NO329700B1 - Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav - Google Patents

Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav Download PDF

Info

Publication number
NO329700B1
NO329700B1 NO20045301A NO20045301A NO329700B1 NO 329700 B1 NO329700 B1 NO 329700B1 NO 20045301 A NO20045301 A NO 20045301A NO 20045301 A NO20045301 A NO 20045301A NO 329700 B1 NO329700 B1 NO 329700B1
Authority
NO
Norway
Prior art keywords
dimethyl
prop
compound
group
formula
Prior art date
Application number
NO20045301A
Other languages
English (en)
Norwegian (no)
Other versions
NO20045301L (no
Inventor
Karine Caumont-Bertrand
Jamila Najib
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of NO20045301L publication Critical patent/NO20045301L/no
Publication of NO329700B1 publication Critical patent/NO329700B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
NO20045301A 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav NO329700B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208571A FR2841900B1 (fr) 2002-07-08 2002-07-08 Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
PCT/FR2003/002127 WO2004005233A1 (fr) 2002-07-08 2003-07-08 Derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations

Publications (2)

Publication Number Publication Date
NO20045301L NO20045301L (no) 2005-02-04
NO329700B1 true NO329700B1 (no) 2010-12-06

Family

ID=29725283

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045301A NO329700B1 (no) 2002-07-08 2004-12-03 Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav

Country Status (24)

Country Link
US (3) US7943661B2 (pl)
EP (1) EP1525177B1 (pl)
JP (1) JP4575771B2 (pl)
KR (1) KR100974577B1 (pl)
CN (1) CN100548960C (pl)
AT (1) ATE365703T1 (pl)
AU (1) AU2003264698B2 (pl)
BR (1) BRPI0312398B8 (pl)
CA (1) CA2490986C (pl)
CY (1) CY1108085T1 (pl)
DE (1) DE60314633T2 (pl)
DK (1) DK1525177T3 (pl)
EA (1) EA011090B1 (pl)
ES (1) ES2287528T3 (pl)
FR (1) FR2841900B1 (pl)
IL (2) IL165696A0 (pl)
MX (1) MXPA05000427A (pl)
NO (1) NO329700B1 (pl)
NZ (1) NZ538051A (pl)
PL (1) PL207362B1 (pl)
PT (1) PT1525177E (pl)
SI (1) SI1525177T1 (pl)
WO (1) WO2004005233A1 (pl)
ZA (1) ZA200501082B (pl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
EA011305B1 (ru) * 2004-01-08 2009-02-27 Жанфит Производные 1,3-дифенилпроп-2-ен-1-она, способ их получения и применение
FR2902789A1 (fr) 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
US20100285126A1 (en) * 2007-08-02 2010-11-11 Rahul Dabre Pharmaceutical compositions of fenofibrate
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
JP5833016B2 (ja) * 2009-11-26 2015-12-16 ジェンフィGenfit 肝障害を処置するための1,3−ジフェニルプロパ−2−エン−1−オン誘導体の使用
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
AU2011254670B2 (en) 2010-05-17 2014-09-25 Genfit Improved preparation of chalcone derivatives
TWI415600B (zh) * 2011-08-10 2013-11-21 Univ Kaohsiung Medical 用於治療動脈粥狀硬化的組合物及其製備方法
US9115073B2 (en) 2011-12-28 2015-08-25 Genfit 1,3-diphenylpropane derivatives, preparations and uses thereof
CN102697757B (zh) * 2012-05-18 2014-06-04 广州军区广州总医院 对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用
CA2897258C (en) 2013-01-18 2021-02-02 Genfit Methods of treatment of fibrosis and cancers
US10442761B2 (en) 2016-02-16 2019-10-15 Concert Pharmaceuticals, Inc. Deuterated GFT-505
AU2017242819B2 (en) * 2016-03-31 2022-06-30 Genfit Methods of treatment of cholestatic diseases
FR3056909B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Composition comprenant au moins un sel pharmaceutiquement acceptable d'elafibranor soluble en milieux aqueux presentant une absorption intestinale amelioree
FR3056908B1 (fr) 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
EP3554503B1 (en) * 2016-12-16 2023-10-04 The Board of Regents of The University of Texas System Inhibitors of bromodomain-containing protein 4 (brd4)
EP3572399A4 (en) * 2017-01-22 2020-01-22 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF GFT-505 AND METHOD OF PREPARING AND USING THE SAME
KR20190117632A (ko) 2017-02-21 2019-10-16 장피트 Ppar 효현제와 fxr 효현제의 병용
US11590108B2 (en) 2017-02-24 2023-02-28 Genfit Pharmaceutical compositions for combination therapy
MX2019012535A (es) 2017-04-18 2020-08-17 Genfit Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).
CN108658908B (zh) 2017-07-31 2019-05-10 广州必贝特医药技术有限公司 1,3-二取代烯酮类化合物及其应用
US11465967B2 (en) 2017-08-04 2022-10-11 Advitech Advisory And Technologies Sa Process for the preparation of elafibranor and novel synthesis intermediates
US20200276178A1 (en) 2017-09-13 2020-09-03 Novartis Ag Combinations comprising fxr agonists
US20200283381A1 (en) 2017-11-16 2020-09-10 Teva Pharmaceuticals International Gmbh Solid state forms of elafibranor
US11332457B2 (en) 2017-11-30 2022-05-17 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Aromatic compound, pharmaceutical composition and use thereof
EP3514541A1 (de) * 2018-01-17 2019-07-24 Siemens Healthcare Diagnostics Products GmbH Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
WO2019186410A1 (en) * 2018-03-27 2019-10-03 Lupin Limited Solid forms of elafibranor and processes thereof
TW202019870A (zh) * 2018-08-03 2020-06-01 法商Genfit公司 艾拉菲諾鹽
WO2020039297A1 (en) * 2018-08-24 2020-02-27 Mankind Pharma Ltd. Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof
WO2020115628A1 (en) * 2018-12-03 2020-06-11 Mankind Pharma Ltd. Solid forms of elafibranor and process of preparation thereof
CN110156648A (zh) * 2019-05-30 2019-08-23 河北科技大学 一种Elafibranor中间体的制备方法
AU2020376223A1 (en) 2019-10-28 2022-06-02 Genfit Combination therapy having antioxydant properties
CN112824380A (zh) * 2019-11-21 2021-05-21 杭州百诚医药科技股份有限公司 α-氟代查耳酮类衍生物及其应用
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法
AU2021219286A1 (en) 2020-02-10 2022-09-22 Genfit Polymorphs of elafibranor
CN114901641A (zh) * 2020-02-28 2022-08-12 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
CA3176020A1 (en) 2020-05-18 2021-11-25 Alice Roudot Elafibranor for the treatment of primary sclerosing cholangitis
EP4203934A1 (en) 2020-08-26 2023-07-05 Genfit Compositions and methods for the treatment of primary biliary cholangitis
CN113230240B (zh) * 2021-03-22 2022-12-27 广州医科大学 1,3-二苯基丙-2-烯-1-酮衍生物及其应用
CN114853686B (zh) 2021-08-23 2023-06-20 中国药科大学 三氮唑酮类化合物及其医药用途
CN115894379A (zh) 2022-01-20 2023-04-04 中国药科大学 海因类化合物及其医药用途
WO2024184365A1 (en) 2023-03-06 2024-09-12 Genfit Solid dosage forms of elafibranor
CN118363355B (zh) * 2024-06-19 2024-08-30 武汉名实生物医药科技有限责任公司 一种产品生产实时监控系统

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558612A (en) * 1968-05-22 1971-01-26 Dow Chemical Co Substituted phenoxyacetic acids
CH593224A5 (pl) * 1973-10-30 1977-11-30 Taisho Pharmaceutical Co Ltd
US3994955A (en) * 1975-01-20 1976-11-30 G. D. Searle & Co. Substituted phenoxydialkylacetic acids and esters
JPS5278856A (en) 1975-12-26 1977-07-02 Taisho Pharmaceut Co Ltd Preparation of chalcone ethers
US4190671A (en) * 1977-03-17 1980-02-26 Biorex Laboratories Limited Chalcone derivatives
JPS5419947A (en) 1977-07-16 1979-02-15 Taisho Pharmaceut Co Ltd Chalcone derivatives
GB8426424D0 (en) * 1984-10-19 1984-11-28 Biorex Laboratories Ltd Chalcone derivatives
JPS6310720A (ja) 1986-07-01 1988-01-18 Nippon Kayaku Co Ltd 5−リポキシゲナ−ゼ阻害剤および抗アレルギ−剤
JPH023670A (ja) * 1988-06-22 1990-01-09 Nippon Oil & Fats Co Ltd アルキルチオカルコン誘導体
CA2003856C (en) * 1988-11-25 1996-01-30 Toshio Satoh Therapeutic agent for renal disorders
JPH0442229A (ja) * 1990-06-08 1992-02-12 Fujitsu Ltd レジスト材料およびパターンの形成方法
JPH05255655A (ja) 1992-03-12 1993-10-05 Kanebo Ltd 紫外線吸収剤
JPH06122623A (ja) 1992-10-09 1994-05-06 Minofuaagen Seiyaku Honpo:Goushi 抗腫瘍剤
US5276058A (en) * 1993-06-09 1994-01-04 Nippon Hypox Laboratories Incorporated 3,4-dihydroxychalcone derivatives
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
WO1998027970A2 (en) * 1996-12-24 1998-07-02 National Research Council Of Canada Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals
EP0947511A1 (en) 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity
WO2000023073A1 (en) 1998-10-20 2000-04-27 Korea Institute Of Science And Technology Bioflavonoids as plasma high density lipoprotein level increasing agent
AU2001228825A1 (en) * 2000-01-27 2001-08-07 Takara Bio Inc. Remedies
MXPA02012660A (es) 2000-06-20 2004-05-14 Atherogenics Inc 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1.
EP1254759B1 (de) 2001-05-03 2009-03-18 Leister Process Technologies Düse zum Schweissen von Kunststoffbahnen oder -folien
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2857361B1 (fr) * 2003-07-08 2005-09-09 Genfit S A PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
EA011305B1 (ru) * 2004-01-08 2009-02-27 Жанфит Производные 1,3-дифенилпроп-2-ен-1-она, способ их получения и применение

Also Published As

Publication number Publication date
US20050176808A1 (en) 2005-08-11
KR20050025327A (ko) 2005-03-14
DK1525177T3 (da) 2007-10-22
DE60314633T2 (de) 2008-02-28
BRPI0312398B8 (pt) 2021-05-25
US20070032543A1 (en) 2007-02-08
MXPA05000427A (es) 2005-09-30
BR0312398A (pt) 2005-04-12
JP2005532385A (ja) 2005-10-27
FR2841900B1 (fr) 2007-03-02
CN1668565A (zh) 2005-09-14
EA011090B1 (ru) 2008-12-30
US7943661B2 (en) 2011-05-17
JP4575771B2 (ja) 2010-11-04
WO2004005233A1 (fr) 2004-01-15
AU2003264698B2 (en) 2009-09-17
US7566737B2 (en) 2009-07-28
CA2490986C (fr) 2012-09-18
EP1525177A1 (fr) 2005-04-27
PT1525177E (pt) 2007-09-06
DE60314633D1 (de) 2007-08-09
PL372809A1 (pl) 2005-08-08
US20110190515A1 (en) 2011-08-04
CY1108085T1 (el) 2014-02-12
ZA200501082B (en) 2007-01-31
US8058308B2 (en) 2011-11-15
BRPI0312398B1 (pt) 2016-11-08
NZ538051A (en) 2007-11-30
AU2003264698A1 (en) 2004-01-23
FR2841900A1 (fr) 2004-01-09
SI1525177T1 (sl) 2007-10-31
CA2490986A1 (fr) 2004-01-15
ES2287528T3 (es) 2007-12-16
IL165696A (en) 2012-09-24
EA200500169A1 (ru) 2005-06-30
KR100974577B1 (ko) 2010-08-06
EP1525177B1 (fr) 2007-06-27
CN100548960C (zh) 2009-10-14
IL165696A0 (en) 2006-01-15
NO20045301L (no) 2005-02-04
ATE365703T1 (de) 2007-07-15
PL207362B1 (pl) 2010-12-31

Similar Documents

Publication Publication Date Title
NO329700B1 (no) Substituerte 1,3-diphenylprop-2-en-1-one derivat og farmasoytiskepreparater derav, samt fremgangsmate til fremstilling derav
US8461212B2 (en) Composition based on substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof
JP2006517954A (ja) アシルグリセロール並びにその窒素−及び硫黄含有類似物の治療上の使用
US7253296B2 (en) Acylated aminopropanediols and analogues and therapeutic uses thereof
FR2864956A1 (fr) Compose derive de 1,3-diphenylprop-2-en-1-one, preparation et utilisations

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees