NO339195B1 - Stilbenderivater og deres anvendelse til binding og avbilding av amyloide plakk, fremgangsmåte for fremstilling av derivatene, farmasøytiske og diagnostiske preparater derav, og deres anvendelse ved hemming av amyloidplakkaggregering hos pattedyr. - Google Patents
Stilbenderivater og deres anvendelse til binding og avbilding av amyloide plakk, fremgangsmåte for fremstilling av derivatene, farmasøytiske og diagnostiske preparater derav, og deres anvendelse ved hemming av amyloidplakkaggregering hos pattedyr. Download PDFInfo
- Publication number
- NO339195B1 NO339195B1 NO20073650A NO20073650A NO339195B1 NO 339195 B1 NO339195 B1 NO 339195B1 NO 20073650 A NO20073650 A NO 20073650A NO 20073650 A NO20073650 A NO 20073650A NO 339195 B1 NO339195 B1 NO 339195B1
- Authority
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- Norway
- Prior art keywords
- ethoxy
- compound
- mmol
- phenyl
- alkyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/02—Monocyclic hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
- A61K31/115—Formaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63669604P | 2004-12-17 | 2004-12-17 | |
| US68639505P | 2005-06-02 | 2005-06-02 | |
| PCT/US2005/045682 WO2006066104A2 (en) | 2004-12-17 | 2005-12-19 | Stilbene derivatives and their use for binding and imaging amyloid plaques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20073650L NO20073650L (no) | 2007-09-14 |
| NO339195B1 true NO339195B1 (no) | 2016-11-14 |
Family
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Family Applications (1)
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| NO20073650A NO339195B1 (no) | 2004-12-17 | 2007-07-16 | Stilbenderivater og deres anvendelse til binding og avbilding av amyloide plakk, fremgangsmåte for fremstilling av derivatene, farmasøytiske og diagnostiske preparater derav, og deres anvendelse ved hemming av amyloidplakkaggregering hos pattedyr. |
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| EP (3) | EP2213652B1 (forum.php) |
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| NO (1) | NO339195B1 (forum.php) |
| NZ (1) | NZ555942A (forum.php) |
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| SI (1) | SI2213652T1 (forum.php) |
| WO (1) | WO2006066104A2 (forum.php) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100947913B1 (ko) * | 2001-08-27 | 2010-03-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 스틸벤 유도체 및 이것을 아밀로이드 플라크의 결합 및영상화에 사용하는 용도 |
| CA2591534C (en) * | 2004-12-17 | 2013-08-06 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| WO2006078384A2 (en) * | 2004-12-17 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use |
| WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
| PT2363392T (pt) | 2006-03-30 | 2017-06-15 | Univ Pennsylvania | Derivados de estirilpiridina e sua utilização para ligação e obtenção de imagens de placas amilóides |
| US20080253967A1 (en) * | 2007-04-13 | 2008-10-16 | Kung Hank F | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques |
| WO2009001046A2 (en) * | 2007-06-22 | 2008-12-31 | The University Court Of The University Of Aberdeen | [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use |
| EP2172444A4 (en) * | 2007-07-04 | 2010-12-22 | Univ Tohoku | PET PROBE WITH FLUORO-SUBSTITUTED ALKOXY GROUP AND HYDROXYGRUPPE |
| EP2205072B1 (en) * | 2007-10-15 | 2013-11-20 | The Salk Institute for Biological Studies | Methods for treating a variety of diseases and conditions, and compounds useful therefor |
| LT2247558T (lt) * | 2008-02-14 | 2022-04-11 | Eli Lilly And Company | Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| JP2011514343A (ja) * | 2008-02-27 | 2011-05-06 | アビッド レディオファーマシューティカルズ、インク． | 放射線標識ａ−ベータ結合化合物を用いたアミロイドプラークのガンマプローブ検出 |
| US8557222B2 (en) | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
| WO2010056900A1 (en) * | 2008-11-13 | 2010-05-20 | Avid Radiopharmaceuticals, Inc. | Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases |
| KR20110106895A (ko) * | 2008-12-22 | 2011-09-29 | 바이엘 파마 악티엔게젤샤프트 | 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법 |
| CN102271716B (zh) * | 2008-12-31 | 2014-11-19 | 阿维德放射性药品公司 | 由甲苯磺酸酯前体合成18f-放射性标记的苯乙烯基吡啶及其稳定的药物组合物 |
| CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
| CN102471177A (zh) * | 2009-07-10 | 2012-05-23 | 拜耳医药股份有限公司 | 低至中压液相色谱在放射性示踪剂纯化中的应用 |
| UY33152A (es) | 2009-12-23 | 2011-07-29 | Bayer Schering Pharma Ag | Formulaciones adecuadas para el diagnostico por imagenes con pet |
| BR112012030946A2 (pt) * | 2010-06-04 | 2016-11-01 | Piramal Imaging Sa | método para a produção de ligante para amiloide beta marcado com f-18 |
| TWI504414B (zh) | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產Ｆ－１８標記之Ａβ配位體之方法 |
| JP2013527211A (ja) | 2010-06-04 | 2013-06-27 | ピラマル イメージング ソシエテ アノニム | Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法 |
| MX345069B (es) * | 2010-06-04 | 2017-01-16 | Piramal Imaging Sa | Método para la producción de ligandos beta amiloide marcados con 18f. |
| EP3263136A1 (en) * | 2010-10-12 | 2018-01-03 | Mayo Foundation for Medical Education and Research | Imaging of meningiomas using stilbene, or biphenylalkyne derivatives |
| WO2012145169A2 (en) | 2011-04-21 | 2012-10-26 | The Regents Of The University Of California | Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles |
| ES2683818T3 (es) * | 2011-06-21 | 2018-09-28 | Piramal Imaging Sa | Formulaciones de estilbeno fluorado aceptables para la formación de imágenes mediante PET |
| KR101291037B1 (ko) * | 2011-10-12 | 2013-08-01 | 사회복지법인 삼성생명공익재단 | 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도 |
| RU2477726C1 (ru) * | 2011-10-18 | 2013-03-20 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение |
| WO2013057199A1 (en) | 2011-10-19 | 2013-04-25 | Piramal Imaging Sa | IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS |
| CN109125745B (zh) | 2012-04-10 | 2022-07-26 | 蓝瑟斯医学影像公司 | 放射性药物合成方法 |
| US9180212B2 (en) * | 2012-05-22 | 2015-11-10 | The Regents Of The University Of California | β-amyloid plaque imaging agents |
| CU20130027A7 (es) | 2013-02-28 | 2014-10-30 | Ct De Neurociencias De Cuba | Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales |
| JP6041751B2 (ja) * | 2013-05-07 | 2016-12-14 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
| JP2014218454A (ja) * | 2013-05-07 | 2014-11-20 | 日本メジフィジックス株式会社 | スチリルピリジン誘導体化合物 |
| KR101891404B1 (ko) * | 2015-12-18 | 2018-08-24 | 주식회사 엘지화학 | 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법 |
| US10675365B2 (en) | 2016-09-29 | 2020-06-09 | Korea Atomic Energy Research Institute | Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
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| WO2003018070A1 (en) * | 2001-08-27 | 2003-03-06 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
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| US4500507A (en) * | 1981-10-30 | 1985-02-19 | Wong Dennis W | Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation |
| JPS60247244A (ja) * | 1984-05-22 | 1985-12-06 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| DD231432A1 (de) * | 1984-11-01 | 1985-12-24 | Univ Leipzig | Material zur silberfreien bildaufzeichnung |
| DD234666A1 (de) | 1984-11-01 | 1986-04-09 | Univ Leipzig | Verfahren zur herstellung von einfachen und substituierten 4-dimethylamino-alpha-halogenstilbenen |
| JPH06329566A (ja) | 1993-05-21 | 1994-11-29 | Asahi Glass Co Ltd | ジフルオロスチルベン誘導体化合物およびそれを含有する液晶組成物 |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5601801A (en) | 1994-08-02 | 1997-02-11 | Merck Frosst Canada, Inc. | Radiolabelled angiotensin converting enzyme inhibitors |
| US5521213A (en) * | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| JP4022951B2 (ja) | 1997-08-06 | 2007-12-19 | 大日本インキ化学工業株式会社 | ジフルオロスチルベン誘導体の製造方法 |
| WO2001084937A1 (en) * | 2000-05-08 | 2001-11-15 | Novozymes A/S | Oxidoreductase mediated antimicrobial activity |
| KR100789847B1 (ko) * | 2004-12-15 | 2007-12-28 | (주)퓨쳐켐 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
| CA2591534C (en) * | 2004-12-17 | 2013-08-06 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| WO2006078384A2 (en) | 2004-12-17 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use |
| WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
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- 2015-02-02 LT LTPA2015005C patent/LTC2213652I2/lt unknown
- 2015-02-04 LU LU92647C patent/LU92647I2/xx unknown
- 2015-02-11 FR FR15C0012C patent/FR15C0012I2/fr active Active
- 2015-02-12 NL NL300719C patent/NL300719I1/nl unknown
- 2015-03-10 BE BE2015C015C patent/BE2015C015I2/nl unknown
- 2015-03-18 HU HUS1500014C patent/HUS1500014I1/hu unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003018070A1 (en) * | 2001-08-27 | 2003-03-06 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
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