MX2019012535A - Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc). - Google Patents

Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).

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Publication number
MX2019012535A
MX2019012535A MX2019012535A MX2019012535A MX2019012535A MX 2019012535 A MX2019012535 A MX 2019012535A MX 2019012535 A MX2019012535 A MX 2019012535A MX 2019012535 A MX2019012535 A MX 2019012535A MX 2019012535 A MX2019012535 A MX 2019012535A
Authority
MX
Mexico
Prior art keywords
elafibranor
acc
acetyl
inhibitor
combination
Prior art date
Application number
MX2019012535A
Other languages
English (en)
Inventor
Benoît Noel
Emeline Descamps
Robert Walczak
Vanessa Legry
Guillaume Vidal
Mathilde Walczak
Carole Belange
Isabelle Delbaere
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of MX2019012535A publication Critical patent/MX2019012535A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un producto de combinación y a su uso en terapia.
MX2019012535A 2017-04-18 2018-04-18 Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc). MX2019012535A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305452 2017-04-18
EP18305150 2018-02-13
PCT/EP2018/059969 WO2018193007A1 (en) 2017-04-18 2018-04-18 Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor

Publications (1)

Publication Number Publication Date
MX2019012535A true MX2019012535A (es) 2020-08-17

Family

ID=61972154

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019012535A MX2019012535A (es) 2017-04-18 2018-04-18 Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).
MX2019012534A MX2019012534A (es) 2017-04-18 2018-04-18 Combinacion de elafibranor o derivados del mismo con un agente anti-ehna, antifibrotico o anticolestasico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019012534A MX2019012534A (es) 2017-04-18 2018-04-18 Combinacion de elafibranor o derivados del mismo con un agente anti-ehna, antifibrotico o anticolestasico.

Country Status (13)

Country Link
US (2) US11478440B2 (es)
EP (2) EP3612175A1 (es)
JP (2) JP7266531B2 (es)
KR (1) KR102699958B1 (es)
CN (2) CN110536682B (es)
AU (2) AU2018254743B2 (es)
BR (2) BR112019021910A2 (es)
CA (2) CA3057940A1 (es)
IL (1) IL269829B (es)
MX (2) MX2019012535A (es)
PH (1) PH12019502348A1 (es)
SG (1) SG11201909168VA (es)
WO (2) WO2018193006A1 (es)

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EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
US12053445B2 (en) * 2016-03-31 2024-08-06 Genfit Methods of treatment of cholestatic diseases
WO2018094265A2 (en) 2016-11-21 2018-05-24 Viking Therapeutics, Inc. Method of treating glycogen storage disease
MX2019011867A (es) 2017-04-03 2020-01-09 Coherus Biosciences Inc Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva.
MX2019012535A (es) 2017-04-18 2020-08-17 Genfit Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).
CA3064940A1 (en) 2017-06-05 2018-12-13 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
US11542256B2 (en) 2017-09-03 2023-01-03 Angion Biomedica Corp. Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors
WO2019071216A1 (en) 2017-10-06 2019-04-11 Gilead Sciences, Inc. POLYTHERAPY COMPRISING AN ACC INHIBITOR
BR112021010916A2 (pt) * 2018-12-05 2021-08-24 Viking Therapeutics, Inc. Composições e métodos para tratamento de distúrbios hepáticos
EP3890747A4 (en) * 2018-12-05 2022-08-03 Viking Therapeutics, Inc. COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND INFLAMMATION
CN113348178A (zh) * 2019-01-28 2021-09-03 枫叶生物技术有限公司 用于治疗肺、肾或肝的纤维化疾病的psmp拮抗剂
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