FI925820A - Bisbenso- eller bensopyrodcykloheptapiperiden-, piperidyliden och pieratzinfoereningar och -kompositioner - Google Patents

Bisbenso- eller bensopyrodcykloheptapiperiden-, piperidyliden och pieratzinfoereningar och -kompositioner Download PDF

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Publication number
FI925820A
FI925820A FI925820A FI925820A FI925820A FI 925820 A FI925820 A FI 925820A FI 925820 A FI925820 A FI 925820A FI 925820 A FI925820 A FI 925820A FI 925820 A FI925820 A FI 925820A
Authority
FI
Finland
Prior art keywords
och
pieratzinfoereningar
cospositioner
bisbenso
bensopyrodcykloheptapiperiden
Prior art date
Application number
FI925820A
Other languages
English (en)
Other versions
FI925820A0 (fi
Inventor
John J Piwinski
Michael J Green
Jesse Wong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI925820A publication Critical patent/FI925820A/fi
Publication of FI925820A0 publication Critical patent/FI925820A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI925820A 1990-06-22 1992-12-22 Bisbenso- eller bensopyrodcykloheptapiperiden-, piperidyliden och pieratzinfoereningar och -kompositioner FI925820A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54228090A 1990-06-22 1990-06-22
PCT/US1991/004162 WO1992000293A1 (en) 1990-06-22 1991-06-21 Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions

Publications (2)

Publication Number Publication Date
FI925820A true FI925820A (fi) 1992-12-22
FI925820A0 FI925820A0 (fi) 1992-12-22

Family

ID=24163110

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925820A FI925820A0 (fi) 1990-06-22 1992-12-22 Bisbenso- eller bensopyrodcykloheptapiperiden-, piperidyliden och pieratzinfoereningar och -kompositioner

Country Status (26)

Country Link
US (1) US5422351A (fi)
EP (1) EP0535152B1 (fi)
JP (1) JPH0761998B2 (fi)
KR (1) KR960012368B1 (fi)
AT (1) ATE126226T1 (fi)
AU (1) AU646878B2 (fi)
CA (1) CA2085878C (fi)
CZ (1) CZ284610B6 (fi)
DE (2) DE122008000047I2 (fi)
DK (1) DK0535152T3 (fi)
ES (1) ES2096657T3 (fi)
FI (1) FI925820A0 (fi)
GR (1) GR3017924T3 (fi)
HK (1) HK186496A (fi)
HU (1) HU220622B1 (fi)
IE (1) IE68935B1 (fi)
IL (1) IL98572A (fi)
NL (1) NL300378I2 (fi)
NO (1) NO303223B1 (fi)
NZ (1) NZ238629A (fi)
OA (1) OA10032A (fi)
PL (1) PL173224B1 (fi)
RU (1) RU2086549C1 (fi)
SK (1) SK374892A3 (fi)
WO (1) WO1992000293A1 (fi)
ZA (1) ZA914764B (fi)

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* Cited by examiner, † Cited by third party
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CA2093646A1 (en) * 1990-10-10 1992-04-11 Jesse K. Wong Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use
JPH06508129A (ja) * 1991-05-23 1994-09-14 シェリング・コーポレーション 新規のベンゾピリドピペリジリデン化合物、組成物、製造法および使用法
CA2114009A1 (en) * 1991-07-23 1993-02-04 Jesse K. Wong Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
JP2974529B2 (ja) * 1992-02-20 1999-11-10 北陸製薬株式会社 両性型三環系化合物
JPH07504905A (ja) * 1992-03-23 1995-06-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗刺激剤として用いるための薬剤
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
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US6075025A (en) * 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
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US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
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US5965570A (en) * 1996-09-13 1999-10-12 Schering Corporation Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
PL332241A1 (en) * 1996-09-13 1999-08-30 Schering Corp Novel tricyclic piperidinyl compounds useful in inhibiting proteinous farnesil transferase
RU2188197C2 (ru) * 1996-10-04 2002-08-27 Ново Нордиск А/С 1,4-дизамещенные пиперазины, способ их получения, фармацевтическая композиция и способ лечения нейрогенного воспаления
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5958940A (en) * 1997-09-11 1999-09-28 Schering Corporation Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
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CN103619839B (zh) * 2011-06-28 2016-06-01 福建省闽东力捷迅药业有限公司 抗-变态反应的苯并环庚并噻吩衍生物
CN103113348B (zh) * 2013-02-18 2015-03-25 扬子江药业集团江苏海慈生物药业有限公司 枸地氯雷他定的假多晶型及其制备方法
CN106588761B (zh) * 2016-11-22 2018-12-14 宜昌东阳光药业股份有限公司 一种氯雷他定中间体的合成方法
CN109608438A (zh) * 2018-12-05 2019-04-12 杭州澳医保灵药业有限公司 中间体化合物、其制备方法和应用、以及富马酸卢帕他定杂质j的制备方法
CN113004245B (zh) * 2019-12-20 2022-04-15 南京亿华药业有限公司 一种地氯雷他定制备方法
CN113880808A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三唑类化合物、制备方法及其医药用途
CN113880801A (zh) 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途
CN115433123A (zh) * 2022-10-08 2022-12-06 上海壮铭生物医药有限公司 一种氯雷他定中间体的制备方法

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Also Published As

Publication number Publication date
ES2096657T3 (es) 1997-03-16
DK0535152T3 (da) 1995-09-25
CA2085878A1 (en) 1991-12-23
RU2086549C1 (ru) 1997-08-10
CZ374892A3 (en) 1993-10-13
HU220622B1 (hu) 2002-03-28
DE69112061T2 (de) 1995-12-14
IL98572A0 (en) 1992-07-15
SK280717B6 (sk) 2000-06-12
NO924955L (no) 1993-02-22
JPH0761998B2 (ja) 1995-07-05
US5422351A (en) 1995-06-06
OA10032A (en) 1996-10-14
PL297300A1 (fi) 1992-07-13
GR3017924T3 (en) 1996-01-31
HK186496A (en) 1996-10-11
IE68935B1 (en) 1996-07-24
FI925820A0 (fi) 1992-12-22
JPH05507092A (ja) 1993-10-14
NO924955D0 (no) 1992-12-21
NL300378I1 (nl) 2009-05-06
SK374892A3 (en) 2000-06-12
NZ238629A (en) 1993-09-27
DE122008000047I2 (de) 2011-06-16
KR960012368B1 (ko) 1996-09-20
ATE126226T1 (de) 1995-08-15
CA2085878C (en) 2000-06-13
EP0535152B1 (en) 1995-08-09
DE69112061D1 (de) 1995-09-14
HU9204079D0 (en) 1993-03-29
HUT63161A (en) 1993-07-28
EP0535152A1 (en) 1993-04-07
ZA914764B (en) 1992-03-25
NO303223B1 (no) 1998-06-15
AU646878B2 (en) 1994-03-10
PL173224B1 (pl) 1998-02-27
IE912124A1 (en) 1992-01-01
CZ284610B6 (cs) 1999-01-13
WO1992000293A1 (en) 1992-01-09
AU8225291A (en) 1992-01-23
NL300378I2 (nl) 2009-09-01
IL98572A (en) 1995-07-31

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