SI1231918T1 - Novel composition based on a thiazolidinedione and metformin and use - Google Patents

Novel composition based on a thiazolidinedione and metformin and use

Info

Publication number
SI1231918T1
SI1231918T1 SI200030697T SI200030697T SI1231918T1 SI 1231918 T1 SI1231918 T1 SI 1231918T1 SI 200030697 T SI200030697 T SI 200030697T SI 200030697 T SI200030697 T SI 200030697T SI 1231918 T1 SI1231918 T1 SI 1231918T1
Authority
SI
Slovenia
Prior art keywords
thiazolidinedione
metformin
composition based
novel composition
novel
Prior art date
Application number
SI200030697T
Other languages
English (en)
Inventor
Karen Lewis
Nicola Jayne Lilliott
Donald MACKENZIE
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1231918(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en
Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en
Priority claimed from GB0013236A external-priority patent/GB0013236D0/en
Priority claimed from GB0013240A external-priority patent/GB0013240D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI1231918T1 publication Critical patent/SI1231918T1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SI200030697T 1999-11-16 2000-11-16 Novel composition based on a thiazolidinedione and metformin and use SI1231918T1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9927120.7A GB9927120D0 (en) 1999-11-16 1999-11-16 Novel composition and use
GBGB9927119.9A GB9927119D0 (en) 1999-11-16 1999-11-16 Novel composition and use
GB0013236A GB0013236D0 (en) 2000-05-31 2000-05-31 Novel composition and use
GB0013240A GB0013240D0 (en) 2000-05-31 2000-05-31 Novel composition and use
PCT/GB2000/004368 WO2001035941A2 (fr) 1999-11-16 2000-11-16 Nouvelle composition et utilisation
EP00976156A EP1231918B1 (fr) 1999-11-16 2000-11-16 Nouvelle composition a base de thiazolidinedione et de metformine et son utilisation

Publications (1)

Publication Number Publication Date
SI1231918T1 true SI1231918T1 (en) 2005-08-31

Family

ID=27447849

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030697T SI1231918T1 (en) 1999-11-16 2000-11-16 Novel composition based on a thiazolidinedione and metformin and use

Country Status (40)

Country Link
US (1) US8236345B2 (fr)
EP (3) EP1520581A1 (fr)
JP (2) JP4865975B2 (fr)
KR (1) KR100760063B1 (fr)
CN (1) CN1222290C (fr)
AP (1) AP1389A (fr)
AR (2) AR030920A1 (fr)
AT (1) ATE292466T1 (fr)
AU (3) AU775654B2 (fr)
BG (1) BG65616B1 (fr)
BR (1) BR0015605A (fr)
CA (1) CA2388846A1 (fr)
CO (1) CO5300392A1 (fr)
CZ (1) CZ302500B6 (fr)
DE (1) DE60019329T2 (fr)
DK (1) DK1231918T3 (fr)
DZ (1) DZ3251A1 (fr)
EA (1) EA004878B1 (fr)
ES (1) ES2240199T3 (fr)
HK (1) HK1049788B (fr)
HR (1) HRP20020416B1 (fr)
HU (1) HU229960B1 (fr)
IL (3) IL149618A0 (fr)
MA (1) MA25567A1 (fr)
ME (1) ME00318B (fr)
MX (1) MXPA02005005A (fr)
MY (1) MY125516A (fr)
NO (1) NO329926B1 (fr)
NZ (1) NZ518946A (fr)
OA (1) OA12513A (fr)
PE (1) PE20011011A1 (fr)
PL (1) PL200943B1 (fr)
PT (1) PT1231918E (fr)
RS (1) RS51343B (fr)
SI (1) SI1231918T1 (fr)
SK (1) SK286985B6 (fr)
TW (1) TWI240626B (fr)
UA (1) UA73150C2 (fr)
UY (1) UY26439A1 (fr)
WO (1) WO2001035941A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1278513B1 (fr) * 2000-05-01 2007-07-18 Aeropharm Technology, LLC Formulation de noyaux
CA2453782A1 (fr) * 2001-07-10 2003-01-23 Kos Life Sciences, Inc. Formulation de noyau comprenant de la troglitazone et un biguanide
GB0203296D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
WO2003105809A1 (fr) * 2002-06-17 2003-12-24 Themis Laboratories Private Limited Comprimes multicouche contenant des thiazolidinediones et des biguanides et procedes de production desdits comprimes
AU2003281181A1 (en) * 2002-07-11 2004-02-02 Takeda Pharmaceutical Company Limited Process for producing coated preparation
US8637512B2 (en) * 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
EP2604266A1 (fr) * 2002-09-20 2013-06-19 Andrx Labs Llc Nouvelle formulation pharmaceutique contenant un biguanide et dérivé de thiazolidinedione
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) * 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
MXPA05007883A (es) 2003-01-29 2005-09-21 Takeda Pharmaceutical Proceso para producir una preparacion recubierta.
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
CA2562391A1 (fr) * 2004-04-14 2005-10-27 Takeda Pharmaceutical Company Limited Preparation pharmaceutique solide
JPWO2006011397A1 (ja) * 2004-07-27 2008-05-01 興和株式会社 糖尿病の予防または治療のための薬剤
WO2006118137A1 (fr) 2005-04-26 2006-11-09 Dainippon Sumitomo Pharma Co., Ltd. Préparation granulaire contenant un dérivé de biguanide
EP1962811B1 (fr) 2005-12-22 2016-04-27 Takeda Pharmaceutical Company Limited Préparation solide contenant un sensibilisateur à l'insuline
FR2896159B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
JP4893750B2 (ja) 2006-12-26 2012-03-07 富士通株式会社 データ圧縮装置およびデータ復元装置
JP5284968B2 (ja) 2007-02-01 2013-09-11 武田薬品工業株式会社 アログリプチンおよびピオグリタゾンを含有する固形製剤
WO2008095263A1 (fr) 2007-02-09 2008-08-14 Alphapharm Pty Ltd Forme pharmaceutique contenant deux ou davantage de principes actifs pharmaceutiques sous des formes physiques différentes
TR200803177A2 (tr) * 2008-05-06 2009-11-23 Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş. Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
EP2789695B1 (fr) 2008-08-12 2019-10-30 Zinfandel Pharmaceuticals, Inc. Traitement de la maladie d'Alzheimer des sujets identifiés en détectant la présence d'un variant génétique dans le gène TOMM40 en rs 1052423
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
FR2951945B1 (fr) * 2009-11-05 2013-08-09 Sanofi Aventis Composition pharmaceutique
PT2498758T (pt) * 2009-11-13 2018-10-23 Astrazeneca Uk Ltd Formulações de comprimido bicamada
EP2441442A1 (fr) 2010-10-08 2012-04-18 LEK Pharmaceuticals d.d. Composition pharmaceutique comprenant un thiazolidinedione
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US11974971B2 (en) 2011-01-07 2024-05-07 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
SI2661266T1 (sl) 2011-01-07 2021-01-29 Anji Pharma (Us) Llc Terapije, na osnovi kemosenzoričnih receptorskih ligandov
US9480663B2 (en) 2011-01-07 2016-11-01 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
GEP201706786B (en) 2011-01-10 2017-12-11 Takeda Pharmaceuticals Co Methods and drug products for treating alzheimer's disease
MX2014008190A (es) 2012-01-06 2015-02-04 Elcelyx Therapeutics Inc Composiciones de biguanida y métodos para tratar transtornos metabólicos.
MX2014008189A (es) 2012-01-06 2015-02-12 Elcelyx Therapeutics Inc Composiciones y metodos para tratar trastornos metabolicos.
CN108451923A (zh) * 2018-05-31 2018-08-28 常州兰陵制药有限公司 盐酸二甲双胍速释胶囊及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4613596Y1 (fr) * 1969-06-02 1971-05-14
DE2347531A1 (de) * 1973-09-21 1975-04-30 Hoechst Ag Arzneizubereitungen zur oralen diabetes-behandlung
DE3856378T2 (de) * 1987-09-04 2000-05-11 Beecham Group Plc Substituierte Thiazolidindionderivate
US4999226A (en) 1988-06-01 1991-03-12 Merrell Dow Pharmaceuticals Inc. Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination
JPH0553521A (ja) 1991-08-28 1993-03-05 Mitsubishi Electric Corp オートトラツキング型crtデイスプレイモニタ
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US6183778B1 (en) 1993-09-21 2001-02-06 Jagotec Ag Pharmaceutical tablet capable of liberating one or more drugs at different release rates
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
DE19539361A1 (de) 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
GB9612496D0 (en) 1996-06-14 1996-08-14 De La Rue Thomas & Co Ltd Security device
PE71699A1 (es) 1997-02-07 1999-08-03 Sepracor Inc Composicion farmaceutica de descarboetoxiloratadina sin lactosa, no higroscopica y anhidra
US20020004515A1 (en) 1997-06-18 2002-01-10 Smith Stephen Alistair Treatment of diabetes with thiazolidinedione and metformin
DE122007000054I1 (de) * 1997-06-18 2007-12-13 Smithkline Beecham Plc Behandlung der Diabetes mit Thiazolidindione und metformin
GB9715295D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6117451A (en) * 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
GB9824893D0 (en) 1998-11-12 1999-01-06 Smithkline Beckman Corp Novel method of treatment
AR023700A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Plc Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
US20040102486A1 (en) 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
SK287038B6 (sk) 1998-11-12 2009-10-07 Smithkline Beecham Plc Farmaceutický prostriedok na postupné uvoľňovanie 5-[4-[2-(N- metyl-N-(2-pyridyl)amino)etoxy]benzyl]tiazolidín-2,4-diónu a metformínu a spôsob jeho výroby
US20040081697A1 (en) 1998-11-12 2004-04-29 Smithkline Beecham P.L.C. Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
JP2003514011A (ja) 1999-11-16 2003-04-15 スミスクライン ビーチャム パブリック リミテッド カンパニー チアゾリジンジオン−塩酸メトホルミンを含む医薬組成物
US6451342B2 (en) 2000-05-01 2002-09-17 Aeropharm Technology Incorporated Core formulation comprised of troglitazone and a biguanide
US6780432B1 (en) 2000-05-01 2004-08-24 Aeropharm Technology, Inc. Core formulation
US6461639B2 (en) 2000-05-01 2002-10-08 Aeropharm Technology, Inc. Core formulation
US6403121B1 (en) 2000-05-01 2002-06-11 Aeropharm Technology Incorporated Core formulation
US6524621B2 (en) 2000-05-01 2003-02-25 Aeropharm Technology Inc. Core formulation
US6296874B1 (en) 2000-05-01 2001-10-02 Aeropharm Technology Incorporated Core formulation comprising troglitazone and abiguanide
GB0318824D0 (en) 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition

Also Published As

Publication number Publication date
SK6792002A3 (en) 2002-09-10
WO2001035941A2 (fr) 2001-05-25
ES2240199T3 (es) 2005-10-16
US8236345B2 (en) 2012-08-07
BG65616B1 (bg) 2009-03-31
CA2388846A1 (fr) 2001-05-25
IL149618A (en) 2008-07-08
HU229960B1 (hu) 2015-03-30
CN1222290C (zh) 2005-10-12
EP1231918B1 (fr) 2005-04-06
AP2002002505A0 (en) 2002-06-30
DE60019329T2 (de) 2006-03-09
MY125516A (en) 2006-08-30
UA73150C2 (uk) 2005-06-15
DE60019329D1 (de) 2005-05-12
MXPA02005005A (es) 2003-10-14
NO20022334L (no) 2002-07-09
WO2001035941A8 (fr) 2002-08-29
HUP0204122A2 (hu) 2003-03-28
KR20030019300A (ko) 2003-03-06
HRP20020416B1 (en) 2011-04-30
JP4865975B2 (ja) 2012-02-01
HK1049788A1 (en) 2003-05-30
EP1913945A3 (fr) 2008-04-30
DK1231918T3 (da) 2005-08-01
DZ3251A1 (fr) 2001-05-25
ME00318B (fr) 2011-05-10
HRP20020416A2 (en) 2004-08-31
PE20011011A1 (es) 2001-10-28
CO5300392A1 (es) 2003-07-31
YU38802A (sh) 2005-03-15
PT1231918E (pt) 2005-08-31
TWI240626B (en) 2005-10-01
HUP0204122A3 (en) 2006-01-30
HK1049788B (zh) 2005-11-04
BR0015605A (pt) 2002-07-09
AU2008207375A1 (en) 2008-09-11
JP2011252007A (ja) 2011-12-15
CN1414852A (zh) 2003-04-30
NZ518946A (en) 2003-10-31
AU775654B2 (en) 2004-08-12
JP2003514012A (ja) 2003-04-15
EP1231918A2 (fr) 2002-08-21
KR100760063B1 (ko) 2007-09-18
AR030920A1 (es) 2003-09-03
EA200200571A1 (ru) 2002-12-26
JP5282130B2 (ja) 2013-09-04
AU2004226955A1 (en) 2004-12-02
AP1389A (en) 2005-04-14
ATE292466T1 (de) 2005-04-15
EP1520581A1 (fr) 2005-04-06
SK286985B6 (sk) 2009-08-06
UY26439A1 (es) 2001-07-31
EA004878B1 (ru) 2004-08-26
CZ302500B6 (cs) 2011-06-22
AU2004226955B2 (en) 2008-08-28
BG106747A (en) 2003-01-31
WO2001035941A3 (fr) 2002-05-23
IL190220A0 (en) 2008-11-03
PL355331A1 (en) 2004-04-19
AU1404001A (en) 2001-05-30
NO20022334D0 (no) 2002-05-15
RS51343B (sr) 2011-02-28
MA25567A1 (fr) 2002-10-01
US20070275054A1 (en) 2007-11-29
MEP34008A (en) 2011-02-10
EP1913945A2 (fr) 2008-04-23
AR057970A2 (es) 2007-12-26
NO329926B1 (no) 2011-01-24
PL200943B1 (pl) 2009-02-27
OA12513A (en) 2006-05-29
IL149618A0 (en) 2002-12-01

Similar Documents

Publication Publication Date Title
SI1231918T1 (en) Novel composition based on a thiazolidinedione and metformin and use
IL149359A0 (en) Novel antidiabetic agents
ZA200203368B (en) Pharmaceutical composition comprising a combination of metformin and glibenclamide.
IL146110A0 (en) Thiazolidinedione derivative and its use as antidiabetic
HUP0202855A3 (en) New herbicidal compositions and use thereof
GB9900227D0 (en) Use of a composition
IL146115A0 (en) Thiazolidinedione derivative and its use as antidiabetic
EG22491A (en) Rest-breaking composition and use thereof
AP2001002331A0 (en) Thiazolidinedione derivative and its use as antidiabetic
HUP0104388A3 (en) Combinations comprising a betha-agonist and a further antidiabetic agent
IL146077A0 (en) Thiazolidinedione derivative and its use as antidiabetic
EP1241257A4 (fr) Polypeptides de type tachykinine et utilisation associee
IL155140A0 (en) A thiazolidinedione derivatives and its use as antidiabetic
GB9916754D0 (en) A composition
GB9911606D0 (en) Composition and use
HUP0500955A3 (en) Cucurbitacin-containing insecticidal composition and a process for its use
SI1325000T1 (sl) Derivat tiazolidindiona in njegova uporaba kot antidiabetik
EG24062A (en) Novel composition and use
SI1173434T1 (en) Thiazolidinedione derivative and its use as antidiabetic
GB9922474D0 (en) Novel composition and use
GB9912193D0 (en) Novel composition and use
GB9927121D0 (en) Novel composition and use
GB9912191D0 (en) Novel composition and use
GB9912190D0 (en) Novel composition and use
GB9912189D0 (en) Novel composition and use