GB1499672A - Tablet formulation - Google Patents

Tablet formulation

Info

Publication number
GB1499672A
GB1499672A GB6758/74A GB675874A GB1499672A GB 1499672 A GB1499672 A GB 1499672A GB 6758/74 A GB6758/74 A GB 6758/74A GB 675874 A GB675874 A GB 675874A GB 1499672 A GB1499672 A GB 1499672A
Authority
GB
United Kingdom
Prior art keywords
potentiator
mixture
weight
meaning given
tablet formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6758/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9820242&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1499672(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB6758/74A priority Critical patent/GB1499672A/en
Priority to JP1838875A priority patent/JPS5545043B2/ja
Priority to SE7501595A priority patent/SE427898B/en
Priority to ES434688A priority patent/ES434688A1/en
Priority to CS75927A priority patent/CS220306B2/en
Priority to AU78170/75A priority patent/AU468465B2/en
Priority to IN270/CAL/75A priority patent/IN141019B/en
Priority to AT108475A priority patent/AT344915B/en
Priority to CH174775A priority patent/CH618432A5/en
Priority to CY1052A priority patent/CY1052A/en
Priority to CA219,982A priority patent/CA980688A/en
Priority to ZM18/75A priority patent/ZM1875A1/en
Priority to FR7504470A priority patent/FR2260993B1/fr
Priority to MC751136A priority patent/MC1053A1/en
Priority to BE153330A priority patent/BE825496A/en
Priority to FI750398A priority patent/FI62219C/en
Priority to ZA00750930A priority patent/ZA75930B/en
Priority to IE278/75A priority patent/IE40599B1/en
Priority to IL46629A priority patent/IL46629A/en
Priority to NL7501680.A priority patent/NL157501C/en
Priority to HU75WE00000519A priority patent/HU171536B/en
Priority to DE2506099A priority patent/DE2506099C2/en
Priority to DK52875A priority patent/DK143247C/en
Priority to PH16805A priority patent/PH14575A/en
Priority to DD184168A priority patent/DD118228A5/xx
Priority to NO750467A priority patent/NO146043C/en
Priority to LU71835A priority patent/LU71835A1/xx
Priority to ZM2976A priority patent/ZM2976A1/en
Priority to MC1136K priority patent/MC181A7/en
Publication of GB1499672A publication Critical patent/GB1499672A/en
Priority to US05/896,297 priority patent/US4209513A/en
Priority to DO1979002763A priority patent/DOP1979002763A/en
Priority to GT197960431A priority patent/GT197960431A/en
Priority to KE3038A priority patent/KE3038A/en
Priority to HK239/80A priority patent/HK23980A/en
Priority to MY54/81A priority patent/MY8100054A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Abstract

2,4-Diamino-5-benzylpyrimidines of the accompanying formula I, in which R<1>, R<2> and R<3> have the meaning given in the Patent Claim, which are contained as a potentiator for sulphonamides in tablets in which a mixture of sulphonamide and potentiator is present in an amount of 80 to 95% by weight, the mixture having a particle size of less than 40 mu m, and which additionally contain a granulating agent and a disintegrating agent which has a swelling capacity of more than 5 ml/g, the total amount of the two agents being not more than 20% by weight, are prepared by reacting a compound of the accompanying formula II, in which X, Y and Z have the meaning given in the Patent Claim, with guanidine and purifying and isolating the process product. <IMAGE>
GB6758/74A 1974-02-14 1974-02-14 Tablet formulation Expired GB1499672A (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB6758/74A GB1499672A (en) 1974-02-14 1974-02-14 Tablet formulation
LU71835A LU71835A1 (en) 1974-02-14 1975-02-13
ZA00750930A ZA75930B (en) 1974-02-14 1975-02-13 Tablet formulation
NL7501680.A NL157501C (en) 1974-02-14 1975-02-13 PHARMACEUTICAL TABLET CONTAINING A COMBINATION OF A 2,4-DIAMINO-5-BENZYL-PYRIMIDINE DERIVATIVE WITH A SULFONAMIDE, BOTH MICRONIZED, IN ADDITION TO AT LEAST A SPLIT AND A GRANULATOR, AT THE SAME TIME, AT THE SAME TIME.
IE278/75A IE40599B1 (en) 1974-02-14 1975-02-13 Tablet formulation
SE7501595A SE427898B (en) 1974-02-14 1975-02-13 SET TO PREPARE TABLES WITH SHORT SUBDIVISION TIME INCLUDING 2,4-DIAMINO-5- (3,4,5-TRIMETOXYBENZYL) PYRIMIDINE AND 3- (4-AMINOBENZENSULPHONAMIDO) -5-METHYLISOXAZOLE
AU78170/75A AU468465B2 (en) 1974-02-14 1975-02-13 Tablet formulation
IN270/CAL/75A IN141019B (en) 1974-02-14 1975-02-13
AT108475A AT344915B (en) 1974-02-14 1975-02-13 METHOD FOR PRODUCING TABLETS
CH174775A CH618432A5 (en) 1974-02-14 1975-02-13 Process for the preparation of a 2,4-diamino-5-benzylpyrimidine intended for the production of tablets
CY1052A CY1052A (en) 1974-02-14 1975-02-13 Tablet formulation
CA219,982A CA980688A (en) 1974-02-14 1975-02-13 Tablet formulation
ZM18/75A ZM1875A1 (en) 1974-02-14 1975-02-13 Tablet formulation
FR7504470A FR2260993B1 (en) 1974-02-14 1975-02-13
MC751136A MC1053A1 (en) 1974-02-14 1975-02-13 MEDICINAL PRODUCT CONTAINING A 2,4-DIAMINO-PYRIMIDINE ER A SULFONAMIDE T A SULFONAMIDE
BE153330A BE825496A (en) 1974-02-14 1975-02-13 TABLETS CONTAINING A COMBINATION OF 2,4-DIAMINOPYRIMIDINE WITH SULFONAMIDE
FI750398A FI62219C (en) 1974-02-14 1975-02-13 FOER FARING FOER FRAMSTAELLNING AV SNABBT SOENDERFALLANDE TABLETTER
JP1838875A JPS5545043B2 (en) 1974-02-14 1975-02-13
ES434688A ES434688A1 (en) 1974-02-14 1975-02-13 Tablet formulation
CS75927A CS220306B2 (en) 1974-02-14 1975-02-13 Method of manufacturing tablets having short breakdown period
IL46629A IL46629A (en) 1974-02-14 1975-02-13 Tablets comprising a 2,4-diaminopyrimidine and a sulphonamide
HU75WE00000519A HU171536B (en) 1974-02-14 1975-02-13 Process for producing tablets, containing sulfonamide and diaminopyrimidine
DE2506099A DE2506099C2 (en) 1974-02-14 1975-02-13 Tablet containing sulfonamide and trimethoprim
DK52875A DK143247C (en) 1974-02-14 1975-02-13 MEDICAL TABLET CONTAINING AS ACTIVE INGREDIENT A 2,4-DIAMINO-5-BENZYLPYRIMIDINE WITH A SULPHONAMIDE
PH16805A PH14575A (en) 1974-02-14 1975-02-13 An improved tablet formulation
DD184168A DD118228A5 (en) 1974-02-14 1975-02-13
NO750467A NO146043C (en) 1974-02-14 1975-02-13 PROCEDURE FOR THE PREPARATION OF TABLETS WITH SHORT DECOMPOSITION TIME
ZM2976A ZM2976A1 (en) 1974-02-14 1976-03-10 Tablet formulation
MC1136K MC181A7 (en) 1974-02-14 1976-04-09 MEDICINAL PRODUCT CONTAINING A 2,4-DIAMINO-PYRIMIDINE E
US05/896,297 US4209513A (en) 1974-02-14 1978-04-14 Tablet formulation
DO1979002763A DOP1979002763A (en) 1974-02-14 1979-05-14 A METHOD FOR PREPARING A TABLET OF A PHARMACEUTICAL FORMULATION
GT197960431A GT197960431A (en) 1974-02-14 1979-11-12 FORMULATION OF BASE TABLETS OF 2,4-DIAMINO-5-BENCILPIRI-MIDINA AND A SULFONAMIDE SUITABLE FOR ORAL ADMINISTRATION.
KE3038A KE3038A (en) 1974-02-14 1980-03-28 Tablet formulation
HK239/80A HK23980A (en) 1974-02-14 1980-05-01 Tablet formulation
MY54/81A MY8100054A (en) 1974-02-14 1981-12-30 Tablet formulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6758/74A GB1499672A (en) 1974-02-14 1974-02-14 Tablet formulation

Publications (1)

Publication Number Publication Date
GB1499672A true GB1499672A (en) 1978-02-01

Family

ID=9820242

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6758/74A Expired GB1499672A (en) 1974-02-14 1974-02-14 Tablet formulation

Country Status (32)

Country Link
JP (1) JPS5545043B2 (en)
AT (1) AT344915B (en)
AU (1) AU468465B2 (en)
BE (1) BE825496A (en)
CA (1) CA980688A (en)
CH (1) CH618432A5 (en)
CS (1) CS220306B2 (en)
CY (1) CY1052A (en)
DD (1) DD118228A5 (en)
DE (1) DE2506099C2 (en)
DK (1) DK143247C (en)
DO (1) DOP1979002763A (en)
ES (1) ES434688A1 (en)
FI (1) FI62219C (en)
FR (1) FR2260993B1 (en)
GB (1) GB1499672A (en)
GT (1) GT197960431A (en)
HK (1) HK23980A (en)
HU (1) HU171536B (en)
IE (1) IE40599B1 (en)
IL (1) IL46629A (en)
IN (1) IN141019B (en)
KE (1) KE3038A (en)
LU (1) LU71835A1 (en)
MC (1) MC1053A1 (en)
MY (1) MY8100054A (en)
NL (1) NL157501C (en)
NO (1) NO146043C (en)
PH (1) PH14575A (en)
SE (1) SE427898B (en)
ZA (1) ZA75930B (en)
ZM (1) ZM1875A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434152A (en) 1981-04-28 1984-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Time-release
US5190760A (en) * 1989-07-08 1993-03-02 Coopers Animal Health Limited Solid pharmaceutical composition

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1533243A (en) * 1975-02-13 1978-11-22 Wellcome Found Tablet formulation
US4115563A (en) * 1977-03-14 1978-09-19 Sterling Drug Inc. Pharmaceutical steroid formulation
GB1601833A (en) * 1978-02-06 1981-11-04 Wellcome Found Antacid formulation
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
GB8915716D0 (en) * 1989-07-08 1989-08-31 Coopers Animal Health Pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1445983A (en) * 1972-11-06 1976-08-11 Wellcome Found Pharmaceutical formulations

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434152A (en) 1981-04-28 1984-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Time-release
US5190760A (en) * 1989-07-08 1993-03-02 Coopers Animal Health Limited Solid pharmaceutical composition

Also Published As

Publication number Publication date
BE825496A (en) 1975-05-29
JPS5545043B2 (en) 1980-11-15
SE427898B (en) 1983-05-24
FR2260993B1 (en) 1978-06-30
AU468465B2 (en) 1976-01-15
ATA108475A (en) 1977-12-15
SE7501595L (en) 1975-08-15
NL157501B (en) 1978-08-15
MC1053A1 (en) 1976-02-20
JPS50116627A (en) 1975-09-12
HU171536B (en) 1978-01-28
IE40599L (en) 1975-08-14
HK23980A (en) 1980-05-09
GT197960431A (en) 1981-05-05
IL46629A0 (en) 1975-05-22
CH618432A5 (en) 1980-07-31
PH14575A (en) 1981-09-24
FR2260993A1 (en) 1975-09-12
FI62219C (en) 1982-12-10
NL7501680A (en) 1975-08-18
DOP1979002763A (en) 1987-06-18
DE2506099C2 (en) 1983-11-03
KE3038A (en) 1980-04-25
NO750467L (en) 1975-08-15
IL46629A (en) 1977-07-31
AT344915B (en) 1978-08-25
NO146043B (en) 1982-04-13
ZM1875A1 (en) 1975-12-22
DD118228A5 (en) 1976-02-20
DK52875A (en) 1975-10-06
NO146043C (en) 1982-08-04
FI750398A (en) 1975-08-15
IE40599B1 (en) 1979-07-04
ES434688A1 (en) 1977-04-01
FI62219B (en) 1982-08-31
DK143247B (en) 1981-08-03
CY1052A (en) 1980-08-01
CS220306B2 (en) 1983-03-25
IN141019B (en) 1977-01-08
LU71835A1 (en) 1975-06-24
NL157501C (en) 1981-07-16
MY8100054A (en) 1981-12-31
DE2506099A1 (en) 1975-08-21
ZA75930B (en) 1976-01-28
CA980688A (en) 1975-12-30
DK143247C (en) 1981-11-30
AU7817075A (en) 1976-01-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19950212