NO329926B1 - Farmasoytisk sammensetning og fremgangsmate for fremstilling derav - Google Patents
Farmasoytisk sammensetning og fremgangsmate for fremstilling derav Download PDFInfo
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- NO329926B1 NO329926B1 NO20022334A NO20022334A NO329926B1 NO 329926 B1 NO329926 B1 NO 329926B1 NO 20022334 A NO20022334 A NO 20022334A NO 20022334 A NO20022334 A NO 20022334A NO 329926 B1 NO329926 B1 NO 329926B1
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- Norway
- Prior art keywords
- carrier
- composition according
- metformin hydrochloride
- thiazolidinedione
- pharmaceutically acceptable
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9927120.7A GB9927120D0 (en) | 1999-11-16 | 1999-11-16 | Novel composition and use |
| GBGB9927119.9A GB9927119D0 (en) | 1999-11-16 | 1999-11-16 | Novel composition and use |
| GB0013236A GB0013236D0 (en) | 2000-05-31 | 2000-05-31 | Novel composition and use |
| GB0013240A GB0013240D0 (en) | 2000-05-31 | 2000-05-31 | Novel composition and use |
| PCT/GB2000/004368 WO2001035941A2 (fr) | 1999-11-16 | 2000-11-16 | Nouvelle composition et utilisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20022334D0 NO20022334D0 (no) | 2002-05-15 |
| NO20022334L NO20022334L (no) | 2002-07-09 |
| NO329926B1 true NO329926B1 (no) | 2011-01-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20022334A NO329926B1 (no) | 1999-11-16 | 2002-05-15 | Farmasoytisk sammensetning og fremgangsmate for fremstilling derav |
Country Status (40)
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| US (1) | US8236345B2 (fr) |
| EP (3) | EP1231918B1 (fr) |
| JP (2) | JP4865975B2 (fr) |
| KR (1) | KR100760063B1 (fr) |
| CN (1) | CN1222290C (fr) |
| AP (1) | AP1389A (fr) |
| AR (2) | AR030920A1 (fr) |
| AT (1) | ATE292466T1 (fr) |
| AU (3) | AU775654B2 (fr) |
| BG (1) | BG65616B1 (fr) |
| BR (1) | BR0015605A (fr) |
| CA (1) | CA2388846A1 (fr) |
| CO (1) | CO5300392A1 (fr) |
| CZ (1) | CZ302500B6 (fr) |
| DE (1) | DE60019329T2 (fr) |
| DK (1) | DK1231918T3 (fr) |
| DZ (1) | DZ3251A1 (fr) |
| EA (1) | EA004878B1 (fr) |
| ES (1) | ES2240199T3 (fr) |
| HK (1) | HK1049788B (fr) |
| HR (1) | HRP20020416B1 (fr) |
| HU (1) | HU229960B1 (fr) |
| IL (3) | IL149618A0 (fr) |
| MA (1) | MA25567A1 (fr) |
| ME (1) | ME00318B (fr) |
| MX (1) | MXPA02005005A (fr) |
| MY (1) | MY125516A (fr) |
| NO (1) | NO329926B1 (fr) |
| NZ (1) | NZ518946A (fr) |
| OA (1) | OA12513A (fr) |
| PE (1) | PE20011011A1 (fr) |
| PL (1) | PL200943B1 (fr) |
| PT (1) | PT1231918E (fr) |
| RS (1) | RS51343B (fr) |
| SI (1) | SI1231918T1 (fr) |
| SK (1) | SK286985B6 (fr) |
| TW (1) | TWI240626B (fr) |
| UA (1) | UA73150C2 (fr) |
| UY (1) | UY26439A1 (fr) |
| WO (1) | WO2001035941A2 (fr) |
Families Citing this family (39)
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| AU2001257456B2 (en) * | 2000-05-01 | 2006-02-09 | Aeropharm Technology, Inc. | A core formulation |
| EP1429740A4 (fr) * | 2001-07-10 | 2005-01-26 | Kos Life Sciences Inc | Formulation de noyau comprenant de la troglitazone et un biguanide |
| GB0203296D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
| WO2003105809A1 (fr) * | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Comprimes multicouche contenant des thiazolidinediones et des biguanides et procedes de production desdits comprimes |
| EP1552832A1 (fr) * | 2002-07-11 | 2005-07-13 | Takeda Pharmaceutical Company Limited | Procede de production d'une preparation recouverte |
| US8637512B2 (en) * | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| CA2499597C (fr) * | 2002-09-20 | 2012-01-17 | Unchalee Kositprapa | Nouvelle preparation pharmaceutique contenant un biguanide et un derive de la thiazolidinedione |
| US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| UA80991C2 (en) * | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| MXPA05007883A (es) | 2003-01-29 | 2005-09-21 | Takeda Pharmaceutical | Proceso para producir una preparacion recubierta. |
| FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
| EP1738754B1 (fr) | 2004-04-14 | 2015-07-15 | Takeda Pharmaceutical Company Limited | Preparation pharmaceutique solide |
| WO2006011397A1 (fr) * | 2004-07-27 | 2006-02-02 | Kowa Company., Ltd. | Médicament pour la prévention ou le traitement du diabète |
| WO2006118137A1 (fr) | 2005-04-26 | 2006-11-09 | Dainippon Sumitomo Pharma Co., Ltd. | Préparation granulaire contenant un dérivé de biguanide |
| MY149306A (en) | 2005-12-22 | 2013-08-30 | Takeda Pharmaceutical | Solid preparation containing an insulin sensitizer |
| FR2896159B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
| WO2008078390A1 (fr) | 2006-12-26 | 2008-07-03 | Fujitsu Limited | Dispositif de compression et de restauration de données |
| TW201350143A (zh) | 2007-02-01 | 2013-12-16 | Takeda Pharmaceutical | 固體型製劑 |
| PL2120878T3 (pl) | 2007-02-09 | 2015-01-30 | Alphapharm Pty Ltd | Postać dawkowania zawierająca dwa czynne składniki farmaceutyczne o różnych postaciach fizycznych |
| TR200803177A2 (tr) * | 2008-05-06 | 2009-11-23 | Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş. | Antihiperglisemik etkili metformîn - pioglitazon formülasyonu. |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| CN102177436B (zh) | 2008-08-12 | 2015-05-13 | 金帆德尔制药股份有限公司 | 鉴定疾病风险因子的方法 |
| FR2951945B1 (fr) * | 2009-11-05 | 2013-08-09 | Sanofi Aventis | Composition pharmaceutique |
| ES2689107T3 (es) * | 2009-11-13 | 2018-11-08 | Astrazeneca Ab | Formulaciones de tabletas bicapa |
| EP2441442A1 (fr) | 2010-10-08 | 2012-04-18 | LEK Pharmaceuticals d.d. | Composition pharmaceutique comprenant un thiazolidinedione |
| EA039943B1 (ru) | 2011-01-07 | 2022-03-30 | Анджи Фарма (Юс) Элэлси | Способ снижения уровней глюкозы в крови у субъекта |
| US9480663B2 (en) | 2011-01-07 | 2016-11-01 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| US9572784B2 (en) | 2011-01-07 | 2017-02-21 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US8796338B2 (en) | 2011-01-07 | 2014-08-05 | Elcelyx Therapeutics, Inc | Biguanide compositions and methods of treating metabolic disorders |
| US11759441B2 (en) | 2011-01-07 | 2023-09-19 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
| SG191399A1 (en) | 2011-01-10 | 2013-08-30 | Zinfandel Pharmaceuticals Inc | Methods and drug products for treating alzheimer's disease |
| EP2800562A2 (fr) | 2012-01-06 | 2014-11-12 | Elcelyx Therapeutics, Inc. | Compositions et procédés de traitement de troubles métaboliques |
| JP2015503582A (ja) | 2012-01-06 | 2015-02-02 | エルセリクス セラピューティクス インコーポレイテッド | ビグアナイド組成物および代謝障害を治療する方法 |
| CN108451923A (zh) * | 2018-05-31 | 2018-08-28 | 常州兰陵制药有限公司 | 盐酸二甲双胍速释胶囊及其制备方法 |
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| JPS4613596Y1 (fr) * | 1969-06-02 | 1971-05-14 | ||
| DE2347531A1 (de) * | 1973-09-21 | 1975-04-30 | Hoechst Ag | Arzneizubereitungen zur oralen diabetes-behandlung |
| DE3856378T2 (de) * | 1987-09-04 | 2000-05-11 | Beecham Group Plc | Substituierte Thiazolidindionderivate |
| US4999226A (en) | 1988-06-01 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination |
| JPH0553521A (ja) | 1991-08-28 | 1993-03-05 | Mitsubishi Electric Corp | オートトラツキング型ｃｒｔデイスプレイモニタ |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| IT1255522B (it) | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| US6183778B1 (en) | 1993-09-21 | 2001-02-06 | Jagotec Ag | Pharmaceutical tablet capable of liberating one or more drugs at different release rates |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| DE19539361A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
| GB9612496D0 (en) | 1996-06-14 | 1996-08-14 | De La Rue Thomas & Co Ltd | Security device |
| PE71699A1 (es) | 1997-02-07 | 1999-08-03 | Sepracor Inc | Composicion farmaceutica de descarboetoxiloratadina sin lactosa, no higroscopica y anhidra |
| US20020004515A1 (en) | 1997-06-18 | 2002-01-10 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and metformin |
| KR20060105005A (ko) * | 1997-06-18 | 2006-10-09 | 스미스클라인비이참피이엘시이 | 티아졸리딘디온 및 메트포르민을 사용한 당뇨병의 치료 |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| AP1224A (en) | 1998-03-19 | 2003-11-14 | Bristol Myers Squibb Co | Biphasic controlled release delivery system for high solubility pharmaceuticals and method. |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US6117451A (en) * | 1998-08-25 | 2000-09-12 | Pharmalogix, Inc. | Direct compression metformin hydrochloride tablets |
| GB9824893D0 (en) | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US20040081697A1 (en) | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20040102486A1 (en) | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| AR023700A1 (es) | 1998-11-12 | 2002-09-04 | Smithkline Beecham Plc | Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina |
| DE69939485D1 (de) | 1998-11-12 | 2008-10-16 | Smithkline Beecham Plc | Arzneimittel zur gesteuerten freisetzung eines insulin sensibilisators und metformin |
| WO2001035940A2 (fr) | 1999-11-16 | 2001-05-25 | Smithkline Beecham P.L.C. | Nouvelle composition et utilisation |
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| US6296874B1 (en) | 2000-05-01 | 2001-10-02 | Aeropharm Technology Incorporated | Core formulation comprising troglitazone and abiguanide |
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| US6451342B2 (en) | 2000-05-01 | 2002-09-17 | Aeropharm Technology Incorporated | Core formulation comprised of troglitazone and a biguanide |
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| GB0318824D0 (en) | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
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2000
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2003
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2004
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