NO330010B1 - Nye derivater av pyridyletanol (fenyl-etyl) aminer som inhibitorer av kolesterolbiosyntese, fremgangsmater for deres fremstilling, anvendelse av forbindelsene og farmasoytiske preparater som inneholder dem - Google Patents

Nye derivater av pyridyletanol (fenyl-etyl) aminer som inhibitorer av kolesterolbiosyntese, fremgangsmater for deres fremstilling, anvendelse av forbindelsene og farmasoytiske preparater som inneholder dem Download PDF

Info

Publication number
NO330010B1
NO330010B1 NO20050833A NO20050833A NO330010B1 NO 330010 B1 NO330010 B1 NO 330010B1 NO 20050833 A NO20050833 A NO 20050833A NO 20050833 A NO20050833 A NO 20050833A NO 330010 B1 NO330010 B1 NO 330010B1
Authority
NO
Norway
Prior art keywords
formula
compounds
pyridyl
ethanol
group
Prior art date
Application number
NO20050833A
Other languages
English (en)
Norwegian (no)
Other versions
NO20050833L (no
Inventor
Breda Rode
Damjana Rozman
Klementina Fon Tacer
Darko Kocjan
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200200177A external-priority patent/SI21268A/sl
Priority claimed from SI200200287A external-priority patent/SI21368A/sl
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of NO20050833L publication Critical patent/NO20050833L/no
Publication of NO330010B1 publication Critical patent/NO330010B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20050833A 2002-07-17 2005-02-16 Nye derivater av pyridyletanol (fenyl-etyl) aminer som inhibitorer av kolesterolbiosyntese, fremgangsmater for deres fremstilling, anvendelse av forbindelsene og farmasoytiske preparater som inneholder dem NO330010B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200200177A SI21268A (sl) 2002-07-17 2002-07-17 Novi derivati piridiletanol (feniletil) aminov kot inhibitorjev biosinteze holesterola, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo
SI200200287A SI21368A (sl) 2002-11-28 2002-11-28 Novi derivati piridiletanol (feniletil) aminov kot inhibitorjev biosinteze holesterola, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo
PCT/SI2003/000021 WO2004007456A1 (en) 2002-07-17 2003-07-09 Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
NO20050833L NO20050833L (no) 2005-04-18
NO330010B1 true NO330010B1 (no) 2011-02-07

Family

ID=30117598

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050833A NO330010B1 (no) 2002-07-17 2005-02-16 Nye derivater av pyridyletanol (fenyl-etyl) aminer som inhibitorer av kolesterolbiosyntese, fremgangsmater for deres fremstilling, anvendelse av forbindelsene og farmasoytiske preparater som inneholder dem

Country Status (16)

Country Link
US (1) US7560474B2 (pl)
EP (1) EP1546105A1 (pl)
JP (1) JP4567448B2 (pl)
KR (1) KR100645412B1 (pl)
CN (1) CN1297540C (pl)
AU (1) AU2003248614B2 (pl)
BR (1) BR0312945A (pl)
CA (1) CA2493004A1 (pl)
EC (1) ECSP055546A (pl)
IL (1) IL166191A (pl)
MX (1) MXPA05000663A (pl)
NO (1) NO330010B1 (pl)
NZ (1) NZ537635A (pl)
PL (1) PL373429A1 (pl)
RU (1) RU2309949C2 (pl)
WO (1) WO2004007456A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3328365A1 (en) * 2015-07-31 2018-06-06 Laboratorios Del. Dr. Esteve, S.A. Use of sigma receptor ligands in dyslipidemia
EP3838287A3 (en) 2016-07-27 2021-07-28 Case Western Reserve University Compounds and methods of promoting myelination
EP3810777A4 (en) 2018-06-21 2022-03-30 Yumanity Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786846A (en) * 1953-06-01 1957-03-26 Reilly Tar & Chem Corp Process of alkylating pyridines
US2792403A (en) * 1955-01-05 1957-05-14 Univ Michigan 2-pyridylethyl-phenylethylalkylamines
NL6707290A (pl) * 1966-05-28 1967-11-29
GB1417029A (en) * 1973-03-07 1975-12-10 Pfizer Ltd Quinazoline-derived amines
JPS5840539B2 (ja) * 1976-03-31 1983-09-06 大塚製薬株式会社 α−置換アミノアルカノイルオキシインド−ル誘導体
DE2817494A1 (de) * 1977-05-03 1978-11-09 Continental Pharma Aminoalkohol-derivat
ZA821436B (en) * 1981-03-06 1983-02-23 Beecham Group Plc Secondary amines
CA1287061C (en) * 1986-06-27 1991-07-30 Roche Holding Ltd. Pyridine ethanolamine derivatives
ZA874449B (en) * 1986-06-27 1987-12-28 F. Hoffmann-La Roche & Co. Aktiengesellschaft Pyridine ethanolamine derivatives
DE3729284A1 (de) * 1987-09-02 1989-03-23 Thomae Gmbh Dr K Neue heteroarylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
GB2305665A (en) * 1995-09-26 1997-04-16 Merck & Co Inc Selective ß3 agonists for the treatment of diabetes aand obesity
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
AUPP796798A0 (en) * 1998-12-30 1999-01-28 Fujisawa Pharmaceutical Co., Ltd. New compound
DZ3493A1 (fr) * 2001-03-29 2002-10-10 Lilly Co Eli N-(2-arylethyl)benzylamines comme antagonistes du recepteur 5-ht6

Also Published As

Publication number Publication date
AU2003248614A1 (en) 2004-02-02
MXPA05000663A (es) 2005-09-20
ECSP055546A (es) 2005-05-30
US20050256172A1 (en) 2005-11-17
WO2004007456A1 (en) 2004-01-22
NZ537635A (en) 2006-11-30
RU2309949C2 (ru) 2007-11-10
CN1297540C (zh) 2007-01-31
EP1546105A1 (en) 2005-06-29
BR0312945A (pt) 2005-07-12
PL373429A1 (pl) 2005-08-22
CA2493004A1 (en) 2004-01-22
JP4567448B2 (ja) 2010-10-20
IL166191A (en) 2010-12-30
NO20050833L (no) 2005-04-18
RU2005104420A (ru) 2005-10-10
US7560474B2 (en) 2009-07-14
KR20050026480A (ko) 2005-03-15
CN1668594A (zh) 2005-09-14
KR100645412B1 (ko) 2006-11-15
IL166191A0 (en) 2006-01-15
JP2005538081A (ja) 2005-12-15
AU2003248614B2 (en) 2007-08-30

Similar Documents

Publication Publication Date Title
DK167439B1 (da) Phenyleddikesyrederivater eller salte deraf, laegemidler indeholdende disse forbindelser, anvendelse af forbindelserne til fremstilling af et laegemiddel, fremgangsmaade til fremstilling af et laegemiddel samt en fremgangsmaade til fremstilling af phenyleddikesyrederivaterne
JP3833116B2 (ja) ビフェニル誘導体、その製法及び薬剤としての使用
US20090018118A1 (en) Heterocyclic compounds
WO2013112323A1 (en) Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
WO1996004260A1 (en) Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes
JPH02250870A (ja) コレステロール生合成抑制性化合物
EP0742209A2 (en) A process for producing an optically active quinolinemevalonolactone and a process for producing an optically active quinolinemevalonic acid salt
NO330010B1 (no) Nye derivater av pyridyletanol (fenyl-etyl) aminer som inhibitorer av kolesterolbiosyntese, fremgangsmater for deres fremstilling, anvendelse av forbindelsene og farmasoytiske preparater som inneholder dem
NO179249B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 4,6- disubstituerte 2,3-dikarboksylsyreindolderivater
EP1490333B1 (en) New atorvastatin salts and pharmaceutical compositions containing them
SK287606B6 (sk) Derivát pyridín-1-oxidu, jeho použitie a spôsob jeho transformácie na farmaceuticky účinné zlúčeniny
EA017631B1 (ru) Кристаллическое основание транс-1-((1r,3s)-3-фенил-6-хлороиндан-1-ил)-3,3-диметилпиперазина
CN108473428B (zh) 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
US7851624B2 (en) Triol form of rosuvastatin and synthesis of rosuvastatin
CN115197117B (zh) 抑制金黄色葡萄球菌胱硫醚-γ-裂解酶的吲哚类衍生物
ZA200500122B (en) Nove derivatives of puridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them
EP0640072B1 (en) Derivatives of pyridine as hydroxylase and lyase inhibitors
JP3637974B2 (ja) ピロリジン誘導体
SI21368A (sl) Novi derivati piridiletanol (feniletil) aminov kot inhibitorjev biosinteze holesterola, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo
US20240294491A1 (en) Salt of heterocyclic compound with anti-malaria activity, and crystals thereof
EP1934182A1 (en) N-substituted pyridinone or pyrimidinone compounds useful as soluble epoxide hydrolase inhibitors
GB2271109A (en) Pharmaceutically active substituted alkylamine derivatives
JPH09255676A (ja) イソベンゾフラノン誘導体
CZ36898A3 (cs) 1-/2-(2,3-Dihydro-1H-inden-1-yl)ethyl/-4-(naft-1-yl)piperazinové deriváty, způsob jejich přípravy a jejich terapeutické použití
GB2026471A (en) Dihydropyridine compound, processes for preparation thereof and pharmaceutical composition of the same

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees