000047C patent/DE122008000047I2/de active Active
- 1991-06-21 DE DE69112061T patent/DE69112061T2/de not_active Expired - Lifetime
- 1991-06-21 CA CA002085878A patent/CA2085878C/en not_active Expired - Lifetime
- 1991-06-21 HU HU9204079A patent/HU220622B1/hu unknown
- 1991-06-21 SK SK3748-92A patent/SK280717B6/sk not_active IP Right Cessation
- 1991-06-21 AT AT91913317T patent/ATE126226T1/de active
- 1991-06-21 WO PCT/US1991/004162 patent/WO1992000293A1/en active IP Right Grant
- 1991-06-21 DK DK91913317.3T patent/DK0535152T3/da active
-
1992
- 1992-12-21 OA OA60320A patent/OA10032A/en unknown
- 1992-12-21 NO NO924955A patent/NO303223B1/no not_active IP Right Cessation
- 1992-12-22 FI FI925820A patent/FI925820A/fi unknown
-
1995
- 1995-10-31 GR GR950403030T patent/GR3017924T3/el unknown
-
1996
- 1996-10-03 HK HK186496A patent/HK186496A/xx not_active IP Right Cessation
-
2009
- 2009-02-25 NL NL300378C patent/NL300378I2/nl unknown
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