NO810291L - Fremgangsmaate for isolering av et fast salt av p-hydroksymandelsyre - Google Patents
Fremgangsmaate for isolering av et fast salt av p-hydroksymandelsyreInfo
- Publication number
- NO810291L NO810291L NO810291A NO810291A NO810291L NO 810291 L NO810291 L NO 810291L NO 810291 A NO810291 A NO 810291A NO 810291 A NO810291 A NO 810291A NO 810291 L NO810291 L NO 810291L
- Authority
- NO
- Norway
- Prior art keywords
- salt
- acid
- solution
- stated
- hydroxymandelic acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 239000007787 solid Substances 0.000 title claims abstract description 12
- 239000002253 acid Substances 0.000 title description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 31
- YHXHKYRQLYQUIH-UHFFFAOYSA-N 4-hydroxymandelic acid Chemical compound OC(=O)C(O)C1=CC=C(O)C=C1 YHXHKYRQLYQUIH-UHFFFAOYSA-N 0.000 claims abstract description 28
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 15
- 150000003863 ammonium salts Chemical class 0.000 claims abstract description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims abstract description 4
- 238000002955 isolation Methods 0.000 claims abstract description 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 5
- QUBXPYXFPIZZLZ-UHFFFAOYSA-N azane;2-hydroxy-2-(4-hydroxyphenyl)acetic acid Chemical compound N.OC(=O)C(O)C1=CC=C(O)C=C1 QUBXPYXFPIZZLZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 37
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 18
- 238000002360 preparation method Methods 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000000605 extraction Methods 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical compound CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 description 5
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- LJCWONGJFPCTTL-UHFFFAOYSA-N 4-hydroxyphenylglycine Chemical compound OC(=O)C(N)C1=CC=C(O)C=C1 LJCWONGJFPCTTL-UHFFFAOYSA-N 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000012065 filter cake Substances 0.000 description 3
- -1 substituted-ammonium Chemical class 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 150000003973 alkyl amines Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 150000003946 cyclohexylamines Chemical class 0.000 description 2
- SLFUXNFVAANERW-UHFFFAOYSA-N ethyl hexanoate;potassium Chemical compound [K].CCCCCC(=O)OCC SLFUXNFVAANERW-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- MJWHARDKCQPQSB-UHFFFAOYSA-M potassium;2-hydroxy-2-(4-hydroxyphenyl)acetate Chemical compound [K+].[O-]C(=O)C(O)C1=CC=C(O)C=C1 MJWHARDKCQPQSB-UHFFFAOYSA-M 0.000 description 2
- 238000005185 salting out Methods 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- OIKHYMJKSSAAPR-UHFFFAOYSA-M sodium;2-hydroxy-2-(4-hydroxyphenyl)acetate;hydrate Chemical compound O.[Na+].[O-]C(=O)C(O)C1=CC=C(O)C=C1 OIKHYMJKSSAAPR-UHFFFAOYSA-M 0.000 description 2
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000220304 Prunus dulcis Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LKHYFCSSVZVVNF-UHFFFAOYSA-N ethyl hexanoate;sodium Chemical compound [Na].CCCCCC(=O)OCC LKHYFCSSVZVVNF-UHFFFAOYSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- PIBARHNFHHEUMJ-UHFFFAOYSA-M potassium;2-hydroxy-2-(4-hydroxyphenyl)acetate;hydrate Chemical compound O.[K+].[O-]C(=O)C(O)C1=CC=C(O)C=C1 PIBARHNFHHEUMJ-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- WINGEFIITRDOLJ-UHFFFAOYSA-N tert-butyl 2-hydroxyacetate Chemical compound CC(C)(C)OC(=O)CO WINGEFIITRDOLJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7927829 | 1979-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO810291L true NO810291L (no) | 1981-02-19 |
Family
ID=10507098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO810291A NO810291L (no) | 1979-08-09 | 1981-01-28 | Fremgangsmaate for isolering av et fast salt av p-hydroksymandelsyre |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4368334A (fr) |
| EP (1) | EP0024181B1 (fr) |
| JP (1) | JPS56500964A (fr) |
| AT (1) | ATE3408T1 (fr) |
| DE (1) | DE3063330D1 (fr) |
| HU (1) | HU182707B (fr) |
| NO (1) | NO810291L (fr) |
| WO (1) | WO1981000404A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4504678A (en) * | 1981-07-20 | 1985-03-12 | Societe Francaise Hoechst | Pure crystalline racemic sodium parahydroxymandelate, process for its preparation and uses thereof |
| GB2187744B (en) * | 1986-03-14 | 1990-01-17 | Kureha Chemical Ind Co Ltd | Process for producing 2, 6-naphthalenedicarboxylic acid |
| FR2638740B1 (fr) * | 1988-11-08 | 1991-07-12 | Hoechst France | Nouveau procede de fabrication industrielle du parahydroxymandelate de sodium |
| NL9202248A (nl) * | 1992-12-23 | 1994-07-18 | Univ Delft Tech | Werkwijze voor het scheiden van de ortho- en para-isomeer van hydroxyamandelzuur of een zout daarvan, de volgens deze werkwijze verkregen ortho- en para-isomeer van hydroxyamandelzuur, alsmede de toepassing van de ortho-isomeer in de bereiding van EDDHA. |
| FR2739618B1 (fr) * | 1995-10-04 | 1998-01-02 | Hoechst France | Complexe orthohydroxymandelate de sodium-phenol-eau, procede de preparation et utilisation pour isolement de l'orthohydroxymandelate de sodium |
| KR980009231A (ko) * | 1996-07-31 | 1998-04-30 | 이승웅 | P-히드록시페닐글리신의 제조방법 |
| FR2760745B1 (fr) * | 1997-03-11 | 1999-05-28 | Hoechst France | Procede industriel de preparation en continu de l'orthohydroxymandelate de sodium |
| NL1010090C2 (nl) * | 1998-09-15 | 2000-03-17 | Gerard Kessels Sociedad Anonim | Werkwijze voor de bereiding van 2- en 4-hydroxyamandelzuur. |
| CA2537804A1 (fr) * | 2003-09-05 | 2005-03-17 | Teva Pharmaceutical Industries Ltd | Procede de recyclage pour l'elaboration de sertraline |
| KR20050029016A (ko) * | 2003-09-19 | 2005-03-24 | (주)경인양행 | 벤조디푸라논계 신규 화합물과 그것의 제조방법 및 그것을이용한 섬유의 염색 또는 인쇄 방법 |
| TW200514826A (en) * | 2003-09-19 | 2005-05-01 | Kyung In Synthetic Corp | Alpha-hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered lactone rings fused to central cyclohexa-1, 4-diene nucleus using the same, and uses of the compounds |
| KR100555624B1 (ko) | 2004-08-26 | 2006-03-03 | (주)경인양행 | 알파-히드록시 벤젠아세틱 엑시드 유도체, 그것에 기반한시클로 헥사-1,4-디엔 모체에 2 개의 5환 락톤링을 가진화합물, 및 그것의 용도 |
| CN101417942B (zh) * | 2007-10-26 | 2011-09-21 | 宝山钢铁股份有限公司 | 一种制备对羟基扁桃酸的方法 |
| CN112812003A (zh) * | 2021-01-12 | 2021-05-18 | 湖南复瑞生物医药技术有限责任公司 | 4-羟基扁桃酸的制备方法 |
| CN114736118B (zh) * | 2022-04-26 | 2023-05-09 | 重庆欣欣向荣精细化工有限公司 | 一种3-甲氧基-4-羟基扁桃酸分离及其高纯度产物制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE32558C (de) * | J. N. GALLAND in Paris | Neuerung an Apparaten zur Rektifikation und Destillation von Spiritus und anderen Flüssigkeiten | ||
| DE2040218A1 (de) * | 1970-08-13 | 1972-02-17 | Technochemie Gmbh | Verfahren zur Herstellung von Mandelsaeure |
| US3725437A (en) * | 1970-09-16 | 1973-04-03 | Sankyo Chem Ind Ltd | Process for the preparation of {60 -hydroxy-{62 -phenypropionic acid derivatives and alkalimetal-or ammonium salts thereof |
| DE2115551C3 (de) * | 1971-03-31 | 1980-01-10 | Haarmann & Reimer Gmbh, 3450 Holzminden | Verfahren zur Herstellung von aromatischen Hydroxyaldehyden |
| JPS5224542B2 (fr) * | 1973-12-19 | 1977-07-01 | ||
| DE2960142D1 (en) * | 1978-02-20 | 1981-03-26 | Diamalt Ag | Process for the preparation of 4-hydroxyphenylacetic acid |
| BE867287A (fr) * | 1978-05-19 | 1978-11-20 | Ici Ltd | Sel de metal alcalin de l'acide p-hydroxy-mandelique |
| FR2427322A1 (fr) * | 1979-06-15 | 1979-12-28 | Hoechst France | Parahydroxymandelate de sodium racemique cristallise, son procede de preparation et son application a la preparation du paraformylphenolate de sodium cristallise |
-
1980
- 1980-08-08 WO PCT/GB1980/000126 patent/WO1981000404A1/fr unknown
- 1980-08-08 US US06/233,606 patent/US4368334A/en not_active Expired - Fee Related
- 1980-08-08 EP EP80302741A patent/EP0024181B1/fr not_active Expired
- 1980-08-08 JP JP50171780A patent/JPS56500964A/ja active Pending
- 1980-08-08 HU HU811239A patent/HU182707B/hu unknown
- 1980-08-08 AT AT80302741T patent/ATE3408T1/de not_active IP Right Cessation
- 1980-08-08 DE DE8080302741T patent/DE3063330D1/de not_active Expired
-
1981
- 1981-01-28 NO NO810291A patent/NO810291L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3063330D1 (en) | 1983-07-07 |
| EP0024181B1 (fr) | 1983-05-18 |
| EP0024181A1 (fr) | 1981-02-25 |
| ATE3408T1 (de) | 1983-06-15 |
| HU182707B (en) | 1984-03-28 |
| US4368334A (en) | 1983-01-11 |
| JPS56500964A (fr) | 1981-07-16 |
| WO1981000404A1 (fr) | 1981-02-19 |
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