NO332976B1 - Kinazolinderivater samt farmasoytisk preparat - Google Patents
Kinazolinderivater samt farmasoytisk preparatInfo
- Publication number
- NO332976B1 NO332976B1 NO20083980A NO20083980A NO332976B1 NO 332976 B1 NO332976 B1 NO 332976B1 NO 20083980 A NO20083980 A NO 20083980A NO 20083980 A NO20083980 A NO 20083980A NO 332976 B1 NO332976 B1 NO 332976B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- salt
- hydrate
- dimethoxy
- methylaminoquinazolin
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 205
- 150000003839 salts Chemical class 0.000 claims abstract description 78
- 208000003251 Pruritus Diseases 0.000 claims abstract description 27
- 230000007803 itching Effects 0.000 claims abstract description 24
- 208000012657 Atopic disease Diseases 0.000 claims abstract description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
- -1 methoxy, ethoxy, 1-propoxy, 2-propoxy, methoxyethoxy, amino, methylamino, dimethylamino, ethylamino Chemical group 0.000 claims description 71
- UKFCRQFQEAFNRG-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-methylbenzoic acid Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(O)=O)C(C)=C1 UKFCRQFQEAFNRG-UHFFFAOYSA-N 0.000 claims description 27
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 15
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 150000003431 steroids Chemical class 0.000 claims description 10
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 9
- 230000001387 anti-histamine Effects 0.000 claims description 9
- 239000000739 antihistaminic agent Substances 0.000 claims description 9
- CAWVDRBRXMORSF-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-ethylbenzoic acid Chemical compound C1=C(C(O)=O)C(CC)=CC(C(=O)NC=2C=C(C=CC=2)C=2C3=CC(OC)=C(OC)C=C3N=C(NC)N=2)=C1 CAWVDRBRXMORSF-UHFFFAOYSA-N 0.000 claims description 7
- ZZQXDZSMUGHTJA-UHFFFAOYSA-N 4-n-[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]-1-n-methylbenzene-1,4-dicarboxamide Chemical compound C1=CC(C(=O)NC)=CC=C1C(=O)NC1=CC=CC(C=2C3=CC(OC)=C(OC)C=C3N=C(NC)N=2)=C1 ZZQXDZSMUGHTJA-UHFFFAOYSA-N 0.000 claims description 7
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 7
- 201000008937 atopic dermatitis Diseases 0.000 claims description 7
- DKNYHLGWEWIHOZ-UHFFFAOYSA-N 2-methoxyethyl 3-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=CC(C(=O)OCCOC)=C1 DKNYHLGWEWIHOZ-UHFFFAOYSA-N 0.000 claims description 4
- DUJAVOVVXUJZES-UHFFFAOYSA-N 2-methoxyethyl 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]benzoate Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(=O)OCCOC)C=C1 DUJAVOVVXUJZES-UHFFFAOYSA-N 0.000 claims description 4
- XSVFNAFRARDFGN-UHFFFAOYSA-N 4-[[3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl]carbamoyl]-2-propan-2-ylbenzoic acid Chemical compound C=12C=C(OC)C(OC)=CC2=NC(NC)=NC=1C(C=1)=CC=CC=1NC(=O)C1=CC=C(C(O)=O)C(C(C)C)=C1 XSVFNAFRARDFGN-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract description 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract description 4
- 125000003277 amino group Chemical group 0.000 abstract 1
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- 239000000203 mixture Substances 0.000 description 44
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- 239000013078 crystal Substances 0.000 description 38
- 238000000034 method Methods 0.000 description 37
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- 239000002904 solvent Substances 0.000 description 31
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- 238000006243 chemical reaction Methods 0.000 description 29
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- 239000002997 ophthalmic solution Substances 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- VUYVXCJTTQJVKJ-UHFFFAOYSA-L palladium(2+);tricyclohexylphosphane;dichloride Chemical compound Cl[Pd]Cl.C1CCCCC1P(C1CCCCC1)C1CCCCC1.C1CCCCC1P(C1CCCCC1)C1CCCCC1 VUYVXCJTTQJVKJ-UHFFFAOYSA-L 0.000 description 1
- OTYPIDNRISCWQY-UHFFFAOYSA-L palladium(2+);tris(2-methylphenyl)phosphane;dichloride Chemical compound Cl[Pd]Cl.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C OTYPIDNRISCWQY-UHFFFAOYSA-L 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- MXQOYLRVSVOCQT-UHFFFAOYSA-N palladium;tritert-butylphosphane Chemical compound [Pd].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C MXQOYLRVSVOCQT-UHFFFAOYSA-N 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000000384 rearing effect Effects 0.000 description 1
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- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- WXAZIUYTQHYBFW-UHFFFAOYSA-N tris(4-methylphenyl)phosphane Chemical compound C1=CC(C)=CC=C1P(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 WXAZIUYTQHYBFW-UHFFFAOYSA-N 0.000 description 1
- DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77462006P | 2006-02-21 | 2006-02-21 | |
| JP2006043273 | 2006-02-21 | ||
| PCT/JP2007/053066 WO2007097317A1 (ja) | 2006-02-21 | 2007-02-20 | ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20083980L NO20083980L (no) | 2008-11-20 |
| NO332976B1 true NO332976B1 (no) | 2013-02-11 |
Family
ID=41429386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083980A NO332976B1 (no) | 2006-02-21 | 2008-09-18 | Kinazolinderivater samt farmasoytisk preparat |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7939540B2 (es) |
| EP (1) | EP1992622B1 (es) |
| CN (1) | CN101389612B (es) |
| AU (1) | AU2007218725B2 (es) |
| CA (1) | CA2637573C (es) |
| MX (1) | MX2008010774A (es) |
| NO (1) | NO332976B1 (es) |
| PL (1) | PL1992622T3 (es) |
| SA (1) | SA07280059B1 (es) |
| WO (1) | WO2007097317A1 (es) |
| ZA (1) | ZA200805756B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007218725B2 (en) | 2006-02-21 | 2011-12-01 | Eisai R & D Management Co., Ltd. | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative |
| WO2008099887A1 (ja) | 2007-02-16 | 2008-08-21 | Eisai R & D Management Co., Ltd. | メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩 |
| CN101687818B (zh) * | 2007-02-19 | 2012-08-22 | 卫材R&D管理有限公司 | 甲基n-[3-(6,7-二甲氧基-2-甲氨基喹唑啉-4-基)苯基]对氨羰基苯甲酸的结晶、无定形物或盐 |
| CN101687819B (zh) | 2007-08-17 | 2013-03-20 | 卫材R&D管理有限公司 | 外用剂 |
| CN102336717B (zh) * | 2007-08-17 | 2013-09-18 | 卫材R&D管理有限公司 | 喹唑啉衍生物 |
| WO2014133020A1 (ja) * | 2013-02-28 | 2014-09-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
| EP3463366A4 (en) * | 2016-06-07 | 2020-01-08 | Dermavant Sciences GmbH | TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND METHODS OF USE THEREOF |
| KR20200097297A (ko) * | 2017-12-07 | 2020-08-18 | 더마반트 사이언시즈 게엠베하 | Pde-4 억제제의 국소 연고 제형 및 피부 병태 치료에서의 이의 용도 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0474126T3 (es) | 1990-09-04 | 1997-04-07 | Fujisawa Pharmaceutical Co | |
| US6115962A (en) * | 1994-03-31 | 2000-09-12 | Southpac Trust International, Inc. | Sleeve for covering a flower pot |
| JP3466305B2 (ja) | 1994-12-12 | 2003-11-10 | 久光製薬株式会社 | 溶解剤および該溶解剤を含有する外用製剤 |
| AU4342997A (en) | 1996-09-13 | 1998-04-02 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
| AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
| JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
| JP3373838B2 (ja) | 1999-10-25 | 2003-02-04 | 山之内製薬株式会社 | ナフチリジン誘導体 |
| AR029185A1 (es) | 1999-10-25 | 2003-06-18 | Yamanouchi Pharma Co Ltd | Derivado de naftiridina |
| CN101491520B (zh) | 2002-05-28 | 2011-03-16 | 尼科梅德有限责任公司 | 局部应用的药物制剂 |
| US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| JP4387717B2 (ja) | 2003-07-11 | 2009-12-24 | 株式会社資生堂 | 油中水型皮膚外用医薬品製剤 |
| US20060258703A1 (en) | 2003-07-17 | 2006-11-16 | Ono Pharmaceutical Co., Ltd. | Remedy for pruritus comprising piperidine derivative as the active ingredient |
| JP2005047909A (ja) | 2003-07-17 | 2005-02-24 | Santen Pharmaceut Co Ltd | ピペリジン誘導体を有効成分とする掻痒治療剤 |
| WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
| JP2008137892A (ja) | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | 止痒剤 |
| AU2007218725B2 (en) | 2006-02-21 | 2011-12-01 | Eisai R & D Management Co., Ltd. | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative |
| WO2008099887A1 (ja) | 2007-02-16 | 2008-08-21 | Eisai R & D Management Co., Ltd. | メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩 |
-
2007
- 2007-02-20 AU AU2007218725A patent/AU2007218725B2/en not_active Ceased
- 2007-02-20 CN CN2007800061130A patent/CN101389612B/zh not_active Expired - Fee Related
- 2007-02-20 PL PL07714569T patent/PL1992622T3/pl unknown
- 2007-02-20 MX MX2008010774A patent/MX2008010774A/es active IP Right Grant
- 2007-02-20 EP EP07714569A patent/EP1992622B1/en active Active
- 2007-02-20 CA CA2637573A patent/CA2637573C/en active Active
- 2007-02-20 WO PCT/JP2007/053066 patent/WO2007097317A1/ja active Application Filing
- 2007-02-20 US US11/707,904 patent/US7939540B2/en active Active
- 2007-02-21 SA SA7280059A patent/SA07280059B1/ar unknown
-
2008
- 2008-07-01 ZA ZA200805756A patent/ZA200805756B/xx unknown
- 2008-09-18 NO NO20083980A patent/NO332976B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20083980L (no) | 2008-11-20 |
| WO2007097317A1 (ja) | 2007-08-30 |
| CA2637573A1 (en) | 2007-08-30 |
| CN101389612A (zh) | 2009-03-18 |
| EP1992622B1 (en) | 2011-07-27 |
| SA07280059B1 (ar) | 2010-11-02 |
| MX2008010774A (es) | 2008-09-01 |
| PL1992622T3 (pl) | 2012-01-31 |
| CN101389612B (zh) | 2011-09-21 |
| EP1992622A4 (en) | 2009-05-06 |
| AU2007218725B2 (en) | 2011-12-01 |
| US7939540B2 (en) | 2011-05-10 |
| AU2007218725A1 (en) | 2007-08-30 |
| CA2637573C (en) | 2013-07-02 |
| EP1992622A1 (en) | 2008-11-19 |
| US20070299094A1 (en) | 2007-12-27 |
| ZA200805756B (en) | 2009-04-29 |
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