NO780799L - Fremgangsmaate til fremstilling av et fast steroid-preparat - Google Patents
Fremgangsmaate til fremstilling av et fast steroid-preparatInfo
- Publication number
- NO780799L NO780799L NO780799A NO780799A NO780799L NO 780799 L NO780799 L NO 780799L NO 780799 A NO780799 A NO 780799A NO 780799 A NO780799 A NO 780799A NO 780799 L NO780799 L NO 780799L
- Authority
- NO
- Norway
- Prior art keywords
- steroid
- preparation
- parts
- conventional excipients
- weight
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title claims description 25
- 238000002360 preparation method Methods 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 12
- 239000007787 solid Substances 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 15
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 13
- 239000008109 sodium starch glycolate Substances 0.000 claims description 13
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 9
- 229940032147 starch Drugs 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- -1 oxo-5a -androstane-2-carbonitrile Chemical compound 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 235000012239 silicon dioxide Nutrition 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LKAJKIOFIWVMDJ-IYRCEVNGSA-N Stanazolol Chemical compound C([C@@H]1CC[C@H]2[C@@H]3CC[C@@]([C@]3(CC[C@@H]2[C@@]1(C)C1)C)(O)C)C2=C1C=NN2 LKAJKIOFIWVMDJ-IYRCEVNGSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 239000003263 anabolic agent Substances 0.000 description 1
- 229940124325 anabolic agent Drugs 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- POZRVZJJTULAOH-LHZXLZLDSA-N danazol Chemical compound C1[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=CC2=C1C=NO2 POZRVZJJTULAOH-LHZXLZLDSA-N 0.000 description 1
- 229960000766 danazol Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 description 1
- 229960000445 ethisterone Drugs 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229960000912 stanozolol Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/777,317 US4115563A (en) | 1977-03-14 | 1977-03-14 | Pharmaceutical steroid formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO780799L true NO780799L (no) | 1978-09-15 |
Family
ID=25109919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO780799A NO780799L (no) | 1977-03-14 | 1978-03-08 | Fremgangsmaate til fremstilling av et fast steroid-preparat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4115563A (de) |
| JP (1) | JPS53115811A (de) |
| AT (1) | AT361633B (de) |
| AU (1) | AU3364978A (de) |
| BE (1) | BE864666A (de) |
| CA (1) | CA1082598A (de) |
| DE (1) | DE2810297A1 (de) |
| DK (1) | DK102978A (de) |
| FI (1) | FI780725A (de) |
| FR (1) | FR2383664A1 (de) |
| GB (1) | GB1578850A (de) |
| IL (1) | IL54073A0 (de) |
| IN (1) | IN148150B (de) |
| IT (1) | IT1094181B (de) |
| LU (1) | LU79203A1 (de) |
| NL (1) | NL7802525A (de) |
| NO (1) | NO780799L (de) |
| PT (1) | PT67748A (de) |
| SE (1) | SE7802724L (de) |
| ZA (1) | ZA78969B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2804048B2 (ja) * | 1987-09-11 | 1998-09-24 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | 高薬物含量医薬組成物およびその製造法 |
| JP2590358B2 (ja) * | 1988-03-01 | 1997-03-12 | 正雄 五十嵐 | 子宮内膜症治療用の子宮内又は膣内投与製剤 |
| GB2292079B (en) * | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| PT1037812E (pt) * | 1997-12-12 | 2003-11-28 | Akzo Nobel Nv | Embalagem para um anel vaginal |
| FR2772617B1 (fr) * | 1997-12-19 | 2001-03-09 | Besins Iscovesco Lab | Comprime de progesterone et son procede de preparation |
| US7491263B2 (en) | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| WO2012120365A1 (en) | 2011-03-07 | 2012-09-13 | Aurobindo Pharma Limited | Stable pharmaceutical composition comprising ethinyl estradiol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135743A (en) * | 1960-06-29 | 1964-06-02 | Sterling Drug Inc | Steroido[2. 3-d]isoxazoles and preparation thereof |
| NL100550C (de) * | 1959-02-16 | |||
| US3296255A (en) * | 1963-11-29 | 1967-01-03 | Sterling Drug Inc | 2-cyano steroids |
| DE1228029C2 (de) * | 1964-05-09 | 1973-05-17 | Merck Ag E | Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation |
| DE2251250C3 (de) * | 1972-10-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten |
| DE2259646C2 (de) * | 1972-12-06 | 1984-11-22 | Hoechst Ag, 6230 Frankfurt | Hochdosierte Tabletten von Cephalosporin-Derivaten sowie Verfahren zu ihrer Herstellung |
| CA1043259A (en) * | 1972-12-08 | 1978-11-28 | Geoffrey F. Thompson | Medicament preparations and vehicles therefor |
| GB1460302A (en) * | 1973-05-23 | 1977-01-06 | Wellcome Found | Tablet formulation |
| GB1499672A (en) * | 1974-02-14 | 1978-02-01 | Wellcome Found | Tablet formulation |
-
1977
- 1977-03-14 US US05/777,317 patent/US4115563A/en not_active Expired - Lifetime
- 1977-04-27 GB GB17610/77A patent/GB1578850A/en not_active Expired
-
1978
- 1978-02-17 IL IL54073A patent/IL54073A0/xx unknown
- 1978-02-20 ZA ZA00780969A patent/ZA78969B/xx unknown
- 1978-02-21 IN IN141/DEL/78A patent/IN148150B/en unknown
- 1978-02-27 AU AU33649/78A patent/AU3364978A/en active Pending
- 1978-03-01 AT AT145978A patent/AT361633B/de not_active IP Right Cessation
- 1978-03-06 FI FI780725A patent/FI780725A/fi not_active Application Discontinuation
- 1978-03-07 IT IT20975/78A patent/IT1094181B/it active
- 1978-03-07 PT PT67748A patent/PT67748A/pt unknown
- 1978-03-08 NL NL7802525A patent/NL7802525A/xx not_active Application Discontinuation
- 1978-03-08 BE BE1008753A patent/BE864666A/xx unknown
- 1978-03-08 DK DK102978A patent/DK102978A/da not_active Application Discontinuation
- 1978-03-08 NO NO780799A patent/NO780799L/no unknown
- 1978-03-09 CA CA298,624A patent/CA1082598A/en not_active Expired
- 1978-03-09 DE DE19782810297 patent/DE2810297A1/de not_active Withdrawn
- 1978-03-09 LU LU79203A patent/LU79203A1/xx unknown
- 1978-03-09 SE SE7802724A patent/SE7802724L/xx unknown
- 1978-03-09 JP JP2712778A patent/JPS53115811A/ja active Pending
- 1978-03-09 FR FR7806867A patent/FR2383664A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2810297A1 (de) | 1978-09-21 |
| US4115563A (en) | 1978-09-19 |
| IT1094181B (it) | 1985-07-26 |
| PT67748A (en) | 1978-04-01 |
| IN148150B (de) | 1980-11-08 |
| AT361633B (de) | 1981-03-25 |
| CA1082598A (en) | 1980-07-29 |
| GB1578850A (en) | 1980-11-12 |
| FR2383664A1 (fr) | 1978-10-13 |
| DK102978A (da) | 1978-09-15 |
| BE864666A (fr) | 1978-09-08 |
| ATA145978A (de) | 1980-08-15 |
| SE7802724L (sv) | 1978-09-15 |
| NL7802525A (nl) | 1978-09-18 |
| LU79203A1 (fr) | 1978-11-27 |
| FI780725A (fi) | 1978-09-15 |
| AU3364978A (en) | 1979-09-06 |
| IT7820975A0 (it) | 1978-03-07 |
| JPS53115811A (en) | 1978-10-09 |
| IL54073A0 (en) | 1978-04-30 |
| ZA78969B (en) | 1979-01-31 |
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